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Target Details

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Name:U-plasminogen activator
Uniprot name:UROK_HUMAN
Accession Numbers:P00749 Q15844 Q16618 Q5SWW9 Q969W6
EC-Number:3.4.21.73
Organism:Homo sapiens
Human
PDB IDs:1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt52941953BindingDB-show
()-oxazepam hemisuccinate sodium salt52945600BindingDB-show
(R)-MEXILETINE180621BindingDB-show
1c5n1747BindingDB-show
1ghw5326545BindingDB-show
1gi95326549BindingDB-show
1o2g447476BindingDB-show
1o2h447478BindingDB-show
1o3h447508BindingDB-show
1o3p5326663BindingDB-show
1owi447734BindingDB-show
2-(2-hydroxyphenyl)-1H-indole-5-carboximidamide1508BindingDB-show
2-AMINO-5-HYDROXY-BENZIMIDAZOLE6323183DrugBank-show
2-aminoquinolin-8-ol4653788BindingDB-show
2-Iminobenzimidazoline13624BindingDB-show
2IN448548BindingDB-show
3-amidinophenylalanine deriv., 135289531DrugBank-show
3-amidinophenylalanine deriv., 359895193BindingDB-show
3-[2-(naphthalen-2-ylsulfonylamino)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl4713329BindingDB-show
4-ABI134348BindingDB-show
5-Amidinoindole122670BindingDB-show
6-carbamimidoyl-N-phenylnaphthalene-2-carboxamide447732BindingDB-show
6-carbamimidoyl-N-phenylnaphthalene-2-carboxamide447732DrugBank-show
6-Chloro-2-(2-Hydroxybiphenyl-3-yl)-1H-Indole-5-Carboxamidine445844BindingDB-show
6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDIN5326553BindingDB-show
6-[N-(1-ISOPROPYL-1,2,3,4-TETRAHYDRO-7-ISOQUINOLINYL)CARBAMYL]-2-NAPHTHALENECARBOXAMIDINE447736DrugBank-show
6-[N-(1-ISOPROPYL-3,4-DIHYDRO-7-ISOQUINOLINYL)CARBAMYL]-2-NAPHTHALENECARBOXAMIDINE447735BindingDB-show
6-[N-(1-ISOPROPYL-3,4-DIHYDRO-7-ISOQUINOLINYL)CARBAMYL]-2-NAPHTHALENECARBOXAMIDINE447735DrugBank-show
6-[N-(4-ETHYL-1,2,3,4-TETRAHYDRO-6-ISOQUINOLINYL)CARBAMYL]-2-NAPHTHALENECARBOXAMIDINE447731DrugBank-show
7-methoxy-8-(1-methylsulfonylpyrazol-4-yl)naphthalene-2-carboximidamide5289529BindingDB-show
7-methoxy-8-(1-methylsulfonylpyrazol-4-yl)naphthalene-2-carboximidamide5289529DrugBank-show
7IN449051BindingDB-show
8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE448610BindingDB-show
8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE448610DrugBank-show
AC1L9UDU456168BindingDB-show
AC1LA1M0459983BindingDB-show
AC1LA1M3459984BindingDB-show
AC1MV8RA3729024BindingDB-show
AC1NAE504475489BindingDB-show
AC1NAE534475490BindingDB-show
AC1NFSP04713320BindingDB-show
AC1NFSP94713323BindingDB-show
AC1NFSRR4713353BindingDB-show
AC1NFSRX4713355BindingDB-show
AC1NFSS04713356BindingDB-show
AC1NFSSR4713365BindingDB-show
AC1NFSSU4713366BindingDB-show
AC1NFSTC4713372BindingDB-show
AC1NFSVO4713404BindingDB-show
AC1NFSWL4713415BindingDB-show
AC1NFSX04713420BindingDB-show
AC1NS0VS5326676BindingDB-show
AC1NS0WF5326684BindingDB-show
AC1NS41B5353305BindingDB-show
AIDS2146923010979BindingDB-show
AIDS21469210126451BindingDB-show
BABIM2387BindingDB-show
Benzenecarboximidamide2332BindingDB-show
Benzenecarboximidamide2332DrugBank-show
beta-hydroxytricarballylic acid311SuperTarget-show
beta-Naphthamidine193409BindingDB-show
CCRIS 4360162636BindingDB-show
Celecoxib2662PROMISCUOUSPMID 16172791show
CHEBI:26425025791491BindingDB-show
CHEBI:26456444331670BindingDB-show
CHEBI:26463240425143BindingDB-show
CHEBI:26465434033704BindingDB-show
CHEBI:26466740424187BindingDB-show
CHEBI:26466844331714BindingDB-show
CHEBI:26466940492822BindingDB-show
CHEBI:26468544331722BindingDB-show
CHEBI:26473523278020BindingDB-show
CHEBI:26474736688502BindingDB-show
CHEBI:26477023278021BindingDB-show
CHEBI:26477225775500BindingDB-show
CHEBI:26478744331765BindingDB-show
CHEBI:26481136688401BindingDB-show
CHEBI:28732644341827BindingDB-show
CHEBI:65227744366338BindingDB-show
CHEBI:65377144285971BindingDB-show
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CHEBI:65377244286269BindingDB-show
CHEBI:65377245266266BindingDB-show
CHEBI:65380644285948BindingDB-show
CHEBI:65380645266296BindingDB-show
CHEMBL10029644331823BindingDB-show
CHEMBL10102744294210BindingDB-show
CHEMBL10106720229530BindingDB-show
CHEMBL10126112459438BindingDB-show
CHEMBL10134329012033BindingDB-show
CHEMBL10155944332049BindingDB-show
CHEMBL10172644331576BindingDB-show
CHEMBL10187818545754BindingDB-show
CHEMBL10200944331672BindingDB-show
CHEMBL10214144331643BindingDB-show
CHEMBL10263144334703BindingDB-show
CHEMBL10406410116936BindingDB-show
CHEMBL10421110225952BindingDB-show
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CHEMBL10539510294146BindingDB-show
CHEMBL10587544336996BindingDB-show
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CHEMBL12469215230351BindingDB-show
CHEMBL12515311824584BindingDB-show
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CID 1031122110624997BindingDB-show
CID 1057828010578280BindingDB-show
CID 1120034610200844BindingDB-show
CID 1124761610181581BindingDB-show
CID 1130783711317532BindingDB-show
CID 471331710816339BindingDB-show
CID 47133274713327BindingDB-show
CID 47133574713357BindingDB-show
CID 53266655326665BindingDB-show
CID 53266695326669BindingDB-show
CID 53266715326671BindingDB-show
CID 53266715326696BindingDB-show
CID 53266905326690BindingDB-show
CID 98951939895194BindingDB-show
CID 993610410815545BindingDB-show
CID1101099511010995BindingDB-show
cyanoguanidine, 344249821BindingDB-show
Dibromopropamidine11974BindingDB-show
FERRIC CITRATE61300SuperTarget-show
Ferric citrate170848SuperTarget-show
FUCOSE439554DrugBank-show
Gallium citrate34058SuperTarget-show
Grassystatin A44255320BindingDB-show
Guanamprazine16231BindingDB-show
Guanamprazine16231DrugBank-show
Guanamprazine16231SuperTarget2 PMIDsshow
Hexamidine65130BindingDB-show
Iodohexamidine dihydrochloride411406BindingDB-show
KBio2_0075702757788BindingDB-show
N-(1-ADAMANTYL)-N'-(4-GUANIDINOBENZYL)UREA4286DrugBank-show
n-(4-carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide4300BindingDB-show
n-(4-carbamimidoyl-phenyl)-2-hydroxy-benzamide4301BindingDB-show
N-[4-(aminomethyl)phenyl]-6-carbamimidoyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide448605BindingDB-show
N-[4-(aminomethyl)phenyl]-6-carbamimidoyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide448605DrugBank-show
N-[4-(aminomethyl)phenyl]-6-carbamimidoylnaphthalene-2-carboxamide447733BindingDB-show
N-[4-(aminomethyl)phenyl]-6-carbamimidoylnaphthalene-2-carboxamide447733DrugBank-show
NSC305825432298BindingDB-show
p-Guanidinobenzoic acid159772BindingDB-show
para-aminobenzamidine1725BindingDB-show
Phenylguanidine16157BindingDB-show
Silibinin5213PROMISCUOUSPMID 16169542show
TRANS-6-(2-PHENYLCYCLOPROPYL)-NAPHTHALENE-2-CARBOXAMIDINE448841DrugBank-show
UK-3562029885167BindingDB-show
ZINC015651961549310BindingDB-show
ZINC039840656338670BindingDB-show
ZINC047729893621643BindingDB-show
Synonyms:
U-plasminogen activator
uPA
Urokinase-type plasminogen activator
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
Q5PY49_HUMAN95.495.4
UROK_MOUSE8269.1
Q59GZ8_HUMAN47.346.9
TPA_HUMAN4332.8
B8ZX62_HUMAN42.832.8
TRY3_HUMAN3625.5
Q96SE8_HUMAN35.535.5
FA9_HUMAN34.122
FA10_HUMAN33.922.6
TRY2_CANFA33.822.9
FA10_BOVIN33.222.6
PROC_HUMAN32.823.4
TRY1_HUMAN32.122.2
THRB_HUMAN32.122
FA7_HUMAN32.121.8
TRY2_MOUSE3220.7
CTRA_BOVIN31.519.5
CP4AA_RAT31.117
PROZ_HUMAN31.118.8
KLK1_HUMAN3119.3
CELA1_PIG30.919.3
KLK2_HORSE30.919.3
TRY1_BOVIN30.821.3
KLK2_RAT30.619.7
Q86UC5_HUMAN30.617.1
TRYB2_HUMAN30.520.3
G3PG_LEIME30.417.6
THRB_BOVIN30.420.2
Q6FHY0_HUMAN30.416.9
PRTN3_HUMAN30.319.3
Protein-Protein Interactions: