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Target Details

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Name:Thymidylate synthase
Uniprot name:TYSY_LACCA
Accession Numbers:P00469
EC-Number:2.1.1.45
Organism:Lactobacillus casei
PDB IDs:1BO7 1BO8 1BP0 1BP6 1BPJ 1JMF 1JMG 1JMH 1JMI 1LCA 1LCB 1LCE 1NJA 1NJB 1NJC 1NJD 1NJE 1TDA 1TDB 1TDC 1THY 1TSL 1TSM 1TSV 1TSW 1TSX 1TSY 1TSZ 1TVU 1TVV 1TVW 1VZA 1VZB 1VZC 1VZD 1VZE 2G86 2G89 2G8A 2G8D 2TDD 2TDM 3BNZ 3BYX 3BZ0 3C06 3C0A 4TMS
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID443388BindingDB-show
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID443388DrugBank-show
1ci7444827BindingDB-show
2-amino-4-(naphthalen-2-ylcarbamoyl)butanoic Acid4178003BindingDB-show
3-[4-(1,2,4-oxadiazol-3-yl)phenyl]-1-phenylurea51049471BindingDB-show
4-CHLORO-3',3"-DIBROMOPHENOL-1,8-NAPHTHALEIN5288329BindingDB-show
4-[[GLUTAMIC ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINE445505BindingDB-show
5,10-METHYLENE-6-HYDROFOLIC ACID6323520DrugBank-show
7-(benzenesulfonyl)quinazoline-2,4-diamine51049470BindingDB-show
7-Deazaguanine96253BindingDB-show
A156448780BindingDB-show
AC1LABD5484977BindingDB-show
AC1MUNZI3643891BindingDB-show
CB 37171405BindingDB-show
CHEBI:11529644269940BindingDB-show
CHEBI:11529744269942BindingDB-show
CHEBI:11532944269955BindingDB-show
CHEBI:11540444269996BindingDB-show
CHEBI:11540744269999BindingDB-show
CHEBI:11541144270005BindingDB-show
CHEBI:11543144270018BindingDB-show
CHEBI:11545544270028BindingDB-show
CHEBI:11546144270032BindingDB-show
CHEBI:11548444270046BindingDB-show
CHEBI:11549144270051BindingDB-show
CHEBI:11554544270073BindingDB-show
CHEBI:11555244270078BindingDB-show
CHEBI:47462544421556BindingDB-show
CHEMBL12463113912572BindingDB-show
CHEMBL17084613691236BindingDB-show
CHEMBL17087419427206BindingDB-show
CHEMBL17148010073043BindingDB-show
CHEMBL17327113912571BindingDB-show
CHEMBL17944844388301BindingDB-show
CHEMBL19263224737646BindingDB-show
CHEMBL19327510456691BindingDB-show
CHEMBL21487216086914BindingDB-show
CHEMBL21513316086913BindingDB-show
CHEMBL21656016086912BindingDB-show
CHEMBL21667516086918BindingDB-show
CHEMBL21722716086919BindingDB-show
CHEMBL21776016086916BindingDB-show
CHEMBL21776510478775BindingDB-show
CHEMBL22327911744008BindingDB-show
CHEMBL2263210457291BindingDB-show
CHEMBL26789044308904BindingDB-show
CHEMBL2931489939145BindingDB-show
CHEMBL29927310676316BindingDB-show
CHEMBL30189511801983BindingDB-show
CHEMBL30206814503207BindingDB-show
CHEMBL36033544388300BindingDB-show
CHEMBL36075844388306BindingDB-show
CHEMBL36260644388299BindingDB-show
CHEMBL36530744398808BindingDB-show
CHEMBL38529623648073BindingDB-show
CHEMBL38589123648076BindingDB-show
CHEMBL38628223648074BindingDB-show
CHEMBL38644216086911BindingDB-show
CHEMBL38668516086910BindingDB-show
CHEMBL38700723648075BindingDB-show
CHEMBL41187116086917BindingDB-show
CHEMBL42569244388290BindingDB-show
CHEMBL43135914503206BindingDB-show
CHEMBL45818424796668BindingDB-show
CHEMBL46366824796666BindingDB-show
CHEMBL46589024203444BindingDB-show
CHEMBL46589124204260BindingDB-show
CHEMBL51065244567483BindingDB-show
CHEMBL51458924796533BindingDB-show
CHEMBL51718224796667BindingDB-show
CHEMBL51807624796532BindingDB-show
CHEMBL5543710438585BindingDB-show
CHEMBL5726910699998BindingDB-show
CHEMBL6638913844742BindingDB-show
CHEMBL6686414186429BindingDB-show
CHEMBL6901613844740BindingDB-show
CHEMBL8964114523666BindingDB-show
CID 1043851010651164BindingDB-show
CID 986792110478474BindingDB-show
CID 987440610651909BindingDB-show
CID 99322769932276BindingDB-show
Dansyl derivatives 11A, (S) isomer51049478BindingDB-show
Dansyl derivatives 12A, (S) isomer51049479BindingDB-show
Dansyl derivatives 14A, (S) isomer51049480BindingDB-show
Dansyl derivatives 15A, (S) isomer51049481BindingDB-show
Dansyl derivatives 16A, (S) isomer51049482BindingDB-show
Dansyl derivatives 17A, (S) isomer51049483BindingDB-show
Dansyl derivatives 19A, (S) isomer51049484BindingDB-show
Dansyl derivatives 20A, (S) isomer51049485BindingDB-show
Dansyl derivatives 22A, (S) isomer9797801BindingDB-show
Dansyl derivatives 3A, (S) isomer51049472BindingDB-show
Dansyl derivatives 4A, (S) isomer51049473BindingDB-show
Dansyl derivatives 5A, (S) isomer51049474BindingDB-show
Dansyl derivatives 6A, (S) isomer51049475BindingDB-show
Dansyl derivatives 7A, (S) isomer51049476BindingDB-show
Dansyl derivatives 9A, (S) isomer51049477BindingDB-show
Dansylhydrazine94442BindingDB-show
Dansyltyrosine deriviative 10B51049495BindingDB-show
Dansyltyrosine deriviative 11B51049496BindingDB-show
Dansyltyrosine deriviative 12B51049497BindingDB-show
Dansyltyrosine deriviative 13B51049498BindingDB-show
Dansyltyrosine deriviative 14B51049499BindingDB-show
Dansyltyrosine deriviative 15B51049500BindingDB-show
Dansyltyrosine deriviative 16B51049501BindingDB-show
Dansyltyrosine deriviative 18B51049502BindingDB-show
Dansyltyrosine deriviative 19B51049503BindingDB-show
Dansyltyrosine deriviative 1B51049486BindingDB-show
Dansyltyrosine deriviative 20B51049504BindingDB-show
Dansyltyrosine deriviative 22B51049505BindingDB-show
Dansyltyrosine deriviative 23B51049506BindingDB-show
Dansyltyrosine deriviative 24B51049507BindingDB-show
Dansyltyrosine deriviative 25B51049508BindingDB-show
Dansyltyrosine deriviative 26B51049509BindingDB-show
Dansyltyrosine deriviative 27B51049510BindingDB-show
Dansyltyrosine deriviative 28B51049511BindingDB-show
Dansyltyrosine deriviative 29B51049512BindingDB-show
Dansyltyrosine deriviative 2B51049487BindingDB-show
Dansyltyrosine deriviative 30B51049513BindingDB-show
Dansyltyrosine deriviative 31B51049514BindingDB-show
Dansyltyrosine deriviative 32B51049515BindingDB-show
Dansyltyrosine deriviative 34B51049516BindingDB-show
Dansyltyrosine deriviative 3B51049488BindingDB-show
Dansyltyrosine deriviative 4B51049489BindingDB-show
Dansyltyrosine deriviative 5B51049490BindingDB-show
Dansyltyrosine deriviative 6B51049491BindingDB-show
Dansyltyrosine deriviative 7B51049492BindingDB-show
Dansyltyrosine deriviative 8B51049493BindingDB-show
Dansyltyrosine deriviative 9B51049494BindingDB-show
Deoxycytidylate13945DrugBank-show
Deoxyribosylthymine monophosphate9700DrugBank-show
deoxyuridylate65063DrugBank-show
FLUORODEOXYURIDYLATE8642DrugBank-show
Lometrexol1773BindingDB-show
Methylaminopterin4112BindingDB-show
Methylaminopterinum72440BindingDB-show
N,O-DIDANSYL-L-TYROSINE446468BindingDB-show
N-[4-[[GLUTAMIC ACID]-CARBONYL]-BENZENE-SULFONYL-D-PROLINYL]-3-AMINO-PROPANOIC ACID445506BindingDB-show
NSC719487403898BindingDB-show
NSC723742405953BindingDB-show
NSC724864406624BindingDB-show
Pemetrexed394493BindingDB-show
Pemetrexed446556BindingDB-show
URACIL1174PROMISCUOUSPMID 110931show
Uracil polynucleotides6030DrugBank-show
ZINC021607882796775BindingDB-show
Synonyms:
Thymidylate synthase
TS
TSase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
TYSY_LACC397.593
B3WE87_LACCB97.292.7
TYSY_ECOLI60.150.3
TYSY_PNECA56.741.5
TYSY_CANAL54.941.4
TYSY_RAT53.640.9
TYSY_HUMAN51.640.2
Q53FB7_HUMAN51.639.9
Q53Y97_HUMAN51.640.2
Q8WYK3_HUMAN46.636.4
TYSY1_BACSU46.131.8
Q8WYK4_HUMAN41.131.8
A85C_MYCTU3318.6
Q27552_CRYPV32.825.3
Q9KQU9_VIBCH32.216.6
O67040_AQUAE31.916.5
HLDD_ECOLI31.816.8
CYPC_BACSU31.619.6
QCR2_YEAST31.519.1
PDXK_MOUSE31.218.3
IOLS_BACSU31.218.6
O58376_PYRHO3117.9
Q8I372_PLAF73115.5
Q0P8G4_CAMJE30.716.4
PCY1B_HUMAN30.516.3
KAPA_YEAST30.517.8
NAGB_ECOLI30.217.2
PH4H_HUMAN30.219.4
BLAC_STAAU30.215.8
CARP2_CANAL29.917.6
Protein-Protein Interactions:
No data available