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Target Details

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Name:Thymidylate synthase
Uniprot name:TYSY_HUMAN
Accession Numbers:P04818
EC-Number:2.1.1.45
Organism:Homo sapiens
Human
PDB IDs:1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EGY 3EHI
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
1-(5-o-phosphonopentofuranosyl)-2,4(1h,3h)-pyrimidinedione1172BindingDB-show
10-Mddf99111BindingDB-show
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID443388BindingDB-show
10-Propargylaminopterin100093BindingDB-show
1ci7444827BindingDB-show
4-CHLORO-3',3"-DIBROMOPHENOL-1,8-NAPHTHALEIN5288329BindingDB-show
4-Psbai132151BindingDB-show
8-Deazafolic acid99100BindingDB-show
A156448780BindingDB-show
AC1L1CAX1816BindingDB-show
AC1L1CCF1834BindingDB-show
AC1L1FXT3439BindingDB-show
AC1L1I3Y4412BindingDB-show
AC1L2SYK127972BindingDB-show
AC1L8FKC425380BindingDB-show
AC1L99JE415410BindingDB-show
AC1LA0MN479428BindingDB-show
AC1LA4KH481401BindingDB-show
AC1LABD5484977BindingDB-show
AC1LABDF484980BindingDB-show
AC1LABDL484982BindingDB-show
AC1LI758899290BindingDB-show
AC1MUNZI3643891BindingDB-show
AC1NBM3S4470178BindingDB-show
AG 85 (pharmaceutical)127860BindingDB-show
Athylenglykol174DrugBank-show
CAPECITABINE60953DrugBank-show
CAPECITABINE60953SuperTarget-show
CB 37053080619BindingDB-show
CB 37171405BindingDB-show
CHEBI:10375744265270BindingDB-show
CHEBI:10391844265353BindingDB-show
CHEBI:11529644269940BindingDB-show
CHEBI:11529744269942BindingDB-show
CHEBI:11532944269955BindingDB-show
CHEBI:11540444269996BindingDB-show
CHEBI:11540744269999BindingDB-show
CHEBI:11541144270005BindingDB-show
CHEBI:11543144270018BindingDB-show
CHEBI:11545544270028BindingDB-show
CHEBI:11546144270032BindingDB-show
CHEBI:11548444270046BindingDB-show
CHEBI:11549144270051BindingDB-show
CHEBI:11554544270073BindingDB-show
CHEBI:11555244270078BindingDB-show
CHEBI:11769744270828BindingDB-show
CHEBI:12651244274408BindingDB-show
CHEBI:12654544274418BindingDB-show
CHEBI:16017944287507BindingDB-show
CHEBI:17131644292649BindingDB-show
CHEBI:17131744292651BindingDB-show
CHEBI:17146422041878BindingDB-show
CHEBI:17168544292781BindingDB-show
CHEBI:17528944294491BindingDB-show
CHEBI:17563944294631BindingDB-show
CHEBI:17564044294633BindingDB-show
CHEBI:17566844294647BindingDB-show
CHEBI:17599044294793BindingDB-show
CHEBI:18975844300722BindingDB-show
CHEBI:20529544307712BindingDB-show
CHEBI:20533544307730BindingDB-show
CHEBI:20540344307750BindingDB-show
CHEBI:36823744374791BindingDB-show
CHEBI:36849544374941BindingDB-show
CHEBI:36892044375142BindingDB-show
CHEBI:36896244375169BindingDB-show
CHEBI:47462544421556BindingDB-show
CHEMBL1066999889551BindingDB-show
CHEMBL109309925181586BindingDB-show
CHEMBL109310025218207BindingDB-show
CHEMBL109625946886831BindingDB-show
CHEMBL11498744341606BindingDB-show
CHEMBL11658944343888BindingDB-show
CHEMBL11733522852489BindingDB-show
CHEMBL11761144343544BindingDB-show
CHEMBL11768744343874BindingDB-show
CHEMBL12295910466947BindingDB-show
CHEMBL12323144347327BindingDB-show
CHEMBL12933044351700BindingDB-show
CHEMBL13242644354802BindingDB-show
CHEMBL13293444354681BindingDB-show
CHEMBL13327944355238BindingDB-show
CHEMBL13417044354724BindingDB-show
CHEMBL13461744354747BindingDB-show
CHEMBL13850044359486BindingDB-show
CHEMBL14032310782798BindingDB-show
CHEMBL14111844360333BindingDB-show
CHEMBL14186910683607BindingDB-show
CHEMBL14217610566619BindingDB-show
CHEMBL1459479931657BindingDB-show
CHEMBL15679544370299BindingDB-show
CHEMBL15770244374355BindingDB-show
CHEMBL15803414778726BindingDB-show
CHEMBL15854244374354BindingDB-show
CHEMBL15879044373966BindingDB-show
CHEMBL15914444374287BindingDB-show
CHEMBL15920944374302BindingDB-show
CHEMBL15921310367759BindingDB-show
CHEMBL15936444374554BindingDB-show
CHEMBL16021510073033BindingDB-show
CHEMBL16102544374552BindingDB-show
CHEMBL16145044374306BindingDB-show
CHEMBL16145744374210BindingDB-show
CHEMBL16156744373979BindingDB-show
CHEMBL16168544374228BindingDB-show
CHEMBL16207644374329BindingDB-show
CHEMBL1621459995228BindingDB-show
CHEMBL16249810334026BindingDB-show
CHEMBL16261310336554BindingDB-show
CHEMBL16275410646139BindingDB-show
CHEMBL16309610423208BindingDB-show
CHEMBL16341010360580BindingDB-show
CHEMBL1634119883283BindingDB-show
CHEMBL16353510038678BindingDB-show
CHEMBL16428910379992BindingDB-show
CHEMBL16456910062475BindingDB-show
CHEMBL16462410356519BindingDB-show
CHEMBL1654539973647BindingDB-show
CHEMBL16568310015079BindingDB-show
CHEMBL16602744377227BindingDB-show
CHEMBL16636944377254BindingDB-show
CHEMBL16716410052314BindingDB-show
CHEMBL16730444378321BindingDB-show
CHEMBL16806944378322BindingDB-show
CHEMBL16836710458720BindingDB-show
CHEMBL16852415131020BindingDB-show
CHEMBL16941144381789BindingDB-show
CHEMBL16950610255175BindingDB-show
CHEMBL16972615131024BindingDB-show
CHEMBL16972715131027BindingDB-show
CHEMBL16992115131017BindingDB-show
CHEMBL17105715131026BindingDB-show
CHEMBL17131415131018BindingDB-show
CHEMBL17148010073043BindingDB-show
CHEMBL17217615131023BindingDB-show
CHEMBL17944844388301BindingDB-show
CHEMBL19263224737646BindingDB-show
CHEMBL19327510456691BindingDB-show
CHEMBL19535511668389BindingDB-show
CHEMBL19557844401729BindingDB-show
CHEMBL19578244401979BindingDB-show
CHEMBL19586744401859BindingDB-show
CHEMBL19587444402132BindingDB-show
CHEMBL19623544402320BindingDB-show
CHEMBL19670644402113BindingDB-show
CHEMBL20161711659960BindingDB-show
CHEMBL20161811515277BindingDB-show
CHEMBL20194111552140BindingDB-show
CHEMBL20209811507922BindingDB-show
CHEMBL20217611717558BindingDB-show
CHEMBL20233711702789BindingDB-show
CHEMBL20249011589874BindingDB-show
CHEMBL2129420096270BindingDB-show
CHEMBL21487216086914BindingDB-show
CHEMBL21513316086913BindingDB-show
CHEMBL21656016086912BindingDB-show
CHEMBL21667516086918BindingDB-show
CHEMBL21722716086919BindingDB-show
CHEMBL21776016086916BindingDB-show
CHEMBL21776510478775BindingDB-show
CHEMBL2229044458290BindingDB-show
CHEMBL22327911744008BindingDB-show
CHEMBL2244944458272BindingDB-show
CHEMBL22486810480274BindingDB-show
CHEMBL22497410433635BindingDB-show
CHEMBL2270813888080BindingDB-show
CHEMBL2279313888079BindingDB-show
CHEMBL2359444458639BindingDB-show
CHEMBL2378444458576BindingDB-show
CHEMBL2459914256510BindingDB-show
CHEMBL2470114542115BindingDB-show
CHEMBL25213224742034BindingDB-show
CHEMBL25213324754835BindingDB-show
CHEMBL25213424754909BindingDB-show
CHEMBL25233824754676BindingDB-show
CHEMBL25358124754977BindingDB-show
CHEMBL25379524754677BindingDB-show
CHEMBL25379624754678BindingDB-show
CHEMBL2588910027953BindingDB-show
CHEMBL26424544298347BindingDB-show
CHEMBL27568515169667BindingDB-show
CHEMBL27846619870328BindingDB-show
CHEMBL27884710060600BindingDB-show
CHEMBL27973221795893BindingDB-show
CHEMBL28014544458588BindingDB-show
CHEMBL28257044278535BindingDB-show
CHEMBL2879922105246BindingDB-show
CHEMBL2882044278530BindingDB-show
CHEMBL2905317822395BindingDB-show
CHEMBL29081513942163BindingDB-show
CHEMBL29154811799891BindingDB-show
CHEMBL29381010358458BindingDB-show
CHEMBL2938239994347BindingDB-show
CHEMBL29487111723407BindingDB-show
CHEMBL29497344287188BindingDB-show
CHEMBL29681644292416BindingDB-show
CHEMBL2977310466996BindingDB-show
CHEMBL29986344295279BindingDB-show
CHEMBL30121810450905BindingDB-show
CHEMBL30125615131016BindingDB-show
CHEMBL30142310499440BindingDB-show
CHEMBL3018449845472BindingDB-show
CHEMBL30614944313275BindingDB-show
CHEMBL30723844313295BindingDB-show
CHEMBL30918423507870BindingDB-show
CHEMBL32138844336792BindingDB-show
CHEMBL32473944343873BindingDB-show
CHEMBL32493244343794BindingDB-show
CHEMBL32574444341618BindingDB-show
CHEMBL32597244343831BindingDB-show
CHEMBL33120810478920BindingDB-show
CHEMBL33340244343832BindingDB-show
CHEMBL33648744359357BindingDB-show
CHEMBL34897944373841BindingDB-show
CHEMBL34972310424058BindingDB-show
CHEMBL34996910404119BindingDB-show
CHEMBL35013010017531BindingDB-show
CHEMBL35140310401573BindingDB-show
CHEMBL35160610359087BindingDB-show
CHEMBL35183910265082BindingDB-show
CHEMBL3518409994788BindingDB-show
CHEMBL35188510020877BindingDB-show
CHEMBL35262015131028BindingDB-show
CHEMBL35319115131041BindingDB-show
CHEMBL35370015131021BindingDB-show
CHEMBL35381315131019BindingDB-show
CHEMBL35424944378252BindingDB-show
CHEMBL35561610369213BindingDB-show
CHEMBL35566210005752BindingDB-show
CHEMBL35656944360983BindingDB-show
CHEMBL36033544388300BindingDB-show
CHEMBL36075844388306BindingDB-show
CHEMBL36260644388299BindingDB-show
CHEMBL36445344401858BindingDB-show
CHEMBL36497544401747BindingDB-show
CHEMBL36530744398808BindingDB-show
CHEMBL3663944285361BindingDB-show
CHEMBL3667413942162BindingDB-show
CHEMBL36990611587749BindingDB-show
CHEMBL37010644402238BindingDB-show
CHEMBL37011611537068BindingDB-show
CHEMBL3706399994380BindingDB-show
CHEMBL37099244401890BindingDB-show
CHEMBL37100544402319BindingDB-show
CHEMBL37166611717559BindingDB-show
CHEMBL37169844401730BindingDB-show
CHEMBL37186010366939BindingDB-show
CHEMBL37191344402257BindingDB-show
CHEMBL37237111639604BindingDB-show
CHEMBL38141344401770BindingDB-show
CHEMBL38172311500463BindingDB-show
CHEMBL38382911594848BindingDB-show
CHEMBL38529623648073BindingDB-show
CHEMBL38589123648076BindingDB-show
CHEMBL38628223648074BindingDB-show
CHEMBL38644216086911BindingDB-show
CHEMBL38668516086910BindingDB-show
CHEMBL38700723648075BindingDB-show
CHEMBL38834011248241BindingDB-show
CHEMBL3890215747121BindingDB-show
CHEMBL38964310433577BindingDB-show
CHEMBL3917544287510BindingDB-show
CHEMBL40030424754609BindingDB-show
CHEMBL40036410471067BindingDB-show
CHEMBL40048510065888BindingDB-show
CHEMBL40107324754976BindingDB-show
CHEMBL40107424754978BindingDB-show
CHEMBL4085015747112BindingDB-show
CHEMBL41187116086917BindingDB-show
CHEMBL4145915747123BindingDB-show
CHEMBL41544744354910BindingDB-show
CHEMBL41692244458294BindingDB-show
CHEMBL4172229911276BindingDB-show
CHEMBL41769644287458BindingDB-show
CHEMBL41776311722523BindingDB-show
CHEMBL41876444278520BindingDB-show
CHEMBL41889423508039BindingDB-show
CHEMBL42328210025269BindingDB-show
CHEMBL42569244388290BindingDB-show
CHEMBL42930824754979BindingDB-show
CHEMBL4308729911146BindingDB-show
CHEMBL43498010402662BindingDB-show
CHEMBL43577844298406BindingDB-show
CHEMBL43676111667192BindingDB-show
CHEMBL44195844458306BindingDB-show
CHEMBL4437639952879BindingDB-show
CHEMBL44671424754675BindingDB-show
CHEMBL44954325107646BindingDB-show
CHEMBL45818424796668BindingDB-show
CHEMBL46366824796666BindingDB-show
CHEMBL46589024203444BindingDB-show
CHEMBL4694544292713BindingDB-show
CHEMBL47674424950542BindingDB-show
CHEMBL47674524950543BindingDB-show
CHEMBL47694524950852BindingDB-show
CHEMBL47715024950853BindingDB-show
CHEMBL47715124950854BindingDB-show
CHEMBL47756624950851BindingDB-show
CHEMBL47778924950539BindingDB-show
CHEMBL47779024950541BindingDB-show
CHEMBL47819124950695BindingDB-show
CHEMBL47819224950696BindingDB-show
CHEMBL47821324950694BindingDB-show
CHEMBL47840324950697BindingDB-show
CHEMBL47840424950698BindingDB-show
CHEMBL4823044292818BindingDB-show
CHEMBL4861944294862BindingDB-show
CHEMBL4902244295580BindingDB-show
CHEMBL49283610404647BindingDB-show
CHEMBL49283744568875BindingDB-show
CHEMBL49283825107644BindingDB-show
CHEMBL49283925107642BindingDB-show
CHEMBL49406725107577BindingDB-show
CHEMBL49512425107645BindingDB-show
CHEMBL49512525107643BindingDB-show
CHEMBL4965144294853BindingDB-show
CHEMBL51065244567483BindingDB-show
CHEMBL51421924950538BindingDB-show
CHEMBL51458924796533BindingDB-show
CHEMBL51531224950693BindingDB-show
CHEMBL51612824950699BindingDB-show
CHEMBL51689124950540BindingDB-show
CHEMBL51718224796667BindingDB-show
CHEMBL51807624796532BindingDB-show
CHEMBL52236344568860BindingDB-show
CHEMBL52251725107640BindingDB-show
CHEMBL53814344221146BindingDB-show
CHEMBL5483344298404BindingDB-show
CHEMBL55029644221346BindingDB-show
CHEMBL55076944221343BindingDB-show
CHEMBL55084244221347BindingDB-show
CHEMBL5516744298405BindingDB-show
CHEMBL55176844221340BindingDB-show
CHEMBL55198544221147BindingDB-show
CHEMBL5526311723304BindingDB-show
CHEMBL5536111779691BindingDB-show
CHEMBL55609144221345BindingDB-show
CHEMBL558849947879BindingDB-show
CHEMBL5600544298346BindingDB-show
CHEMBL56091244221145BindingDB-show
CHEMBL56321244221539BindingDB-show
CHEMBL56400444221144BindingDB-show
CHEMBL56427744221143BindingDB-show
CHEMBL56493744221344BindingDB-show
CHEMBL56517944221538BindingDB-show
CHEMBL5652310380195BindingDB-show
CHEMBL5661110358404BindingDB-show
CHEMBL5663710363363BindingDB-show
CHEMBL566629954209BindingDB-show
CHEMBL5697744300967BindingDB-show
CHEMBL5700215169677BindingDB-show
CHEMBL5733310780759BindingDB-show
CHEMBL5742010402730BindingDB-show
CHEMBL5744444300934BindingDB-show
CHEMBL5920310358405BindingDB-show
CHEMBL59667246231368BindingDB-show
CHEMBL59667346231370BindingDB-show
CHEMBL59668046231372BindingDB-show
CHEMBL59668146231373BindingDB-show
CHEMBL59788546231409BindingDB-show
CHEMBL59809046231411BindingDB-show
CHEMBL59829246231412BindingDB-show
CHEMBL59829346231413BindingDB-show
CHEMBL60210446231369BindingDB-show
CHEMBL60472246231410BindingDB-show
CHEMBL6063944300964BindingDB-show
CHEMBL60989646231371BindingDB-show
CHEMBL61198446231414BindingDB-show
CHEMBL6170810477651BindingDB-show
CHEMBL7322923507999BindingDB-show
CHEMBL7431123507843BindingDB-show
CHEMBL7477223507946BindingDB-show
CHEMBL7477323507995BindingDB-show
CHEMBL7527644313293BindingDB-show
CHEMBL7588844313235BindingDB-show
CHEMBL7634944313366BindingDB-show
CHEMBL783844265324BindingDB-show
CHEMBL9614844327287BindingDB-show
CHEMBL967115169697BindingDB-show
chlorcycloguanil9049BindingDB-show
CID 1002844610480639BindingDB-show
CID 1007491210255630BindingDB-show
CID 1099387010993870BindingDB-show
CID 1167188010146179BindingDB-show
CID 1182653311826533BindingDB-show
CID 986792110478474BindingDB-show
CID 99322769932276BindingDB-show
CID98470199847019BindingDB-show
Dansylhydrazine94442BindingDB-show
Deoxyfluorouridine5790DrugBank-show
Deoxyfluorouridine5790PROMISCUOUS2 PMIDsshow
Deoxyribosylthymine monophosphate9700DrugBank-show
deoxyuridylate65063DrugBank-show
Diaminopyritamin4993BindingDB-show
Dpmabg158351BindingDB-show
Dpmmabg158376BindingDB-show
Fluorouracilum3385DrugBank-show
Fluorouracilum3385PROMISCUOUS3 PMIDsshow
Fluorouracilum3385SuperTarget2 PMIDsshow
Gemcitabine stereoisomer60750DrugBank-show
Gemcitabine stereoisomer60750SuperTarget-show
GHC44201386BindingDB-show
GHW11248226BindingDB-show
GPB5288461BindingDB-show
GW184360863BindingDB-show
L-Cysteine, mercaptoethanol mixed disulfide170018DrugBank-show
LEUCOVORIN54575DrugBank-show
Leucovorin143DrugBank-show
Leucovorin6006DrugBank-show
LEUCOVORIN54575SuperTarget-show
Leucovorin143SuperTarget-show
Leucovorin6006SuperTarget-show
Methopterine92929BindingDB-show
Methylaminopterin4112BindingDB-show
Methylaminopterinum126941BindingDB-show
Methylaminopterinum72440BindingDB-show
Monothioethyleneglycol1567DrugBank-show
N,O-DIDANSYL-L-TYROSINE446468BindingDB-show
n-(4-{[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]amino}benzoyl)glutamic468708BindingDB-show
Nolatrexed108189BindingDB-show
NSC25082230335BindingDB-show
NSC330776332634BindingDB-show
NSC407817437081BindingDB-show
NSC719487403898BindingDB-show
NSC720934404585BindingDB-show
NSC722174405137BindingDB-show
NSC722177405140BindingDB-show
NSC723742405953BindingDB-show
Pemetrexed446556BindingDB-show
Pemetrexed394493BindingDB-show
Pemetrexed446556BindingDB-show
Pemetrexed60843DrugBank-show
Pemetrexed60843SuperTargetPMID 16472713show
Pteroylmonoglutamate3405BindingDB-show
Raltitrexed104758BindingDB-show
Raltitrexed104758DrugBank-show
Raltitrexed104758PROMISCUOUS8 PMIDsshow
Raltitrexed104758SuperTarget-show
Riboflavin710BindingDB-show
STK646311368341BindingDB-show
Tetracycline CMT-33047716BindingDB-show
Tetrahydrohomofolate259501BindingDB-show
TOSYL-D-PROLINE445504BindingDB-show
Trifluoromethyldeoxyuridine6256DrugBank-show
Synonyms:
Thymidylate synthase
TS
TSase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
Q53FB7_HUMAN10099.7
Q53Y97_HUMAN100100
TYSY_RAT92.187.3
Q8WYK3_HUMAN89.189.1
Q8WYK4_HUMAN73.573.5
TYSY_PNECA70.456.7
TYSY_CANAL65.856
TYSY_ECOLI60.446.3
TYSY_LACCA51.640.2
B3WE87_LACCB51.641.3
TYSY_LACC351.641.3
TYSY1_BACSU48.633.2
Q27552_CRYPV39.731.3
DRTS_PLAFK3526.6
DRTS_PLABA3526.9
O54288_SULSF3418.8
PANC_ECOLI33.417.3
Q9UEH3_HUMAN32.219.4
TAUD_ECOLI3221.2
ANM1_RAT31.917.1
BIEA_RAT31.915.9
1433C_TOBAC31.715.4
ASTA_PSEAE31.516.9
NCF4_HUMAN31.416.8
THA_SHEEP31.218.1
AROF_THEMA31.119.2
BIRA_ECOLI3119.9
KCNK2_HUMAN3116.5
PNMT_HUMAN30.920.6
ASPQ_PSEPK30.618.9
Protein-Protein Interactions: