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Target Details

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Name:Alteplase
Uniprot name:TPA_HUMAN
Accession Numbers:A8K022 P00750 Q15103 Q503B0 Q6PJA5 Q7Z7N2 Q86YK8 Q9BU99 Q9BZW1
EC-Number:3.4.21.68
Organism:Homo sapiens
Human
PDB IDs:1A5H 1BDA 1PK2 1PML 1RTF 1TPG 1TPK 1TPM 1TPN
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
1fax122129BindingDB-show
1ghw5326545BindingDB-show
1gi95326549BindingDB-show
1o2g447476BindingDB-show
1o2h447478BindingDB-show
1o3h447508BindingDB-show
1o3p5326663BindingDB-show
1owi447734BindingDB-show
2-(2-hydroxyphenyl)-1H-indole-5-carboximidamide1508BindingDB-show
2feq23586156BindingDB-show
2jh59911502BindingDB-show
2uwo10095865BindingDB-show
2uwp10343728BindingDB-show
330942-05-710275777BindingDB-show
4-HYDROXY-3-[2-OXO-3-(THIENO[3,2-B]PYRIDINE-2-SULFONYLAMINO)-PYRROLIDIN-1-YLMETHYL]-BENZAMIDINE5326514BindingDB-show
4-iodobenzo[b]thiophene-2-carboxamidine1746BindingDB-show
4-[[1-methyl-5-[(2-methylbenzimidazol-1-yl)methyl]benzimidazol-2-yl]methylamino]benzenecarboximidamide445756BindingDB-show
6-carbamimidoyl-N-phenylnaphthalene-2-carboxamide447732BindingDB-show
6-CHLORO-2-(2-HYDROXY-BIPHENYL-3-YL)-1H-INDOLE-5-CARBOXAMIDINE445843BindingDB-show
6-Chloro-2-(2-Hydroxybiphenyl-3-yl)-1H-Indole-5-Carboxamidine445844BindingDB-show
6-FLUORO-2-(2-HYDROXY-3-ISOBUTOXY-PHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDIN5326553BindingDB-show
6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBO445849BindingDB-show
6-[N-(1-ISOPROPYL-3,4-DIHYDRO-7-ISOQUINOLINYL)CARBAMYL]-2-NAPHTHALENECARBOXAMIDINE447735BindingDB-show
7-methoxy-8-(1-methylsulfonylpyrazol-4-yl)naphthalene-2-carboximidamide5289529BindingDB-show
8-(PYRIMIDIN-2-YLAMINO)NAPHTHALENE-2-CARBOXIMIDAMIDE448610BindingDB-show
Ac-Phe-pro-boroarg-OH122296BindingDB-show
AC1L9GOC444655BindingDB-show
AC1MPW2P3392032BindingDB-show
AC1MV8RA3729024BindingDB-show
AC1NS0VS5326676BindingDB-show
AC1NS0WF5326684BindingDB-show
AC1NS41B5353305BindingDB-show
AC1O0UPY6102526BindingDB-show
AC1O0UQP6102594BindingDB-show
AC1O0UQS6102595BindingDB-show
AC1O1DKC6119062BindingDB-show
AC1O1DKF6119063BindingDB-show
AC1OCEOE6917805BindingDB-show
AIDS21469210126451BindingDB-show
APC-1081823646618BindingDB-show
APC-1141723646620BindingDB-show
APC-900823646617BindingDB-show
APC-985023646621BindingDB-show
Benzenecarboximidamide2332BindingDB-show
beta-Naphthamidine193409BindingDB-show
BIBM10159953722BindingDB-show
BIBT08719600423BindingDB-show
CA-2123644682BindingDB-show
CA-2223646779BindingDB-show
CA-2423646782BindingDB-show
CA-2523646784BindingDB-show
CHEBI:64697544347413BindingDB-show
CHEBI:65188844347286BindingDB-show
CHEBI:65227744366338BindingDB-show
CHEMBL10175944330628BindingDB-show
CHEMBL10255244335014BindingDB-show
CHEMBL10406410116936BindingDB-show
CHEMBL10421110225952BindingDB-show
CHEMBL10450510278414BindingDB-show
CHEMBL10490421707001BindingDB-show
CHEMBL10539510294146BindingDB-show
CHEMBL10581944338049BindingDB-show
CHEMBL10774344335624BindingDB-show
CHEMBL10787244339283BindingDB-show
CHEMBL10791110648370BindingDB-show
CHEMBL10820210529121BindingDB-show
CHEMBL10834999866964BindingDB-show
CHEMBL1084479799627BindingDB-show
CHEMBL10871710742217BindingDB-show
CHEMBL10927444339119BindingDB-show
CHEMBL10928711149953BindingDB-show
CHEMBL10953511188793BindingDB-show
CHEMBL10975121705171BindingDB-show
CHEMBL11035844339233BindingDB-show
CHEMBL11103644339192BindingDB-show
CHEMBL11133811361949BindingDB-show
CHEMBL11143211186243BindingDB-show
CHEMBL11147111473486BindingDB-show
CHEMBL11154311774107BindingDB-show
CHEMBL11156711739438BindingDB-show
CHEMBL11166011347670BindingDB-show
CHEMBL11598210048688BindingDB-show
CHEMBL11613644343561BindingDB-show
CHEMBL11613710482360BindingDB-show
CHEMBL11640544343829BindingDB-show
CHEMBL11640644343830BindingDB-show
CHEMBL117244949798729BindingDB-show
CHEMBL11744944343849BindingDB-show
CHEMBL11751144343575BindingDB-show
CHEMBL11766944343631BindingDB-show
CHEMBL11780344343886BindingDB-show
CHEMBL12289444347573BindingDB-show
CHEMBL12515311824584BindingDB-show
CHEMBL12670710959252BindingDB-show
CHEMBL12727810871563BindingDB-show
CHEMBL12740711782862BindingDB-show
CHEMBL1279099884570BindingDB-show
CHEMBL13572344356715BindingDB-show
CHEMBL13856810505479BindingDB-show
CHEMBL13890544359104BindingDB-show
CHEMBL13949044358802BindingDB-show
CHEMBL13991044358868BindingDB-show
CHEMBL13998044358860BindingDB-show
CHEMBL14035944359105BindingDB-show
CHEMBL14134744359090BindingDB-show
CHEMBL14158444359053BindingDB-show
CHEMBL14183444359039BindingDB-show
CHEMBL14831744367340BindingDB-show
CHEMBL1519399915041BindingDB-show
CHEMBL15356544367430BindingDB-show
CHEMBL15498544367372BindingDB-show
CHEMBL15969544376100BindingDB-show
CHEMBL16246144376426BindingDB-show
CHEMBL16317420641745BindingDB-show
CHEMBL17225644386179BindingDB-show
CHEMBL17236044385679BindingDB-show
CHEMBL17292844383519BindingDB-show
CHEMBL17383244386493BindingDB-show
CHEMBL17411144386185BindingDB-show
CHEMBL1744999959749BindingDB-show
CHEMBL17455844386059BindingDB-show
CHEMBL17473144385607BindingDB-show
CHEMBL17474044385869BindingDB-show
CHEMBL1747509959268BindingDB-show
CHEMBL17479144385891BindingDB-show
CHEMBL17481344385990BindingDB-show
CHEMBL17487044386418BindingDB-show
CHEMBL17496818727607BindingDB-show
CHEMBL17501444386242BindingDB-show
CHEMBL17503118727852BindingDB-show
CHEMBL17503344385611BindingDB-show
CHEMBL17512244385768BindingDB-show
CHEMBL17512544386371BindingDB-show
CHEMBL17513018727836BindingDB-show
CHEMBL17514244386322BindingDB-show
CHEMBL17532944385769BindingDB-show
CHEMBL17621044387104BindingDB-show
CHEMBL17624344386934BindingDB-show
CHEMBL17626818727834BindingDB-show
CHEMBL17645144385488BindingDB-show
CHEMBL17651544385770BindingDB-show
CHEMBL17667144385729BindingDB-show
CHEMBL17673644385673BindingDB-show
CHEMBL17675744385771BindingDB-show
CHEMBL17685644386484BindingDB-show
CHEMBL17710944385779BindingDB-show
CHEMBL17725144386893BindingDB-show
CHEMBL17744444387206BindingDB-show
CHEMBL17755744385833BindingDB-show
CHEMBL17774544386804BindingDB-show
CHEMBL18159544392423BindingDB-show
CHEMBL18159944392416BindingDB-show
CHEMBL18222044392401BindingDB-show
CHEMBL18230310216518BindingDB-show
CHEMBL18230944392427BindingDB-show
CHEMBL18246010287785BindingDB-show
CHEMBL18295944392413BindingDB-show
CHEMBL18302144392382BindingDB-show
CHEMBL18534521707121BindingDB-show
CHEMBL1876710054209BindingDB-show
CHEMBL18982316086320BindingDB-show
CHEMBL19448610024183BindingDB-show
CHEMBL19467010052373BindingDB-show
CHEMBL19759310051489BindingDB-show
CHEMBL19784310390490BindingDB-show
CHEMBL19841610003356BindingDB-show
CHEMBL19862911720955BindingDB-show
CHEMBL19873510390121BindingDB-show
CHEMBL19892310409093BindingDB-show
CHEMBL19897810324635BindingDB-show
CHEMBL20590411948634BindingDB-show
CHEMBL2060420595260BindingDB-show
CHEMBL20620544411094BindingDB-show
CHEMBL2076610007890BindingDB-show
CHEMBL20798144411137BindingDB-show
CHEMBL20814010479438BindingDB-show
CHEMBL2091810389039BindingDB-show
CHEMBL2093444274089BindingDB-show
CHEMBL210529803558BindingDB-show
CHEMBL2114020595328BindingDB-show
CHEMBL21321616086340BindingDB-show
CHEMBL21453916086349BindingDB-show
CHEMBL21481416086336BindingDB-show
CHEMBL21596116086316BindingDB-show
CHEMBL22190610297977BindingDB-show
CHEMBL22468916658356BindingDB-show
CHEMBL22671616658680BindingDB-show
CHEMBL2274219952109BindingDB-show
CHEMBL22758316658352BindingDB-show
CHEMBL22758416658357BindingDB-show
CHEMBL22778116658631BindingDB-show
CHEMBL22778216658353BindingDB-show
CHEMBL22794016658354BindingDB-show
CHEMBL2339929954980BindingDB-show
CHEMBL23608144433791BindingDB-show
CHEMBL23706544434808BindingDB-show
CHEMBL23770544434815BindingDB-show
CHEMBL23849124750417BindingDB-show
CHEMBL23849316718760BindingDB-show
CHEMBL2387079827867BindingDB-show
CHEMBL23870816718759BindingDB-show
CHEMBL2389029912856BindingDB-show
CHEMBL23891324748791BindingDB-show
CHEMBL23911816718757BindingDB-show
CHEMBL23933144436704BindingDB-show
CHEMBL23953516718808BindingDB-show
CHEMBL23953616718712BindingDB-show
CHEMBL23974716718671BindingDB-show
CHEMBL26397716086310BindingDB-show
CHEMBL26476044303778BindingDB-show
CHEMBL2653159910164BindingDB-show
CHEMBL27794944274017BindingDB-show
CHEMBL278529850467BindingDB-show
CHEMBL27948611755188BindingDB-show
CHEMBL28117510391999BindingDB-show
CHEMBL2828309937406BindingDB-show
CHEMBL28443644278104BindingDB-show
CHEMBL2876149956559BindingDB-show
CHEMBL2884910472893BindingDB-show
CHEMBL28938944286453BindingDB-show
CHEMBL29162244304105BindingDB-show
CHEMBL292059822176BindingDB-show
CHEMBL29230044303804BindingDB-show
CHEMBL29248844304046BindingDB-show
CHEMBL29297744303805BindingDB-show
CHEMBL29326023646623BindingDB-show
CHEMBL29365744303933BindingDB-show
CHEMBL29406744303866BindingDB-show
CHEMBL2941219805415BindingDB-show
CHEMBL29450944303935BindingDB-show
CHEMBL29477644304192BindingDB-show
CHEMBL2978359826716BindingDB-show
CHEMBL30003044298525BindingDB-show
CHEMBL30291344303873BindingDB-show
CHEMBL30333544303733BindingDB-show
CHEMBL30336744303843BindingDB-show
CHEMBL30397044304097BindingDB-show
CHEMBL30397844303854BindingDB-show
CHEMBL30421944303912BindingDB-show
CHEMBL30534944303875BindingDB-show
CHEMBL30644810391699BindingDB-show
CHEMBL31633411068806BindingDB-show
CHEMBL3169019807008BindingDB-show
CHEMBL31713744330835BindingDB-show
CHEMBL31768244330665BindingDB-show
CHEMBL31836310903566BindingDB-show
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CHEMBL31899810074230BindingDB-show
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CHEMBL31904710157296BindingDB-show
CHEMBL31926421707080BindingDB-show
CHEMBL3196710248900BindingDB-show
CHEMBL31999744326715BindingDB-show
CHEMBL32023344334488BindingDB-show
CHEMBL3204939949275BindingDB-show
CHEMBL32074911244460BindingDB-show
CHEMBL32081721706943BindingDB-show
CHEMBL3211459804775BindingDB-show
CHEMBL32131910140847BindingDB-show
CHEMBL32146610185292BindingDB-show
CHEMBL32151010946869BindingDB-show
CHEMBL32182218771297BindingDB-show
CHEMBL32184844339277BindingDB-show
CHEMBL32290110696955BindingDB-show
CHEMBL32323244339232BindingDB-show
CHEMBL32324144339270BindingDB-show
CHEMBL32338711350400BindingDB-show
CHEMBL3237839935925BindingDB-show
CHEMBL32503544343885BindingDB-show
CHEMBL32509421192457BindingDB-show
CHEMBL32641944339231BindingDB-show
CHEMBL32659444343560BindingDB-show
CHEMBL32778944326209BindingDB-show
CHEMBL32877211782463BindingDB-show
CHEMBL32889344326182BindingDB-show
CHEMBL32926610142245BindingDB-show
CHEMBL32991210185816BindingDB-show
CHEMBL33001144325764BindingDB-show
CHEMBL33020644330847BindingDB-show
CHEMBL33023411004109BindingDB-show
CHEMBL33046044326725BindingDB-show
CHEMBL33079144347623BindingDB-show
CHEMBL33141644343833BindingDB-show
CHEMBL33287044347533BindingDB-show
CHEMBL33323844347479BindingDB-show
CHEMBL33647144358867BindingDB-show
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CHEMBL34351844358866BindingDB-show
CHEMBL34622244367355BindingDB-show
CHEMBL34660744367382BindingDB-show
CHEMBL34826644367444BindingDB-show
CHEMBL35058744376252BindingDB-show
CHEMBL35203944375987BindingDB-show
CHEMBL35499644383242BindingDB-show
CHEMBL35537644376417BindingDB-show
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CHEMBL35600710258264BindingDB-show
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CHEMBL35707910474680BindingDB-show
CHEMBL36019544392430BindingDB-show
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CHEMBL36260044392403BindingDB-show
CHEMBL36635844385772BindingDB-show
CHEMBL36664744386250BindingDB-show
CHEMBL36666644386366BindingDB-show
CHEMBL36673110027758BindingDB-show
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CHEMBL36696444385724BindingDB-show
CHEMBL36700444386622BindingDB-show
CHEMBL36734044386542BindingDB-show
CHEMBL36795310480463BindingDB-show
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CHEMBL36874418727841BindingDB-show
CHEMBL36891444386642BindingDB-show
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CHEMBL36902344386841BindingDB-show
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CHEMBL37219410098302BindingDB-show
CHEMBL37462311419694BindingDB-show
CHEMBL3776819893177BindingDB-show
CHEMBL38426316086318BindingDB-show
CHEMBL38515816086308BindingDB-show
CHEMBL38589716086338BindingDB-show
CHEMBL38590016086312BindingDB-show
CHEMBL38624916086344BindingDB-show
CHEMBL38627516086342BindingDB-show
CHEMBL39031016658633BindingDB-show
CHEMBL39134416718762BindingDB-show
CHEMBL39191624748789BindingDB-show
CHEMBL39196824749175BindingDB-show
CHEMBL39196944436702BindingDB-show
CHEMBL39229744434835BindingDB-show
CHEMBL39359116049247BindingDB-show
CHEMBL39359216718807BindingDB-show
CHEMBL39397916718713BindingDB-show
CHEMBL39412944434818BindingDB-show
CHEMBL3947544286428BindingDB-show
CHEMBL39838011237163BindingDB-show
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CID 982347810717029BindingDB-show
CID 98691569869156BindingDB-show
CID 98951939895194BindingDB-show
CID 99345909934590BindingDB-show
CID 993610410815545BindingDB-show
CID1101099511010995BindingDB-show
CRA-1081823646619BindingDB-show
cyanoguanidine, 344249821BindingDB-show
cyclic deriv. 339843775BindingDB-show
cyclic deriv. 3416658181BindingDB-show
cyclic deriv. 3516658183BindingDB-show
cycloleucine deriv. 399956922BindingDB-show
cycloleucine deriv. 4016658250BindingDB-show
cycloleucine deriv. 4316658290BindingDB-show
cycloleucine deriv. 449956843BindingDB-show
cycloleucine deriv. 459935474BindingDB-show
Dabigatran216210BindingDB-show
efegatran122267BindingDB-show
Epsilcapramine564DrugBank-show
ESP5438BindingDB-show
ESX444753BindingDB-show
G179055326937BindingDB-show
Guanamprazine16231BindingDB-show
Iloprost6443959DrugBank-show
L865288687BindingDB-show
N-(1-ADAMANTYL)-N'-(4-GUANIDINOBENZYL)UREA4286BindingDB-show
n-(4-carbamimidoyl-3-choro-phenyl)-2-hydroxy-3-iodo-5-methyl-benzamide4300BindingDB-show
n-(4-carbamimidoyl-phenyl)-2-hydroxy-benzamide4301BindingDB-show
N-[4-(aminomethyl)phenyl]-6-carbamimidoyl-4-(pyrimidin-2-ylamino)naphthalene-2-carboxamide448605BindingDB-show
N-[4-(aminomethyl)phenyl]-6-carbamimidoylnaphthalene-2-carboxamide447733BindingDB-show
Razaxaban204102BindingDB-show
RPR12084410322586BindingDB-show
substituted glycine deriv. 1616658742BindingDB-show
substituted glycine deriv. 1716658407BindingDB-show
substituted glycine deriv. 1816658745BindingDB-show
substituted glycine deriv. 1916658408BindingDB-show
substituted glycine deriv. 2216657876BindingDB-show
substituted glycine deriv. 2316657879BindingDB-show
substituted glycine deriv. 2416657882BindingDB-show
substituted glycine deriv. 2516657950BindingDB-show
substituted glycine deriv. 279930716BindingDB-show
substituted glycine deriv. 289822928BindingDB-show
substituted glycine deriv. 299802514BindingDB-show
substituted glycine deriv. 3016658031BindingDB-show
Sulfonamidopyrrolidinone 20a10790446BindingDB-show
TAK-44211641515BindingDB-show
Tranexamsaeure5526DrugBank-show
Synonyms:
Alteplase
Reteplase
t-PA
t-plasminogen activator
Tissue-type plasminogen activator
tPA
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
B8ZX62_HUMAN99.899.8
UROK_MOUSE43.731.3
UROK_HUMAN4332.8
Q5PY49_HUMAN42.432.6
THRB_MOUSE37.326
FA9_HUMAN36.425
THRB_BOVIN36.225.6
FA10_HUMAN35.924.3
THRB_HUMAN34.925.4
PROC_HUMAN34.523.4
FA11_HUMAN3423.2
FA7_HUMAN33.923.5
FA10_BOVIN33.224.9
CFAB_HUMAN31.619
HGF_HUMAN31.320.9
PROZ_HUMAN31.219.7
MASP2_RAT29.921.1
Q71SG6_HUMAN29.618.6
PLMN_HUMAN29.322
CHK1_YEAST29.217.1
DEXT_PENMI29.217.2
PAOX_HUMAN2917.9
HAO_NITEU28.917.8
AMYB_HORVU28.718.9
EXAA_PSEAE28.417.3
C1S_HUMAN28.218.5
DOPO_HUMAN28.116.2
MDHP_FLABI28.115.8
PP2BC_HUMAN27.817
ASM_MOUSE27.717.6
Protein-Protein Interactions: