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Target Details

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Name:DNA topoisomerase 2-alpha
Uniprot name:TOP2A_HUMAN
Accession Numbers:P11388 Q71UN1 Q71UQ5 Q9HB24 Q9HB25 Q9HB26 Q9UP44 Q9UQP9
EC-Number:5.99.1.3
Organism:Homo sapiens
Human
PDB IDs:1LWZ 1ZXM 1ZXN
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt46888247BindingDB-show
()-oxazepam hemisuccinate sodium salt46888245BindingDB-show
()-oxazepam hemisuccinate sodium salt24970451BindingDB-show
()-oxazepam hemisuccinate sodium salt21580556BindingDB-show
()-oxazepam hemisuccinate sodium salt46888249BindingDB-show
()-oxazepam hemisuccinate sodium salt46888313BindingDB-show
()-oxazepam hemisuccinate sodium salt46888308BindingDB-show
()-oxazepam hemisuccinate sodium salt44479228BindingDB-show
()-oxazepam hemisuccinate sodium salt46888307BindingDB-show
()-oxazepam hemisuccinate sodium salt46888254BindingDB-show
()-oxazepam hemisuccinate sodium salt46888251BindingDB-show
1-Cyclopropyl-6,8-difluoro-7-(4-hydroxyphenyl)-4-quinolone-3-carboxylic acid119367BindingDB-show
1230314812303148BindingDB-show
20(S)-Ginsenoside Rg39918693BindingDB-show
3-Quinolinecarboxylic acid,122796BindingDB-show
4-(aminomethyl)-1-(2-diethylaminoethylamino)thioxanthen-9-one9998338BindingDB-show
4457783744577837BindingDB-show
AC1L8G5Q400718BindingDB-show
AC1LA62S462428BindingDB-show
AC1LA62Y462430BindingDB-show
AC1LA631462431BindingDB-show
Acridinylanisidide2179BindingDB-show
Acridinylanisidide2179DrugBank-show
Acridinylanisidide2179PROMISCUOUS5 PMIDsshow
Acridinylanisidide2179SuperTargetPMID 14504921show
Adriablastin31703BindingDB-show
Adriablastin31703DrugBank-show
Adriablastin31703SuperTarget-show
anthrapyrazolone72116BindingDB-show
Bakuchicin3083848BindingDB-show
Betulin72326BindingDB-show
Betulin7067889BindingDB-show
Camptothecine24360BindingDB-show
CHEBI:38600444382963BindingDB-show
CHEBI:38620944383049BindingDB-show
CHEBI:38623844383062BindingDB-show
CHEBI:58517911876091BindingDB-show
CHEBI:588795439525BindingDB-show
CHEBI:64616644327182BindingDB-show
CHEBI:64881344384084BindingDB-show
CHEMBL10828310322576BindingDB-show
CHEMBL10840410248698BindingDB-show
CHEMBL10849344339418BindingDB-show
CHEMBL109433446887589BindingDB-show
CHEMBL109433546887590BindingDB-show
CHEMBL109467346888244BindingDB-show
CHEMBL109467621636448BindingDB-show
CHEMBL109467846888246BindingDB-show
CHEMBL10946810414142BindingDB-show
CHEMBL109468046888248BindingDB-show
CHEMBL109468246888250BindingDB-show
CHEMBL109468446888252BindingDB-show
CHEMBL109468546888253BindingDB-show
CHEMBL109468746888255BindingDB-show
CHEMBL109468846888256BindingDB-show
CHEMBL109468946888257BindingDB-show
CHEMBL109469046888258BindingDB-show
CHEMBL109469146888259BindingDB-show
CHEMBL109469246888260BindingDB-show
CHEMBL109500446887678BindingDB-show
CHEMBL109500512912322BindingDB-show
CHEMBL109500646887679BindingDB-show
CHEMBL109500846887680BindingDB-show
CHEMBL109501446888296BindingDB-show
CHEMBL109501646888298BindingDB-show
CHEMBL109501746888299BindingDB-show
CHEMBL109501846888300BindingDB-show
CHEMBL109501946888301BindingDB-show
CHEMBL109533946888311BindingDB-show
CHEMBL10953444339222BindingDB-show
CHEMBL109534046888312BindingDB-show
CHEMBL109534946888320BindingDB-show
CHEMBL109535046888321BindingDB-show
CHEMBL109535146888322BindingDB-show
CHEMBL109535246888323BindingDB-show
CHEMBL109535346888324BindingDB-show
CHEMBL109672846887682BindingDB-show
CHEMBL109692646202546BindingDB-show
CHEMBL109703346887586BindingDB-show
CHEMBL109703446887587BindingDB-show
CHEMBL109738746887588BindingDB-show
CHEMBL10974310447591BindingDB-show
CHEMBL10988010453745BindingDB-show
CHEMBL10992244339644BindingDB-show
CHEMBL10992810346280BindingDB-show
CHEMBL10994210066958BindingDB-show
CHEMBL1112619976692BindingDB-show
CHEMBL11150210471090BindingDB-show
CHEMBL11159210255039BindingDB-show
CHEMBL11173544339652BindingDB-show
CHEMBL11308144338931BindingDB-show
CHEMBL11530210452276BindingDB-show
CHEMBL11566544342104BindingDB-show
CHEMBL12091510362559BindingDB-show
CHEMBL1211929866430BindingDB-show
CHEMBL12144210622496BindingDB-show
CHEMBL12154710576072BindingDB-show
CHEMBL12166610671228BindingDB-show
CHEMBL12271611794504BindingDB-show
CHEMBL12846644352907BindingDB-show
CHEMBL12984044352864BindingDB-show
CHEMBL12989244352841BindingDB-show
CHEMBL12990844353588BindingDB-show
CHEMBL13004744353051BindingDB-show
CHEMBL13009715224741BindingDB-show
CHEMBL13033244353548BindingDB-show
CHEMBL13036815224739BindingDB-show
CHEMBL1303819910942BindingDB-show
CHEMBL13053844353054BindingDB-show
CHEMBL13054744352952BindingDB-show
CHEMBL13060444352794BindingDB-show
CHEMBL13062744353499BindingDB-show
CHEMBL13066244352825BindingDB-show
CHEMBL13070644352840BindingDB-show
CHEMBL13083815224742BindingDB-show
CHEMBL13088944352809BindingDB-show
CHEMBL13120844352823BindingDB-show
CHEMBL13149144353715BindingDB-show
CHEMBL13160044353648BindingDB-show
CHEMBL13167744353654BindingDB-show
CHEMBL13209818654132BindingDB-show
CHEMBL13221344352834BindingDB-show
CHEMBL13231944355264BindingDB-show
CHEMBL13253344355298BindingDB-show
CHEMBL13265644352857BindingDB-show
CHEMBL13320944355276BindingDB-show
CHEMBL13346644353853BindingDB-show
CHEMBL13375744353655BindingDB-show
CHEMBL1337809888201BindingDB-show
CHEMBL13378444353638BindingDB-show
CHEMBL13380244353667BindingDB-show
CHEMBL13453644355373BindingDB-show
CHEMBL13549113009345BindingDB-show
CHEMBL13549210053929BindingDB-show
CHEMBL13588144355300BindingDB-show
CHEMBL13597013009351BindingDB-show
CHEMBL13709844356834BindingDB-show
CHEMBL13726311796931BindingDB-show
CHEMBL13933544359157BindingDB-show
CHEMBL14003644359074BindingDB-show
CHEMBL14201644358947BindingDB-show
CHEMBL1839510017730BindingDB-show
CHEMBL1845644272132BindingDB-show
CHEMBL1854411483874BindingDB-show
CHEMBL18564044396529BindingDB-show
CHEMBL18637344396595BindingDB-show
CHEMBL18700944396520BindingDB-show
CHEMBL1884039802791BindingDB-show
CHEMBL18908844396563BindingDB-show
CHEMBL18966744396567BindingDB-show
CHEMBL18970344396511BindingDB-show
CHEMBL18979344399396BindingDB-show
CHEMBL18983644399556BindingDB-show
CHEMBL19084144399370BindingDB-show
CHEMBL19100144399503BindingDB-show
CHEMBL19121644399372BindingDB-show
CHEMBL1914311771062BindingDB-show
CHEMBL192749997468BindingDB-show
CHEMBL19300244399554BindingDB-show
CHEMBL19325144399445BindingDB-show
CHEMBL1954169837937BindingDB-show
CHEMBL2025544273652BindingDB-show
CHEMBL2081144273597BindingDB-show
CHEMBL2109644273600BindingDB-show
CHEMBL2110821197160BindingDB-show
CHEMBL2122144273624BindingDB-show
CHEMBL2126344273617BindingDB-show
CHEMBL2126519037238BindingDB-show
CHEMBL2126744273699BindingDB-show
CHEMBL25618111188178BindingDB-show
CHEMBL25685610318315BindingDB-show
CHEMBL25685711406001BindingDB-show
CHEMBL2590810598750BindingDB-show
CHEMBL26298244352824BindingDB-show
CHEMBL26646315226993BindingDB-show
CHEMBL26701744264825BindingDB-show
CHEMBL26725144264901BindingDB-show
CHEMBL26770744264828BindingDB-show
CHEMBL26845844264878BindingDB-show
CHEMBL26913944264915BindingDB-show
CHEMBL26980044456381BindingDB-show
CHEMBL27021844456311BindingDB-show
CHEMBL270649886271BindingDB-show
CHEMBL27085744456350BindingDB-show
CHEMBL27106344456314BindingDB-show
CHEMBL2723310646103BindingDB-show
CHEMBL2754210501735BindingDB-show
CHEMBL27700844273560BindingDB-show
CHEMBL27701144273491BindingDB-show
CHEMBL27703944273561BindingDB-show
CHEMBL27740844273700BindingDB-show
CHEMBL27766744273526BindingDB-show
CHEMBL27807144273527BindingDB-show
CHEMBL27810144273646BindingDB-show
CHEMBL27852644273605BindingDB-show
CHEMBL27903544273618BindingDB-show
CHEMBL27910110355929BindingDB-show
CHEMBL2794819928668BindingDB-show
CHEMBL28060910341523BindingDB-show
CHEMBL28102210521963BindingDB-show
CHEMBL28243617874201BindingDB-show
CHEMBL28265544273599BindingDB-show
CHEMBL28376644273598BindingDB-show
CHEMBL28720510547820BindingDB-show
CHEMBL29577544292318BindingDB-show
CHEMBL29681244292646BindingDB-show
CHEMBL2983610478426BindingDB-show
CHEMBL29836814501368BindingDB-show
CHEMBL29841244292660BindingDB-show
CHEMBL3005310049918BindingDB-show
CHEMBL3009910618929BindingDB-show
CHEMBL3010410456245BindingDB-show
CHEMBL30185110916071BindingDB-show
CHEMBL31952914969596BindingDB-show
CHEMBL31993914969592BindingDB-show
CHEMBL32035410045694BindingDB-show
CHEMBL32049544338996BindingDB-show
CHEMBL32232510094097BindingDB-show
CHEMBL32249144339290BindingDB-show
CHEMBL32395710245925BindingDB-show
CHEMBL32442644338938BindingDB-show
CHEMBL32508844342018BindingDB-show
CHEMBL32554310342927BindingDB-show
CHEMBL32558816092339BindingDB-show
CHEMBL32627410364521BindingDB-show
CHEMBL32666410385895BindingDB-show
CHEMBL32766314969604BindingDB-show
CHEMBL32871914969588BindingDB-show
CHEMBL32938514969599BindingDB-show
CHEMBL33099610785350BindingDB-show
CHEMBL33280510668643BindingDB-show
CHEMBL3336419933099BindingDB-show
CHEMBL33433713009352BindingDB-show
CHEMBL33438644353863BindingDB-show
CHEMBL33446113009355BindingDB-show
CHEMBL33460844352953BindingDB-show
CHEMBL33538744356604BindingDB-show
CHEMBL33564310765128BindingDB-show
CHEMBL33568344352936BindingDB-show
CHEMBL33594044355294BindingDB-show
CHEMBL33644344359116BindingDB-show
CHEMBL33662644355299BindingDB-show
CHEMBL33676744352822BindingDB-show
CHEMBL33720511796932BindingDB-show
CHEMBL33752644356605BindingDB-show
CHEMBL33766615224740BindingDB-show
CHEMBL33896644355546BindingDB-show
CHEMBL33896713009346BindingDB-show
CHEMBL33937910812579BindingDB-show
CHEMBL33978144352808BindingDB-show
CHEMBL34284444359158BindingDB-show
CHEMBL34422644359112BindingDB-show
CHEMBL34447844359075BindingDB-show
CHEMBL35993244387020BindingDB-show
CHEMBL36235344396485BindingDB-show
CHEMBL36443144396581BindingDB-show
CHEMBL36461144396484BindingDB-show
CHEMBL40188611313757BindingDB-show
CHEMBL40540513009354BindingDB-show
CHEMBL40690144355295BindingDB-show
CHEMBL41402210426517BindingDB-show
CHEMBL41970323692500BindingDB-show
CHEMBL42189944353647BindingDB-show
CHEMBL42226544352833BindingDB-show
CHEMBL42279144352839BindingDB-show
CHEMBL42298844356807BindingDB-show
CHEMBL42353410765129BindingDB-show
CHEMBL42608744399306BindingDB-show
CHEMBL42716418655846BindingDB-show
CHEMBL42833944264881BindingDB-show
CHEMBL42845344273654BindingDB-show
CHEMBL42993044456349BindingDB-show
CHEMBL43338914969602BindingDB-show
CHEMBL43385544355186BindingDB-show
CHEMBL43387544359032BindingDB-show
CHEMBL43423744355547BindingDB-show
CHEMBL43465044359159BindingDB-show
CHEMBL4348129909677BindingDB-show
CHEMBL4351919808998BindingDB-show
CHEMBL43724944341578BindingDB-show
CHEMBL4388144292374BindingDB-show
CHEMBL4406429868285BindingDB-show
CHEMBL44163111740959BindingDB-show
CHEMBL4443299979116BindingDB-show
CHEMBL44565344396489BindingDB-show
CHEMBL44970044352850BindingDB-show
CHEMBL45112316048967BindingDB-show
CHEMBL45316625113738BindingDB-show
CHEMBL4560544292667BindingDB-show
CHEMBL4575544292319BindingDB-show
CHEMBL4588114501361BindingDB-show
CHEMBL4588713958508BindingDB-show
CHEMBL4592344292578BindingDB-show
CHEMBL46284721602071BindingDB-show
CHEMBL46284810961552BindingDB-show
CHEMBL46489711049543BindingDB-show
CHEMBL46689344574831BindingDB-show
CHEMBL470279887873BindingDB-show
CHEMBL4725510618700BindingDB-show
CHEMBL4752644290621BindingDB-show
CHEMBL478859909579BindingDB-show
CHEMBL4805944292144BindingDB-show
CHEMBL48955214167260BindingDB-show
CHEMBL49118815601738BindingDB-show
CHEMBL4938114501400BindingDB-show
CHEMBL4954510068583BindingDB-show
CHEMBL4966644292541BindingDB-show
CHEMBL49889825164720BindingDB-show
CHEMBL50130214194010BindingDB-show
CHEMBL5055114501369BindingDB-show
CHEMBL50558044567395BindingDB-show
CHEMBL50625725164921BindingDB-show
CHEMBL50768812912363BindingDB-show
CHEMBL50840714194006BindingDB-show
CHEMBL51171244567396BindingDB-show
CHEMBL54235745260072BindingDB-show
CHEMBL54935744249747BindingDB-show
CHEMBL57144444249746BindingDB-show
CHEMBL57355245481989BindingDB-show
CHEMBL57358145481988BindingDB-show
CHEMBL57561025165123BindingDB-show
CHEMBL57564125165124BindingDB-show
CHEMBL57564525165319BindingDB-show
CHEMBL57579525164923BindingDB-show
CHEMBL57580125165125BindingDB-show
CHEMBL59286246229825BindingDB-show
CHEMBL6157310937930BindingDB-show
CHEMBL6499344305415BindingDB-show
CHEMBL721644264768BindingDB-show
CHEMBL736844264839BindingDB-show
CHEMBL739244264761BindingDB-show
CHEMBL753419013347BindingDB-show
CHEMBL756244264872BindingDB-show
CHEMBL756444264862BindingDB-show
CHEMBL761844264845BindingDB-show
CHEMBL768944264866BindingDB-show
CHEMBL769044264867BindingDB-show
CHEMBL770444264883BindingDB-show
CHEMBL772244264807BindingDB-show
CHEMBL776944264851BindingDB-show
CHEMBL779415226990BindingDB-show
CHEMBL783115226994BindingDB-show
CHEMBL784815226992BindingDB-show
CHEMBL787744264916BindingDB-show
CHEMBL796044264910BindingDB-show
CHEMBL797215226995BindingDB-show
CHEMBL799144264850BindingDB-show
CHEMBL799944264968BindingDB-show
CHEMBL806344264902BindingDB-show
CHEMBL813844264877BindingDB-show
CHEMBL816115226989BindingDB-show
CHEMBL9432114969593BindingDB-show
CHEMBL9450614969597BindingDB-show
CHEMBL9467114969591BindingDB-show
CHEMBL9650914969600BindingDB-show
CHEMBL9670514969595BindingDB-show
CHEMBL9708714969601BindingDB-show
CHEMBL9731514969603BindingDB-show
CHEMBL9763814969598BindingDB-show
Cholesterolum5997BindingDB-show
CID 1048058611799152BindingDB-show
CID 1074729810101245BindingDB-show
CID 1178810111788101BindingDB-show
CID 43244811679800BindingDB-show
CID 983158210009964BindingDB-show
CID 990793010474948BindingDB-show
CID 995443410365443BindingDB-show
CID 995443410252167BindingDB-show
CID 99544349954434BindingDB-show
Ciprofloxacin monohydrochloride2764BindingDB-show
Ciprofloxacin monohydrochloride2764DrugBank-show
Ciprofloxacin monohydrochloride2764SuperTarget-show
Cpfdm-3-qca130078BindingDB-show
Demethyl Epipodophyllotoxin Ethylidine Glucoside36462BindingDB-show
Demethyl Epipodophyllotoxin Ethylidine Glucoside36462DrugBank-show
Demethyl Epipodophyllotoxin Ethylidine Glucoside36462SuperTarget-show
demethylzeylasterone10391130BindingDB-show
DEXTROFLOXACINE4583DrugBank-show
DEXTROFLOXACINE4583SuperTarget-show
Dextrorazoxane71384DrugBank-show
Dextrorazoxane71384SuperTarget-show
Dihydroxyanthraquinone4212BindingDB-show
Dihydroxyanthraquinone4212DrugBank-show
Dihydroxyanthraquinone2950DrugBank-show
Dihydroxyanthraquinone6293DrugBank-show
Dihydroxyanthraquinone4212PROMISCUOUSPMID 15057963show
Dihydroxyanthraquinone2950PROMISCUOUSPMID 15057963show
Dihydroxyanthraquinone6293PROMISCUOUSPMID 15057963show
Dihydroxyanthraquinone4212SuperTarget-show
Dihydroxyanthraquinone2950SuperTarget-show
Dihydroxyanthraquinone6293SuperTarget-show
Enoxacin Sesquihydrate3229DrugBank-show
Enoxacin Sesquihydrate3229SuperTarget-show
Epidoxorubicin41867DrugBank-show
Epidoxorubicin65348DrugBank-show
Epidoxorubicin41867SuperTarget-show
Epidoxorubicin65348SuperTarget-show
Epipodophyllotoxin10607DrugBank-show
FLEROXACIN3357SuperTarget-show
Gatifloxacin5379DrugBank-show
gatifloxacin969463DrugBank-show
Genisterin5280961DrugBank-show
Genisterin5280961PROMISCUOUSPMID 2548712show
ginsenoside-Rb19898279BindingDB-show
Gynostemma Extract46887681BindingDB-show
Gypenoside XII9918692BindingDB-show
Icrf 193115150BindingDB-show
Idarubicin hydrochloride42890DrugBank-show
IDARUBICIN HYDROCHLORIDE3685DrugBank-show
Idarubicin hydrochloride42890SuperTarget-show
IDARUBICIN HYDROCHLORIDE3685SuperTarget-show
Levofloxacin149096BindingDB-show
Levofloxacin149096DrugBank-show
Lomefloxacin hydrochloride3948DrugBank-show
Lucanthone monohydrochloride10180DrugBank-show
LUOTONIN A10334120BindingDB-show
Methyl abiesolidate637031BindingDB-show
Moxifloxacin hydrochloride152946DrugBank-show
N-(((1-(2-(Diethylamino)ethyl)amino)-9-oxo-9H-thioxanthen-4-yl)methyl)methanesulfonamide3035776BindingDB-show
Nalidixate4421PROMISCUOUSPMID 7521751show
Nalidixate4421SuperTarget-show
NCI60_016687372648BindingDB-show
Norfloxacine4539DrugBank-show
Norfloxacine4539SuperTarget-show
NSC666097380482BindingDB-show
NSC690430391373BindingDB-show
NSC713081400717BindingDB-show
olean-12-ene-3beta,24-diol14167253BindingDB-show
Orthurine4628SuperTarget-show
Pefloxacine51081DrugBank-show
Pefloxacine51081SuperTarget-show
Piroxantrone5362372BindingDB-show
Rubex6916127BindingDB-show
Sparfloxacin60464DrugBank-show
Sparfloxacin60464SuperTarget-show
ST0563536610299BindingDB-show
TENIPOSIDE34698DrugBank-show
Teniposide5396DrugBank-show
TENIPOSIDE34698SuperTarget-show
Teniposide5396SuperTarget-show
topostatin44559995BindingDB-show
Trovafloxacin62959DrugBank-show
UK 15487087BindingDB-show
Valrubicin41744DrugBank-show
Valrubicin41744SuperTarget-show
Viminalol73170BindingDB-show
Win 58161129581BindingDB-show
Synonyms:
DNA topoisomerase 2-alpha
DNA topoisomerase II, alpha isozyme
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
TOP2A_RAT93.288.7
Q14TE9_RAT77.666.9
TOP2B_HUMAN77.366.7
TOP2_YEAST5741.3
TOP2_CRIFA40.226.3
ROCK1_HUMAN32.317.7
Q9F0I5_PAEMA28.717.2
EGFR_MOUSE28.717.1
POL_HV1B128.717.3
VGFR2_HUMAN28.617
EGFR_HUMAN28.516.4
POL_HV1A228.216.1
EEA1_HUMAN2814.5
BLM_HUMAN2815.6
KDM5D_HUMAN27.814.9
KCNH7_HUMAN27.516.1
GCA_DICDI27.513.9
ERBB2_HUMAN27.515.7
POL_HV1Z227.416.1
Q547U9_HUMAN27.315.1
NMDE1_HUMAN27.315.1
POL_HV1H227.116.3
POL_HV1N52715.9
Q59FN5_HUMAN2714.7
TETX_CLOTE2714.1
POLG_DEN2T26.915.8
MYO3_YEAST26.715.1
ERBB4_HUMAN26.715.7
CHD1_HUMAN26.716
DAPK1_HUMAN26.514.9
Protein-Protein Interactions: