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Target Details

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Name:DNA topoisomerase 1
Uniprot name:TOP1_HUMAN
Accession Numbers:A8KA78 O43256 P11387 Q12855 Q12856 Q15610 Q5TFY3 Q9UJN0
EC-Number:5.99.1.2
Organism:Homo sapiens
Human
PDB IDs:1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt46888247BindingDB-show
()-oxazepam hemisuccinate sodium salt46888245BindingDB-show
()-oxazepam hemisuccinate sodium salt24970451BindingDB-show
()-oxazepam hemisuccinate sodium salt21580556BindingDB-show
()-oxazepam hemisuccinate sodium salt46888249BindingDB-show
()-oxazepam hemisuccinate sodium salt46888313BindingDB-show
()-oxazepam hemisuccinate sodium salt46888308BindingDB-show
()-oxazepam hemisuccinate sodium salt44479228BindingDB-show
()-oxazepam hemisuccinate sodium salt46888307BindingDB-show
()-oxazepam hemisuccinate sodium salt46888254BindingDB-show
()-oxazepam hemisuccinate sodium salt46888251BindingDB-show
(4r)-4-ethyl-4-hydroxy-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14184196BindingDB-show
10,11-Methylenedioxycamptothecin72403BindingDB-show
20(S)-Ginsenoside Rg39918693BindingDB-show
4439957844399578BindingDB-show
4457783744577837BindingDB-show
7-Ethyl-10,11-methylenedioxy-20-S-camptothecin123614BindingDB-show
7-Ethylcamptothecin127584BindingDB-show
9-Aminocamptothecin72402BindingDB-show
AC1LAHQQ468670BindingDB-show
AC1LASDY494163BindingDB-show
AC1LCGB7629317BindingDB-show
Acridine carboxamide107805BindingDB-show
Acridinylanisidide2179BindingDB-show
Adriablastin31703BindingDB-show
Ambap3691479501BindingDB-show
beta,beta-Dimethylacrylalkannin479499BindingDB-show
Camptothecin analog104842BindingDB-show
Camptothecine24360BindingDB-show
Camptothecine24360DrugBank-show
CHEBI:1074274330531BindingDB-show
CHEBI:55626644268668BindingDB-show
CHEBI:58458012303949BindingDB-show
CHEBI:64606544324342BindingDB-show
CHEBI:64610044324258BindingDB-show
CHEBI:65182944324269BindingDB-show
CHEBI:6518455459176BindingDB-show
CHEBI:65186344324260BindingDB-show
Chebulagic acid442674BindingDB-show
CHEMBL109433446887589BindingDB-show
CHEMBL109433546887590BindingDB-show
CHEMBL109467346888244BindingDB-show
CHEMBL109467621636448BindingDB-show
CHEMBL109467846888246BindingDB-show
CHEMBL109468046888248BindingDB-show
CHEMBL109468246888250BindingDB-show
CHEMBL109468446888252BindingDB-show
CHEMBL109468546888253BindingDB-show
CHEMBL109468746888255BindingDB-show
CHEMBL109468846888256BindingDB-show
CHEMBL109468946888257BindingDB-show
CHEMBL109469046888258BindingDB-show
CHEMBL109469146888259BindingDB-show
CHEMBL109469246888260BindingDB-show
CHEMBL109500446887678BindingDB-show
CHEMBL109500512912322BindingDB-show
CHEMBL109500646887679BindingDB-show
CHEMBL109500846887680BindingDB-show
CHEMBL109501446888296BindingDB-show
CHEMBL109501646888298BindingDB-show
CHEMBL109501746888299BindingDB-show
CHEMBL109501846888300BindingDB-show
CHEMBL109501946888301BindingDB-show
CHEMBL109533946888311BindingDB-show
CHEMBL109534046888312BindingDB-show
CHEMBL109534946888320BindingDB-show
CHEMBL109535046888321BindingDB-show
CHEMBL109535146888322BindingDB-show
CHEMBL109535246888323BindingDB-show
CHEMBL109535346888324BindingDB-show
CHEMBL109672846887682BindingDB-show
CHEMBL109703346887586BindingDB-show
CHEMBL11177944340751BindingDB-show
CHEMBL11188944340971BindingDB-show
CHEMBL11223522671105BindingDB-show
CHEMBL11223944340974BindingDB-show
CHEMBL11260244340902BindingDB-show
CHEMBL11731544565954BindingDB-show
CHEMBL124058344604383BindingDB-show
CHEMBL124310746914768BindingDB-show
CHEMBL124313546914769BindingDB-show
CHEMBL124313642598388BindingDB-show
CHEMBL124316546914770BindingDB-show
CHEMBL124316646914919BindingDB-show
CHEMBL124319846914920BindingDB-show
CHEMBL124319946914921BindingDB-show
CHEMBL124322942598389BindingDB-show
CHEMBL124323046914922BindingDB-show
CHEMBL124326446914923BindingDB-show
CHEMBL124332525241943BindingDB-show
CHEMBL124335552948084BindingDB-show
CHEMBL12831544352476BindingDB-show
CHEMBL1292610362222BindingDB-show
CHEMBL1319011755151BindingDB-show
CHEMBL1322710006466BindingDB-show
CHEMBL13231944355264BindingDB-show
CHEMBL13253344355298BindingDB-show
CHEMBL13320944355276BindingDB-show
CHEMBL1334910482208BindingDB-show
CHEMBL1335511756382BindingDB-show
CHEMBL13453644355373BindingDB-show
CHEMBL1352344268675BindingDB-show
CHEMBL1352744268667BindingDB-show
CHEMBL13549113009345BindingDB-show
CHEMBL13549210053929BindingDB-show
CHEMBL13588144355300BindingDB-show
CHEMBL13597013009351BindingDB-show
CHEMBL1370710411417BindingDB-show
CHEMBL137469889178BindingDB-show
CHEMBL1377110321913BindingDB-show
CHEMBL1378710453728BindingDB-show
CHEMBL1384810092735BindingDB-show
CHEMBL1393510460355BindingDB-show
CHEMBL1399810452851BindingDB-show
CHEMBL15932210745521BindingDB-show
CHEMBL16290410768284BindingDB-show
CHEMBL1630069982858BindingDB-show
CHEMBL16300710600972BindingDB-show
CHEMBL16316210506494BindingDB-show
CHEMBL16850544381326BindingDB-show
CHEMBL1688229983085BindingDB-show
CHEMBL16897544381291BindingDB-show
CHEMBL16899444383263BindingDB-show
CHEMBL17040911743236BindingDB-show
CHEMBL17053244382872BindingDB-show
CHEMBL17119410453990BindingDB-show
CHEMBL17124044383179BindingDB-show
CHEMBL17226844383210BindingDB-show
CHEMBL1728609980993BindingDB-show
CHEMBL17382010455018BindingDB-show
CHEMBL17423310387840BindingDB-show
CHEMBL17442811756340BindingDB-show
CHEMBL18154744395196BindingDB-show
CHEMBL18409444395078BindingDB-show
CHEMBL1841009865934BindingDB-show
CHEMBL18530644395100BindingDB-show
CHEMBL18654113192381BindingDB-show
CHEMBL18812113192383BindingDB-show
CHEMBL18927022569139BindingDB-show
CHEMBL19008644399713BindingDB-show
CHEMBL19023044399679BindingDB-show
CHEMBL19060620758668BindingDB-show
CHEMBL19111244399377BindingDB-show
CHEMBL19260520758666BindingDB-show
CHEMBL19269344399714BindingDB-show
CHEMBL19285544399697BindingDB-show
CHEMBL1954169837937BindingDB-show
CHEMBL1997844273528BindingDB-show
CHEMBL2025544273652BindingDB-show
CHEMBL2081144273597BindingDB-show
CHEMBL2109644273600BindingDB-show
CHEMBL2110821197160BindingDB-show
CHEMBL2122144273624BindingDB-show
CHEMBL2126344273617BindingDB-show
CHEMBL2126519037238BindingDB-show
CHEMBL2126744273699BindingDB-show
CHEMBL24277016721067BindingDB-show
CHEMBL25870224939224BindingDB-show
CHEMBL25891942598162BindingDB-show
CHEMBL26561910340112BindingDB-show
CHEMBL26618244273647BindingDB-show
CHEMBL26635510457437BindingDB-show
CHEMBL26646844312069BindingDB-show
CHEMBL26660310317856BindingDB-show
CHEMBL2669612632564BindingDB-show
CHEMBL26704910460280BindingDB-show
CHEMBL26727510384526BindingDB-show
CHEMBL26743544265918BindingDB-show
CHEMBL26829010323343BindingDB-show
CHEMBL26897810252111BindingDB-show
CHEMBL26951910460329BindingDB-show
CHEMBL2732210064551BindingDB-show
CHEMBL27373410366776BindingDB-show
CHEMBL27502910094894BindingDB-show
CHEMBL27513410319267BindingDB-show
CHEMBL2755389981804BindingDB-show
CHEMBL2764489999214BindingDB-show
CHEMBL27646011741224BindingDB-show
CHEMBL27700844273560BindingDB-show
CHEMBL27701144273491BindingDB-show
CHEMBL27703944273561BindingDB-show
CHEMBL27740844273700BindingDB-show
CHEMBL27743244273653BindingDB-show
CHEMBL27766744273526BindingDB-show
CHEMBL27807144273527BindingDB-show
CHEMBL27810144273646BindingDB-show
CHEMBL27852644273605BindingDB-show
CHEMBL27875744273623BindingDB-show
CHEMBL27903544273618BindingDB-show
CHEMBL2794819928668BindingDB-show
CHEMBL28229944276312BindingDB-show
CHEMBL28243617874201BindingDB-show
CHEMBL28265544273599BindingDB-show
CHEMBL28376644273598BindingDB-show
CHEMBL28688222912790BindingDB-show
CHEMBL29005623442826BindingDB-show
CHEMBL29188510832854BindingDB-show
CHEMBL29385910664256BindingDB-show
CHEMBL29502444290797BindingDB-show
CHEMBL29603444290586BindingDB-show
CHEMBL29635028392752BindingDB-show
CHEMBL29635144290683BindingDB-show
CHEMBL29650020089392BindingDB-show
CHEMBL29679744290589BindingDB-show
CHEMBL29685644290591BindingDB-show
CHEMBL2972559907879BindingDB-show
CHEMBL29759444290602BindingDB-show
CHEMBL30378510712777BindingDB-show
CHEMBL30393510023217BindingDB-show
CHEMBL31079514083910BindingDB-show
CHEMBL31185510795337BindingDB-show
CHEMBL31190244317168BindingDB-show
CHEMBL31230610699214BindingDB-show
CHEMBL31269044312296BindingDB-show
CHEMBL31402523666382BindingDB-show
CHEMBL31495024878308BindingDB-show
CHEMBL32057444340972BindingDB-show
CHEMBL32057544340973BindingDB-show
CHEMBL32126244340970BindingDB-show
CHEMBL32271144340930BindingDB-show
CHEMBL32271244340931BindingDB-show
CHEMBL32339444340908BindingDB-show
CHEMBL32360144340904BindingDB-show
CHEMBL32476544340907BindingDB-show
CHEMBL32500544340782BindingDB-show
CHEMBL32583944340969BindingDB-show
CHEMBL32846144324236BindingDB-show
CHEMBL3296649889281BindingDB-show
CHEMBL33007244324256BindingDB-show
CHEMBL33406444340932BindingDB-show
CHEMBL33433713009352BindingDB-show
CHEMBL33436044355564BindingDB-show
CHEMBL33446113009355BindingDB-show
CHEMBL33486944355330BindingDB-show
CHEMBL33594044355294BindingDB-show
CHEMBL33660344355293BindingDB-show
CHEMBL33662644355299BindingDB-show
CHEMBL33896644355546BindingDB-show
CHEMBL33896713009346BindingDB-show
CHEMBL3410289874048BindingDB-show
CHEMBL34960110814294BindingDB-show
CHEMBL35011810097407BindingDB-show
CHEMBL35027010577898BindingDB-show
CHEMBL35055310768720BindingDB-show
CHEMBL35270944381032BindingDB-show
CHEMBL35280010317270BindingDB-show
CHEMBL3535889802955BindingDB-show
CHEMBL35408310433196BindingDB-show
CHEMBL35443210412775BindingDB-show
CHEMBL35467144380930BindingDB-show
CHEMBL35528544380928BindingDB-show
CHEMBL35956744395034BindingDB-show
CHEMBL36081211465894BindingDB-show
CHEMBL36159444395054BindingDB-show
CHEMBL36319222569126BindingDB-show
CHEMBL36375211317647BindingDB-show
CHEMBL36436044395040BindingDB-show
CHEMBL36452822569131BindingDB-show
CHEMBL36482744395116BindingDB-show
CHEMBL3665944283835BindingDB-show
CHEMBL36667544383741BindingDB-show
CHEMBL36728144383864BindingDB-show
CHEMBL36764944384424BindingDB-show
CHEMBL36825810456398BindingDB-show
CHEMBL36860144383740BindingDB-show
CHEMBL3688129979625BindingDB-show
CHEMBL36961644383814BindingDB-show
CHEMBL36983610369338BindingDB-show
CHEMBL36984744384483BindingDB-show
CHEMBL37047644399667BindingDB-show
CHEMBL37112122569130BindingDB-show
CHEMBL37228044399636BindingDB-show
CHEMBL3819421918498BindingDB-show
CHEMBL38691944311922BindingDB-show
CHEMBL39090444428913BindingDB-show
CHEMBL39647344428908BindingDB-show
CHEMBL40540513009354BindingDB-show
CHEMBL40690144355295BindingDB-show
CHEMBL40715742598163BindingDB-show
CHEMBL41391744381325BindingDB-show
CHEMBL41866810523895BindingDB-show
CHEMBL41895144324266BindingDB-show
CHEMBL42132110039843BindingDB-show
CHEMBL42288610816483BindingDB-show
CHEMBL42292210095286BindingDB-show
CHEMBL42380810626137BindingDB-show
CHEMBL42398110769272BindingDB-show
CHEMBL42845344273654BindingDB-show
CHEMBL43187214680464BindingDB-show
CHEMBL43262244340622BindingDB-show
CHEMBL43294914440698BindingDB-show
CHEMBL43384144340903BindingDB-show
CHEMBL43385544355186BindingDB-show
CHEMBL43423744355547BindingDB-show
CHEMBL4351919808998BindingDB-show
CHEMBL43588820758669BindingDB-show
CHEMBL43648744399668BindingDB-show
CHEMBL44028144276082BindingDB-show
CHEMBL44031344317204BindingDB-show
CHEMBL44435244383861BindingDB-show
CHEMBL4444110177790BindingDB-show
CHEMBL44591411800135BindingDB-show
CHEMBL44627644565960BindingDB-show
CHEMBL4468044291373BindingDB-show
CHEMBL44706944565948BindingDB-show
CHEMBL4474744290711BindingDB-show
CHEMBL4476510110293BindingDB-show
CHEMBL44782644565945BindingDB-show
CHEMBL44876044565964BindingDB-show
CHEMBL44983144565956BindingDB-show
CHEMBL45099144565946BindingDB-show
CHEMBL45244544565947BindingDB-show
CHEMBL45473444565937BindingDB-show
CHEMBL45532644565950BindingDB-show
CHEMBL45532844565943BindingDB-show
CHEMBL46343744567153BindingDB-show
CHEMBL46373844565952BindingDB-show
CHEMBL4638044290804BindingDB-show
CHEMBL46559212304067BindingDB-show
CHEMBL4685344290796BindingDB-show
CHEMBL470279887873BindingDB-show
CHEMBL47456144565958BindingDB-show
CHEMBL4752444291412BindingDB-show
CHEMBL4752644290621BindingDB-show
CHEMBL47568344565941BindingDB-show
CHEMBL4784844290590BindingDB-show
CHEMBL47872044565961BindingDB-show
CHEMBL478859909579BindingDB-show
CHEMBL49910344565949BindingDB-show
CHEMBL49979544565938BindingDB-show
CHEMBL50005944565939BindingDB-show
CHEMBL50130214194010BindingDB-show
CHEMBL50267944565962BindingDB-show
CHEMBL50305144565957BindingDB-show
CHEMBL50325244565940BindingDB-show
CHEMBL50581544565955BindingDB-show
CHEMBL50690244565944BindingDB-show
CHEMBL50700644565966BindingDB-show
CHEMBL50729544565959BindingDB-show
CHEMBL50768644565953BindingDB-show
CHEMBL50768812912363BindingDB-show
CHEMBL50810844565963BindingDB-show
CHEMBL50840714194006BindingDB-show
CHEMBL50954444565965BindingDB-show
CHEMBL51000644565942BindingDB-show
CHEMBL54008645265433BindingDB-show
CHEMBL54009045265491BindingDB-show
CHEMBL54277545262797BindingDB-show
CHEMBL54300010094004BindingDB-show
CHEMBL54323745262743BindingDB-show
CHEMBL54557845262666BindingDB-show
CHEMBL55403845259269BindingDB-show
CHEMBL55540945262773BindingDB-show
CHEMBL6043710592763BindingDB-show
CHEMBL6055210546958BindingDB-show
CHEMBL6234710689215BindingDB-show
CHEMBL6252210758977BindingDB-show
CHEMBL6276310830478BindingDB-show
CHEMBL6288310664445BindingDB-show
CHEMBL6312010544565BindingDB-show
CHEMBL640369841114BindingDB-show
CHEMBL6430710785294BindingDB-show
CHEMBL6438210832803BindingDB-show
CHEMBL6487410509674BindingDB-show
CHEMBL6492710050056BindingDB-show
CHEMBL6543610088917BindingDB-show
CHEMBL6711510429784BindingDB-show
CHEMBL7235344311921BindingDB-show
CHEMBL7262710550144BindingDB-show
CHEMBL7282810439475BindingDB-show
CHEMBL7300244311920BindingDB-show
CHEMBL7440610676714BindingDB-show
CHEMBL7445944312295BindingDB-show
CHEMBL7834413714338BindingDB-show
CHEMBL7843213798535BindingDB-show
CHEMBL7910344317608BindingDB-show
CHEMBL8013844317205BindingDB-show
CHEMBL879410342846BindingDB-show
CHEMBL880410341278BindingDB-show
CHEMBL880510475609BindingDB-show
CHEMBL880610089766BindingDB-show
CHEMBL883410316745BindingDB-show
CHEMBL8860513711981BindingDB-show
CHEMBL8888044324318BindingDB-show
CHEMBL8891218336742BindingDB-show
CHEMBL894010053305BindingDB-show
CHEMBL8988744324446BindingDB-show
CHEMBL9013644324306BindingDB-show
CHEMBL9029514761165BindingDB-show
CHEMBL9029624878514BindingDB-show
CHEMBL9041324878522BindingDB-show
CHEMBL9043623666383BindingDB-show
CHEMBL9063644324458BindingDB-show
CHEMBL907619953190BindingDB-show
CHEMBL9101744324235BindingDB-show
CHEMBL910519932270BindingDB-show
CHEMBL9110415589450BindingDB-show
CHEMBL9111713471631BindingDB-show
CHEMBL914810317744BindingDB-show
CHEMBL9149544324457BindingDB-show
CHEMBL916410069578BindingDB-show
CHEMBL91969978041BindingDB-show
CHEMBL925910075573BindingDB-show
CHEMBL926610385329BindingDB-show
CHEMBL9312244324330BindingDB-show
CHEMBL932010069443BindingDB-show
CHEMBL933810410326BindingDB-show
CHEMBL946910093224BindingDB-show
CHEMBL949910451907BindingDB-show
CHEMBL951810345156BindingDB-show
CHEMBL952344265889BindingDB-show
ChemDiv3_0022846620659BindingDB-show
CID 1000056410000564BindingDB-show
CID 1000056410091894BindingDB-show
CID 1000056410363086BindingDB-show
CID 1034651710346517BindingDB-show
CID 1034802210348022BindingDB-show
CID 1034802210099547BindingDB-show
CID 1036420411742280BindingDB-show
CID 1036420411742279BindingDB-show
CID 1036420410364204BindingDB-show
CID 1036524610455248BindingDB-show
CID 1040927310409274BindingDB-show
CID 1040927310001587BindingDB-show
CID 1040927310409273BindingDB-show
CID 1178810111788101BindingDB-show
CID 43244811679800BindingDB-show
CID 99751009975100BindingDB-show
CID 99815779981577BindingDB-show
Crystoserpine5770BindingDB-show
Demethyl Epipodophyllotoxin Ethylidine Glucoside36462BindingDB-show
Elaidinsaeure637517BindingDB-show
Gallanilide80427BindingDB-show
ginsenoside-Rb19898279BindingDB-show
Gynostemma Extract46887681BindingDB-show
Gypenoside XII9918692BindingDB-show
Hycamptamine60700BindingDB-show
Hycamptamine60700DrugBank-show
Hydroxycamptothecine97226BindingDB-show
irinotecan hydrochloride60838DrugBank-show
Irinotecan hydrochloride74990DrugBank-show
irinotecan hydrochloride60838SuperTargetPMID 015041737show
Irinotecan hydrochloride74990SuperTargetPMID 015041737show
Isobutylshikonin479500BindingDB-show
Lucanthone monohydrochloride10180DrugBank-show
nchembio.188-comp4110366723BindingDB-show
Netropsin4461BindingDB-show
NSC117027419666BindingDB-show
NSC158393292564BindingDB-show
NSC3029912538BindingDB-show
NSC36939465567BindingDB-show
NSC369395190763BindingDB-show
NSC606174366358BindingDB-show
NSC609959184095BindingDB-show
NSC609960184078BindingDB-show
NSC629971131182BindingDB-show
NSC658832377390BindingDB-show
NSC81574231860BindingDB-show
Oelsauere445639BindingDB-show
Oprea1_05140820544405BindingDB-show
Propionylshikonin153984BindingDB-show
Rubex6916127BindingDB-show
Shikonin479503BindingDB-show
Sodium stibogluconate16685683DrugBank-show
Stallimycin3115BindingDB-show
topostatin44559995BindingDB-show
Topotecan5515BindingDB-show
Topotecan monohydrochloride60699BindingDB-show
Topotecan monohydrochloride60699PROMISCUOUS4 PMIDsshow
Topotecan monohydrochloride60699SuperTargetPMID 016278418show
Viminalol73170BindingDB-show
Yohimbinsaeure72131BindingDB-show
Synonyms:
DNA topoisomerase 1
DNA topoisomerase I
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
TOP1M_HUMAN6351.3
Q9NJG8_LEIDO38.927.1
CHEA_THEMA31.217.1
Q4W5E3_HUMAN31.117.5
CNGA1_HUMAN31.117.5
IDH_AZOVI30.817.5
LOX5_RAT30.115
MCM7_HUMAN29.916.2
KPCB_RAT29.815.7
KPCB_HUMAN29.815.8
LOX5_HUMAN29.714.9
ENPL_HUMAN29.616.5
ENPL_CANFA29.616.2
DNLJ_ENTFA29.416.1
SYCC_HUMAN29.416.3
LOX5_MOUSE29.415.2
MALQ_THELI2915.5
SYTC_HUMAN28.716.6
Q6I7E7_STAAU28.716.3
BTK_HUMAN28.617.1
STA5B_HUMAN28.614.9
CACP_HUMAN28.115.5
SYM_ECOLI28.116.4
Q9WYA5_THEMA28.116.2
ALBU_BOVIN2817
PDE10_HUMAN27.915.3
RFCS_PYRFU27.915.3
CTNB1_HUMAN27.914.7
CTNB1_MOUSE27.914.7
CAT1_NEUCR27.815
Protein-Protein Interactions: