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Target Details

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Name:Aurora kinase A
Uniprot name:STK6_HUMAN
Accession Numbers:O14965 O60445 O75873 Q9BQD6 Q9UPG5
EC-Number:2.7.11.1
Organism:Homo sapiens
Human
PDB IDs:1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2-amino-pyrazolopyridine, 2925093261BindingDB-show
2-amino-pyrazolopyridine, 3725093264BindingDB-show
2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL1587957BindingDB-show
2c4g23586142BindingDB-show
2e9n10050156BindingDB-show
2j4z11751305BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1511361885BindingDB-show
3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1811407074BindingDB-show
4-aminopyrazole quinazoline, 325138093BindingDB-show
4-aminopyrazole quinazoline, 425138094BindingDB-show
4-aminopyrazole quinazoline, 611249657BindingDB-show
4-aminopyrazole quinazoline, 725138095BindingDB-show
5-Amido-pyrrolopyrazole 9a11994444BindingDB-show
5-Amido-pyrrolopyrazole 9b11442557BindingDB-show
7-bromo-indirubin-3'-oxime11846148BindingDB-show
ABT-86911485656BindingDB-show
AC1N9NXE4388543BindingDB-show
AC1NTGE75403336BindingDB-show
Adenosindiphosphorsaeure6022DrugBank-show
Adenyldeoxyriboside60961SuperTarget-show
Adenyldeoxyriboside13730SuperTarget-show
AMG 70611667893BindingDB-show
Arabinofuranosyladenine21704SuperTarget-show
AST-48711409972BindingDB-show
Aurora Kinase Inhibitor III9549303BindingDB-show
Benzo(f)-1,3-benzodioxolo(6,5,4-cd)indol-5(6H)-one, 8-hydroxy-158883BindingDB-show
Bio2_0004136610353BindingDB-show
Canertinib156414BindingDB-show
Cdk2/9 Inhibitor447961BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL107729111580208BindingDB-show
CHEMBL107772946883135BindingDB-show
CHEMBL107806046883136BindingDB-show
CHEMBL107806146883137BindingDB-show
CHEMBL107882746883054BindingDB-show
CHEMBL107882846883055BindingDB-show
CHEMBL107890611523891BindingDB-show
CHEMBL107953846883180BindingDB-show
CHEMBL107971346883181BindingDB-show
CHEMBL108215211560568BindingDB-show
CHEMBL108229146866896BindingDB-show
CHEMBL108249246867016BindingDB-show
CHEMBL108250746867947BindingDB-show
CHEMBL108259725153836BindingDB-show
CHEMBL108283046867948BindingDB-show
CHEMBL108283146867949BindingDB-show
CHEMBL108315046830766BindingDB-show
CHEMBL108315111632150BindingDB-show
CHEMBL108315211718021BindingDB-show
CHEMBL108348411744184BindingDB-show
CHEMBL108349046868648BindingDB-show
CHEMBL108349146868649BindingDB-show
CHEMBL108377146868352BindingDB-show
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CHEMBL108406746866786BindingDB-show
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CHEMBL108445146890253BindingDB-show
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CHEMBL108462910430000BindingDB-show
CHEMBL108463010340715BindingDB-show
CHEMBL108463346890314BindingDB-show
CHEMBL108463446890315BindingDB-show
CHEMBL108463646889922BindingDB-show
CHEMBL108471511646645BindingDB-show
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CHEMBL108485946866785BindingDB-show
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CHEMBL108488723585534BindingDB-show
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CHEMBL108488946867015BindingDB-show
CHEMBL108492625242324BindingDB-show
CHEMBL108496946830768BindingDB-show
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CHEMBL117354446855195BindingDB-show
CHEMBL117354546855196BindingDB-show
CHEMBL117358546855041BindingDB-show
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CHEMBL121470846847848BindingDB-show
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CHEMBL129007250908681BindingDB-show
CHEMBL18514016723801BindingDB-show
CHEMBL19025211305344BindingDB-show
CHEMBL19140211167062BindingDB-show
CHEMBL19181610156505BindingDB-show
CHEMBL19257510111728BindingDB-show
CHEMBL19947644405869BindingDB-show
CHEMBL19954744405872BindingDB-show
CHEMBL19976544405864BindingDB-show
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CHEMBL20039544405896BindingDB-show
CHEMBL20052511604623BindingDB-show
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CHEMBL20119711628500BindingDB-show
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CHEMBL46579324983495BindingDB-show
CHEMBL47219324880024BindingDB-show
CHEMBL47220225138107BindingDB-show
CHEMBL47238225271180BindingDB-show
CHEMBL47238325271518BindingDB-show
CHEMBL47254444562431BindingDB-show
CHEMBL47254525063262BindingDB-show
CHEMBL47294644564820BindingDB-show
CHEMBL47304044579993BindingDB-show
CHEMBL47335144564953BindingDB-show
CHEMBL47335444564911BindingDB-show
CHEMBL47355344156917BindingDB-show
CHEMBL47355616042971BindingDB-show
CHEMBL47355744564910BindingDB-show
CHEMBL47376144564955BindingDB-show
CHEMBL47434644564860BindingDB-show
CHEMBL47434744564861BindingDB-show
CHEMBL47454344564862BindingDB-show
CHEMBL47454444564863BindingDB-show
CHEMBL47535144564817BindingDB-show
CHEMBL47535244564819BindingDB-show
CHEMBL48152244568212BindingDB-show
CHEMBL48196844570599BindingDB-show
CHEMBL48196944570600BindingDB-show
CHEMBL48262116666862BindingDB-show
CHEMBL48266314293776BindingDB-show
CHEMBL48277444591672BindingDB-show
CHEMBL48277810094732BindingDB-show
CHEMBL48277910388447BindingDB-show
CHEMBL48296816041424BindingDB-show
CHEMBL48345116666861BindingDB-show
CHEMBL48400610435854BindingDB-show
CHEMBL48400710112131BindingDB-show
CHEMBL48460144591670BindingDB-show
CHEMBL48460910343860BindingDB-show
CHEMBL48467816666806BindingDB-show
CHEMBL48487616666859BindingDB-show
CHEMBL48495010200408BindingDB-show
CHEMBL48495110252549BindingDB-show
CHEMBL48508116666860BindingDB-show
CHEMBL48518610412796BindingDB-show
CHEMBL48533744591671BindingDB-show
CHEMBL48535110322308BindingDB-show
CHEMBL48864524894996BindingDB-show
CHEMBL48864624894992BindingDB-show
CHEMBL48881124894997BindingDB-show
CHEMBL48982016666911BindingDB-show
CHEMBL49055544565015BindingDB-show
CHEMBL49104516666857BindingDB-show
CHEMBL49124316666757BindingDB-show
CHEMBL49167744565069BindingDB-show
CHEMBL49168644565013BindingDB-show
CHEMBL49316944219632BindingDB-show
CHEMBL49656925190710BindingDB-show
CHEMBL49675425190713BindingDB-show
CHEMBL50415525190709BindingDB-show
CHEMBL50516744579957BindingDB-show
CHEMBL50537944579994BindingDB-show
CHEMBL50771425124150BindingDB-show
CHEMBL50792716666858BindingDB-show
CHEMBL50943524894883BindingDB-show
CHEMBL51147844562420BindingDB-show
CHEMBL51293344564748BindingDB-show
CHEMBL51307625138103BindingDB-show
CHEMBL51401644564864BindingDB-show
CHEMBL51492944564821BindingDB-show
CHEMBL51494144564954BindingDB-show
CHEMBL51494244156909BindingDB-show
CHEMBL51559844564818BindingDB-show
CHEMBL51600325190712BindingDB-show
CHEMBL51764744570554BindingDB-show
CHEMBL51774525271513BindingDB-show
CHEMBL51864625271515BindingDB-show
CHEMBL51866625138102BindingDB-show
CHEMBL51880344564789BindingDB-show
CHEMBL51898144591701BindingDB-show
CHEMBL52097516666910BindingDB-show
CHEMBL52110524893974BindingDB-show
CHEMBL52120124894995BindingDB-show
CHEMBL52221425190715BindingDB-show
CHEMBL52256325190711BindingDB-show
CHEMBL52260144579918BindingDB-show
CHEMBL52278544565014BindingDB-show
CHEMBL52289125138278BindingDB-show
CHEMBL52392325190714BindingDB-show
CHEMBL52921724894888BindingDB-show
CHEMBL52966324894117BindingDB-show
CHEMBL54932210268530BindingDB-show
CHEMBL5494699924047BindingDB-show
CHEMBL5495369901007BindingDB-show
CHEMBL5508259858715BindingDB-show
CHEMBL55163310222721BindingDB-show
CHEMBL55163410292186BindingDB-show
CHEMBL55203310159519BindingDB-show
CHEMBL55203810267834BindingDB-show
CHEMBL55226544241614BindingDB-show
CHEMBL55238510157920BindingDB-show
CHEMBL5525009925230BindingDB-show
CHEMBL55646010182284BindingDB-show
CHEMBL55727910273410BindingDB-show
CHEMBL55768245272990BindingDB-show
CHEMBL55851245273505BindingDB-show
CHEMBL55990010134576BindingDB-show
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CHEMBL56055620604194BindingDB-show
CHEMBL56106644241613BindingDB-show
CHEMBL56161745269587BindingDB-show
CHEMBL56183410111694BindingDB-show
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CHEMBL56241510270356BindingDB-show
CHEMBL5624169947412BindingDB-show
CHEMBL56249745267893BindingDB-show
CHEMBL56368216719269BindingDB-show
CHEMBL56429021991073BindingDB-show
CHEMBL56445910179215BindingDB-show
CHEMBL56494110179373BindingDB-show
CHEMBL56518323545854BindingDB-show
CHEMBL5652059901505BindingDB-show
CHEMBL59123045142014BindingDB-show
CHEMBL59146345139797BindingDB-show
CHEMBL59146711416146BindingDB-show
CHEMBL59225646233288BindingDB-show
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CHEMBL59322146225597BindingDB-show
CHEMBL59324546225598BindingDB-show
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CHEMBL59329246225635BindingDB-show
CHEMBL59329346225679BindingDB-show
CHEMBL59329446225680BindingDB-show
CHEMBL59330646225611BindingDB-show
CHEMBL59376046225632BindingDB-show
CHEMBL59377046225668BindingDB-show
CHEMBL59386046225657BindingDB-show
CHEMBL59390546225649BindingDB-show
CHEMBL59390846225666BindingDB-show
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CHEMBL59735245142015BindingDB-show
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CHEMBL59797745139610BindingDB-show
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CHEMBL59840146233220BindingDB-show
CHEMBL59898645141802BindingDB-show
CHEMBL59898745142011BindingDB-show
CHEMBL59898845142013BindingDB-show
CHEMBL59921045139609BindingDB-show
CHEMBL59922445139989BindingDB-show
CHEMBL59940145142246BindingDB-show
CHEMBL59942745139990BindingDB-show
CHEMBL59942845139991BindingDB-show
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CHEMBL59963145141800BindingDB-show
CHEMBL59982445139427BindingDB-show
CHEMBL60039445139795BindingDB-show
CHEMBL60079546232443BindingDB-show
CHEMBL60087645139613BindingDB-show
CHEMBL60247146232555BindingDB-show
CHEMBL60247246232556BindingDB-show
CHEMBL60290445139614BindingDB-show
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CHEMBL60308045139798BindingDB-show
CHEMBL60309746232590BindingDB-show
CHEMBL60310845139794BindingDB-show
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CHEMBL60409245139426BindingDB-show
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CHEMBL60471210429593BindingDB-show
CHEMBL60489346225641BindingDB-show
CHEMBL60499246225647BindingDB-show
CHEMBL60515345139611BindingDB-show
CHEMBL60520845142243BindingDB-show
CHEMBL60535045142012BindingDB-show
CHEMBL60577445139429BindingDB-show
CHEMBL60578145139428BindingDB-show
CHEMBL60600045139612BindingDB-show
CHEMBL60640945139992BindingDB-show
CHEMBL60642845139799BindingDB-show
CHEMBL60646612000650BindingDB-show
CHEMBL60718745139430BindingDB-show
CHEMBL60785245142016BindingDB-show
CHEMBL60844445142245BindingDB-show
CHEMBL61021845141801BindingDB-show
CHIR-26511656518BindingDB-show
CID 1023987310175126BindingDB-show
CID 1023987310239873BindingDB-show
CID 1031186810311867BindingDB-show
CID 1133028411330284BindingDB-show
CID 1148795811487958BindingDB-show
CID 1148795811994445BindingDB-show
CID 1149662911696609BindingDB-show
CID 1163472511634725BindingDB-show
CID 1184670211846702BindingDB-show
CID 1184670211846701BindingDB-show
CID 1184687811846877BindingDB-show
CID 1184687811846878BindingDB-show
CID 1184702811847028BindingDB-show
CID 1184702811847027BindingDB-show
CID 1199444111994441BindingDB-show
CK8447962BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
GSK-3 Inhibitor XIII6419766BindingDB-show
GSK1904529A25124816BindingDB-show
GW-258011617559BindingDB-show
HPM5494424BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
indirubin deriv. 8h6538812BindingDB-show
indirubin deriv. 9b6538813BindingDB-show
Indirubin-3monoxime5326739BindingDB-show
InSolution™ GSK-3 Inhibitor IX5287844BindingDB-show
K00590a6610278BindingDB-show
K00598a9549299BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_371224995524BindingDB-show
Kinome_6366420138BindingDB-show
Kinome_71446886323BindingDB-show
Kinome_75610320107BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
MLN805411712649BindingDB-show
MLS0000520821251356BindingDB-show
monastrol2987927BindingDB-show
N6-Hexylaminopurine1870BindingDB-show
nchembio.90-comp111715767BindingDB-show
Pazopanib10113978BindingDB-show
PHA-68063211249084BindingDB-show
PHOSPHONOTHREONINE3246323DrugBank-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Pyrazoleanthrone8515BindingDB-show
pyrazoloquinazoline deriv., 616221284BindingDB-show
pyrazoloquinazoline deriv., 716221285BindingDB-show
pyrazoloquinazoline deriv., 810175096BindingDB-show
pyrazoloquinazoline deriv., 916221286BindingDB-show
pyrimidylpyrrole, 10a44482037BindingDB-show
pyrimidylpyrrole, 10c44482038BindingDB-show
pyrimidylpyrrole, 10d44481494BindingDB-show
pyrimidylpyrrole, 11a44482039BindingDB-show
pyrimidylpyrrole, 11b44481495BindingDB-show
pyrimidylpyrrole, 11c44482040BindingDB-show
pyrimidylpyrrole, 11d44482041BindingDB-show
pyrimidylpyrrole, 11f44482303BindingDB-show
pyrimidylpyrrole, 11g44481764BindingDB-show
pyrimidylpyrrole, 11h44482304BindingDB-show
pyrimidylpyrrole, 11i44481765BindingDB-show
pyrimidylpyrrole, 11j44482305BindingDB-show
pyrimidylpyrrole, 11k44482306BindingDB-show
pyrimidylpyrrole, 11l44481766BindingDB-show
pyrimidylpyrrole, 11m44482307BindingDB-show
pyrimidylpyrrole, 9a44481490BindingDB-show
pyrimidylpyrrole, 9b44481768BindingDB-show
pyrimidylpyrrole, 9c44481491BindingDB-show
pyrimidylpyrrole, 9d44481769BindingDB-show
pyrimidylpyrrole, 9e44481492BindingDB-show
pyrimidylpyrrole, 9f44482036BindingDB-show
quinazoline deriv. 1023646077BindingDB-show
quinazoline deriv. 1123646078BindingDB-show
quinazoline deriv. 323646072BindingDB-show
quinazoline deriv. 423646073BindingDB-show
quinazoline deriv. 511519624BindingDB-show
quinazoline deriv. 623646074BindingDB-show
quinazoline deriv. 823646076BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1133_Selleck24771867BindingDB-show
S1147_Selleck16007391BindingDB-show
S1152_Selleck24180719BindingDB-show
S1519_Selleck16202152BindingDB-show
S1524_Selleck11338033BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SMR0000245003241232BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
ST0817185205832BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Sulfanilamidopyrimidine5215BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Z4844480711BindingDB-show
ZINC000169785329009BindingDB-show
ZM-4474399914412BindingDB-show
Synonyms:
Aurora kinase A
Aurora-A
Aurora-related kinase 1
Aurora/IPL1-related kinase 1
Breast tumor-amplified kinase
hARK1
Serine/threonine kinase 15
Serine/threonine-protein kinase 6
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
KAPA_YEAST41.426
MP2K3_MOUSE40.223.3
MP2K4_HUMAN39.122.2
PIM1_HUMAN3824.2
PAK1_CAEEL37.722.5
AKT1_MOUSE37.523.7
MP2K7_HUMAN37.320.4
KAPCB_RAT37.122.9
KAPCB_MOUSE37.122.9
KAPCB_HUMAN36.922.7
Q9Y6B5_HUMAN36.920.5
KAPCA_HUMAN36.721.6
KAPCA_PIG36.721.6
KAPCA_RAT36.721.6
KAPCA_MOUSE36.421.3
KAPCA_BOVIN36.421.3
KAPCG_HUMAN36.423
MP2K6_MOUSE35.921.3
MP2K1_RAT35.619.7
MP2K1_MOUSE35.619.7
MP2K1_HUMAN35.319.5
MP2K2_RAT35.219.7
MAPK2_HUMAN34.921.9
CDK15_HUMAN34.320.5
MP2K2_MOUSE34.118.8
ACVR1_HUMAN3419.2
AKT1_HUMAN33.622
CSK_HUMAN33.618.3
MP2K2_HUMAN33.218.6
KPEL_DROME33.219.4
Protein-Protein Interactions: