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Name:DHOdehase
Uniprot name:PYRD_HUMAN
Accession Numbers:A8K8C8 Q02127 Q6P176
EC-Number:1.3.5.2
Organism:Homo sapiens
Human
PDB IDs:1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 3F1Q 3FJ6 3FJL 3G0U 3G0X
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(4-Chloro-phenyl)-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-amine741601BindingDB-show
2-CYANO-3-HYDROXY-N-(4-TRIFLUOROMETHYL-PHENYL)-BUTYRAMIDE1550DrugBank-show
2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide773693BindingDB-show
2-[(4-phenylbenzoyl)amino]benzoic Acid914489BindingDB-show
2-[2-[[5-(2-chlorophenyl)-2-furyl]methylidene]hydrazinyl]benzoic Acid9663654BindingDB-show
3-AMIDO-5-BIPHENYL-BENZOIC ACID5287459BindingDB-show
3-AMIDO-5-BIPHENYL-BENZOIC ACID5287459DrugBank-show
3-Amino-2-(1,1'-biphenyl)-4-yl-6-fluoro-4-quinolinecarboxylic acid131419BindingDB-show
3FT9547914BindingDB-show
AC1NPZRD5167181BindingDB-show
AMX0110690749BindingDB-show
AMX0323647298BindingDB-show
AMX0410691466BindingDB-show
AMX0510738106BindingDB-show
AMX0610852951BindingDB-show
AMX0710830342BindingDB-show
AMX0810687946BindingDB-show
AMX1010643787BindingDB-show
ASN 069788191460771BindingDB-show
Atovaquone74989DrugBank-show
Atovaquone74989SuperTargetPMID 10681344show
BAS 06978675517858BindingDB-show
BAS 06978692777184BindingDB-show
bicyclic compound 104605417BindingDB-show
bicyclic compound 712454047BindingDB-show
Biphenquinate57030BindingDB-show
biphenyl compound 1116102643BindingDB-show
biphenyl compound 1216102646BindingDB-show
biphenyl compound 1316102644BindingDB-show
biphenyl compound 1416102645BindingDB-show
Biphenyl-4-ylcarbamoyl Thiophene Analog 1223647304BindingDB-show
BREQUINAR ANALOG1543BindingDB-show
BREQUINAR ANALOG1543DrugBank-show
BREQUINAR SODIUM23663964BindingDB-show
CHEMBL10400144336357BindingDB-show
CHEMBL10413644336456BindingDB-show
CHEMBL10414644336155BindingDB-show
CHEMBL10416744336188BindingDB-show
CHEMBL10420923668976BindingDB-show
CHEMBL10430223671801BindingDB-show
CHEMBL10471244336303BindingDB-show
CHEMBL10476644336436BindingDB-show
CHEMBL10482444336438BindingDB-show
CHEMBL10517523693316BindingDB-show
CHEMBL10646744336254BindingDB-show
CHEMBL10651544336262BindingDB-show
CHEMBL10652944336238BindingDB-show
CHEMBL10667444336310BindingDB-show
CHEMBL10686523671800BindingDB-show
CHEMBL10693044336317BindingDB-show
CHEMBL10720923699195BindingDB-show
CHEMBL10722423699196BindingDB-show
CHEMBL10736244336326BindingDB-show
CHEMBL10741744336370BindingDB-show
CHEMBL10764244336469BindingDB-show
CHEMBL10821344336445BindingDB-show
CHEMBL10832744336282BindingDB-show
CHEMBL108492744631846BindingDB-show
CHEMBL108492844631844BindingDB-show
CHEMBL108874244631845BindingDB-show
CHEMBL11620610657722BindingDB-show
CHEMBL11694610800984BindingDB-show
CHEMBL11812510682218BindingDB-show
CHEMBL11816810540764BindingDB-show
CHEMBL11839510516983BindingDB-show
CHEMBL11845510587807BindingDB-show
CHEMBL11846810565707BindingDB-show
CHEMBL11848910519719BindingDB-show
CHEMBL11849910492984BindingDB-show
CHEMBL11858610828593BindingDB-show
CHEMBL11864510830186BindingDB-show
CHEMBL11864710544308BindingDB-show
CHEMBL11872710829333BindingDB-show
CHEMBL11889410635802BindingDB-show
CHEMBL11892110710291BindingDB-show
CHEMBL11899710759927BindingDB-show
CHEMBL11919310515945BindingDB-show
CHEMBL11956410849345BindingDB-show
CHEMBL11967610759123BindingDB-show
CHEMBL11969710488180BindingDB-show
CHEMBL11978010516844BindingDB-show
CHEMBL11980110680597BindingDB-show
CHEMBL12064010491179BindingDB-show
CHEMBL12189810703799BindingDB-show
CHEMBL1338025263431BindingDB-show
CHEMBL14130411825758BindingDB-show
CHEMBL14133811038663BindingDB-show
CHEMBL14244411016730BindingDB-show
CHEMBL14334511762691BindingDB-show
CHEMBL14355210938858BindingDB-show
CHEMBL1436289824035BindingDB-show
CHEMBL14386810895558BindingDB-show
CHEMBL15412121084669BindingDB-show
CHEMBL15415144369486BindingDB-show
CHEMBL15421421084763BindingDB-show
CHEMBL15433644369555BindingDB-show
CHEMBL15437221084721BindingDB-show
CHEMBL15451321084723BindingDB-show
CHEMBL15461344369554BindingDB-show
CHEMBL15462310457096BindingDB-show
CHEMBL15490844369777BindingDB-show
CHEMBL15553044369833BindingDB-show
CHEMBL15554844369738BindingDB-show
CHEMBL15559744369747BindingDB-show
CHEMBL15573221084690BindingDB-show
CHEMBL15700444369871BindingDB-show
CHEMBL15710510342449BindingDB-show
CHEMBL15716444369870BindingDB-show
CHEMBL15727721084739BindingDB-show
CHEMBL19336521084741BindingDB-show
CHEMBL19337144403188BindingDB-show
CHEMBL19402344403235BindingDB-show
CHEMBL19407544403243BindingDB-show
CHEMBL19439522042531BindingDB-show
CHEMBL19477621084857BindingDB-show
CHEMBL19495444403250BindingDB-show
CHEMBL19495544403251BindingDB-show
CHEMBL19516344403240BindingDB-show
CHEMBL19524621084860BindingDB-show
CHEMBL19562244403236BindingDB-show
CHEMBL19617344403223BindingDB-show
CHEMBL19618121084730BindingDB-show
CHEMBL19625622042533BindingDB-show
CHEMBL1971949820008BindingDB-show
CHEMBL19745544403229BindingDB-show
CHEMBL19755321084801BindingDB-show
CHEMBL19936111524688BindingDB-show
CHEMBL19950123647302BindingDB-show
CHEMBL19957423647297BindingDB-show
CHEMBL20069923647299BindingDB-show
CHEMBL20085623647300BindingDB-show
CHEMBL20085823647301BindingDB-show
CHEMBL20089423647307BindingDB-show
CHEMBL20089523647308BindingDB-show
CHEMBL20243115942658BindingDB-show
CHEMBL21670616099935BindingDB-show
CHEMBL21791814498165BindingDB-show
CHEMBL21791916099918BindingDB-show
CHEMBL21795916099917BindingDB-show
CHEMBL21805116099971BindingDB-show
CHEMBL21805216099929BindingDB-show
CHEMBL21806216099999BindingDB-show
CHEMBL21808316100004BindingDB-show
CHEMBL21808414498174BindingDB-show
CHEMBL21808514498179BindingDB-show
CHEMBL21816914498175BindingDB-show
CHEMBL21846414498162BindingDB-show
CHEMBL21858316099923BindingDB-show
CHEMBL21870014498163BindingDB-show
CHEMBL21872716099968BindingDB-show
CHEMBL21878016099919BindingDB-show
CHEMBL21917416099978BindingDB-show
CHEMBL21923316099900BindingDB-show
CHEMBL21936416099914BindingDB-show
CHEMBL21948916100000BindingDB-show
CHEMBL21952016100011BindingDB-show
CHEMBL21964814498150BindingDB-show
CHEMBL26721016099905BindingDB-show
CHEMBL28773044286358BindingDB-show
CHEMBL28813744286041BindingDB-show
CHEMBL28838144286187BindingDB-show
CHEMBL28870823673359BindingDB-show
CHEMBL28885244286092BindingDB-show
CHEMBL28907144285758BindingDB-show
CHEMBL28947014773532BindingDB-show
CHEMBL28955544286140BindingDB-show
CHEMBL28985444285510BindingDB-show
CHEMBL29067444285831BindingDB-show
CHEMBL29091013960668BindingDB-show
CHEMBL29126844286046BindingDB-show
CHEMBL29749744294414BindingDB-show
CHEMBL29856844294214BindingDB-show
CHEMBL30316744310718BindingDB-show
CHEMBL30440144310374BindingDB-show
CHEMBL30500244310352BindingDB-show
CHEMBL30505244310384BindingDB-show
CHEMBL30521544310640BindingDB-show
CHEMBL30528444310382BindingDB-show
CHEMBL30610044310357BindingDB-show
CHEMBL30678410064328BindingDB-show
CHEMBL30683144310381BindingDB-show
CHEMBL30776844310624BindingDB-show
CHEMBL30814110404208BindingDB-show
CHEMBL31879844336322BindingDB-show
CHEMBL32020444336252BindingDB-show
CHEMBL32024523686481BindingDB-show
CHEMBL32106044336240BindingDB-show
CHEMBL32116344336258BindingDB-show
CHEMBL32210044336227BindingDB-show
CHEMBL32227444336242BindingDB-show
CHEMBL32285544336260BindingDB-show
CHEMBL32292944336305BindingDB-show
CHEMBL32466844336266BindingDB-show
CHEMBL32669244336350BindingDB-show
CHEMBL32696010805428BindingDB-show
CHEMBL33090110680043BindingDB-show
CHEMBL33139910755169BindingDB-show
CHEMBL33248010711746BindingDB-show
CHEMBL33327610587934BindingDB-show
CHEMBL33334410752727BindingDB-show
CHEMBL33340410512886BindingDB-show
CHEMBL33411710565785BindingDB-show
CHEMBL33431710825617BindingDB-show
CHEMBL34169411135071BindingDB-show
CHEMBL34192510048413BindingDB-show
CHEMBL34222011102808BindingDB-show
CHEMBL34514744369573BindingDB-show
CHEMBL34544644369844BindingDB-show
CHEMBL34546444369748BindingDB-show
CHEMBL34565221084734BindingDB-show
CHEMBL34568544369749BindingDB-show
CHEMBL34570110454174BindingDB-show
CHEMBL34714821084760BindingDB-show
CHEMBL3482709948506BindingDB-show
CHEMBL34887144369512BindingDB-show
CHEMBL34957744369868BindingDB-show
CHEMBL35178621084752BindingDB-show
CHEMBL35843521084746BindingDB-show
CHEMBL35917110029745BindingDB-show
CHEMBL3604713960639BindingDB-show
CHEMBL3698113960629BindingDB-show
CHEMBL37000821084803BindingDB-show
CHEMBL37022823647309BindingDB-show
CHEMBL37148223647305BindingDB-show
CHEMBL37173215942657BindingDB-show
CHEMBL37210121084861BindingDB-show
CHEMBL37256111703683BindingDB-show
CHEMBL37443216099913BindingDB-show
CHEMBL37542516100015BindingDB-show
CHEMBL37581516099916BindingDB-show
CHEMBL3810439861992BindingDB-show
CHEMBL3824223673369BindingDB-show
CHEMBL38316523647303BindingDB-show
CHEMBL38403916100006BindingDB-show
CHEMBL3842123673384BindingDB-show
CHEMBL3844044286047BindingDB-show
CHEMBL38454316100003BindingDB-show
CHEMBL3847623673428BindingDB-show
CHEMBL38498316099926BindingDB-show
CHEMBL38589316099894BindingDB-show
CHEMBL3861413960632BindingDB-show
CHEMBL38615916100001BindingDB-show
CHEMBL3862044285921BindingDB-show
CHEMBL3863944285821BindingDB-show
CHEMBL3866944286048BindingDB-show
CHEMBL38670016100005BindingDB-show
CHEMBL3869210364016BindingDB-show
CHEMBL38728816100002BindingDB-show
CHEMBL3882044286071BindingDB-show
CHEMBL3895344286040BindingDB-show
CHEMBL3897844286221BindingDB-show
CHEMBL3898613960640BindingDB-show
CHEMBL3899744285511BindingDB-show
CHEMBL3912844286043BindingDB-show
CHEMBL3915144286361BindingDB-show
CHEMBL3916213960650BindingDB-show
CHEMBL3916744285869BindingDB-show
CHEMBL3918823673385BindingDB-show
CHEMBL3919144285691BindingDB-show
CHEMBL3932544285498BindingDB-show
CHEMBL3939744285877BindingDB-show
CHEMBL3944844285965BindingDB-show
CHEMBL3947210000399BindingDB-show
CHEMBL3997144285497BindingDB-show
CHEMBL4009313960654BindingDB-show
CHEMBL4018244285515BindingDB-show
CHEMBL4022013960663BindingDB-show
CHEMBL41605744286125BindingDB-show
CHEMBL4171914498146BindingDB-show
CHEMBL41772223699180BindingDB-show
CHEMBL4179944286387BindingDB-show
CHEMBL41806244285885BindingDB-show
CHEMBL41887010541884BindingDB-show
CHEMBL41963144310311BindingDB-show
CHEMBL42629923647306BindingDB-show
CHEMBL43076044294190BindingDB-show
CHEMBL43242710803940BindingDB-show
CHEMBL43344513960681BindingDB-show
CHEMBL4363844285854BindingDB-show
CHEMBL4363944285855BindingDB-show
CHEMBL43748025263432BindingDB-show
CHEMBL44066044285816BindingDB-show
CHEMBL44127644336420BindingDB-show
CHEMBL44203010929378BindingDB-show
CHEMBL44537510496492BindingDB-show
CHEMBL4569144294295BindingDB-show
CHEMBL47581424882195BindingDB-show
CHEMBL4824444294461BindingDB-show
CHEMBL4853144294171BindingDB-show
CHEMBL4875344293976BindingDB-show
CHEMBL4892823699181BindingDB-show
CHEMBL4908944294412BindingDB-show
CHEMBL4912944293941BindingDB-show
CHEMBL4921444294460BindingDB-show
CHEMBL49252925263414BindingDB-show
CHEMBL49272025263434BindingDB-show
CHEMBL4932844293943BindingDB-show
CHEMBL4933144294221BindingDB-show
CHEMBL4951644293728BindingDB-show
CHEMBL4956944293730BindingDB-show
CHEMBL4969744294227BindingDB-show
CHEMBL4984044294426BindingDB-show
CHEMBL4991323663733BindingDB-show
CHEMBL5027944293961BindingDB-show
CHEMBL5044144293959BindingDB-show
CHEMBL5049423699179BindingDB-show
CHEMBL5049923699178BindingDB-show
CHEMBL5108223668107BindingDB-show
CHEMBL5124344294217BindingDB-show
CHEMBL5192744294237BindingDB-show
CHEMBL6765644310365BindingDB-show
CHEMBL6853944310364BindingDB-show
CHEMBL6913115858807BindingDB-show
CHEMBL6966844310375BindingDB-show
CHEMBL7026144310373BindingDB-show
CHEMBL7054444310355BindingDB-show
CHEMBL7070844310310BindingDB-show
CHEMBL7115444310325BindingDB-show
CHEMBL7132044310717BindingDB-show
CHEMBL7168244310695BindingDB-show
CHEMBL7179544310719BindingDB-show
CHEMBL7193444310351BindingDB-show
CHEMBL7195844310720BindingDB-show
cyanocyclopropylpropenamide, 1142617941BindingDB-show
cyanocyclopropylpropenamide, 442617939BindingDB-show
cyanohydroxybutenamide, 1042617940BindingDB-show
cyanohydroxybutenamide, 1742617942BindingDB-show
cyanohydroxybutenamide, 1842617943BindingDB-show
cyanohydroxybutenamide, 1942617944BindingDB-show
cyanohydroxybutenamide, 2042617945BindingDB-show
cyanohydroxybutenamide, 2142617946BindingDB-show
cyanohydroxybutenamide, 2242617947BindingDB-show
cyanohydroxybutenamide, 2342617948BindingDB-show
cyanohydroxybutenamide, 2442617949BindingDB-show
cyanohydroxybutenamide, 2542617950BindingDB-show
cyanohydroxybutenamide, 2642617951BindingDB-show
cyanohydroxybutenamide, 2742617952BindingDB-show
cyanohydroxybutenamide, 2842617953BindingDB-show
cyanohydroxybutenamide, 2942617954BindingDB-show
cyclosporin A5280754BindingDB-show
Decylamine oxide62452DrugBank-show
Essigsaeure176DrugBank-show
Huanghuahaosu68827SuperTargetPMID 8050525show
Hydroxycinchophene10239BindingDB-show
Inhibitor 111530041BindingDB-show
Inhibitor 516777509BindingDB-show
Inhibitor 613707619BindingDB-show
Leflunomide3899BindingDB-show
Leflunomide3899DrugBank-show
Leflunomide3899SuperTargetPMID 16120318show
MLS000033310653193BindingDB-show
Molkensaeure967DrugBank-show
monocyclic compound 94221076BindingDB-show
NSC158963292798BindingDB-show
Polyporin11056PROMISCUOUSPMID 10658902show
Riboflavin710DrugBank-show
RS 61980444960BindingDB-show
S 8660130331BindingDB-show
ST061370865225BindingDB-show
STK562517660996BindingDB-show
STK564643523003BindingDB-show
Teriflunomide5479847BindingDB-show
tricyclic compound 516102641BindingDB-show
tricyclic compound 616102642BindingDB-show
ZINC00077123699033BindingDB-show
ZINC00246776768067BindingDB-show
ZINC00259081773731BindingDB-show
ZINC00259089773737BindingDB-show
ZINC00304653799056BindingDB-show
ZINC00304714799096BindingDB-show
ZINC00342068823850BindingDB-show
ZINC00437020870967BindingDB-show
ZINC00455239883701BindingDB-show
ZINC008262321101328BindingDB-show
ZINC01242850517728BindingDB-show
ZINC025557343851642BindingDB-show
ZINC045991692852875BindingDB-show
ZINC049231547416167BindingDB-show
Synonyms:
DHOdehase
Dihydroorotate dehydrogenase, mitochondrial
Dihydroorotate oxidase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
PYRD_RAT93.488.6
PYRD_MOUSE92.787.6
PYRD_ECOLI50.735.7
PYRD_PLAF740.426.7
PYRDA_LACLC34.719.5
LEU3_THIFE33.622.4
GOX_SPIOL32.520
BIOF_ECOLI32.520.7
LDHA_HUMAN32.419.3
KCRU_MOUSE32.120.6
PDK3_MOUSE31.917.8
VG10_BPPH231.817
KCRM_PIG31.718.4
Q7TNA8_RAT31.618
SSPP_STAAU31.617.2
HXK4_RAT31.518
KCRM_HUMAN31.517.9
Q5JU19_HUMAN31.518.9
AADAT_HUMAN31.417.6
KCRB_RABIT31.420.8
MTDC_HUMAN31.318.1
HEM1_METKA31.117.6
AROA_STRPN31.119
MURA_ENTCC31.118.7
Q9YGA6_THELI3118.8
THIK_YEAST3117.6
P83696_ALCXX3119.9
KCRB_CHICK3119.6
PEPQ_PYRHO3116.4
MTD1_YEAST30.918.2
Protein-Protein Interactions:
Uniprot nameSource
PYR5_HUMANPMID 15608231