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Target Details

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Name:Gag-Pol polyprotein
Uniprot name:POL_HV1B1
Accession Numbers:P03366 P03368
EC-Number:-
Organism:HIV-1
Human immunodeficiency virus type 1
isolate BH10 group M subtype B
PDB IDs:1A9M 1AJV 1AJX 1AXA 1BQM 1BQN 1D4H 1D4I 1D4J 1DLO 1DW6 1EBK 1EBW 1EBY 1EBZ 1EC0 1EC1 1EC2 1EC3 1EET 1G35 1GNM 1GNN 1GNO 1HAR 1HBV 1HEF 1HEG 1HIH 1HMV 1HNI 1HNV 1HOS 1HPS 1HPZ 1HQE 1HQU 1HRH 1HTE 1HTF 1HTG 1HVI 1HVK 1HVP 1HVU 1HYS 1IKV 1IKW 1IKX 1IKY 1J5O 1KJH 1MER 1MES 1MET 1MEU 1N5Y 1N6Q 1NPA 1NPV 1NPW 1QE1 1QMC 1R0A 1RDH 1RTD 1RVL 1RVM 1RVN 1RVO 1RVP 1RVQ 1RVR 1S6P 1S6Q 1S9E 1S9G 1SBG 1SUQ 1SV5 1T03 1T05 1T7K 1TV6 1TVR 1UWB 1W5V 1W5W 1W5X 1W5Y 1YT9 1ZP8 1ZPA 1ZSF 1ZSR 2AQU 2B5J 2B6A 2BAN 2BB9 2BBB 2BE2 2EXF 2G69 2HB3 2HMI 2HNZ 2HS1 2HS2 2I4D 2I4U 2I4V 2I4W 2I4X 2I5J 2IAJ 2IC3 2IDW 2IEO 2UXZ 2UY0 2VG5 2VG6 2VG7 2ZD1 2ZE2 3BGR 3DLK 3GGA 3GGV 3GGX 3HVT 3TLH
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
(3S)-TETRAHYDROFURAN-3-YL (1R,2S)-3-[4-((1R)-2-{[(S)-AMINO(HYDROXY)METHYL]OXY}-2,3-DIHYDRO-1H-INDEN-1-YL)-2-BENZYL-3-OXOPYRROLIDIN-2-YL]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE5287501DrugBank-show
2-[4-(HYDROXY-METHOXY-METHYL)-BENZYL]-7-(4-HYDROXYMETHYL-BENZYL)-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-1LAMBDA6-[1,2,7]THIADIAZEPANE-4,5-DIOL5287647DrugBank-show
AIDS212229448667DrugBank-show
C2-Symmetric inhibitor 6445307DrugBank-show
C2-Symmetric inhibitor 9445308DrugBank-show
Cyclic Sulfamide deriv. 13445754DrugBank-show
Cyclic Urea 1a444290DrugBank-show
Cyclooctylpyranonesulfonamide deriv. 8b470374DrugBank-show
Darunavir213039DrugBank-show
Diol-Based HIV-1 protease inhibitor 4449129DrugBank-show
Essigsaeure176DrugBank-show
INHIBITOR BEA403449115DrugBank-show
L-Mannaric acid drivatives444974DrugBank-show
L-Mannaric Diamide deriv.445304DrugBank-show
L-Mannaric Diamide deriv.445303DrugBank-show
Lopinavir92727DrugBank-show
Methylsulfinylmethane679DrugBank-show
MK-944a5481481DrugBank-show
Monothioethyleneglycol1567DrugBank-show
N-[2(S)-CYCLOPENTYL-1(R)-HYDROXY-3(R)METHYL]-5-[(2(S)-TERTIARY-BUTYLAMINO-CARBONYL)-4-(N1-(2)-(N-METHYLPIPERAZINYL)-3-CHLORO-PYRAZINYL-5-CARBONYL)-PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYL-PENTANAMIDE444756DrugBank-show
symmetric/asymmetric inhibitor 3445305DrugBank-show
symmetric/asymmetric inhibitor 9445309DrugBank-show
TERT-BUTYLOXYCARBONYL GROUP61207DrugBank-show
[[PHENYLMETHYLOXY-CARBONYL]-ALANINYL]-VALINYL-[PHENYL-1-HYDROXYPROP-2-YL]-AMINE444425DrugBank-show
Synonyms:
Gag-Pol polyprotein
Pr160Gag-Pol
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
POL_HV1H29998.3
POL_HV1N598.296
POL_HV1Y297.996.2
POL_HV1A297.895.4
POL_HV1Z296.692.8
POL_HV2RO73.256.5
POL_SIVM17256.2
POL_HV2BE67.552.4
POL_FIVPE37.726.1
POL_EIAVY35.324.4
POL_RSVSA34.422
Q59FN5_HUMAN31.617
BXB_CLOBO30.316
KIF1A_HUMAN29.316.1
SYEP_HUMAN2915.6
MDR1_HUMAN2914.5
TRAI1_ECOLI28.717.4
TOP2A_HUMAN28.717.3
Q86UX3_HUMAN28.615.8
Q4JFL8_RAT28.617.6
P3C2A_HUMAN28.614.6
MRP5_HUMAN28.515.4
Q59FK6_HUMAN28.515.5
NOS1_RAT28.416.5
NOS1_MOUSE28.316.4
MED1_HUMAN28.316.5
TOP2A_RAT28.216.4
ROCK1_HUMAN28.115.6
CA2D2_HUMAN27.915.9
CHD1_HUMAN27.515.5
Protein-Protein Interactions:
No data available