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Target Details

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Name:Prostaglandin G/H synthase 2
Uniprot name:PGH2_MOUSE
Accession Numbers:Q05769
EC-Number:1.14.99.1
Organism:Mouse
Mus musculus
PDB IDs:1CVU 1CX2 1DCX 1DD0 1DDX 1PXX 3PGH 4COX 5COX 6COX
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt44559170BindingDB-show
()-oxazepam hemisuccinate sodium salt44559171BindingDB-show
(Z)-5-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-2-thioxo-thiazolidin-4-one1514885BindingDB-show
1,3-di(2-thienyl)prop-2-en-1-one5463038BindingDB-show
1,3-di(furan-2-yl)prop-2-en-1-one5705708BindingDB-show
1,3-Diphenylisobenzothiophene282476BindingDB-show
1-((4-Methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole115239BindingDB-show
1-((4-Methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole115239PROMISCUOUS2 PMIDsshow
1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE1396DrugBank-show
1-pyridin-2-yl-3-thiophen-2-yl-prop-2-en-1-one6244095BindingDB-show
2-((1-Naphthalenyloxy)methyl)quinoline176149BindingDB-show
2-fluoro-4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide9858791BindingDB-show
3-(2-furyl)-1-pyridin-2-yl-prop-2-en-1-one5854189BindingDB-show
3-(4-methylphenylsulfonyl)-2-propenenitrile5353431PROMISCUOUSPMID 15319438show
3-(furan-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one5915551BindingDB-show
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide9865808PROMISCUOUSPMID 11956061show
4-[3-(4-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]benzenesulfonamide11530051BindingDB-show
5,7-diphenyl-2,3-dihydro-1H-pyrrolizine11032604BindingDB-show
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole4306515PROMISCUOUS5 PMIDsshow
52885375288537DrugBank-show
9-Phenylnonanohydroxamic acid188382BindingDB-show
AA-516/314090511206916BindingDB-show
AC1NWOUH5709436BindingDB-show
AC1NXG0X5804842BindingDB-show
AC1O1CTP6068962BindingDB-show
AC1O1KQO6099176BindingDB-show
AC1O2DDI6172473BindingDB-show
AC1O3ZVG6296545BindingDB-show
AC1OXDZ67946378BindingDB-show
ApoMefenamic4044PROMISCUOUSPMID 18292449show
Arachidonsaeure444899PROMISCUOUSPMID 12925531show
Arachidonyltrifluoromethane5280436PROMISCUOUSPMID 18641670show
Arthrocine1548887PROMISCUOUS2 PMIDsshow
Benzylideneacetophenone637760BindingDB-show
Butacortelone3672BindingDB-show
Celecoxib2662BindingDB-show
Celecoxib2662PROMISCUOUS3 PMIDsshow
CHEBI:64764644361026BindingDB-show
CHEBI:64765044360805BindingDB-show
CHEBI:65225544360806BindingDB-show
CHEBI:65235244361176BindingDB-show
CHEMBL107663846880558BindingDB-show
CHEMBL107663946880559BindingDB-show
CHEMBL107664046880560BindingDB-show
CHEMBL107664146880561BindingDB-show
CHEMBL107664246880562BindingDB-show
CHEMBL107664346880563BindingDB-show
CHEMBL107664446880564BindingDB-show
CHEMBL107664546880565BindingDB-show
CHEMBL107667246880619BindingDB-show
CHEMBL107667346880620BindingDB-show
CHEMBL107667446880621BindingDB-show
CHEMBL107667546880622BindingDB-show
CHEMBL128874252946891BindingDB-show
CHEMBL128874352943251BindingDB-show
CHEMBL128878150908698BindingDB-show
CHEMBL128878252949357BindingDB-show
CHEMBL128878352946892BindingDB-show
CHEMBL128878452948111BindingDB-show
CHEMBL128880150908697BindingDB-show
CHEMBL128880250908699BindingDB-show
CHEMBL13959110737046BindingDB-show
CHEMBL13972115521964BindingDB-show
CHEMBL1401679797804BindingDB-show
CHEMBL14017110737653BindingDB-show
CHEMBL14020611792168BindingDB-show
CHEMBL14053323301367BindingDB-show
CHEMBL14072610497468BindingDB-show
CHEMBL1408049816911BindingDB-show
CHEMBL14087610592771BindingDB-show
CHEMBL14099110756729BindingDB-show
CHEMBL14129844361004BindingDB-show
CHEMBL14131210546816BindingDB-show
CHEMBL1420389860939BindingDB-show
CHEMBL1426509903294BindingDB-show
CHEMBL14357344360698BindingDB-show
CHEMBL14854510409583BindingDB-show
CHEMBL1578110428486BindingDB-show
CHEMBL157919885325BindingDB-show
CHEMBL1590411726707BindingDB-show
CHEMBL1604810247770BindingDB-show
CHEMBL1612710644006BindingDB-show
CHEMBL1625110807549BindingDB-show
CHEMBL1627210474682BindingDB-show
CHEMBL1643410022305BindingDB-show
CHEMBL1655011725274BindingDB-show
CHEMBL1667410642552BindingDB-show
CHEMBL1673310830576BindingDB-show
CHEMBL1681418949817BindingDB-show
CHEMBL1681910592859BindingDB-show
CHEMBL1682618949862BindingDB-show
CHEMBL168279972454BindingDB-show
CHEMBL1682810019929BindingDB-show
CHEMBL1684311793298BindingDB-show
CHEMBL1685510339513BindingDB-show
CHEMBL1687818949838BindingDB-show
CHEMBL1689118949854BindingDB-show
CHEMBL1691210019928BindingDB-show
CHEMBL1697710085620BindingDB-show
CHEMBL1698110591367BindingDB-show
CHEMBL1710410043311BindingDB-show
CHEMBL1721844271139BindingDB-show
CHEMBL1722911743608BindingDB-show
CHEMBL19135244400379BindingDB-show
CHEMBL19194111749869BindingDB-show
CHEMBL19267844400364BindingDB-show
CHEMBL19278911476820BindingDB-show
CHEMBL19481811328054BindingDB-show
CHEMBL19539144400419BindingDB-show
CHEMBL19604144404395BindingDB-show
CHEMBL23759223634884BindingDB-show
CHEMBL23762623634643BindingDB-show
CHEMBL23781123634762BindingDB-show
CHEMBL23781323634763BindingDB-show
CHEMBL23802723634883BindingDB-show
CHEMBL24191644428623BindingDB-show
CHEMBL24212744428625BindingDB-show
CHEMBL24212944428628BindingDB-show
CHEMBL24336344428632BindingDB-show
CHEMBL24362744428617BindingDB-show
CHEMBL24379744428629BindingDB-show
CHEMBL2487424825528BindingDB-show
CHEMBL27379310662613BindingDB-show
CHEMBL27445718949825BindingDB-show
CHEMBL2751889927833BindingDB-show
CHEMBL27606210853313BindingDB-show
CHEMBL27650610640473BindingDB-show
CHEMBL27691610063767BindingDB-show
CHEMBL27712410593696BindingDB-show
CHEMBL27751510785517BindingDB-show
CHEMBL27772110360396BindingDB-show
CHEMBL27804010544875BindingDB-show
CHEMBL27824610452888BindingDB-show
CHEMBL27930810781005BindingDB-show
CHEMBL27933610574210BindingDB-show
CHEMBL27975518949863BindingDB-show
CHEMBL2798019884791BindingDB-show
CHEMBL28022610406427BindingDB-show
CHEMBL28032610831725BindingDB-show
CHEMBL28047110570515BindingDB-show
CHEMBL28184724825529BindingDB-show
CHEMBL31079410564901BindingDB-show
CHEMBL31283710805973BindingDB-show
CHEMBL31342810542025BindingDB-show
CHEMBL31542111571968BindingDB-show
CHEMBL31594410666518BindingDB-show
CHEMBL33537110493608BindingDB-show
CHEMBL33760123301373BindingDB-show
CHEMBL34165213638864BindingDB-show
CHEMBL34328044360981BindingDB-show
CHEMBL34331110494397BindingDB-show
CHEMBL3433399926403BindingDB-show
CHEMBL3437019796332BindingDB-show
CHEMBL34371610664252BindingDB-show
CHEMBL3440859881981BindingDB-show
CHEMBL34503810710333BindingDB-show
CHEMBL36339844400316BindingDB-show
CHEMBL36423844400333BindingDB-show
CHEMBL36496044400334BindingDB-show
CHEMBL37147744404327BindingDB-show
CHEMBL38844544428624BindingDB-show
CHEMBL38937944428626BindingDB-show
CHEMBL39111323636491BindingDB-show
CHEMBL39315923634642BindingDB-show
CHEMBL39453316072103BindingDB-show
CHEMBL39838223634644BindingDB-show
CHEMBL39838323634885BindingDB-show
CHEMBL39838423634886BindingDB-show
CHEMBL41707310447836BindingDB-show
CHEMBL43100710595880BindingDB-show
CHEMBL43814723635009BindingDB-show
CHEMBL43831644428633BindingDB-show
CHEMBL44113223635010BindingDB-show
CHEMBL4416639883124BindingDB-show
CHEMBL44765544569821BindingDB-show
CHEMBL45041544569854BindingDB-show
CHEMBL45135824951165BindingDB-show
CHEMBL45367744569819BindingDB-show
CHEMBL46059844569817BindingDB-show
CHEMBL46123044569851BindingDB-show
CHEMBL46227244569118BindingDB-show
CHEMBL46599144569895BindingDB-show
CHEMBL46680044569786BindingDB-show
CHEMBL46680744569852BindingDB-show
CHEMBL46847444569818BindingDB-show
CHEMBL46847544569820BindingDB-show
CHEMBL46848344569897BindingDB-show
CHEMBL46957425261943BindingDB-show
CHEMBL46978525261944BindingDB-show
CHEMBL47653624951166BindingDB-show
CHEMBL47736224951012BindingDB-show
CHEMBL47841524951011BindingDB-show
CHEMBL47905324899209BindingDB-show
CHEMBL47905424951163BindingDB-show
CHEMBL4856810064410BindingDB-show
CHEMBL49255425256831BindingDB-show
CHEMBL49286844569065BindingDB-show
CHEMBL49329744569103BindingDB-show
CHEMBL49349244569085BindingDB-show
CHEMBL49349344569087BindingDB-show
CHEMBL49349744569104BindingDB-show
CHEMBL49389844569044BindingDB-show
CHEMBL49470044569042BindingDB-show
CHEMBL49490444569043BindingDB-show
CHEMBL49490525141402BindingDB-show
CHEMBL49531844569067BindingDB-show
CHEMBL50544844569068BindingDB-show
CHEMBL51193644569896BindingDB-show
CHEMBL51335744569853BindingDB-show
CHEMBL51547824899975BindingDB-show
CHEMBL51628924951164BindingDB-show
CHEMBL51696244569305BindingDB-show
CHEMBL51767524951013BindingDB-show
CHEMBL52216644569084BindingDB-show
CHEMBL52233344569102BindingDB-show
CHEMBL52338844569066BindingDB-show
CHEMBL52351544569086BindingDB-show
CHEMBL52355144569101BindingDB-show
CHEMBL52372044569025BindingDB-show
CHEMBL56195944224199BindingDB-show
CHEMBL58908744818280BindingDB-show
CHEMBL58916644818282BindingDB-show
CHEMBL58916746229713BindingDB-show
CHEMBL58941046229714BindingDB-show
CHEMBL58981244818111BindingDB-show
CHEMBL58981323729118BindingDB-show
CHEMBL60016744818281BindingDB-show
CHEMBL60084444818112BindingDB-show
CHEMBL60223744818110BindingDB-show
CHEMBL60295146229201BindingDB-show
CHEMBL60478146229731BindingDB-show
CHEMBL60516116757526BindingDB-show
CHEMBL60582044138220BindingDB-show
CHEMBL822929926728BindingDB-show
CHEMBL8232510519073BindingDB-show
CHEMBL8399010221422BindingDB-show
CHEMBL8459910517096BindingDB-show
CHEMBL8467010827845BindingDB-show
CHEMBL8478510780497BindingDB-show
CHEMBL8483711506646BindingDB-show
CHEMBL8545510637730BindingDB-show
CHEMBL8564910012992BindingDB-show
CHEMBL8602310036789BindingDB-show
CHEMBL8615311492422BindingDB-show
CHEMBL8741711535860BindingDB-show
Ci 9876444394BindingDB-show
CID 234899234901BindingDB-show
CID 98606479860647BindingDB-show
CID 98835859883585BindingDB-show
CID 99298319929831BindingDB-show
CID 99549639954963BindingDB-show
DADHP155766BindingDB-show
Darbufelone6444826BindingDB-show
DEXIBUPROFEN39912BindingDB-show
Dichlofenac3033BindingDB-show
Dichlofenac3033PROMISCUOUSPMID 12925531show
Dinoprostone5280360PROMISCUOUSPMID 12972806show
Dinoprostone158PROMISCUOUSPMID 12972806show
Diphenyl isoindoline606734BindingDB-show
Epipodophyllotoxin10607BindingDB-show
ERBSTATIN58035PROMISCUOUSPMID 7534189show
Exisulind5472495PROMISCUOUSPMID 11118042show
Flogovital4495PROMISCUOUS3 PMIDsshow
FLURBIPROFEN3394BindingDB-show
Imrecoxib11682175BindingDB-show
Indomethacin derivative, 2310810285BindingDB-show
Indomethacin derivative, 810766544BindingDB-show
indomethacin phenethylamide4292BindingDB-show
Indomethacinum3715BindingDB-show
Meclofenamate4037BindingDB-show
Merck Frosst Tricyclic127923PROMISCUOUSPMID 18292081show
Methanandamide6321351PROMISCUOUSPMID 12958151show
Mofezolac4237PROMISCUOUSPMID 14991580show
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide4553BindingDB-show
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide4553PROMISCUOUS2 PMIDsshow
NSC1109365376088BindingDB-show
NSC293558325253BindingDB-show
NSC6577635467683BindingDB-show
NSC7985354119BindingDB-show
Octyl beta-glucopyranoside62852DrugBank-show
Prostaglandin H2445049DrugBank-show
Rofecoxib5090BindingDB-show
Rofecoxib5090PROMISCUOUS3 PMIDsshow
Spermine NONOate5259PROMISCUOUSPMID 11287117show
Sulindac sulfide5352624PROMISCUOUSPMID 11118042show
Way 121520192268BindingDB-show
Wogonin5281703BindingDB-show
ZINC040106565338978BindingDB-show
ZINC064326677972918BindingDB-show
Synonyms:
COX-2
Cyclooxygenase-2
Glucocorticoid-regulated inflammatory cyclooxygenase
Gripghs
Macrophage activation-associated marker protein P71/73
PES-2
PGH synthase 2
PGHS-2
PHS II
Prostaglandin G/H synthase 2
Prostaglandin H2 synthase 2
Prostaglandin-endoperoxide synthase 2
TIS10 protein
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
PGH2_RAT98.296
PGH2_RABIT95.990.4
PGH2_CAVPO94.988.4
PGH2_BOVIN94.587.4
PGH2_SHEEP93.986.4
PGH2_HUMAN93.286.8
PGH1_SHEEP7559.6
PGH1_MOUSE7560.9
PGH1_HUMAN74.660.5
PGH1_RAT74.459.7
PGH1_RABIT73.459.7
Q8IZA9_HUMAN5147.4
S22AB_HUMAN3219.1
DRTS_PLAFK3115.2
FRDA_SHEON30.917.1
LIP1_CANRU30.718.2
CPT2_HUMAN30.717
DRTS_PLABA30.616.5
CP4Z1_HUMAN30.517.9
SAP_HUMAN30.417.6
ASNS_HUMAN30.318
CRY1_ARATH30.217.9
NIRS_PARPN3017.9
G6PI_MOUSE29.916.5
GATB_HUMAN29.817.5
CP4X1_HUMAN29.818
PERE_HUMAN29.816.8
SPTC2_MOUSE29.417.3
GCYB1_HUMAN29.317.1
ACVR1_HUMAN29.217.4
Protein-Protein Interactions:
No data available