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Target Details

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Name:3-phosphoinositide-dependent protein kinase 1
Uniprot name:PDPK1_HUMAN
Accession Numbers:O15530 Q6FI20
EC-Number:2.7.11.1
Organism:Homo sapiens
Human
PDB IDs:1H1W 1OKY 1OKZ 1UU3 1UU7 1UU8 1UU9 1UVR 1W1D 1W1G 1W1H 1Z5M 2BIY 2PE0 2PE1 2PE2 2R7B 2VKI 3H9O 3HRC 3HRF
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt49798578BindingDB-show
2pe023647610BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
7-Hydroxystaurosporine72271BindingDB-show
7-Hydroxystaurosporine72271DrugBank-show
ABO11581204BindingDB-show
ABT-86911485656BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Bisindolylmaleimide I2396BindingDB-show
bisindolylmaleimide ii2397BindingDB-show
BX-20111311693BindingDB-show
BX-320657138BindingDB-show
BX-51711161844BindingDB-show
BX-79510077147BindingDB-show
BX-91211754511BindingDB-show
C24H22N4O22403BindingDB-show
Canertinib156414BindingDB-show
Celecoxib2662DrugBank-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:410592398BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL108908224822704BindingDB-show
CHEMBL109432046192858BindingDB-show
CHEMBL109432146192859BindingDB-show
CHEMBL109463746192860BindingDB-show
CHEMBL109527846192856BindingDB-show
CHEMBL109527925060410BindingDB-show
CHEMBL109528525060675BindingDB-show
CHEMBL109529444620952BindingDB-show
CHEMBL109561246193129BindingDB-show
CHEMBL109562146192989BindingDB-show
CHEMBL109562246192991BindingDB-show
CHEMBL109593146193131BindingDB-show
CHEMBL109627125060411BindingDB-show
CHEMBL109760244608012BindingDB-show
CHEMBL109760446193130BindingDB-show
CHEMBL109795525060409BindingDB-show
CHEMBL109795646192857BindingDB-show
CHEMBL109797246193132BindingDB-show
CHEMBL109797346193133BindingDB-show
CHEMBL109830246192992BindingDB-show
CHEMBL10998110073694BindingDB-show
CHEMBL117112549798540BindingDB-show
CHEMBL117119249798446BindingDB-show
CHEMBL117122549798471BindingDB-show
CHEMBL117132949798577BindingDB-show
CHEMBL117141549798541BindingDB-show
CHEMBL117141649798542BindingDB-show
CHEMBL117195549798539BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL128997510475366BindingDB-show
CHEMBL20442044410960BindingDB-show
CHEMBL20678344410717BindingDB-show
CHEMBL20703744410829BindingDB-show
CHEMBL20713011620055BindingDB-show
CHEMBL20723544410869BindingDB-show
CHEMBL20724644410851BindingDB-show
CHEMBL20744511691173BindingDB-show
CHEMBL20767444410720BindingDB-show
CHEMBL20771811532676BindingDB-show
CHEMBL20781511526238BindingDB-show
CHEMBL20804844410949BindingDB-show
CHEMBL20828611373886BindingDB-show
CHEMBL21100311661959BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL23515817754724BindingDB-show
CHEMBL23516017754723BindingDB-show
CHEMBL23537717754761BindingDB-show
CHEMBL23538017754449BindingDB-show
CHEMBL23560217754397BindingDB-show
CHEMBL23578323648180BindingDB-show
CHEMBL23599823648219BindingDB-show
CHEMBL23647417754398BindingDB-show
CHEMBL23813323648181BindingDB-show
CHEMBL23833717754539BindingDB-show
CHEMBL2819579869943BindingDB-show
CHEMBL37696744410954BindingDB-show
CHEMBL37777244410959BindingDB-show
CHEMBL37837044410948BindingDB-show
CHEMBL37960111682843BindingDB-show
CHEMBL38000644410723BindingDB-show
CHEMBL38038611516978BindingDB-show
CHEMBL38045444411048BindingDB-show
CHEMBL38088944411161BindingDB-show
CHEMBL38282244410955BindingDB-show
CHEMBL38282344410956BindingDB-show
CHEMBL38324644411183BindingDB-show
CHEMBL38376044410953BindingDB-show
CHEMBL39155017754450BindingDB-show
CHEMBL39332817754582BindingDB-show
CHEMBL42560111562171BindingDB-show
CHEMBL43788544410844BindingDB-show
CHEMBL54144544222819BindingDB-show
CHEMBL54964744220086BindingDB-show
CHEMBL55019544219896BindingDB-show
CHEMBL55294744221122BindingDB-show
CHEMBL56059544220085BindingDB-show
CHEMBL56497044221121BindingDB-show
CHEMBL8540310489322BindingDB-show
CHIR-26511656518BindingDB-show
CID 1150286711495680BindingDB-show
CID 1150286711502867BindingDB-show
CID 1153204811532048BindingDB-show
CID 1153204811546457BindingDB-show
CID 1159688111531799BindingDB-show
CID 1159688111596881BindingDB-show
CID 1171930511719305BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
DEBROMOHYMENIALDISINE5288032BindingDB-show
Dibenzo[c,f][2,7]naphthyridine, 1323648179BindingDB-show
Dibenzo[c,f][2,7]naphthyridine, 1917754762BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
IDZ5327123BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
Indolinone based compound, 1311151075BindingDB-show
Indolinone based compound, 1411256709BindingDB-show
Indolinone based compound, 1523647605BindingDB-show
Indolinone based compound, 1611165945BindingDB-show
Indolinone based compound, 1711430140BindingDB-show
Indolinone based compound, 1811293497BindingDB-show
Indolinone based compound, 1923647606BindingDB-show
Indolinone based compound, 2011383042BindingDB-show
Indolinone based compound, 2111417334BindingDB-show
Indolinone based compound, 2211453730BindingDB-show
Indolinone based compound, 2a11370369BindingDB-show
Indolinone based compound, 2b23647592BindingDB-show
Indolinone based compound, 2c11325683BindingDB-show
Indolinone based compound, 2d11440050BindingDB-show
Indolinone based compound, 3a11246027BindingDB-show
Indolinone based compound, 3b11373564BindingDB-show
Indolinone based compound, 3c11407608BindingDB-show
Indolinone based compound, 3d23647593BindingDB-show
Indolinone based compound, 3e11165629BindingDB-show
Indolinone based compound, 3f11750389BindingDB-show
Indolinone based compound, 7a23647594BindingDB-show
Indolinone based compound, 7b11588244BindingDB-show
Indolinone based compound, 7c23647595BindingDB-show
Indolinone based compound, 7d23647596BindingDB-show
Indolinone based compound, 7e23647597BindingDB-show
Indolinone based compound, 7f23647598BindingDB-show
Indolinone based compound, 7g23647599BindingDB-show
Indolinone based compound, 7h23647600BindingDB-show
Indolinone based compound, 7i23647601BindingDB-show
Indolinone based compound, 7j23647602BindingDB-show
Indolinone based compound, 7k23647603BindingDB-show
Indolinone based compound, 7l23647604BindingDB-show
Indolinone based inhibitor, 1b23647607BindingDB-show
Indolinone based inhibitor, 1c21957747BindingDB-show
Indolinone based inhibitor, 1d23647608BindingDB-show
Indolinone based inhibitor, 1e11989153BindingDB-show
Indolinone based inhibitor, 1f23647609BindingDB-show
Indolinone based inhibitor, 1g21957734BindingDB-show
Indolinone based inhibitor, 2b23647611BindingDB-show
Indolinone based inhibitor, 2c23647612BindingDB-show
Indolinone based inhibitor, 2d23647613BindingDB-show
Indolinone based inhibitor, 2e23647614BindingDB-show
Indolinone based inhibitor, 2f10131254BindingDB-show
Indolinone based inhibitor, 3a23647615BindingDB-show
Indolinone based inhibitor, 3b23647616BindingDB-show
Indolinone based inhibitor, 3c23647617BindingDB-show
Indolinone based inhibitor, 3d23644715BindingDB-show
Indolinone based inhibitor, 3e23647618BindingDB-show
Indolinone based inhibitor, 3f23647619BindingDB-show
Indolinone based inhibitor, 3g23647620BindingDB-show
Indolinone based inhibitor, 3h11447681BindingDB-show
Indolinone based inhibitor, 3i23647621BindingDB-show
Indolinone based inhibitor, 3j23647622BindingDB-show
Indolinone based inhibitor, 3k11323104BindingDB-show
Indolinone based inhibitor, 4a21051556BindingDB-show
Indolinone based inhibitor, 4b11461275BindingDB-show
Indolinone based inhibitor, 4c23647623BindingDB-show
Indolinone based inhibitor, 4d23647624BindingDB-show
Indolinone based inhibitor, 4e21957770BindingDB-show
Indolinone based inhibitor, 4f21957724BindingDB-show
Indolinone based inhibitor, 4g23647625BindingDB-show
Indolinone based inhibitor, 4h23647626BindingDB-show
Indolinone based inhibitor, 4j11738018BindingDB-show
Indolinone based inhibitor, 4k23647627BindingDB-show
Indolinone based inhibitor, 4l21957818BindingDB-show
Inositol 1,3,4,5-tetrakisphosphate107758DrugBank-show
JNK Inhibitor V11422035BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_377417754396BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
MLN805411712649BindingDB-show
nchembio.208-comp244141940BindingDB-show
nchembio.208-comp32728593BindingDB-show
nchembio.208-comp444141941BindingDB-show
oxindole i5908088BindingDB-show
Pazopanib10113978BindingDB-show
Phosphatidalserine68841DrugBank-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
STAUROSPORINE44259DrugBank-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Trihydroxypropane753SuperTarget-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
3-phosphoinositide-dependent protein kinase 1
hPDK1
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
ARBK2_HUMAN36.421.1
KAPCB_RAT35.822.4
KAPCB_MOUSE35.822.4
KAPCA_RAT34.921.9
KAPCA_MOUSE34.822
ARBK1_HUMAN34.419.9
Q8CHM5_MOUSE34.220.6
KCC2A_RAT34.221.1
CHK1_SCHPO3419.8
AKT1_MOUSE33.720.3
AKT1_HUMAN32.719.7
KS6B1_BOVIN32.622.4
AAPK2_HUMAN32.518.3
KAPA_YEAST32.421.1
KAPCA_BOVIN32.420.3
KS6B1_HUMAN32.422.3
KAPCA_PIG32.219.9
KAPCA_HUMAN32.220.3
KAPCB_HUMAN32.120.7
KAPCG_HUMAN31.820.4
O35535_RAT31.517.5
HYES_HUMAN31.116.2
STK6_HUMAN30.919.9
Q3UC49_MOUSE30.916.7
CHK1_USTMA30.718.8
MYRA_SINAL30.618.2
TIG_SHIFL30.517.4
LACG_LACLA30.518.5
PHYB_ASPAW30.418.5
ATPB_HUMAN30.416.8
Protein-Protein Interactions: