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Target Details

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Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Uniprot name:PDE4C_HUMAN
Accession Numbers:Q08493 Q9UN44 Q9UN45 Q9UN46 Q9UPJ6
EC-Number:3.1.4.17
Organism:Homo sapiens
Human
PDB IDs:1LXU 2QYM
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(R)-ROLIPRAM448055BindingDB-show
1,3-Dipropyl-7-methylxanthine161713BindingDB-show
1,3-Dipropylxanthine169317BindingDB-show
1-Methyl-3-butylxanthine169316BindingDB-show
1-Methylhydrazin-4-(3,5-dimethyl-1-pyrazolyl)pyridazino(4,5-b)indole5487421BindingDB-show
1-MPX174907BindingDB-show
1-Propylxanthine128525BindingDB-show
185954-27-29896267BindingDB-show
2fm56420181BindingDB-show
3-(2-ethoxyphenyl)-7-methyl-9-propyl-1,2,4,8-tetrazabicyclo[4.3.0]nona-3,69966536BindingDB-show
3-Amino-6-methyl-5-phenyl-2(1H)-pyridinone133461BindingDB-show
3-Butylxanthine218667BindingDB-show
4-(1,3-benzodioxol-5-yl)pyrrolidin-2-one659516BindingDB-show
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine127928BindingDB-show
4-(3-hydroxy-4-methoxy-phenyl)pyrrolidin-2-one10130484BindingDB-show
4-phenylpyrrolidin-2-one121397BindingDB-show
4-[4-methoxy-3-[(2S)-5-phenylpentan-2-yl]oxy-phenyl]benzoic Acid10786618BindingDB-show
4436737744367377BindingDB-show
5-Butyl-3-methyl-3H-imidazo(4,5-c)(1,8)naphthyridin-4(5H)-one3071975BindingDB-show
5-Dotmm-indol-2-one5487233BindingDB-show
5-Phenyl-1H-imidazo(4,5-c)(1,8)naphthyridin-4(5H)-one126487BindingDB-show
6-Chloro-2-piperazino-4-dimethylamino-7-benzylamino-pteridine3024655BindingDB-show
6-Chloro-4,7-bis(dimethylamino)-2-piperazino-pteridine3024653BindingDB-show
7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine130604BindingDB-show
9-Benzylaminopurine20262BindingDB-show
AC1L2LO323102BindingDB-show
AC1LA4PI461663BindingDB-show
AC1LB4S0551348BindingDB-show
AC1LBYIM566496BindingDB-show
AC1LI7H5899745BindingDB-show
AC1ME6AI2822850BindingDB-show
AC1ME6AK2822851BindingDB-show
AC1ME6AO2822853BindingDB-show
AC1ME6B02822859BindingDB-show
AC1ME6C42822879BindingDB-show
AC1ME6CM2822888BindingDB-show
AC1NRRTH5271722BindingDB-show
AC1O4WLE6420180BindingDB-show
AC1OCFIT6918510BindingDB-show
Adibendan65867BindingDB-show
AIDS026878464987BindingDB-show
AIDS029875461664BindingDB-show
Antistenocardin3108BindingDB-show
BAS 01204984694543BindingDB-show
BAS 05209654667701BindingDB-show
BCPMP192356BindingDB-show
BRN 48770043071959BindingDB-show
BRN 48770843071939BindingDB-show
BRN 48811443071940BindingDB-show
BRN 58808943071969BindingDB-show
BRN 58827023071971BindingDB-show
Bufrolin72103BindingDB-show
CHEBI:11099644380171BindingDB-show
CHEBI:12096444272080BindingDB-show
CHEBI:16215644288398BindingDB-show
CHEBI:16298744288868BindingDB-show
CHEBI:16301744288883BindingDB-show
CHEBI:16309244288935BindingDB-show
CHEBI:16312144288955BindingDB-show
CHEBI:20694144308405BindingDB-show
CHEBI:20694244308406BindingDB-show
CHEBI:20694444308407BindingDB-show
CHEBI:20699844308423BindingDB-show
CHEBI:20709644308456BindingDB-show
CHEBI:20712344308462BindingDB-show
CHEBI:20712644308463BindingDB-show
CHEBI:20728344308532BindingDB-show
CHEBI:20751844308617BindingDB-show
CHEBI:20751944308618BindingDB-show
CHEBI:20756244308636BindingDB-show
CHEBI:20780244308737BindingDB-show
CHEBI:24424244322900BindingDB-show
CHEBI:38352910279831BindingDB-show
CHEBI:64333544268010BindingDB-show
CHEBI:64335044268031BindingDB-show
CHEBI:64335144268030BindingDB-show
CHEBI:64335744267968BindingDB-show
CHEBI:64336044268037BindingDB-show
CHEBI:64336644268011BindingDB-show
CHEBI:64336844267978BindingDB-show
CHEBI:64337444268036BindingDB-show
CHEBI:64461844292332BindingDB-show
CHEBI:64476844294524BindingDB-show
CHEBI:64481344292338BindingDB-show
CHEBI:64488344294707BindingDB-show
CHEBI:64549344310610BindingDB-show
CHEBI:64549544310611BindingDB-show
CHEBI:64551844310937BindingDB-show
CHEBI:64560044315374BindingDB-show
CHEBI:64561944315152BindingDB-show
CHEBI:64562844315173BindingDB-show
CHEBI:64563044315149BindingDB-show
CHEBI:64563944315150BindingDB-show
CHEBI:64564144315373BindingDB-show
CHEBI:64567944315393BindingDB-show
CHEBI:64571544314915BindingDB-show
CHEBI:64604444322253BindingDB-show
CHEBI:64611544324326BindingDB-show
CHEBI:65019444268029BindingDB-show
CHEBI:65021244267962BindingDB-show
CHEBI:65021344267979BindingDB-show
CHEBI:65021844267980BindingDB-show
CHEBI:65031544268038BindingDB-show
CHEBI:65033744268017BindingDB-show
CHEBI:65035344267977BindingDB-show
CHEBI:65037344268018BindingDB-show
CHEBI:65102544292317BindingDB-show
CHEBI:65108044292316BindingDB-show
CHEBI:65121644310450BindingDB-show
CHEBI:65125944310957BindingDB-show
CHEBI:65128544310893BindingDB-show
CHEBI:65130244315343BindingDB-show
CHEBI:65131944315185BindingDB-show
CHEBI:65133444314847BindingDB-show
CHEBI:65137444314757BindingDB-show
CHEBI:65141544315109BindingDB-show
CHEBI:65142844315108BindingDB-show
CHEBI:65161244333150BindingDB-show
CHEMBL10111715716995BindingDB-show
CHEMBL10136844334301BindingDB-show
CHEMBL10147944334271BindingDB-show
CHEMBL10202044334341BindingDB-show
CHEMBL10231044334414BindingDB-show
CHEMBL10250344334422BindingDB-show
CHEMBL10263510456205BindingDB-show
CHEMBL10274110071094BindingDB-show
CHEMBL10275844334251BindingDB-show
CHEMBL10287644334302BindingDB-show
CHEMBL10300744334310BindingDB-show
CHEMBL10478044334347BindingDB-show
CHEMBL10776644338778BindingDB-show
CHEMBL10796810002457BindingDB-show
CHEMBL10798211426917BindingDB-show
CHEMBL10820544338541BindingDB-show
CHEMBL10863844338550BindingDB-show
CHEMBL10888410681943BindingDB-show
CHEMBL10942710613420BindingDB-show
CHEMBL10955010492654BindingDB-show
CHEMBL10957410706416BindingDB-show
CHEMBL10963910492653BindingDB-show
CHEMBL10975410541661BindingDB-show
CHEMBL10996514963574BindingDB-show
CHEMBL11030444339609BindingDB-show
CHEMBL11081944338111BindingDB-show
CHEMBL11098411289015BindingDB-show
CHEMBL11107110704792BindingDB-show
CHEMBL1111719966486BindingDB-show
CHEMBL11138144338556BindingDB-show
CHEMBL11146611775599BindingDB-show
CHEMBL11148610515565BindingDB-show
CHEMBL11199010608890BindingDB-show
CHEMBL11336815606258BindingDB-show
CHEMBL122143446933992BindingDB-show
CHEMBL12225018381680BindingDB-show
CHEMBL122361849865602BindingDB-show
CHEMBL122361949865603BindingDB-show
CHEMBL122362049865604BindingDB-show
CHEMBL122362149865605BindingDB-show
CHEMBL122368449865642BindingDB-show
CHEMBL122368549865643BindingDB-show
CHEMBL122368646933994BindingDB-show
CHEMBL122368746933993BindingDB-show
CHEMBL122465349866243BindingDB-show
CHEMBL122471749866268BindingDB-show
CHEMBL122471849866269BindingDB-show
CHEMBL122471949866270BindingDB-show
CHEMBL122472049866271BindingDB-show
CHEMBL122472149866272BindingDB-show
CHEMBL12326615384033BindingDB-show
CHEMBL12333018381597BindingDB-show
CHEMBL1234039928261BindingDB-show
CHEMBL1234610768238BindingDB-show
CHEMBL1235509846658BindingDB-show
CHEMBL12378244349135BindingDB-show
CHEMBL123839912467BindingDB-show
CHEMBL1239939927063BindingDB-show
CHEMBL1241210648008BindingDB-show
CHEMBL1251239825739BindingDB-show
CHEMBL12567110648358BindingDB-show
CHEMBL12582810812634BindingDB-show
CHEMBL1259910669693BindingDB-show
CHEMBL12658110552011BindingDB-show
CHEMBL12716715931307BindingDB-show
CHEMBL12814610779997BindingDB-show
CHEMBL12846110661817BindingDB-show
CHEMBL12847644352934BindingDB-show
CHEMBL12869110497499BindingDB-show
CHEMBL12878810567025BindingDB-show
CHEMBL12890015931313BindingDB-show
CHEMBL13018210027501BindingDB-show
CHEMBL13023444353093BindingDB-show
CHEMBL13050312905389BindingDB-show
CHEMBL13051410826458BindingDB-show
CHEMBL13080644352997BindingDB-show
CHEMBL13084144353156BindingDB-show
CHEMBL13089944353125BindingDB-show
CHEMBL13095744353114BindingDB-show
CHEMBL13105910564633BindingDB-show
CHEMBL13108944352984BindingDB-show
CHEMBL13127510400587BindingDB-show
CHEMBL13137110330676BindingDB-show
CHEMBL13148344353157BindingDB-show
CHEMBL13156544352955BindingDB-show
CHEMBL13181844352954BindingDB-show
CHEMBL13200110378132BindingDB-show
CHEMBL13205210037104BindingDB-show
CHEMBL13205944353124BindingDB-show
CHEMBL13210710827879BindingDB-show
CHEMBL13215644352576BindingDB-show
CHEMBL13226710690761BindingDB-show
CHEMBL13227310663161BindingDB-show
CHEMBL13234644352733BindingDB-show
CHEMBL13250544353102BindingDB-show
CHEMBL13365210502542BindingDB-show
CHEMBL13423744352903BindingDB-show
CHEMBL13426144355596BindingDB-show
CHEMBL13444110741142BindingDB-show
CHEMBL13530410648088BindingDB-show
CHEMBL1356219850007BindingDB-show
CHEMBL1374009950240BindingDB-show
CHEMBL13865811826119BindingDB-show
CHEMBL14138010548443BindingDB-show
CHEMBL14189010784906BindingDB-show
CHEMBL14223811754697BindingDB-show
CHEMBL14278210292282BindingDB-show
CHEMBL14285810548964BindingDB-show
CHEMBL14292211764545BindingDB-show
CHEMBL14296910093297BindingDB-show
CHEMBL14307710667701BindingDB-show
CHEMBL14379810572058BindingDB-show
CHEMBL14404710344870BindingDB-show
CHEMBL14419644363056BindingDB-show
CHEMBL14428710504383BindingDB-show
CHEMBL14434110342601BindingDB-show
CHEMBL14437010571952BindingDB-show
CHEMBL14437410041530BindingDB-show
CHEMBL14440010408375BindingDB-show
CHEMBL14445210646132BindingDB-show
CHEMBL14454510349233BindingDB-show
CHEMBL14460510833764BindingDB-show
CHEMBL14465610004422BindingDB-show
CHEMBL14494010039809BindingDB-show
CHEMBL14497810456913BindingDB-show
CHEMBL1451599985391BindingDB-show
CHEMBL14522510575041BindingDB-show
CHEMBL14539010602385BindingDB-show
CHEMBL14549910577926BindingDB-show
CHEMBL14551510404378BindingDB-show
CHEMBL14591910808709BindingDB-show
CHEMBL14592544365050BindingDB-show
CHEMBL14596710664379BindingDB-show
CHEMBL14604844365046BindingDB-show
CHEMBL14616510343476BindingDB-show
CHEMBL14639244365049BindingDB-show
CHEMBL14686544365476BindingDB-show
CHEMBL14694610064555BindingDB-show
CHEMBL14756410641529BindingDB-show
CHEMBL14797744364909BindingDB-show
CHEMBL14848044365004BindingDB-show
CHEMBL14858444365547BindingDB-show
CHEMBL14885144364924BindingDB-show
CHEMBL1488939981320BindingDB-show
CHEMBL14908144365387BindingDB-show
CHEMBL14919344365522BindingDB-show
CHEMBL14950044365343BindingDB-show
CHEMBL14955944365144BindingDB-show
CHEMBL14961244365523BindingDB-show
CHEMBL14977744365386BindingDB-show
CHEMBL14978344365208BindingDB-show
CHEMBL14998844364932BindingDB-show
CHEMBL15003844365068BindingDB-show
CHEMBL15010644365094BindingDB-show
CHEMBL15163444365329BindingDB-show
CHEMBL15199610669027BindingDB-show
CHEMBL15346910783989BindingDB-show
CHEMBL1556819886413BindingDB-show
CHEMBL15613914801674BindingDB-show
CHEMBL1561409930122BindingDB-show
CHEMBL15718114801673BindingDB-show
CHEMBL15828610571743BindingDB-show
CHEMBL16009310717022BindingDB-show
CHEMBL16102610247726BindingDB-show
CHEMBL16111510451184BindingDB-show
CHEMBL16146510711281BindingDB-show
CHEMBL16160210547592BindingDB-show
CHEMBL16171410691724BindingDB-show
CHEMBL1617409928390BindingDB-show
CHEMBL16218810805427BindingDB-show
CHEMBL16266344377154BindingDB-show
CHEMBL16515844377249BindingDB-show
CHEMBL16632044377233BindingDB-show
CHEMBL16652713728290BindingDB-show
CHEMBL16652910664248BindingDB-show
CHEMBL1671669842857BindingDB-show
CHEMBL16725810591652BindingDB-show
CHEMBL1673899800710BindingDB-show
CHEMBL16748610589452BindingDB-show
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CHEMBL1689499934594BindingDB-show
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CHEMBL16974618957476BindingDB-show
CHEMBL16983410495633BindingDB-show
CHEMBL16984344381943BindingDB-show
CHEMBL187459818343BindingDB-show
CHEMBL19212411244170BindingDB-show
CHEMBL19277911372218BindingDB-show
CHEMBL19455111175537BindingDB-show
CHEMBL19515511153159BindingDB-show
CHEMBL19544611416279BindingDB-show
CHEMBL19696922083724BindingDB-show
CHEMBL19738610183769BindingDB-show
CHEMBL19749444405467BindingDB-show
CHEMBL19843244405507BindingDB-show
CHEMBL19846410205978BindingDB-show
CHEMBL19852710210579BindingDB-show
CHEMBL19856420814950BindingDB-show
CHEMBL19867444405510BindingDB-show
CHEMBL19872222083604BindingDB-show
CHEMBL199849885343BindingDB-show
CHEMBL20090611438405BindingDB-show
CHEMBL20272944409751BindingDB-show
CHEMBL20312444409461BindingDB-show
CHEMBL20435344409654BindingDB-show
CHEMBL20444918734933BindingDB-show
CHEMBL20447144409744BindingDB-show
CHEMBL20452210289786BindingDB-show
CHEMBL20477744409787BindingDB-show
CHEMBL20510544409558BindingDB-show
CHEMBL20514044409660BindingDB-show
CHEMBL2053110718949BindingDB-show
CHEMBL20548244409937BindingDB-show
CHEMBL20558244409556BindingDB-show
CHEMBL20565410125445BindingDB-show
CHEMBL20568644409759BindingDB-show
CHEMBL20573744409977BindingDB-show
CHEMBL20579744409995BindingDB-show
CHEMBL20584044409981BindingDB-show
CHEMBL20584144409982BindingDB-show
CHEMBL20585310236419BindingDB-show
CHEMBL20585444409576BindingDB-show
CHEMBL20594444409651BindingDB-show
CHEMBL20597610193093BindingDB-show
CHEMBL20599244409653BindingDB-show
CHEMBL20608744409769BindingDB-show
CHEMBL20612744409749BindingDB-show
CHEMBL20648044409754BindingDB-show
CHEMBL20659210153372BindingDB-show
CHEMBL20671444409956BindingDB-show
CHEMBL20675344409746BindingDB-show
CHEMBL20678044409796BindingDB-show
CHEMBL20682644409772BindingDB-show
CHEMBL20696810196609BindingDB-show
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CHEMBL20728710171570BindingDB-show
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CHEMBL20777544410914BindingDB-show
CHEMBL20781610193005BindingDB-show
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CHEMBL20828010236397BindingDB-show
CHEMBL20829944409962BindingDB-show
CHEMBL20830044409963BindingDB-show
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CHEMBL2095810576010BindingDB-show
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CHEMBL2130510525153BindingDB-show
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CHEMBL2181039810934BindingDB-show
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CHEMBL2410712905388BindingDB-show
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CHEMBL2475210232923BindingDB-show
CHEMBL2483911199145BindingDB-show
CHEMBL2519210674875BindingDB-show
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CHEMBL2604213815992BindingDB-show
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CHEMBL9104244324391BindingDB-show
CHEMBL9106410479468BindingDB-show
CHEMBL9124510594814BindingDB-show
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CHEMBL9204310646809BindingDB-show
CHEMBL9231510804455BindingDB-show
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CHEMBL9249110524067BindingDB-show
CHEMBL9332722663370BindingDB-show
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CHEMBL9400944325479BindingDB-show
CHEMBL9425544325316BindingDB-show
CHEMBL9873944330960BindingDB-show
CHEMBL9921244330813BindingDB-show
CI-9303021729BindingDB-show
CID 1011883510744528BindingDB-show
CID 1011956310119564BindingDB-show
CID 1011956310119563BindingDB-show
CID 1013859010837144BindingDB-show
CID 1020762210696971BindingDB-show
CID 1020781510649414BindingDB-show
CID 1022970910301548BindingDB-show
CID 1052567710525677BindingDB-show
CID 1078958310789583BindingDB-show
CID 1081405310814053BindingDB-show
CID 1101724111039077BindingDB-show
CID 1137331211373312BindingDB-show
CID 1163266410668502BindingDB-show
CID 1174287611742876BindingDB-show
CID 1174287610342086BindingDB-show
CID 382432011826264BindingDB-show
CID 98264359826435BindingDB-show
CID 984410910982315BindingDB-show
CID 984410911003969BindingDB-show
CID 98534989853498BindingDB-show
CID 985349810232106BindingDB-show
CID 98655149865514BindingDB-show
CID 99087829843744BindingDB-show
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CK 2130127770BindingDB-show
CK 2289127769BindingDB-show
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NSC409920349956BindingDB-show
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NSC638021367855BindingDB-show
NSC717847403193BindingDB-show
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Oprea1_08384916619271BindingDB-show
Papaverine Monohydrochloride4680BindingDB-show
PELRINONE55920BindingDB-show
Piclamilast154575BindingDB-show
Pseudotheophylline2153BindingDB-show
Pseudoxanthine1188BindingDB-show
Purine analog70639BindingDB-show
RO 20-17245087BindingDB-show
Roflumilast449193BindingDB-show
ROLIPRAM5092BindingDB-show
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S2224_Selleck9818682BindingDB-show
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t-10329874535BindingDB-show
Tadalafil110635BindingDB-show
Theophilcholine5426BindingDB-show
Trequinsin hydrochloride5537BindingDB-show
Vardenafil110634BindingDB-show
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zaprinast5722BindingDB-show
Zardaverine5723BindingDB-show
ZINC00057347158961BindingDB-show
ZINC00057348158962BindingDB-show
ZINC001709072822887BindingDB-show
ZINC001710552823055BindingDB-show
ZINC00171073557426BindingDB-show
ZINC001710792823068BindingDB-show
ZINC015371403636010BindingDB-show
ZINC030462662800759BindingDB-show
ZINC04363773608456BindingDB-show
ZINC043637992822835BindingDB-show
ZINC04363805557364BindingDB-show
ZINC043639052822864BindingDB-show
ZINC053885837659902BindingDB-show
Synonyms:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
DPDE1
PDE21
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
PDE4D_MOUSE73.963.4
PDE4B_HUMAN7361.5
PDE4D_HUMAN71.461.5
PDE4A_HUMAN6455.5
PDE1B_HUMAN39.524.3
PDE9A_HUMAN3921.9
PDE7A_HUMAN34.121.1
PDE6B_CANFA33.319.8
CLPB_THET832.318.9
PDE7B_HUMAN32.219.4
PDE10_HUMAN32.219.4
PDE5A_BOVIN31.819
Q59F04_HUMAN31.718.8
GYS1_MOUSE31.217.7
CAT1_NEUCR31.218
PDE6A_BOVIN3117
PDE10_RAT30.918.2
GFPT2_HUMAN30.916.3
PDE2A_MOUSE30.818.7
ECHA_HUMAN30.817.4
PDE6A_CANFA30.616.9
CNGA1_HUMAN30.517.8
GYS1_HUMAN30.517.4
KPCD_MOUSE30.416.3
GYS2_MOUSE30.316.4
TGM4_HUMAN30.217
Q499P2_RAT3018
LEF_BACAN29.916.8
PDE5A_RAT29.916.3
HTPG_ECOLI29.818.2
Protein-Protein Interactions:
Uniprot nameSource
PDE4C_HUMANPMID 14668322