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Target Details

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Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Uniprot name:PDE4B_HUMAN
Accession Numbers:O15443 Q07343
EC-Number:3.1.4.17
Organism:Homo sapiens
Human
PDB IDs:1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3HC8 3HDZ
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(R)-MESOPRAM5287536DrugBank-show
(R)-ROLIPRAM448055DrugBank-show
185954-27-29896267BindingDB-show
1xm6449190BindingDB-show
AC1MVTY73713518BindingDB-show
AC1N657H4254532BindingDB-show
AC1N8BN34316226BindingDB-show
CHEBI:64993844438583BindingDB-show
CHEMBL108968646884133BindingDB-show
CHEMBL108968746884134BindingDB-show
CHEMBL109001646830337BindingDB-show
CHEMBL109001746884135BindingDB-show
CHEMBL109003146884170BindingDB-show
CHEMBL109003246884171BindingDB-show
CHEMBL109004846884366BindingDB-show
CHEMBL109004946884367BindingDB-show
CHEMBL109037346830338BindingDB-show
CHEMBL109040546884368BindingDB-show
CHEMBL109070146884255BindingDB-show
CHEMBL109070246884256BindingDB-show
CHEMBL109070346884257BindingDB-show
CHEMBL109106246884298BindingDB-show
CHEMBL109144746884299BindingDB-show
CHEMBL109144846884300BindingDB-show
CHEMBL109145146884033BindingDB-show
CHEMBL109180746884094BindingDB-show
CHEMBL109209946884416BindingDB-show
CHEMBL109214246884095BindingDB-show
CHEMBL109216546884096BindingDB-show
CHEMBL109216646884097BindingDB-show
CHEMBL109279446884216BindingDB-show
CHEMBL109307046884217BindingDB-show
CHEMBL109307146884218BindingDB-show
CHEMBL109309446884219BindingDB-show
CHEMBL109334746884136BindingDB-show
CHEMBL109402346884172BindingDB-show
CHEMBL109521024849885BindingDB-show
CHEMBL109522523649292BindingDB-show
CHEMBL109522624849572BindingDB-show
CHEMBL109586524849255BindingDB-show
CHEMBL109681224849380BindingDB-show
CHEMBL109681324849714BindingDB-show
CHEMBL109681424849668BindingDB-show
CHEMBL109819224958040BindingDB-show
CHEMBL109819324957666BindingDB-show
CHEMBL109850224958042BindingDB-show
CHEMBL109850324958421BindingDB-show
CHEMBL109854124849669BindingDB-show
CHEMBL109854224849709BindingDB-show
CHEMBL109877824958416BindingDB-show
CHEMBL109881824849846BindingDB-show
CHEMBL109884424849618BindingDB-show
CHEMBL109916324849256BindingDB-show
CHEMBL109916424849257BindingDB-show
CHEMBL109932224849847BindingDB-show
CHEMBL122143446933992BindingDB-show
CHEMBL122361849865602BindingDB-show
CHEMBL122361949865603BindingDB-show
CHEMBL122362049865604BindingDB-show
CHEMBL122362149865605BindingDB-show
CHEMBL122368449865642BindingDB-show
CHEMBL122368549865643BindingDB-show
CHEMBL122368646933994BindingDB-show
CHEMBL122368746933993BindingDB-show
CHEMBL122465349866243BindingDB-show
CHEMBL122471749866268BindingDB-show
CHEMBL122471849866269BindingDB-show
CHEMBL122471949866270BindingDB-show
CHEMBL122472049866271BindingDB-show
CHEMBL122472149866272BindingDB-show
CHEMBL125559746915888BindingDB-show
CHEMBL125577211628421BindingDB-show
CHEMBL125718811525525BindingDB-show
CHEMBL125718911705339BindingDB-show
CHEMBL125730511525902BindingDB-show
CHEMBL125730611540543BindingDB-show
CHEMBL125742111648915BindingDB-show
CHEMBL125753611633996BindingDB-show
CHEMBL125753711626787BindingDB-show
CHEMBL125765411648288BindingDB-show
CHEMBL125765549780549BindingDB-show
CHEMBL125777711584000BindingDB-show
CHEMBL125777811713455BindingDB-show
CHEMBL125812411641556BindingDB-show
CHEMBL125823811576136BindingDB-show
CHEMBL125823911555069BindingDB-show
CHEMBL125835749780545BindingDB-show
CHEMBL125846911719711BindingDB-show
CHEMBL125847011532832BindingDB-show
CHEMBL125857911612979BindingDB-show
CHEMBL125858011511603BindingDB-show
CHEMBL125868949780546BindingDB-show
CHEMBL125869049780547BindingDB-show
CHEMBL125880649780548BindingDB-show
CHEMBL125880711532316BindingDB-show
CHEMBL125892111711290BindingDB-show
CHEMBL125892211662453BindingDB-show
CHEMBL14449110639193BindingDB-show
CHEMBL14449910335857BindingDB-show
CHEMBL14463310686898BindingDB-show
CHEMBL14464910615343BindingDB-show
CHEMBL14482310381125BindingDB-show
CHEMBL15753522456845BindingDB-show
CHEMBL1578129975276BindingDB-show
CHEMBL15843122456850BindingDB-show
CHEMBL1584879948833BindingDB-show
CHEMBL15861644373185BindingDB-show
CHEMBL15864444373203BindingDB-show
CHEMBL15897744372911BindingDB-show
CHEMBL15898244372973BindingDB-show
CHEMBL16014444373136BindingDB-show
CHEMBL16018544373307BindingDB-show
CHEMBL16036044372709BindingDB-show
CHEMBL16046344372706BindingDB-show
CHEMBL16060344373061BindingDB-show
CHEMBL19696922083724BindingDB-show
CHEMBL19738610183769BindingDB-show
CHEMBL19749444405467BindingDB-show
CHEMBL19843244405507BindingDB-show
CHEMBL19846410205978BindingDB-show
CHEMBL19852710210579BindingDB-show
CHEMBL19856420814950BindingDB-show
CHEMBL19867444405510BindingDB-show
CHEMBL19872222083604BindingDB-show
CHEMBL20090611438405BindingDB-show
CHEMBL20444918734933BindingDB-show
CHEMBL20452210289786BindingDB-show
CHEMBL20659210153372BindingDB-show
CHEMBL20696810196609BindingDB-show
CHEMBL20742421865595BindingDB-show
CHEMBL20755921865599BindingDB-show
CHEMBL20777544410914BindingDB-show
CHEMBL20799621865620BindingDB-show
CHEMBL20810010196916BindingDB-show
CHEMBL20814921865627BindingDB-show
CHEMBL20823644410864BindingDB-show
CHEMBL20838210197046BindingDB-show
CHEMBL20929510196396BindingDB-show
CHEMBL21084044410882BindingDB-show
CHEMBL2181039810934BindingDB-show
CHEMBL21865310177031BindingDB-show
CHEMBL21879316103072BindingDB-show
CHEMBL21899015434926BindingDB-show
CHEMBL24868344441803BindingDB-show
CHEMBL24928544441813BindingDB-show
CHEMBL24948644441818BindingDB-show
CHEMBL24969144441827BindingDB-show
CHEMBL24993344441840BindingDB-show
CHEMBL25013716727125BindingDB-show
CHEMBL25110744441833BindingDB-show
CHEMBL25129844441788BindingDB-show
CHEMBL25129944441790BindingDB-show
CHEMBL25171244441796BindingDB-show
CHEMBL27059744453416BindingDB-show
CHEMBL27063444453781BindingDB-show
CHEMBL2863349885877BindingDB-show
CHEMBL29185344302299BindingDB-show
CHEMBL29224544302569BindingDB-show
CHEMBL29230811742832BindingDB-show
CHEMBL29465744302362BindingDB-show
CHEMBL29470944302604BindingDB-show
CHEMBL30058844302457BindingDB-show
CHEMBL30105344302318BindingDB-show
CHEMBL30162244302664BindingDB-show
CHEMBL30263210091864BindingDB-show
CHEMBL30554044302290BindingDB-show
CHEMBL3076469840066BindingDB-show
CHEMBL34324410543370BindingDB-show
CHEMBL34516744373488BindingDB-show
CHEMBL34521044373280BindingDB-show
CHEMBL34541844373279BindingDB-show
CHEMBL3454729908333BindingDB-show
CHEMBL34587744373180BindingDB-show
CHEMBL34608344372695BindingDB-show
CHEMBL34694644373305BindingDB-show
CHEMBL34933344373291BindingDB-show
CHEMBL35048244373457BindingDB-show
CHEMBL3522459926935BindingDB-show
CHEMBL37022010195164BindingDB-show
CHEMBL37108922083784BindingDB-show
CHEMBL37770944410870BindingDB-show
CHEMBL37868110196596BindingDB-show
CHEMBL37976810129145BindingDB-show
CHEMBL38032110289848BindingDB-show
CHEMBL38093310312566BindingDB-show
CHEMBL38168110185841BindingDB-show
CHEMBL38216810152836BindingDB-show
CHEMBL38254510183196BindingDB-show
CHEMBL38322510128917BindingDB-show
CHEMBL38383721865580BindingDB-show
CHEMBL39825444441794BindingDB-show
CHEMBL39845444441798BindingDB-show
CHEMBL39929744441823BindingDB-show
CHEMBL39929844441825BindingDB-show
CHEMBL39938511635241BindingDB-show
CHEMBL39969044441802BindingDB-show
CHEMBL39989844441804BindingDB-show
CHEMBL40007944441784BindingDB-show
CHEMBL40027644441792BindingDB-show
CHEMBL40097644441831BindingDB-show
CHEMBL40112044441816BindingDB-show
CHEMBL40112144441820BindingDB-show
CHEMBL40118624180492BindingDB-show
CHEMBL40134544441837BindingDB-show
CHEMBL4020011742611BindingDB-show
CHEMBL41723344302300BindingDB-show
CHEMBL42841544441786BindingDB-show
CHEMBL42948444441800BindingDB-show
CHEMBL43094544302395BindingDB-show
CHEMBL43409222456843BindingDB-show
CHEMBL43702044441829BindingDB-show
CHEMBL46606811773870BindingDB-show
CHEMBL46628044574673BindingDB-show
CHEMBL46648142629121BindingDB-show
CHEMBL55105211993169BindingDB-show
CHEMBL56747011992634BindingDB-show
CHEMBL57332411449090BindingDB-show
CHEMBL5811215192730BindingDB-show
CHEMBL5878744302363BindingDB-show
CHEMBL5900310338622BindingDB-show
CHEMBL59150124963293BindingDB-show
CHEMBL5938644302374BindingDB-show
CHEMBL5982044302392BindingDB-show
CHEMBL6011844302345BindingDB-show
CHEMBL6018744302614BindingDB-show
CHEMBL6021744302570BindingDB-show
CHEMBL6032511794796BindingDB-show
CHEMBL6082944302642BindingDB-show
CHEMBL6088744302319BindingDB-show
CHEMBL6128444302636BindingDB-show
CHEMBL6165944302271BindingDB-show
CHEMBL6172744302662BindingDB-show
CHEMBL6185644302055BindingDB-show
CHEMBL6187644302582BindingDB-show
CHEMBL6198244302421BindingDB-show
CHEMBL709039865970BindingDB-show
CHEMBL778269799389BindingDB-show
CHEMBL9037523218492BindingDB-show
CHEMBL9155144324331BindingDB-show
CHEMBL915719995407BindingDB-show
CI-9303021729BindingDB-show
CID 1011956310119564BindingDB-show
CID 1011956310119563BindingDB-show
CID 1022970910301548BindingDB-show
CID 1101724111039077BindingDB-show
CID 98534989853498BindingDB-show
CID 985349810232106BindingDB-show
Cilomilast151170BindingDB-show
Cilostazole2754DrugBank-show
Cilostazole2754PROMISCUOUSPMID 17392505show
Cordemcura3698DrugBank-show
Cordemcura3698PROMISCUOUSPMID 9004165show
Dihydroxypropyltheophylline3182DrugBank-show
Dihydroxypropyltheophylline3182SuperTarget-show
Dimethyloxohexylxanthine4740DrugBank-show
Dimethyloxohexylxanthine4740SuperTarget-show
ENPROFYLLINE1676DrugBank-show
Erythro-9-(2 Hydroxy 3-Nonyl)Adenine149790BindingDB-show
FILAMINAST9578243DrugBank-show
GYKI-133803058801BindingDB-show
Ibudilast3671BindingDB-show
L-Cysteine, mercaptoethanol mixed disulfide170018DrugBank-show
Methyltheobromide2519DrugBank-show
Methyltheobromide2519SuperTargetPMID 8936347show
Milrinone4197PROMISCUOUS3 PMIDsshow
Milrinone4197SuperTargetPMID 16554006show
Muskeladenylsaeure6083DrugBank-show
NPV9999276BindingDB-show
Papaverine Monohydrochloride4680DrugBank-show
Papaverine monohydrochloride6084DrugBank-show
Papaverine Monohydrochloride4680PROMISCUOUS2 PMIDsshow
Papaverine monohydrochloride6084PROMISCUOUS2 PMIDsshow
Phosphodiesterase 4 Inhibitor656969DrugBank-show
Piclamilast154575BindingDB-show
Poly 8-bromoadenylic acid168120DrugBank-show
Pseudotheophylline2153DrugBank-show
Pseudotheophylline2153PROMISCUOUSPMID 8257597show
Pseudotheophylline2153SuperTargetPMID 16750981show
Pyrazole carboxylic ester 20656968DrugBank-show
RO 20-17245087BindingDB-show
Roflumilast449193BindingDB-show
ROLIPRAM5092BindingDB-show
ROLIPRAM158758DrugBank-show
ROLIPRAM5092DrugBank-show
S2224_Selleck9818682BindingDB-show
SCH-3515919802841BindingDB-show
V112949844400BindingDB-show
V11294 Analogue 5a11386897BindingDB-show
V11294 Analogue 5b11443760BindingDB-show
V11294 Analogue 5c11179896BindingDB-show
V11294 Analogue 5d11283750BindingDB-show
V11294 Analogue 5e11443441BindingDB-show
V11294 Analogue 5f11214587BindingDB-show
V11294 Analogue 5g23646741BindingDB-show
V11294 Analogue 5h11306698BindingDB-show
V11294 Analogue 5i23646742BindingDB-show
V11294 Analogue 5j11433797BindingDB-show
V11294 Analogue 5k11456440BindingDB-show
V11294 Analogue 5l23646743BindingDB-show
V11294 Analogue 5m11477773BindingDB-show
V11294 Analogue 5n11238279BindingDB-show
V11294 Analogue 5o11249748BindingDB-show
V11294 Analogue 5p11478659BindingDB-show
V11294 Analogue 5q11318772BindingDB-show
V11294 Analogue 5r23646744BindingDB-show
V11294 Analogue 5s23672869BindingDB-show
V11294 Analogue 5t11226695BindingDB-show
V11294 Analogue 5u23646745BindingDB-show
V11294 Analogue 5v11375325BindingDB-show
V11294 Analogue 8a11442865BindingDB-show
V11294 Analogue 8b23646746BindingDB-show
V11294 Analogue 8c23646747BindingDB-show
zaprinast5722BindingDB-show
Synonyms:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
DPDE4
PDE32
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
PDE4D_MOUSE79.170.1
PDE4C_HUMAN7361.5
PDE4D_HUMAN67.660
PDE4A_HUMAN62.455
PDE9A_HUMAN38.921.7
PDE1B_HUMAN38.322.1
PDE6C_BOVIN3519.7
PDE10_HUMAN33.318
PDE5A_RAT32.918.6
PDE5A_CANFA32.818
TGM3_HUMAN32.717.2
CHEA_THEMA32.616.8
PDE7A_HUMAN32.418.8
PDE5A_HUMAN31.917.6
PDE10_RAT31.717.4
STA5B_HUMAN31.517.2
PDE6A_CANFA31.317.3
CAN1_HUMAN31.118.6
TGM3L_HUMAN30.817.9
GFPT1_HUMAN30.716.2
AMPD1_RAT30.417.3
KINH_NEUCR30.415.3
GYS1_MOUSE30.316.3
Q59675_9GAMM30.117.8
B5RQL7_BORRA30.115.3
AMPD3_HUMAN30.117.5
MCCA_HUMAN3015.4
P3H1_HUMAN3017.6
KPCD1_HUMAN29.916.9
RDRP_I56A029.716.5
Protein-Protein Interactions: