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Target Details

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Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Uniprot name:PDE4A_HUMAN
Accession Numbers:O75522 O76092 P27815 Q16255 Q16691 Q5DM53 Q6PMT2 Q8IVA7 Q8WUQ3 Q9H3H2
EC-Number:3.1.4.17
Organism:Homo sapiens
Human
PDB IDs:2QYK 3I8V
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(R)-ROLIPRAM448055BindingDB-show
185954-27-29896267BindingDB-show
2,5-Diphenylfuran70387BindingDB-show
3,6-bis(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine662872BindingDB-show
3-(3-methoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]th4363048BindingDB-show
4-(2-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-phenylethyl)pyridine127928BindingDB-show
6-(2,5-dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,3849553BindingDB-show
6-(2,5-dimethoxyphenyl)-3-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,662394BindingDB-show
6-(3,4-dimethoxyphenyl)-3-(2-fluorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,43548051BindingDB-show
6-(3,4-dimethoxyphenyl)-3-(2-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,662965BindingDB-show
6-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,3435529BindingDB-show
6-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,1499306BindingDB-show
8-(3-azidophenyl)-6-[(4-iodoimidazol-1-yl)methyl]quinoline10456505BindingDB-show
AC1L4DOB183812BindingDB-show
AC1MVTY73713518BindingDB-show
AC1N657H4254532BindingDB-show
Antistenocardin3108DrugBank-show
CHEMBL10271844333328BindingDB-show
CHEMBL10278444332983BindingDB-show
CHEMBL10363544332982BindingDB-show
CHEMBL10385944332890BindingDB-show
CHEMBL10516444332908BindingDB-show
CHEMBL10524344332875BindingDB-show
CHEMBL108537423624262BindingDB-show
CHEMBL108611024802717BindingDB-show
CHEMBL10928044339577BindingDB-show
CHEMBL10989944339599BindingDB-show
CHEMBL11093716038022BindingDB-show
CHEMBL11150644339586BindingDB-show
CHEMBL11169944339585BindingDB-show
CHEMBL11368644339633BindingDB-show
CHEMBL122143446933992BindingDB-show
CHEMBL122361849865602BindingDB-show
CHEMBL122361949865603BindingDB-show
CHEMBL122362049865604BindingDB-show
CHEMBL122362149865605BindingDB-show
CHEMBL122368449865642BindingDB-show
CHEMBL122368549865643BindingDB-show
CHEMBL122368646933994BindingDB-show
CHEMBL122368746933993BindingDB-show
CHEMBL122465349866243BindingDB-show
CHEMBL122471749866268BindingDB-show
CHEMBL122471849866269BindingDB-show
CHEMBL122471949866270BindingDB-show
CHEMBL122472049866271BindingDB-show
CHEMBL122472149866272BindingDB-show
CHEMBL12357610646520BindingDB-show
CHEMBL12457510547238BindingDB-show
CHEMBL125559746915888BindingDB-show
CHEMBL125577211628421BindingDB-show
CHEMBL125718811525525BindingDB-show
CHEMBL125718911705339BindingDB-show
CHEMBL125742111648915BindingDB-show
CHEMBL125753611633996BindingDB-show
CHEMBL125753711626787BindingDB-show
CHEMBL125765411648288BindingDB-show
CHEMBL125765549780549BindingDB-show
CHEMBL125777811713455BindingDB-show
CHEMBL125812411641556BindingDB-show
CHEMBL125847011532832BindingDB-show
CHEMBL125880649780548BindingDB-show
CHEMBL125880711532316BindingDB-show
CHEMBL125892111711290BindingDB-show
CHEMBL125892211662453BindingDB-show
CHEMBL12658710841260BindingDB-show
CHEMBL12720110837787BindingDB-show
CHEMBL1279449819356BindingDB-show
CHEMBL12799410642995BindingDB-show
CHEMBL15828610571743BindingDB-show
CHEMBL16111510451184BindingDB-show
CHEMBL16146510711281BindingDB-show
CHEMBL16160210547592BindingDB-show
CHEMBL16171410691724BindingDB-show
CHEMBL1617409928390BindingDB-show
CHEMBL16218810805427BindingDB-show
CHEMBL16248521251047BindingDB-show
CHEMBL16287044377131BindingDB-show
CHEMBL16331144377118BindingDB-show
CHEMBL16419944377173BindingDB-show
CHEMBL16456421251043BindingDB-show
CHEMBL16480044377445BindingDB-show
CHEMBL16529821251056BindingDB-show
CHEMBL16568720640414BindingDB-show
CHEMBL16577344377148BindingDB-show
CHEMBL16588920640412BindingDB-show
CHEMBL16624544377130BindingDB-show
CHEMBL16629721251089BindingDB-show
CHEMBL16629944377348BindingDB-show
CHEMBL19696922083724BindingDB-show
CHEMBL19738610183769BindingDB-show
CHEMBL19749444405467BindingDB-show
CHEMBL19843244405507BindingDB-show
CHEMBL19846410205978BindingDB-show
CHEMBL19852710210579BindingDB-show
CHEMBL19856420814950BindingDB-show
CHEMBL19867444405510BindingDB-show
CHEMBL19872222083604BindingDB-show
CHEMBL20090611438405BindingDB-show
CHEMBL20444918734933BindingDB-show
CHEMBL20452210289786BindingDB-show
CHEMBL20659210153372BindingDB-show
CHEMBL20696810196609BindingDB-show
CHEMBL20742421865595BindingDB-show
CHEMBL20755921865599BindingDB-show
CHEMBL20777544410914BindingDB-show
CHEMBL20799621865620BindingDB-show
CHEMBL20810010196916BindingDB-show
CHEMBL20814921865627BindingDB-show
CHEMBL20823644410864BindingDB-show
CHEMBL20838210197046BindingDB-show
CHEMBL20929510196396BindingDB-show
CHEMBL21084044410882BindingDB-show
CHEMBL2181039810934BindingDB-show
CHEMBL21865310177031BindingDB-show
CHEMBL21879316103072BindingDB-show
CHEMBL21899015434926BindingDB-show
CHEMBL26600044282368BindingDB-show
CHEMBL28409144282707BindingDB-show
CHEMBL28438644282159BindingDB-show
CHEMBL28447944282270BindingDB-show
CHEMBL28450619959342BindingDB-show
CHEMBL28485244282737BindingDB-show
CHEMBL28497319959348BindingDB-show
CHEMBL28524744282723BindingDB-show
CHEMBL28548844282358BindingDB-show
CHEMBL28550044282699BindingDB-show
CHEMBL28576644281894BindingDB-show
CHEMBL28589544282295BindingDB-show
CHEMBL28611844282077BindingDB-show
CHEMBL28611944282388BindingDB-show
CHEMBL2862249808191BindingDB-show
CHEMBL2862949953237BindingDB-show
CHEMBL2863349885877BindingDB-show
CHEMBL28639244282483BindingDB-show
CHEMBL28642144282176BindingDB-show
CHEMBL28660344282409BindingDB-show
CHEMBL28692144282472BindingDB-show
CHEMBL28699844281936BindingDB-show
CHEMBL28702644282109BindingDB-show
CHEMBL28711444282297BindingDB-show
CHEMBL28716744281908BindingDB-show
CHEMBL28730719959383BindingDB-show
CHEMBL28734844282235BindingDB-show
CHEMBL2873599938153BindingDB-show
CHEMBL28737744282741BindingDB-show
CHEMBL28901244282324BindingDB-show
CHEMBL28902344282374BindingDB-show
CHEMBL28945344281838BindingDB-show
CHEMBL29080144282028BindingDB-show
CHEMBL2947179915714BindingDB-show
CHEMBL2999319829952BindingDB-show
CHEMBL3014419850032BindingDB-show
CHEMBL3076469840066BindingDB-show
CHEMBL31030310162604BindingDB-show
CHEMBL31810844332873BindingDB-show
CHEMBL31844444329639BindingDB-show
CHEMBL31980944329633BindingDB-show
CHEMBL31985844332874BindingDB-show
CHEMBL32131644332896BindingDB-show
CHEMBL3215344282341BindingDB-show
CHEMBL32186444339676BindingDB-show
CHEMBL32254510065530BindingDB-show
CHEMBL3233129916436BindingDB-show
CHEMBL32345110990391BindingDB-show
CHEMBL3242744281858BindingDB-show
CHEMBL32454244339632BindingDB-show
CHEMBL32584619361675BindingDB-show
CHEMBL32692120583506BindingDB-show
CHEMBL32698144339619BindingDB-show
CHEMBL3302144282742BindingDB-show
CHEMBL33064144329669BindingDB-show
CHEMBL3309044282311BindingDB-show
CHEMBL3341944281860BindingDB-show
CHEMBL3353544281965BindingDB-show
CHEMBL33908310404815BindingDB-show
CHEMBL34037910531401BindingDB-show
CHEMBL34536010545177BindingDB-show
CHEMBL34581210611778BindingDB-show
CHEMBL34963521251062BindingDB-show
CHEMBL3501144282287BindingDB-show
CHEMBL35062721251069BindingDB-show
CHEMBL35100721251066BindingDB-show
CHEMBL3511879850277BindingDB-show
CHEMBL35150010661230BindingDB-show
CHEMBL35161310664015BindingDB-show
CHEMBL35190010810934BindingDB-show
CHEMBL35191510682163BindingDB-show
CHEMBL3521819959377BindingDB-show
CHEMBL3523444282738BindingDB-show
CHEMBL3534644281839BindingDB-show
CHEMBL3535044282705BindingDB-show
CHEMBL3539044282073BindingDB-show
CHEMBL3539144281910BindingDB-show
CHEMBL3544044282345BindingDB-show
CHEMBL35493121251090BindingDB-show
CHEMBL3556244282474BindingDB-show
CHEMBL3560744282160BindingDB-show
CHEMBL3567244282255BindingDB-show
CHEMBL3570344281889BindingDB-show
CHEMBL3595444282647BindingDB-show
CHEMBL3600644282463BindingDB-show
CHEMBL3600744282464BindingDB-show
CHEMBL3607719959346BindingDB-show
CHEMBL3624244282743BindingDB-show
CHEMBL3634844282725BindingDB-show
CHEMBL3647110407016BindingDB-show
CHEMBL3655944282282BindingDB-show
CHEMBL37022010195164BindingDB-show
CHEMBL37108922083784BindingDB-show
CHEMBL37770944410870BindingDB-show
CHEMBL37868110196596BindingDB-show
CHEMBL37976810129145BindingDB-show
CHEMBL38032110289848BindingDB-show
CHEMBL38093310312566BindingDB-show
CHEMBL38168110185841BindingDB-show
CHEMBL38216810152836BindingDB-show
CHEMBL38254510183196BindingDB-show
CHEMBL38322510128917BindingDB-show
CHEMBL38383721865580BindingDB-show
CHEMBL40834544332880BindingDB-show
CHEMBL41604119959396BindingDB-show
CHEMBL41604544282092BindingDB-show
CHEMBL41639944281877BindingDB-show
CHEMBL4177769825776BindingDB-show
CHEMBL41823144282706BindingDB-show
CHEMBL4184169955864BindingDB-show
CHEMBL41878544329642BindingDB-show
CHEMBL41941610565073BindingDB-show
CHEMBL42045444329666BindingDB-show
CHEMBL42099944329702BindingDB-show
CHEMBL42325244377340BindingDB-show
CHEMBL43180644329684BindingDB-show
CHEMBL43382844281818BindingDB-show
CHEMBL44486544377295BindingDB-show
CHEMBL44583344282072BindingDB-show
CHEMBL45257844562336BindingDB-show
CHEMBL45617144588589BindingDB-show
CHEMBL45617212991318BindingDB-show
CHEMBL45617344588591BindingDB-show
CHEMBL45680810274114BindingDB-show
CHEMBL45810622391998BindingDB-show
CHEMBL46460044589077BindingDB-show
CHEMBL46480244589079BindingDB-show
CHEMBL46480322391985BindingDB-show
CHEMBL4648049932192BindingDB-show
CHEMBL46606811773870BindingDB-show
CHEMBL46628044574673BindingDB-show
CHEMBL46648142629121BindingDB-show
CHEMBL48475310115569BindingDB-show
CHEMBL48554710274246BindingDB-show
CHEMBL48562010297996BindingDB-show
CHEMBL4856299919680BindingDB-show
CHEMBL49947744588590BindingDB-show
CHEMBL51136844589078BindingDB-show
CHEMBL51456444588592BindingDB-show
CHEMBL51919310113183BindingDB-show
CHEMBL55105211993169BindingDB-show
CHEMBL5633044300524BindingDB-show
CHEMBL565759936981BindingDB-show
CHEMBL56747011992634BindingDB-show
CHEMBL569719916317BindingDB-show
CHEMBL5709544300149BindingDB-show
CHEMBL571319827594BindingDB-show
CHEMBL575249828771BindingDB-show
CHEMBL5775744300777BindingDB-show
CHEMBL5776744300789BindingDB-show
CHEMBL59150124963293BindingDB-show
CHEMBL611919849838BindingDB-show
CHEMBL778269799389BindingDB-show
CHEMBL7843944317802BindingDB-show
CHEMBL7844644318012BindingDB-show
CHEMBL7860744317799BindingDB-show
CHEMBL7880610863652BindingDB-show
CHEMBL7913744318013BindingDB-show
CHEMBL8149144317818BindingDB-show
CHEMBL8253444317996BindingDB-show
CHEMBL9037523218492BindingDB-show
CHEMBL9155144324331BindingDB-show
CHEMBL915719995407BindingDB-show
CHEMBL9571544329630BindingDB-show
CHEMBL9597944329893BindingDB-show
CHEMBL9603444329894BindingDB-show
CHEMBL9603944329683BindingDB-show
CHEMBL9721344329685BindingDB-show
CHEMBL9721444329686BindingDB-show
CHEMBL9778544329640BindingDB-show
CHEMBL9781710322207BindingDB-show
CHEMBL9786644329613BindingDB-show
CHEMBL9866244329651BindingDB-show
CHEMBL9873044329668BindingDB-show
CHEMBL9910144329511BindingDB-show
CHEMBL9947044329482BindingDB-show
CI-9303021729BindingDB-show
CID 1011956310119564BindingDB-show
CID 1011956310119563BindingDB-show
CID 1022970910301548BindingDB-show
CID 1101724111039077BindingDB-show
CID 98252889825288BindingDB-show
CID 98534989853498BindingDB-show
CID 985349810232106BindingDB-show
Cilomilast151170BindingDB-show
Cilostazole2754DrugBank-show
Cilostazole2754PROMISCUOUSPMID 17392505show
Dihydroxypropyltheophylline3182DrugBank-show
Dimethyloxohexylxanthine4740DrugBank-show
ENPROFYLLINE1676DrugBank-show
Erythro-9-(2 Hydroxy 3-Nonyl)Adenine149790BindingDB-show
Ibudilast3671BindingDB-show
Iloprost6443959DrugBank-show
KF182803071941BindingDB-show
Milrinone4197DrugBank-show
Milrinone4197PROMISCUOUS3 PMIDsshow
MLS0000947795771474BindingDB-show
NPV9999276BindingDB-show
Phentolamine Methanesulfonate5775DrugBank-show
Piclamilast154575BindingDB-show
Pseudotheophylline2153DrugBank-show
Pseudotheophylline2153PROMISCUOUSPMID 8257597show
Pseudotheophylline2153SuperTargetPMID 16750981show
ROLIPRAM5092BindingDB-show
S2224_Selleck9818682BindingDB-show
SMR00131765917757146BindingDB-show
Tadalafil110635DrugBank-show
triazolopyridazine, 1744143459BindingDB-show
triazolopyridazine, 1842647289BindingDB-show
triazolothiadiazine, 1044143458BindingDB-show
triazolothiadiazine, 10D17757130BindingDB-show
triazolothiadiazine, 10E17757137BindingDB-show
triazolothiadiazine, 10F17757144BindingDB-show
triazolothiadiazine, 10G17757150BindingDB-show
triazolothiadiazine, 10H17757156BindingDB-show
triazolothiadiazine, 10J17757164BindingDB-show
triazolothiadiazine, 10K44143470BindingDB-show
triazolothiadiazine, 11A17757116BindingDB-show
triazolothiadiazine, 11B17757121BindingDB-show
triazolothiadiazine, 11C17757125BindingDB-show
triazolothiadiazine, 11D17757131BindingDB-show
triazolothiadiazine, 11E17757138BindingDB-show
triazolothiadiazine, 11F17757145BindingDB-show
triazolothiadiazine, 11G17757151BindingDB-show
triazolothiadiazine, 11H17757157BindingDB-show
triazolothiadiazine, 11I17757160BindingDB-show
triazolothiadiazine, 11J17757165BindingDB-show
triazolothiadiazine, 11K44143471BindingDB-show
triazolothiadiazine, 2244142087BindingDB-show
triazolothiadiazine, 2344142091BindingDB-show
triazolothiadiazine, 2444142095BindingDB-show
triazolothiadiazine, 2544142099BindingDB-show
triazolothiadiazine, 2644143460BindingDB-show
triazolothiadiazine, 2844142088BindingDB-show
triazolothiadiazine, 2944142093BindingDB-show
triazolothiadiazine, 3044142096BindingDB-show
triazolothiadiazine, 3144142100BindingDB-show
triazolothiadiazine, 3244143461BindingDB-show
triazolothiadiazine, 3444142089BindingDB-show
triazolothiadiazine, 3544142097BindingDB-show
triazolothiadiazine, 3644142101BindingDB-show
triazolothiadiazine, 3744143462BindingDB-show
triazolothiadiazine, 3844143463BindingDB-show
triazolothiadiazine, 3944143464BindingDB-show
triazolothiadiazine, 4044143465BindingDB-show
triazolothiadiazine, 4144142102BindingDB-show
triazolothiadiazine, 4244143466BindingDB-show
triazolothiadiazine, 5D17757132BindingDB-show
triazolothiadiazine, 5E17757139BindingDB-show
triazolothiadiazine, 5H17757158BindingDB-show
triazolothiadiazine, 5J17757166BindingDB-show
triazolothiadiazine, 5K17757173BindingDB-show
triazolothiadiazine, 644142090BindingDB-show
triazolothiadiazine, 6A17757112BindingDB-show
triazolothiadiazine, 6B17757118BindingDB-show
triazolothiadiazine, 6C17757123BindingDB-show
triazolothiadiazine, 6D17757126BindingDB-show
triazolothiadiazine, 6E17757133BindingDB-show
triazolothiadiazine, 6F17757140BindingDB-show
triazolothiadiazine, 6G17757147BindingDB-show
triazolothiadiazine, 6H17757152BindingDB-show
triazolothiadiazine, 6I17757159BindingDB-show
triazolothiadiazine, 6J17757161BindingDB-show
triazolothiadiazine, 6K17757168BindingDB-show
triazolothiadiazine, 744142094BindingDB-show
triazolothiadiazine, 7A17757113BindingDB-show
triazolothiadiazine, 7B17757119BindingDB-show
triazolothiadiazine, 7D17757127BindingDB-show
triazolothiadiazine, 7E17757134BindingDB-show
triazolothiadiazine, 7F17757141BindingDB-show
triazolothiadiazine, 7G17757148BindingDB-show
triazolothiadiazine, 7H17757153BindingDB-show
triazolothiadiazine, 7I17757175BindingDB-show
triazolothiadiazine, 7J17757162BindingDB-show
triazolothiadiazine, 844142098BindingDB-show
triazolothiadiazine, 8A17757114BindingDB-show
triazolothiadiazine, 8D17757128BindingDB-show
triazolothiadiazine, 8E17757135BindingDB-show
triazolothiadiazine, 8F17757142BindingDB-show
triazolothiadiazine, 8H17757154BindingDB-show
triazolothiadiazine, 8J17757163BindingDB-show
triazolothiadiazine, 8K17757169BindingDB-show
triazolothiadiazine, 944142103BindingDB-show
triazolothiadiazine, 9A17757115BindingDB-show
triazolothiadiazine, 9B17757120BindingDB-show
triazolothiadiazine, 9C17757124BindingDB-show
triazolothiadiazine, 9D17757129BindingDB-show
triazolothiadiazine, 9E17757136BindingDB-show
triazolothiadiazine, 9F17757143BindingDB-show
triazolothiadiazine, 9G17757149BindingDB-show
triazolothiadiazine, 9H17757155BindingDB-show
triazolothiadiazine, 9I44143467BindingDB-show
triazolothiadiazine, 9J44143468BindingDB-show
triazolothiadiazine, 9K44143469BindingDB-show
V112949844400BindingDB-show
V11294 Analogue 5a11386897BindingDB-show
V11294 Analogue 5b11443760BindingDB-show
V11294 Analogue 5c11179896BindingDB-show
V11294 Analogue 5d11283750BindingDB-show
V11294 Analogue 5e11443441BindingDB-show
V11294 Analogue 5f11214587BindingDB-show
V11294 Analogue 5g23646741BindingDB-show
V11294 Analogue 5h11306698BindingDB-show
V11294 Analogue 5i23646742BindingDB-show
V11294 Analogue 5j11433797BindingDB-show
V11294 Analogue 5k11456440BindingDB-show
V11294 Analogue 5l23646743BindingDB-show
V11294 Analogue 5m11477773BindingDB-show
V11294 Analogue 5n11238279BindingDB-show
V11294 Analogue 5o11249748BindingDB-show
V11294 Analogue 5p11478659BindingDB-show
V11294 Analogue 5q11318772BindingDB-show
V11294 Analogue 5r23646744BindingDB-show
V11294 Analogue 5s23672869BindingDB-show
V11294 Analogue 5t11226695BindingDB-show
V11294 Analogue 5u23646745BindingDB-show
V11294 Analogue 5v11375325BindingDB-show
V11294 Analogue 8a11442865BindingDB-show
V11294 Analogue 8b23646746BindingDB-show
V11294 Analogue 8c23646747BindingDB-show
zaprinast5722BindingDB-show
ZINC00529516935803BindingDB-show
ZINC050252053261457BindingDB-show
ZINC050472603492181BindingDB-show
ZINC050718293835979BindingDB-show
ZINC051194573829988BindingDB-show
ZINC051236923393127BindingDB-show
ZINC051237433788138BindingDB-show
ZINC067366734558271BindingDB-show
Synonyms:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
DPDE2
PDE46
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
PDE4C_HUMAN6455.5
PDE4D_HUMAN63.553.9
PDE4D_MOUSE63.153.9
PDE4B_HUMAN62.455
C1TC_HUMAN31.318.1
GYRA_HAEIN30.816.4
PDE1B_HUMAN30.317.7
HS90A_HUMAN29.916.6
DNLI1_HUMAN29.818.6
PDE6C_BOVIN29.617.7
B4DK80_HUMAN29.217.5
PDE2A_MOUSE29.216.9
RTCB_PYRHO29.217.5
P85A_HUMAN29.118
PDE2A_HUMAN29.117.4
CLAT_HUMAN2917
TGM1_HUMAN2917
DGKZ_RAT28.917.6
HYSA_STRA328.615.1
PKHA4_HUMAN28.619
PDE10_HUMAN28.516
Q9X2W8_RHOCE28.318.2
PDE5A_HUMAN28.316.6
PDE9A_HUMAN28.217.1
NCBP1_HUMAN28.215.3
PDE11_RAT28.216.5
Q12843_HUMAN28.116.6
GFPT2_HUMAN28.114.7
IDE_HUMAN28.117.2
DNLI3_HUMAN2815.8
Protein-Protein Interactions: