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Target Details

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Name:Dual specificity mitogen-activated protein kinase kinase 2
Uniprot name:MP2K2_HUMAN
Accession Numbers:P36507
EC-Number:2.7.12.2
Organism:Homo sapiens
Human
PDB IDs:1S9I
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2′-Amino-3′-methoxyflavone4713PROMISCUOUSPMID 12970258show
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide6918454BindingDB-show
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide6918454PROMISCUOUS3 PMIDsshow
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
ABT-86911485656BindingDB-show
AC1NYX5U5842956BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Benzydamine Monohydrochoride12555PROMISCUOUSPMID 12970098show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL23362611278372BindingDB-show
CHEMBL23362711404033BindingDB-show
CHEMBL23362811150337BindingDB-show
CHEMBL23381811449997BindingDB-show
CHEMBL23423711234608BindingDB-show
CHEMBL23488711213014BindingDB-show
CHEMBL23488911269976BindingDB-show
CHEMBL23489011166713BindingDB-show
CHEMBL23577711154664BindingDB-show
CHEMBL23577811213013BindingDB-show
CHEMBL23577911482748BindingDB-show
CHEMBL23578044431779BindingDB-show
CHEMBL23599511260128BindingDB-show
CHEMBL23725611429515BindingDB-show
CHEMBL23725711165914BindingDB-show
CHEMBL23725811385135BindingDB-show
CHEMBL23746923630906BindingDB-show
CHEMBL24345711403394BindingDB-show
CHEMBL2444889803891BindingDB-show
CHEMBL31651044328636BindingDB-show
CHEMBL31653644328755BindingDB-show
CHEMBL31663544328708BindingDB-show
CHEMBL31772044328542BindingDB-show
CHEMBL31893944328673BindingDB-show
CHEMBL32949244328573BindingDB-show
CHEMBL33019544328691BindingDB-show
CHEMBL33039344328484BindingDB-show
CHEMBL38757444428116BindingDB-show
CHEMBL39113511464600BindingDB-show
CHEMBL39119911818670BindingDB-show
CHEMBL39197511437715BindingDB-show
CHEMBL39328211177427BindingDB-show
CHEMBL39328311439219BindingDB-show
CHEMBL39523111189634BindingDB-show
CHEMBL39654844428115BindingDB-show
CHEMBL39663111406147BindingDB-show
CHEMBL39663211408896BindingDB-show
CHEMBL39781111362025BindingDB-show
CHEMBL39781211372988BindingDB-show
CHEMBL44223511338183BindingDB-show
CHEMBL56888045485676BindingDB-show
CHEMBL56892045485664BindingDB-show
CHEMBL56892145485665BindingDB-show
CHEMBL56934045485640BindingDB-show
CHEMBL56958845485666BindingDB-show
CHEMBL57047445485687BindingDB-show
CHEMBL57048845485654BindingDB-show
CHEMBL57113745485590BindingDB-show
CHEMBL57158045485645BindingDB-show
CHEMBL57179745485646BindingDB-show
CHEMBL57182345485625BindingDB-show
CHEMBL57222545485600BindingDB-show
CHEMBL57730445485609BindingDB-show
CHEMBL58367945485677BindingDB-show
CHEMBL9456544328664BindingDB-show
CHEMBL9506944328504BindingDB-show
CHEMBL9540044328774BindingDB-show
CHEMBL9572844328643BindingDB-show
CHEMBL9590544328789BindingDB-show
CHEMBL9706744328623BindingDB-show
CHEMBL972059970051BindingDB-show
CHEMBL9740644328431BindingDB-show
CHEMBL9758644328308BindingDB-show
CHEMBL9772444328572BindingDB-show
CHIR-26511656518BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
G0668_SIGMA6603857BindingDB-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
L-7900709806182BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
Lopac-U-1205354033BindingDB-show
MLN805411712649BindingDB-show
Pazopanib10113978BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
pyrimidine imidazole compound 1447721BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB 203580176155BindingDB-show
SB-4315424521392BindingDB-show
SB2422359863367BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Succinonitrile, bis(amino(o-aminophenylthio)methylene)-3006531BindingDB-show
Succinonitrile, bis(amino(o-aminophenylthio)methylene)-3006531PROMISCUOUSPMID 12566304show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Tocris-19625166BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 2
ERK activator kinase 2
MAP kinase kinase 2
MAPK/ERK kinase 2
MAPKK 2
MEK2
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
MP2K2_RAT9894
MP2K2_MOUSE97.594
MP2K1_MOUSE8779.6
MP2K1_HUMAN8779.6
MP2K1_RAT8779.6
MP2K3_MOUSE49.130.6
MP2K7_HUMAN47.430.6
MP2K6_MOUSE45.130.8
MP2K4_HUMAN44.931.1
MSK1_TOBAC39.724.1
CDK2_HUMAN37.921.8
KAPCA_MOUSE37.520.8
KAPCA_RAT37.520.5
CDK6_HUMAN3723.8
A4D1G0_HUMAN3723.8
CDK15_HUMAN36.921.7
KAPCB_HUMAN36.920.6
CDK7_HUMAN36.824.6
KAPCA_HUMAN36.720.7
KAPCA_PIG36.720.7
KAPCA_BOVIN36.520.7
KAPCG_HUMAN36.320
KAPCB_RAT36.119.2
KAPCB_MOUSE36.119.2
KAPA_YEAST35.619
O75100_HUMAN34.819.8
CDK9_HUMAN34.821.8
MK01_RAT34.419.2
MK01_MOUSE34.419.2
MK01_HUMAN34.319.1
Protein-Protein Interactions: