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Target Details

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Name:Dual specificity mitogen-activated protein kinase kinase 1
Uniprot name:MP2K1_HUMAN
Accession Numbers:Q02750
EC-Number:2.7.12.2
Organism:Homo sapiens
Human
PDB IDs:1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
10E-Hymenialdisine3036831BindingDB-show
2′-Amino-3′-methoxyflavone4713BindingDB-show
2′-Amino-3′-methoxyflavone4713PROMISCUOUS3 PMIDsshow
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide6918454BindingDB-show
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide6918454PROMISCUOUS3 PMIDsshow
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3-cyanoquinoline, 1025218824BindingDB-show
3-cyanoquinoline, 325218822BindingDB-show
3-cyanoquinoline, 425218823BindingDB-show
3-cyanoquinoline, 721704852BindingDB-show
3-cyanoquinoline, 810303277BindingDB-show
3-cyanoquinoline, 99806897BindingDB-show
4261065742610657BindingDB-show
5-BROMO-N-(2,3-DIHYDROXYPROPOXY)-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]BENZAMIDE448535DrugBank-show
ABT-86911485656BindingDB-show
AC1MBJGN2726555BindingDB-show
AC1MBJGW2726558BindingDB-show
AC1MBJHN2726567BindingDB-show
AC1MO5SY3338590BindingDB-show
AC1NYX5U5842956BindingDB-show
AC1Q2MII14171391BindingDB-show
Aldisin3085877BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Benzydamine Monohydrochoride12555PROMISCUOUSPMID 12970098show
BMS-53692410390396BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:30525144348997BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL1023019890746BindingDB-show
CHEMBL10237444333650BindingDB-show
CHEMBL10278644333854BindingDB-show
CHEMBL10522010461359BindingDB-show
CHEMBL10564244333834BindingDB-show
CHEMBL10648944333813BindingDB-show
CHEMBL10696610905857BindingDB-show
CHEMBL116963125187544BindingDB-show
CHEMBL116974649797945BindingDB-show
CHEMBL116981349797967BindingDB-show
CHEMBL116981424784164BindingDB-show
CHEMBL116999625186685BindingDB-show
CHEMBL116999825187248BindingDB-show
CHEMBL116999925186961BindingDB-show
CHEMBL117019125187543BindingDB-show
CHEMBL117059649797965BindingDB-show
CHEMBL117080249797966BindingDB-show
CHEMBL117080425186686BindingDB-show
CHEMBL117080525186687BindingDB-show
CHEMBL117101225186963BindingDB-show
CHEMBL117101325186960BindingDB-show
CHEMBL117101449798006BindingDB-show
CHEMBL117101525188088BindingDB-show
CHEMBL117131225186684BindingDB-show
CHEMBL117168225186959BindingDB-show
CHEMBL117252125187538BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL128858249839480BindingDB-show
CHEMBL19753844143344BindingDB-show
CHEMBL19921016085320BindingDB-show
CHEMBL19974911188772BindingDB-show
CHEMBL19977411669238BindingDB-show
CHEMBL19986011384425BindingDB-show
CHEMBL20096922179466BindingDB-show
CHEMBL20113644406797BindingDB-show
CHEMBL20115611165133BindingDB-show
CHEMBL20118620791601BindingDB-show
CHEMBL20120022179480BindingDB-show
CHEMBL20120322179532BindingDB-show
CHEMBL20124620791616BindingDB-show
CHEMBL20125122179671BindingDB-show
CHEMBL20126922179615BindingDB-show
CHEMBL20130220791598BindingDB-show
CHEMBL20137911236142BindingDB-show
CHEMBL20138422179638BindingDB-show
CHEMBL20138920791639BindingDB-show
CHEMBL20141711611241BindingDB-show
CHEMBL20142611281076BindingDB-show
CHEMBL20162911418932BindingDB-show
CHEMBL20163011690375BindingDB-show
CHEMBL20169111523601BindingDB-show
CHEMBL20171622179618BindingDB-show
CHEMBL20176820791608BindingDB-show
CHEMBL20178020791606BindingDB-show
CHEMBL20181922179728BindingDB-show
CHEMBL20183322473189BindingDB-show
CHEMBL20206322179588BindingDB-show
CHEMBL20212844407254BindingDB-show
CHEMBL20214220791607BindingDB-show
CHEMBL20214322179547BindingDB-show
CHEMBL20217720791507BindingDB-show
CHEMBL20221120791618BindingDB-show
CHEMBL20222820791561BindingDB-show
CHEMBL20228620791535BindingDB-show
CHEMBL20235522179713BindingDB-show
CHEMBL20235620791412BindingDB-show
CHEMBL20238520791619BindingDB-show
CHEMBL20254520791617BindingDB-show
CHEMBL20277144406798BindingDB-show
CHEMBL20309622179488BindingDB-show
CHEMBL20313811395411BindingDB-show
CHEMBL20325711603973BindingDB-show
CHEMBL20325811689297BindingDB-show
CHEMBL20341420791615BindingDB-show
CHEMBL20341711617424BindingDB-show
CHEMBL20409444407284BindingDB-show
CHEMBL20414722179590BindingDB-show
CHEMBL20453520791510BindingDB-show
CHEMBL20872714171390BindingDB-show
CHEMBL20877816727892BindingDB-show
CHEMBL20932016727869BindingDB-show
CHEMBL20942844413990BindingDB-show
CHEMBL20948944414003BindingDB-show
CHEMBL20950244414026BindingDB-show
CHEMBL20952044414021BindingDB-show
CHEMBL20967516727913BindingDB-show
CHEMBL20984544413998BindingDB-show
CHEMBL20986844414550BindingDB-show
CHEMBL21007244413985BindingDB-show
CHEMBL21015416727880BindingDB-show
CHEMBL21120144414373BindingDB-show
CHEMBL21131616727911BindingDB-show
CHEMBL21135944414372BindingDB-show
CHEMBL21138244414025BindingDB-show
CHEMBL21148816727872BindingDB-show
CHEMBL21154644413993BindingDB-show
CHEMBL21179621808053BindingDB-show
CHEMBL21206116727895BindingDB-show
CHEMBL21211044414011BindingDB-show
CHEMBL21221422255964BindingDB-show
CHEMBL21230516727881BindingDB-show
CHEMBL21247416655058BindingDB-show
CHEMBL21248044413976BindingDB-show
CHEMBL21316744414396BindingDB-show
CHEMBL21316844414398BindingDB-show
CHEMBL21356244414006BindingDB-show
CHEMBL21356344414007BindingDB-show
CHEMBL21365144414420BindingDB-show
CHEMBL21379744413996BindingDB-show
CHEMBL21384716727891BindingDB-show
CHEMBL21399244414374BindingDB-show
CHEMBL21403244417787BindingDB-show
CHEMBL21406716727876BindingDB-show
CHEMBL21434916727912BindingDB-show
CHEMBL21442544417783BindingDB-show
CHEMBL21458744417801BindingDB-show
CHEMBL21461344417788BindingDB-show
CHEMBL21461444417789BindingDB-show
CHEMBL21463644417802BindingDB-show
CHEMBL21468344417806BindingDB-show
CHEMBL21473444417791BindingDB-show
CHEMBL21475244417796BindingDB-show
CHEMBL21481644417795BindingDB-show
CHEMBL21490144417800BindingDB-show
CHEMBL21497744417804BindingDB-show
CHEMBL21501144417792BindingDB-show
CHEMBL21501244417793BindingDB-show
CHEMBL21503844417797BindingDB-show
CHEMBL21518522255988BindingDB-show
CHEMBL21519344417782BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL21620144417812BindingDB-show
CHEMBL21632544417809BindingDB-show
CHEMBL21644944417814BindingDB-show
CHEMBL21650044417815BindingDB-show
CHEMBL21683211613319BindingDB-show
CHEMBL21683344417807BindingDB-show
CHEMBL21711744417771BindingDB-show
CHEMBL21712644417779BindingDB-show
CHEMBL21713044417769BindingDB-show
CHEMBL21731044417768BindingDB-show
CHEMBL21735544417776BindingDB-show
CHEMBL21741444417780BindingDB-show
CHEMBL21741544417781BindingDB-show
CHEMBL21741644417785BindingDB-show
CHEMBL21783244417774BindingDB-show
CHEMBL21783344417775BindingDB-show
CHEMBL25311625167109BindingDB-show
CHEMBL26303944417810BindingDB-show
CHEMBL26547844417773BindingDB-show
CHEMBL26578620791505BindingDB-show
CHEMBL26969644417786BindingDB-show
CHEMBL27975844279881BindingDB-show
CHEMBL28166210164464BindingDB-show
CHEMBL28236144279996BindingDB-show
CHEMBL28297644279943BindingDB-show
CHEMBL28595644279526BindingDB-show
CHEMBL28624444279777BindingDB-show
CHEMBL28785210185838BindingDB-show
CHEMBL28808121704856BindingDB-show
CHEMBL3026844279868BindingDB-show
CHEMBL3035921704772BindingDB-show
CHEMBL3051644279911BindingDB-show
CHEMBL3054010118314BindingDB-show
CHEMBL3055121704776BindingDB-show
CHEMBL3059722466681BindingDB-show
CHEMBL3072811755998BindingDB-show
CHEMBL3076322466740BindingDB-show
CHEMBL3079010185285BindingDB-show
CHEMBL3114310228676BindingDB-show
CHEMBL3114944279890BindingDB-show
CHEMBL3138444279651BindingDB-show
CHEMBL3149717903650BindingDB-show
CHEMBL3163944279624BindingDB-show
CHEMBL31651044328636BindingDB-show
CHEMBL31653644328755BindingDB-show
CHEMBL31663544328708BindingDB-show
CHEMBL317339978125BindingDB-show
CHEMBL31772044328542BindingDB-show
CHEMBL3180644279650BindingDB-show
CHEMBL31893944328673BindingDB-show
CHEMBL31989411729539BindingDB-show
CHEMBL32068844333792BindingDB-show
CHEMBL32104510206034BindingDB-show
CHEMBL32107844333771BindingDB-show
CHEMBL32333610457505BindingDB-show
CHEMBL3273009927943BindingDB-show
CHEMBL32949244328573BindingDB-show
CHEMBL33019544328691BindingDB-show
CHEMBL33038844328167BindingDB-show
CHEMBL33039344328484BindingDB-show
CHEMBL33772810225656BindingDB-show
CHEMBL35616414056555BindingDB-show
CHEMBL36999220791410BindingDB-show
CHEMBL37102722179683BindingDB-show
CHEMBL37109544405504BindingDB-show
CHEMBL37165811496376BindingDB-show
CHEMBL37169311439749BindingDB-show
CHEMBL37196920791599BindingDB-show
CHEMBL37260011633097BindingDB-show
CHEMBL37541044414575BindingDB-show
CHEMBL37560915984125BindingDB-show
CHEMBL37728820791586BindingDB-show
CHEMBL37749720791626BindingDB-show
CHEMBL37754722255979BindingDB-show
CHEMBL37759144414015BindingDB-show
CHEMBL37759244414016BindingDB-show
CHEMBL37773411632737BindingDB-show
CHEMBL37778344414397BindingDB-show
CHEMBL37801444414009BindingDB-show
CHEMBL37827844413995BindingDB-show
CHEMBL37829644414022BindingDB-show
CHEMBL37835122255970BindingDB-show
CHEMBL37838522179477BindingDB-show
CHEMBL37849322255982BindingDB-show
CHEMBL37868844414024BindingDB-show
CHEMBL37871944414010BindingDB-show
CHEMBL37883344414027BindingDB-show
CHEMBL37893816727873BindingDB-show
CHEMBL38029516727871BindingDB-show
CHEMBL38032844414028BindingDB-show
CHEMBL38076521025113BindingDB-show
CHEMBL38245620791602BindingDB-show
CHEMBL38261622179680BindingDB-show
CHEMBL38309820791605BindingDB-show
CHEMBL38310822179674BindingDB-show
CHEMBL38385844417803BindingDB-show
CHEMBL38401244417808BindingDB-show
CHEMBL38478444417794BindingDB-show
CHEMBL38505944417813BindingDB-show
CHEMBL38520344417790BindingDB-show
CHEMBL38543944415335BindingDB-show
CHEMBL38544644417784BindingDB-show
CHEMBL38570344417772BindingDB-show
CHEMBL38582016727889BindingDB-show
CHEMBL38590516126717BindingDB-show
CHEMBL38604244415333BindingDB-show
CHEMBL38623044417770BindingDB-show
CHEMBL38637344415334BindingDB-show
CHEMBL38645744417805BindingDB-show
CHEMBL38646944417811BindingDB-show
CHEMBL38718444417798BindingDB-show
CHEMBL41363644417778BindingDB-show
CHEMBL41413910324074BindingDB-show
CHEMBL41485620791416BindingDB-show
CHEMBL41933344328201BindingDB-show
CHEMBL42489744417799BindingDB-show
CHEMBL42598044417777BindingDB-show
CHEMBL42684011485916BindingDB-show
CHEMBL43733144417767BindingDB-show
CHEMBL44035611064594BindingDB-show
CHEMBL45027144588815BindingDB-show
CHEMBL47864924856363BindingDB-show
CHEMBL48339816720763BindingDB-show
CHEMBL48436844588735BindingDB-show
CHEMBL48521144588733BindingDB-show
CHEMBL48523744588761BindingDB-show
CHEMBL48523844588763BindingDB-show
CHEMBL4852859983303BindingDB-show
CHEMBL48528644580077BindingDB-show
CHEMBL48537744588713BindingDB-show
CHEMBL48557444588760BindingDB-show
CHEMBL48561544588813BindingDB-show
CHEMBL48905825211064BindingDB-show
CHEMBL48966144588812BindingDB-show
CHEMBL48981244580107BindingDB-show
CHEMBL49042325211459BindingDB-show
CHEMBL49102944580231BindingDB-show
CHEMBL49122825101222BindingDB-show
CHEMBL49143444580056BindingDB-show
CHEMBL49143544580058BindingDB-show
CHEMBL49163544580059BindingDB-show
CHEMBL49572910479082BindingDB-show
CHEMBL49654344580758BindingDB-show
CHEMBL49675244580759BindingDB-show
CHEMBL4975639864418BindingDB-show
CHEMBL49779144580755BindingDB-show
CHEMBL49779244580757BindingDB-show
CHEMBL50724944591740BindingDB-show
CHEMBL51920644588712BindingDB-show
CHEMBL52002544588714BindingDB-show
CHEMBL52014225181191BindingDB-show
CHEMBL52101344588732BindingDB-show
CHEMBL52132044588734BindingDB-show
CHEMBL52150244588762BindingDB-show
CHEMBL52212944580057BindingDB-show
CHEMBL52257910089048BindingDB-show
CHEMBL52355944580420BindingDB-show
CHEMBL52411144588814BindingDB-show
CHEMBL52427444580756BindingDB-show
CHEMBL55226544241614BindingDB-show
CHEMBL55851245273505BindingDB-show
CHEMBL56106644241613BindingDB-show
CHEMBL58963046224908BindingDB-show
CHEMBL59132546225169BindingDB-show
CHEMBL8083721024393BindingDB-show
CHEMBL9456544328664BindingDB-show
CHEMBL9458644328248BindingDB-show
CHEMBL9495644328224BindingDB-show
CHEMBL9496544328247BindingDB-show
CHEMBL9497144328502BindingDB-show
CHEMBL9500210345719BindingDB-show
CHEMBL9505744328662BindingDB-show
CHEMBL9506944328504BindingDB-show
CHEMBL9540044328774BindingDB-show
CHEMBL9572844328643BindingDB-show
CHEMBL9590544328789BindingDB-show
CHEMBL9706744328623BindingDB-show
CHEMBL972059970051BindingDB-show
CHEMBL9740644328431BindingDB-show
CHEMBL9746344328249BindingDB-show
CHEMBL9758644328308BindingDB-show
CHEMBL9771444328166BindingDB-show
CHEMBL9772444328572BindingDB-show
CHEMBL9813044328252BindingDB-show
CHEMBL9813144328253BindingDB-show
CHEMBL997439911005BindingDB-show
CHIR-26511656518BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
DEBROMOHYMENIALDISINE5288032BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
Gefitinib123631PROMISCUOUSPMID 18377894show
GW-258011617559BindingDB-show
Hymenialdisine3035462BindingDB-show
Hymenialdisine, 11b9930243BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
InSolution™ Casein Kinase II Inhibitor, DMAT5326976BindingDB-show
JNK Inhibitor V11422035BindingDB-show
K00599a9549300BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
Lopac-U-1205354033BindingDB-show
Lopac0_0012179951825BindingDB-show
MLN805411712649BindingDB-show
Oroidin6312649BindingDB-show
Pazopanib10113978BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Succinonitrile, bis(amino(o-aminophenylthio)methylene)-3006531BindingDB-show
Succinonitrile, bis(amino(o-aminophenylthio)methylene)-3006531PROMISCUOUSPMID 12566304show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
thieno[2,3-c]pyridine, 725218754BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 1
ERK activator kinase 1
MAP kinase kinase 1
MAPK/ERK kinase 1
MAPKK 1
MEK1
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
MP2K1_RAT99.799.2
MP2K1_MOUSE99.599
MP2K2_HUMAN8779.6
MP2K2_MOUSE86.679.6
MP2K2_RAT86.579.1
MP2K6_MOUSE50.631.9
MP2K7_HUMAN47.529.6
MP2K3_MOUSE45.529.9
MP2K4_HUMAN42.929.3
MSK1_TOBAC41.122.9
A4D1G0_HUMAN38.623.1
CDK6_HUMAN38.623.1
C4R3V7_PICPG38.222.1
CDC2H_PLAFK35.822.1
CDK2_HUMAN35.822
CDK1_HUMAN35.823.1
KAPA_YEAST35.419.1
STK6_HUMAN35.319.5
CDK9_HUMAN35.221.9
KAPCB_HUMAN34.919.8
KAPCA_MOUSE34.819.8
KAPCA_RAT34.819.5
Q5KU03_MOUSE34.622.3
GSK3B_MOUSE34.622.3
KAPCA_PIG34.519.5
KAPCA_HUMAN34.519.5
GSK3B_HUMAN34.422.5
CDK5_MOUSE34.420.9
KAPCA_BOVIN34.319.3
CDK7_HUMAN34.221.9
Protein-Protein Interactions: