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Target Details

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Name:Matrix metalloproteinase-8
Uniprot name:MMP8_HUMAN
Accession Numbers:P22894 Q45F99
EC-Number:3.4.24.34
Organism:Homo sapiens
Human
PDB IDs:1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE445018BindingDB-show
1-HYDROXYAMINE-2-ISOBUTYLMALONIC ACID6323374DrugBank-show
1mmp5289314BindingDB-show
2-(BIPHENYL-4-SULFONYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID444698DrugBank-show
2-THIOMETHYL-3-PHENYLPROPANOIC ACID5287850DrugBank-show
2NI5326979BindingDB-show
2ow99896504BindingDB-show
3-(4-Hexyloxy-phenyl)-succinamic acid651854BindingDB-show
3-PHENYL-3-({[4-(4-PYRIDIN-4-YLPHENYL)THIEN-2-YL]CARBONYL}AMINO)PROPANOIC ACID448942BindingDB-show
4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE3342298BindingDB-show
5-methyl-5-(4-phenoxyphenyl)barbituric acid1836BindingDB-show
AC1L42OX177347BindingDB-show
AC1MORIH3348132BindingDB-show
Actinonine443600BindingDB-show
alpha-sulfone 27b11697283BindingDB-show
alpha-sulfone 27d11532911BindingDB-show
alpha-sulfone 27e11719408BindingDB-show
alpha-sulfone 27g11561491BindingDB-show
alpha-sulfone 35a11633617BindingDB-show
alpha-sulfone 35c11533203BindingDB-show
alpha-sulfone 35d11561839BindingDB-show
alpha-sulfone 35f9890734BindingDB-show
alpha-sulfone 35g11705503BindingDB-show
alpha-sulfone 35h11684850BindingDB-show
AMINOMETHYLAMIDE69020DrugBank-show
BATIMASTAT5362422DrugBank-show
Benzenesulfohyd69033BindingDB-show
beta-sulfone 7b9867183BindingDB-show
beta-sulfone 7c11613649BindingDB-show
beta-sulfone 7d11548264BindingDB-show
beta-sulfone 7e11641261BindingDB-show
beta-sulfone 7f11526076BindingDB-show
Butan-2-ylcarbamoylphosphonic Acid11286824BindingDB-show
CDS1_004684716696BindingDB-show
CGS 27023A446504BindingDB-show
CHEBI:25545044327809BindingDB-show
CHEBI:25616444328146BindingDB-show
CHEBI:400836914621BindingDB-show
CHEBI:55358844318493BindingDB-show
CHEBI:5535889888897BindingDB-show
CHEBI:64427644282954BindingDB-show
CHEBI:65119044300218BindingDB-show
CHEBI:65405744580108BindingDB-show
CHEMBL10010044329712BindingDB-show
CHEMBL10027344329644BindingDB-show
CHEMBL10067810566915BindingDB-show
CHEMBL10237310828912BindingDB-show
CHEMBL10287310592232BindingDB-show
CHEMBL10312910665403BindingDB-show
CHEMBL10320010632558BindingDB-show
CHEMBL10348010689487BindingDB-show
CHEMBL10372210570236BindingDB-show
CHEMBL104549889190BindingDB-show
CHEMBL10487010783212BindingDB-show
CHEMBL10535210759449BindingDB-show
CHEMBL108231746871741BindingDB-show
CHEMBL108231822485381BindingDB-show
CHEMBL10823819802768BindingDB-show
CHEMBL108423846871738BindingDB-show
CHEMBL108450946871739BindingDB-show
CHEMBL108451046871740BindingDB-show
CHEMBL10849410183064BindingDB-show
CHEMBL108525720735209BindingDB-show
CHEMBL10921410136680BindingDB-show
CHEMBL10935310296785BindingDB-show
CHEMBL10957910136924BindingDB-show
CHEMBL10960311016072BindingDB-show
CHEMBL10965511101785BindingDB-show
CHEMBL10977010116107BindingDB-show
CHEMBL10980611730086BindingDB-show
CHEMBL10986110138303BindingDB-show
CHEMBL11075010206106BindingDB-show
CHEMBL11097010162900BindingDB-show
CHEMBL11117910204303BindingDB-show
CHEMBL11125710274748BindingDB-show
CHEMBL1114509932290BindingDB-show
CHEMBL11167810114318BindingDB-show
CHEMBL1118569866250BindingDB-show
CHEMBL11382710709191BindingDB-show
CHEMBL11435715524389BindingDB-show
CHEMBL11480415524388BindingDB-show
CHEMBL11487811967143BindingDB-show
CHEMBL11508215524390BindingDB-show
CHEMBL11518944342614BindingDB-show
CHEMBL11526310439082BindingDB-show
CHEMBL11533010648524BindingDB-show
CHEMBL11571244341538BindingDB-show
CHEMBL1161509817358BindingDB-show
CHEMBL11652310800736BindingDB-show
CHEMBL11652910809988BindingDB-show
CHEMBL11655710337314BindingDB-show
CHEMBL11658810544776BindingDB-show
CHEMBL11664110851204BindingDB-show
CHEMBL11675210662922BindingDB-show
CHEMBL11729644344739BindingDB-show
CHEMBL11731610775444BindingDB-show
CHEMBL11750344343534BindingDB-show
CHEMBL11766444343507BindingDB-show
CHEMBL11793210540548BindingDB-show
CHEMBL11799710787883BindingDB-show
CHEMBL11906110623565BindingDB-show
CHEMBL13783523523891BindingDB-show
CHEMBL13790044360002BindingDB-show
CHEMBL13792944359924BindingDB-show
CHEMBL13796644359670BindingDB-show
CHEMBL13818144359739BindingDB-show
CHEMBL13826444359889BindingDB-show
CHEMBL13827344359790BindingDB-show
CHEMBL13833844359563BindingDB-show
CHEMBL13840044359888BindingDB-show
CHEMBL13853544359665BindingDB-show
CHEMBL13861344359641BindingDB-show
CHEMBL13864323523890BindingDB-show
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CHEMBL13869644359760BindingDB-show
CHEMBL13881422642543BindingDB-show
CHEMBL13885823523900BindingDB-show
CHEMBL13895344359507BindingDB-show
CHEMBL13954244359659BindingDB-show
CHEMBL14015244360784BindingDB-show
CHEMBL14030544359536BindingDB-show
CHEMBL14033544359720BindingDB-show
CHEMBL14036844359719BindingDB-show
CHEMBL14042644359662BindingDB-show
CHEMBL14043944359925BindingDB-show
CHEMBL14045444359746BindingDB-show
CHEMBL14054344359678BindingDB-show
CHEMBL14060244359813BindingDB-show
CHEMBL14086344359661BindingDB-show
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CHEMBL14167323523881BindingDB-show
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CHEMBL17338244383842BindingDB-show
CHEMBL17437344384021BindingDB-show
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CHEMBL18341044391352BindingDB-show
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CHEMBL19792144405997BindingDB-show
CHEMBL19826211284983BindingDB-show
CHEMBL19924111456566BindingDB-show
CHEMBL20027444406655BindingDB-show
CHEMBL20038544405998BindingDB-show
CHEMBL2073059868333BindingDB-show
CHEMBL20800910160968BindingDB-show
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CHEMBL22750144422743BindingDB-show
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CHEMBL22759844422723BindingDB-show
CHEMBL22782444422720BindingDB-show
CHEMBL22814144422749BindingDB-show
CHEMBL22818744422736BindingDB-show
CHEMBL22818844422737BindingDB-show
CHEMBL23403416730519BindingDB-show
CHEMBL23452925181080BindingDB-show
CHEMBL23453025178145BindingDB-show
CHEMBL23473525181081BindingDB-show
CHEMBL23509523657422BindingDB-show
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CHEMBL23591623657418BindingDB-show
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CHEMBL23677023657421BindingDB-show
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CHEMBL23717723655717BindingDB-show
CHEMBL2373849999879BindingDB-show
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CHEMBL24207344428777BindingDB-show
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CHEMBL26292110503952BindingDB-show
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CHEMBL26629244264020BindingDB-show
CHEMBL26793944263913BindingDB-show
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CHEMBL26901944264036BindingDB-show
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CHEMBL27779244321801BindingDB-show
CHEMBL28001710648390BindingDB-show
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CHEMBL28690444280411BindingDB-show
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CHEMBL29037710030422BindingDB-show
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CHEMBL29175710766518BindingDB-show
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CHEMBL29189811792994BindingDB-show
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CHEMBL29263611792237BindingDB-show
CHEMBL29265710742536BindingDB-show
CHEMBL29265944299821BindingDB-show
CHEMBL29267144299758BindingDB-show
CHEMBL29291610810983BindingDB-show
CHEMBL29304410740215BindingDB-show
CHEMBL29330510552732BindingDB-show
CHEMBL29335710650906BindingDB-show
CHEMBL2933599842741BindingDB-show
CHEMBL29350410780743BindingDB-show
CHEMBL29352810579086BindingDB-show
CHEMBL29357144299812BindingDB-show
CHEMBL29416744299989BindingDB-show
CHEMBL29437444299996BindingDB-show
CHEMBL29442610792571BindingDB-show
CHEMBL29465444300007BindingDB-show
CHEMBL29468010551771BindingDB-show
CHEMBL29489610763804BindingDB-show
CHEMBL29506619366816BindingDB-show
CHEMBL29748810502327BindingDB-show
CHEMBL29816711754739BindingDB-show
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CHEMBL29881444300058BindingDB-show
CHEMBL29882210761730BindingDB-show
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CHEMBL29902044300183BindingDB-show
CHEMBL29902310503708BindingDB-show
CHEMBL29909110597516BindingDB-show
CHEMBL29960010741956BindingDB-show
CHEMBL29966410813119BindingDB-show
CHEMBL29972044299999BindingDB-show
CHEMBL299769951986BindingDB-show
CHEMBL2999369821077BindingDB-show
CHEMBL30016211754185BindingDB-show
CHEMBL30036210670896BindingDB-show
CHEMBL30069719366867BindingDB-show
CHEMBL30080710693698BindingDB-show
CHEMBL30082944300199BindingDB-show
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CHEMBL30101444300051BindingDB-show
CHEMBL30104844300223BindingDB-show
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CHEMBL30117710650624BindingDB-show
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CHEMBL30162644300231BindingDB-show
CHEMBL30167510623424BindingDB-show
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CHEMBL30190044300015BindingDB-show
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CHEMBL30231144311313BindingDB-show
CHEMBL30236810624005BindingDB-show
CHEMBL30295444310825BindingDB-show
CHEMBL30315544311187BindingDB-show
CHEMBL30391810571396BindingDB-show
CHEMBL30404510524337BindingDB-show
CHEMBL30461744311268BindingDB-show
CHEMBL30522244311335BindingDB-show
CHEMBL30578044311566BindingDB-show
CHEMBL30618910252900BindingDB-show
CHEMBL30622410787938BindingDB-show
CHEMBL30647010694510BindingDB-show
CHEMBL30652410838922BindingDB-show
CHEMBL30687110719476BindingDB-show
CHEMBL30691244310863BindingDB-show
CHEMBL30705710078499BindingDB-show
CHEMBL30709010600844BindingDB-show
CHEMBL30795844311212BindingDB-show
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CHEMBL30803210647658BindingDB-show
CHEMBL3080444280323BindingDB-show
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CHEMBL3082779851911BindingDB-show
CHEMBL30839744310789BindingDB-show
CHEMBL30842910668823BindingDB-show
CHEMBL30859810718058BindingDB-show
CHEMBL31024910695491BindingDB-show
CHEMBL31100410098250BindingDB-show
CHEMBL31109711059620BindingDB-show
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CHEMBL31136744316269BindingDB-show
CHEMBL3116444280285BindingDB-show
CHEMBL31210010885834BindingDB-show
CHEMBL31330723645870BindingDB-show
CHEMBL31334011812791BindingDB-show
CHEMBL31335610478059BindingDB-show
CHEMBL31336044321746BindingDB-show
CHEMBL31338644321967BindingDB-show
CHEMBL31347244321932BindingDB-show
CHEMBL31348310478481BindingDB-show
CHEMBL31368923645879BindingDB-show
CHEMBL31377611757336BindingDB-show
CHEMBL31380223645878BindingDB-show
CHEMBL31389644321783BindingDB-show
CHEMBL31419944321965BindingDB-show
CHEMBL31504644321782BindingDB-show
CHEMBL31511411071831BindingDB-show
CHEMBL31531923645862BindingDB-show
CHEMBL31549523645871BindingDB-show
CHEMBL31584344321540BindingDB-show
CHEMBL31590144322214BindingDB-show
CHEMBL31620044321601BindingDB-show
CHEMBL31639423645872BindingDB-show
CHEMBL31695444329623BindingDB-show
CHEMBL31699710198038BindingDB-show
CHEMBL31723110586834BindingDB-show
CHEMBL31802344329742BindingDB-show
CHEMBL3181909825927BindingDB-show
CHEMBL31825244330147BindingDB-show
CHEMBL31845544329405BindingDB-show
CHEMBL31866411367571BindingDB-show
CHEMBL31871644329741BindingDB-show
CHEMBL3189709974516BindingDB-show
CHEMBL32121310138589BindingDB-show
CHEMBL3216339845875BindingDB-show
CHEMBL32171710832036BindingDB-show
CHEMBL32224610565981BindingDB-show
CHEMBL32266010740519BindingDB-show
CHEMBL32279510136925BindingDB-show
CHEMBL32283310805200BindingDB-show
CHEMBL32387415524387BindingDB-show
CHEMBL32388544341652BindingDB-show
CHEMBL32436944344565BindingDB-show
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CHEMBL32503710696773BindingDB-show
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CHEMBL32516310395015BindingDB-show
CHEMBL32548810658451BindingDB-show
CHEMBL32592444343526BindingDB-show
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CHEMBL32676044343404BindingDB-show
CHEMBL32710844341611BindingDB-show
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CHEMBL32928744329713BindingDB-show
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CHEMBL33270911799180BindingDB-show
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CHEMBL33776144359740BindingDB-show
CHEMBL33779310665669BindingDB-show
CHEMBL3391544282968BindingDB-show
CHEMBL3408510413076BindingDB-show
CHEMBL34160423523909BindingDB-show
CHEMBL3420610389113BindingDB-show
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CHEMBL34330144359704BindingDB-show
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CHEMBL34381823523893BindingDB-show
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CHEMBL34441044359923BindingDB-show
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CHEMBL36699744384356BindingDB-show
CHEMBL36733144384146BindingDB-show
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CHEMBL44909244316470BindingDB-show
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CHEMBL5299410737552BindingDB-show
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CHEMBL56367944219902BindingDB-show
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CHEMBL9251244326185BindingDB-show
CHEMBL9283520639531BindingDB-show
CHEMBL9297044326225BindingDB-show
CHEMBL9315520639540BindingDB-show
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CHEMBL9425618395616BindingDB-show
CHEMBL9499744328203BindingDB-show
CHEMBL9506844328155BindingDB-show
CHEMBL9548344329622BindingDB-show
CHEMBL9561444329725BindingDB-show
CHEMBL9576311194666BindingDB-show
CHEMBL9643811207122BindingDB-show
CHEMBL9647344326232BindingDB-show
CHEMBL9703411147931BindingDB-show
CHEMBL9705712671872BindingDB-show
CHEMBL9738244329672BindingDB-show
CHEMBL9738923692637BindingDB-show
CHEMBL9761411447356BindingDB-show
CHEMBL9770911817193BindingDB-show
CHEMBL9783844328189BindingDB-show
CHEMBL9793644329886BindingDB-show
CHEMBL9795111470070BindingDB-show
CHEMBL9801744329910BindingDB-show
CHEMBL9804410453826BindingDB-show
CHEMBL9891744329636BindingDB-show
CHEMBL9914844329694BindingDB-show
CHEMBL9918910094362BindingDB-show
CHEMBL9998144329927BindingDB-show
CID 1046264010462640BindingDB-show
CID 1129417911294179BindingDB-show
CID 99836049983604BindingDB-show
Cipemastat9824350BindingDB-show
DB03622446505DrugBank-show
EIN6540261BindingDB-show
Ethylcarbamoylphosphonic Acid11205873BindingDB-show
FIN6852147BindingDB-show
Glycitein5317750PROMISCUOUSPMID 12552999show
Grassystatin A44255320BindingDB-show
Hydroxamate 1010837740BindingDB-show
Hydroxamate 1110001582BindingDB-show
Hydroxamate 1210594000BindingDB-show
Hydroxamate 1310500340BindingDB-show
Hydroxamate 1410042482BindingDB-show
Hydroxamate 1510707457BindingDB-show
Hydroxamate 1623645528BindingDB-show
Hydroxamate 1723645529BindingDB-show
Hydroxamate 1815296597BindingDB-show
Hydroxamate 1910740485BindingDB-show
Hydroxamate 2011792968BindingDB-show
Hydroxamate 216916013BindingDB-show
Hydroxamate 2223645531BindingDB-show
Hydroxamate 2323645530BindingDB-show
Hydroxamate 2410524562BindingDB-show
Hydroxamate 2510717400BindingDB-show
Hydroxamate 2610833334BindingDB-show
Hydroxamate 2710591505BindingDB-show
Hydroxamate 2810792025BindingDB-show
Hydroxamate 2910766622BindingDB-show
Hydroxamate 3010549329BindingDB-show
Hydroxamate 3111799753BindingDB-show
Hydroxamate 3210671441BindingDB-show
Hydroxamate 3310810684BindingDB-show
Hydroxamate 3410529602BindingDB-show
Hydroxamate 3510456675BindingDB-show
Hydroxamate 3610500886BindingDB-show
Hydroxamate 3723645532BindingDB-show
Hydroxamate 3823645533BindingDB-show
Hydroxamate 3911036991BindingDB-show
Hydroxamate 4023645534BindingDB-show
Hydroxamate 4123645535BindingDB-show
Hydroxamate 4223645536BindingDB-show
Hydroxamate 4323645537BindingDB-show
Hydroxamate 4410027203BindingDB-show
Hydroxamate 4523645538BindingDB-show
Hydroxamate 710523292BindingDB-show
Hydroxamate 810758013BindingDB-show
Hydroxamate 910445302BindingDB-show
Hydroxysulfonamide 4723644662BindingDB-show
Hydroxysulfonamide 4823644663BindingDB-show
Hydroxysulfonamide 4923645539BindingDB-show
Hydroxysulfonamide 5023645540BindingDB-show
Hydroxysulfonamide 5112447203BindingDB-show
Hydroxysulfonamide 5223645541BindingDB-show
Hydroxysulfonamide 5412635074BindingDB-show
Hydroxysulfonamide 575220706BindingDB-show
Hydroxysulfonamide 5810081163BindingDB-show
Hydroxysulfonamide 5923645542BindingDB-show
Hydroxysulfonamide 6023645543BindingDB-show
Hydroxysulfonamide 6123645544BindingDB-show
Hydroxysulfonamide 6223645545BindingDB-show
Hydroxysulfonamide 6523645546BindingDB-show
Hydroxysulfonamide 6612635073BindingDB-show
Hydroxysulfonamide 6711009332BindingDB-show
Hydroxysulfonamide 6823645547BindingDB-show
Hydroxysulfonamide 6910610114BindingDB-show
Hydroxysulfonamide 7023645548BindingDB-show
Ilomastat132519BindingDB-show
Marimastat119031BindingDB-show
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID194777BindingDB-show
Methylcarbamoylphosphonic Acid11457732BindingDB-show
Methylsulphamic acid77754BindingDB-show
MMP-2 Inhibitor III10044321BindingDB-show
mmp-8 inhibitor i10761128BindingDB-show
N-(2-Isobutyl-3-(N'-hydroxycarbonylamido)propanoyl)-O-methyltyrosinemethylamide128564BindingDB-show
N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carbox4229BindingDB-show
N1-Hydroxysulfanilamide240910BindingDB-show
NSC139458283995BindingDB-show
NSC528513352863BindingDB-show
p-Bromo-N-hydroxybenzenesulfonamide121255BindingDB-show
Peakdale1_0005433649035BindingDB-show
Prinomastat466151BindingDB-show
Propylcarbamoylphosphonic Acid11400989BindingDB-show
pyrazolopyridine, 4925022681BindingDB-show
RRS478379BindingDB-show
S279543420BindingDB-show
ST072428644601BindingDB-show
ST0815032047223BindingDB-show
tetracycline5280962BindingDB-show
thiol-aryl sulfone, 8b23627203BindingDB-show
ZINC005803562800809BindingDB-show
Zincov22099199BindingDB-show
Synonyms:
Matrix metalloproteinase-8
MMP-8
Neutrophil collagenase
PMNL collagenase
PMNL-CL
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
MMP1_HUMAN73.157.2
MMP1_RABIT71.957.9
MMP3_HUMAN68.149.9
MMP3_CANFA67.550.8
MMP3_RABIT66.950.2
MMP3_MOUSE66.748
MMP10_HUMAN65.848.9
MMP13_MOUSE64.548.1
MMP13_RAT64.147.5
MMP12_HUMAN63.646.8
MMP13_HUMAN62.447.6
MMP12_MOUSE58.342.3
MMP11_MOUSE46.633.1
MMP14_HUMAN43.930
MMP16_HUMAN43.230.4
MMP28_HUMAN41.729.3
MMP2_HUMAN41.231.3
MMP2_RAT40.730.9
MMP2_MOUSE40.230.5
MMP9_HUMAN34.423.8
MMP9_RAT34.424.4
MMP9_CANFA34.325
MMP7_HUMAN33.526.1
Q46220_CLOPE33.316.8
MMP9_MOUSE32.823.1
Q60711_MOUSE32.218.6
SQD1_ARATH31.818.6
HXK_SCHMA31.619.3
PHR_ECOLI31.516.7
IIGP1_MOUSE31.316.8
Protein-Protein Interactions: