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Target Details

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Name:Mitogen-activated protein kinase 10
Uniprot name:MK10_HUMAN
Accession Numbers:A6NFS3 P53779 Q15707 Q49AP1
EC-Number:2.7.11.24
Organism:Homo sapiens
Human
PDB IDs:1JNK 1PMN 1PMQ 1PMU 1PMV 2B1P 2EXC 2O0U 2O2U 2OK1 2P33 2R9S 2WAJ 2ZDT 2ZDU 3CGF 3CGO 3DA6 3FI2 3FI3 3FV8 3G90 3G9L 3G9N
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine449054BindingDB-show
2oji23647154BindingDB-show
2ojj15942697BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3cgf24801862BindingDB-show
3ds624941253BindingDB-show
449811-01-216220188BindingDB-show
ABT-86911485656BindingDB-show
ADENYLYL IMIDODIPHOSPHATE33113DrugBank-show
AIZ9549178BindingDB-show
AMG 70611667893BindingDB-show
aminopyridine deriv. 111715520BindingDB-show
AST-48711409972BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:65405311478148BindingDB-show
CHEBI:65405311478147BindingDB-show
CHEBI:65412111353317BindingDB-show
CHEBI:65412111353316BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL1040749796455BindingDB-show
CHEMBL107672122353185BindingDB-show
CHEMBL107992145375859BindingDB-show
CHEMBL108027944634494BindingDB-show
CHEMBL108058210093433BindingDB-show
CHEMBL108090246865325BindingDB-show
CHEMBL108119646879806BindingDB-show
CHEMBL108673646880951BindingDB-show
CHEMBL108900744138038BindingDB-show
CHEMBL109401346884198BindingDB-show
CHEMBL109401446884199BindingDB-show
CHEMBL121517144197572BindingDB-show
CHEMBL121530446864283BindingDB-show
CHEMBL121552444198874BindingDB-show
CHEMBL121552646901260BindingDB-show
CHEMBL122247449864785BindingDB-show
CHEMBL122256549864850BindingDB-show
CHEMBL122299046933384BindingDB-show
CHEMBL122299249865153BindingDB-show
CHEMBL122320324959046BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL128785752949737BindingDB-show
CHEMBL128785952943626BindingDB-show
CHEMBL128788652941226BindingDB-show
CHEMBL128788752942436BindingDB-show
CHEMBL128788846869071BindingDB-show
CHEMBL128791452946059BindingDB-show
CHEMBL128791546869075BindingDB-show
CHEMBL128791652948519BindingDB-show
CHEMBL128794452944873BindingDB-show
CHEMBL128794546869147BindingDB-show
CHEMBL128797446869611BindingDB-show
CHEMBL128797546869609BindingDB-show
CHEMBL128800446869223BindingDB-show
CHEMBL128800546869671BindingDB-show
CHEMBL128800646869677BindingDB-show
CHEMBL128803752942482BindingDB-show
CHEMBL128803846869740BindingDB-show
CHEMBL128803946869742BindingDB-show
CHEMBL128806752948565BindingDB-show
CHEMBL128806846869000BindingDB-show
CHEMBL128806952946092BindingDB-show
CHEMBL128809852941286BindingDB-show
CHEMBL128809946869877BindingDB-show
CHEMBL128810046868930BindingDB-show
CHEMBL128812752944909BindingDB-show
CHEMBL128812846869149BindingDB-show
CHEMBL128812952942507BindingDB-show
CHEMBL128815752950113BindingDB-show
CHEMBL128815852944914BindingDB-show
CHEMBL128815952948593BindingDB-show
CHEMBL128816049839481BindingDB-show
CHEMBL128818624535122BindingDB-show
CHEMBL128818726704995BindingDB-show
CHEMBL128818825660569BindingDB-show
CHEMBL128821452946145BindingDB-show
CHEMBL128821552949817BindingDB-show
CHEMBL128821652949818BindingDB-show
CHEMBL128824352946152BindingDB-show
CHEMBL128824452947386BindingDB-show
CHEMBL128824552948602BindingDB-show
CHEMBL128827152947399BindingDB-show
CHEMBL128827252942532BindingDB-show
CHEMBL128827352946172BindingDB-show
CHEMBL128829752947421BindingDB-show
CHEMBL128829852947422BindingDB-show
CHEMBL128829952944962BindingDB-show
CHEMBL128893143623574BindingDB-show
CHEMBL128893252941649BindingDB-show
CHEMBL128893352943427BindingDB-show
CHEMBL128896452947095BindingDB-show
CHEMBL128896552942227BindingDB-show
CHEMBL128896652941011BindingDB-show
CHEMBL128899352943431BindingDB-show
CHEMBL19349444402034BindingDB-show
CHEMBL19356344402178BindingDB-show
CHEMBL19398344402306BindingDB-show
CHEMBL19399244402311BindingDB-show
CHEMBL19480644404813BindingDB-show
CHEMBL19518844402083BindingDB-show
CHEMBL19629544402321BindingDB-show
CHEMBL19684744402226BindingDB-show
CHEMBL19704144402312BindingDB-show
CHEMBL19709611604958BindingDB-show
CHEMBL19726744402183BindingDB-show
CHEMBL19761310215642BindingDB-show
CHEMBL19769810172440BindingDB-show
CHEMBL19826144404438BindingDB-show
CHEMBL19842744404432BindingDB-show
CHEMBL19868710152189BindingDB-show
CHEMBL19875616007071BindingDB-show
CHEMBL19882110151272BindingDB-show
CHEMBL19913644404797BindingDB-show
CHEMBL19924744404444BindingDB-show
CHEMBL20263944408908BindingDB-show
CHEMBL20266644408909BindingDB-show
CHEMBL20296110477561BindingDB-show
CHEMBL20300910092520BindingDB-show
CHEMBL20305944408641BindingDB-show
CHEMBL20322544408825BindingDB-show
CHEMBL20328911740117BindingDB-show
CHEMBL20353510247954BindingDB-show
CHEMBL20379210384407BindingDB-show
CHEMBL20383944408944BindingDB-show
CHEMBL20442044410960BindingDB-show
CHEMBL20475744408669BindingDB-show
CHEMBL20507844408670BindingDB-show
CHEMBL20540210091293BindingDB-show
CHEMBL20556110384284BindingDB-show
CHEMBL20567210452031BindingDB-show
CHEMBL20646644408936BindingDB-show
CHEMBL20678344410717BindingDB-show
CHEMBL20703744410829BindingDB-show
CHEMBL20713011620055BindingDB-show
CHEMBL20723544410869BindingDB-show
CHEMBL20724644410851BindingDB-show
CHEMBL20744511691173BindingDB-show
CHEMBL20767444410720BindingDB-show
CHEMBL20771811532676BindingDB-show
CHEMBL20781511526238BindingDB-show
CHEMBL20804844410949BindingDB-show
CHEMBL20828611373886BindingDB-show
CHEMBL21100311661959BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL21594316086114BindingDB-show
CHEMBL21814144419182BindingDB-show
CHEMBL21819444419211BindingDB-show
CHEMBL21821944419146BindingDB-show
CHEMBL21836744419151BindingDB-show
CHEMBL21865744419174BindingDB-show
CHEMBL21865844419202BindingDB-show
CHEMBL21911244419144BindingDB-show
CHEMBL22022716115351BindingDB-show
CHEMBL22050416049812BindingDB-show
CHEMBL22054744419155BindingDB-show
CHEMBL22060744419156BindingDB-show
CHEMBL22065844419216BindingDB-show
CHEMBL22069644419163BindingDB-show
CHEMBL22075844419129BindingDB-show
CHEMBL22081044419130BindingDB-show
CHEMBL22081144419161BindingDB-show
CHEMBL22081244419191BindingDB-show
CHEMBL22086444419220BindingDB-show
CHEMBL22086544419221BindingDB-show
CHEMBL22107544419168BindingDB-show
CHEMBL22112644419169BindingDB-show
CHEMBL22112844419226BindingDB-show
CHEMBL22116416115350BindingDB-show
CHEMBL22117944419227BindingDB-show
CHEMBL22122744419158BindingDB-show
CHEMBL22122944419217BindingDB-show
CHEMBL22125244419136BindingDB-show
CHEMBL22131544419137BindingDB-show
CHEMBL22174544419135BindingDB-show
CHEMBL22191644419214BindingDB-show
CHEMBL22196344419116BindingDB-show
CHEMBL22200844419128BindingDB-show
CHEMBL23465511955790BindingDB-show
CHEMBL24533544440223BindingDB-show
CHEMBL24533644440225BindingDB-show
CHEMBL24553311655237BindingDB-show
CHEMBL24572411538129BindingDB-show
CHEMBL24573244440229BindingDB-show
CHEMBL24573344440230BindingDB-show
CHEMBL24593644440236BindingDB-show
CHEMBL24635617748275BindingDB-show
CHEMBL24654344440217BindingDB-show
CHEMBL24654444440219BindingDB-show
CHEMBL24654544440220BindingDB-show
CHEMBL24817616129582BindingDB-show
CHEMBL24837044440161BindingDB-show
CHEMBL24861244444034BindingDB-show
CHEMBL24864444444010BindingDB-show
CHEMBL24864544444016BindingDB-show
CHEMBL24879044444025BindingDB-show
CHEMBL24879144444026BindingDB-show
CHEMBL24879244444027BindingDB-show
CHEMBL24883044444012BindingDB-show
CHEMBL24883144444013BindingDB-show
CHEMBL24883244444014BindingDB-show
CHEMBL24883344444018BindingDB-show
CHEMBL24898244444029BindingDB-show
CHEMBL24898324779711BindingDB-show
CHEMBL24898444444030BindingDB-show
CHEMBL24918444444033BindingDB-show
CHEMBL24999844444019BindingDB-show
CHEMBL25001744444039BindingDB-show
CHEMBL25019944444021BindingDB-show
CHEMBL25040916750106BindingDB-show
CHEMBL25276110398628BindingDB-show
CHEMBL25276244444991BindingDB-show
CHEMBL25276344444992BindingDB-show
CHEMBL25317444444994BindingDB-show
CHEMBL25444310149689BindingDB-show
CHEMBL25465110269964BindingDB-show
CHEMBL25485810372770BindingDB-show
CHEMBL2650329914027BindingDB-show
CHEMBL2819579869943BindingDB-show
CHEMBL31955623532567BindingDB-show
CHEMBL36335511293880BindingDB-show
CHEMBL36360044402086BindingDB-show
CHEMBL3653599957797BindingDB-show
CHEMBL37051611227435BindingDB-show
CHEMBL37208210225532BindingDB-show
CHEMBL37230144402284BindingDB-show
CHEMBL37374044419119BindingDB-show
CHEMBL37419344419143BindingDB-show
CHEMBL37426916216351BindingDB-show
CHEMBL37443144419203BindingDB-show
CHEMBL37479544419215BindingDB-show
CHEMBL37542816115352BindingDB-show
CHEMBL37579544419222BindingDB-show
CHEMBL37609644419118BindingDB-show
CHEMBL37696744410954BindingDB-show
CHEMBL37777244410959BindingDB-show
CHEMBL37837044410948BindingDB-show
CHEMBL3785919826147BindingDB-show
CHEMBL37925410472936BindingDB-show
CHEMBL37960111682843BindingDB-show
CHEMBL38000644410723BindingDB-show
CHEMBL38038611516978BindingDB-show
CHEMBL38045444411048BindingDB-show
CHEMBL38062510021870BindingDB-show
CHEMBL38072410066845BindingDB-show
CHEMBL38088944411161BindingDB-show
CHEMBL38282244410955BindingDB-show
CHEMBL38282344410956BindingDB-show
CHEMBL38317710236389BindingDB-show
CHEMBL38324644411183BindingDB-show
CHEMBL38334844404434BindingDB-show
CHEMBL38367844408826BindingDB-show
CHEMBL38376044410953BindingDB-show
CHEMBL3837709982333BindingDB-show
CHEMBL38379944404441BindingDB-show
CHEMBL3839559892736BindingDB-show
CHEMBL38399444419110BindingDB-show
CHEMBL38421944419170BindingDB-show
CHEMBL38495144419152BindingDB-show
CHEMBL38517744419175BindingDB-show
CHEMBL38601044419138BindingDB-show
CHEMBL38666116086104BindingDB-show
CHEMBL38676011843159BindingDB-show
CHEMBL38725344419150BindingDB-show
CHEMBL39261444440221BindingDB-show
CHEMBL39261544440224BindingDB-show
CHEMBL39386144440228BindingDB-show
CHEMBL39849344444028BindingDB-show
CHEMBL39869144444031BindingDB-show
CHEMBL39916710310219BindingDB-show
CHEMBL3991689814292BindingDB-show
CHEMBL40005422261071BindingDB-show
CHEMBL40086244444036BindingDB-show
CHEMBL40086344444038BindingDB-show
CHEMBL40112344444024BindingDB-show
CHEMBL40357244444011BindingDB-show
CHEMBL40670310109823BindingDB-show
CHEMBL42560111562171BindingDB-show
CHEMBL42646644402203BindingDB-show
CHEMBL43001444444037BindingDB-show
CHEMBL43436844419183BindingDB-show
CHEMBL43456044419145BindingDB-show
CHEMBL43629144402200BindingDB-show
CHEMBL43770610475988BindingDB-show
CHEMBL43788544410844BindingDB-show
CHEMBL4405669928616BindingDB-show
CHEMBL44181110094511BindingDB-show
CHEMBL45259844129168BindingDB-show
CHEMBL47442525154767BindingDB-show
CHEMBL47864924856363BindingDB-show
CHEMBL48154544571730BindingDB-show
CHEMBL48233625262260BindingDB-show
CHEMBL4852859983303BindingDB-show
CHEMBL48528644580077BindingDB-show
CHEMBL48532324801863BindingDB-show
CHEMBL49316944219632BindingDB-show
CHEMBL49367011848309BindingDB-show
CHEMBL49367124854903BindingDB-show
CHEMBL49370824854902BindingDB-show
CHEMBL49407224963046BindingDB-show
CHEMBL49422144219633BindingDB-show
CHEMBL49427025129829BindingDB-show
CHEMBL49427225129830BindingDB-show
CHEMBL49446911848825BindingDB-show
CHEMBL49447025129831BindingDB-show
CHEMBL49533011848567BindingDB-show
CHEMBL49572910479082BindingDB-show
CHEMBL49612944580358BindingDB-show
CHEMBL49735044580449BindingDB-show
CHEMBL49735344580778BindingDB-show
CHEMBL4975639864418BindingDB-show
CHEMBL50724944591740BindingDB-show
CHEMBL52173444580532BindingDB-show
CHEMBL52188744580689BindingDB-show
CHEMBL52257910089048BindingDB-show
CHEMBL52355944580420BindingDB-show
CHEMBL52663944580649BindingDB-show
CHEMBL54938545270264BindingDB-show
CHEMBL5494539866076BindingDB-show
CHEMBL54965345271077BindingDB-show
CHEMBL55053445271952BindingDB-show
CHEMBL55093845271954BindingDB-show
CHEMBL55093945271955BindingDB-show
CHEMBL55102445270368BindingDB-show
CHEMBL55114044188627BindingDB-show
CHEMBL55134145271958BindingDB-show
CHEMBL55201845270253BindingDB-show
CHEMBL55207945271067BindingDB-show
CHEMBL55242345270255BindingDB-show
CHEMBL55248745271069BindingDB-show
CHEMBL55248845271071BindingDB-show
CHEMBL55368945271054BindingDB-show
CHEMBL55406045271938BindingDB-show
CHEMBL55427645270229BindingDB-show
CHEMBL55672145273750BindingDB-show
CHEMBL55692545273755BindingDB-show
CHEMBL55700345273721BindingDB-show
CHEMBL55701245267669BindingDB-show
CHEMBL55797145273742BindingDB-show
CHEMBL55925445272784BindingDB-show
CHEMBL55968745267668BindingDB-show
CHEMBL55988545267671BindingDB-show
CHEMBL55994945268560BindingDB-show
CHEMBL56034445268567BindingDB-show
CHEMBL56054145268570BindingDB-show
CHEMBL56154045268539BindingDB-show
CHEMBL56168545267696BindingDB-show
CHEMBL56193244517743BindingDB-show
CHEMBL56200945269427BindingDB-show
CHEMBL56291945272802BindingDB-show
CHEMBL56297445273739BindingDB-show
CHEMBL56305745271967BindingDB-show
CHEMBL56354545270248BindingDB-show
CHEMBL56438945271053BindingDB-show
CHEMBL56442845273754BindingDB-show
CHEMBL56444745267667BindingDB-show
CHEMBL56461145268557BindingDB-show
CHEMBL56461645267701BindingDB-show
CHEMBL56474545272788BindingDB-show
CHEMBL56499945269419BindingDB-show
CHEMBL56538145488146BindingDB-show
CHEMBL56556445488127BindingDB-show
CHEMBL56811644627684BindingDB-show
CHEMBL57055444627681BindingDB-show
CHEMBL57102344627683BindingDB-show
CHEMBL57143444627682BindingDB-show
CHEMBL57161944627578BindingDB-show
CHEMBL57162644627582BindingDB-show
CHEMBL57213345271070BindingDB-show
CHEMBL57228244627579BindingDB-show
CHEMBL57228344627580BindingDB-show
CHEMBL58489925222587BindingDB-show
CHEMBL58572544627583BindingDB-show
CHEMBL58591644627581BindingDB-show
CHEMBL58595125222038BindingDB-show
CHIR-26511656518BindingDB-show
CID 1150286711495680BindingDB-show
CID 1150286711502867BindingDB-show
CID 1153204811532048BindingDB-show
CID 1153204811546457BindingDB-show
CID 1159688111531799BindingDB-show
CID 1159688111596881BindingDB-show
CID 1171930511719305BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
imidazole-pyrimidine compound 1447872BindingDB-show
imidazole-pyrimidine compound 1447872DrugBank-show
imidazole-pyrimidine compound 2447873BindingDB-show
imidazole-pyrimidine compound 2447873DrugBank-show
JNK10364826BindingDB-show
JNK Inhibitor V11422035BindingDB-show
JNK Inhibitor VIII11624601BindingDB-show
Kinome_301911658882BindingDB-show
Kinome_302411539329BindingDB-show
Kinome_302711640926BindingDB-show
Kinome_302811590363BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
Methyl 3-[(2-phenylacetyl)amino]thiophene-2-carboxylate4079571BindingDB-show
MLN805411712649BindingDB-show
MLS0003278649581781BindingDB-show
Oprea1_1297669818586BindingDB-show
Pazopanib10113978BindingDB-show
phenantroline compound 35326727BindingDB-show
phenantroline compound 35326727DrugBank-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Pyrazoleanthrone8515BindingDB-show
Pyrazoleanthrone8515DrugBank-show
Pyrrole Carboxamide Analog 5a23647148BindingDB-show
Pyrrole Carboxamide Analog 5b23647149BindingDB-show
Pyrrole Carboxamide Analog 5c23647150BindingDB-show
Pyrrole Carboxamide Analog 5d23647151BindingDB-show
Pyrrole Carboxamide Analog 5e23647152BindingDB-show
Pyrrole Carboxamide Analog 5j23647157BindingDB-show
Pyrrole Carboxamide Analog 5k23647158BindingDB-show
Pyrrole Carboxamide Analog 5l23647159BindingDB-show
Pyrrole Carboxamide Analog 5m23647160BindingDB-show
Pyrrole Carboxamide Analog 5n23647161BindingDB-show
Pyrrole Carboxamide Analog 5o23647162BindingDB-show
Pyrrole Carboxamide Analog 6a23647163BindingDB-show
Pyrrole Carboxamide Analog 6b23647164BindingDB-show
Pyrrole Carboxamide Analog 6c23647165BindingDB-show
Pyrrole Carboxamide Analog 6d23647166BindingDB-show
Pyrrole Carboxamide Analog 6e23647167BindingDB-show
Pyrrole Carboxamide Analog 6f23647168BindingDB-show
Pyrrole Carboxamide Analog 6g23647169BindingDB-show
Pyrrole Carboxamide Analog 6h23647170BindingDB-show
Pyrrole Carboxamide Analog 6i23647171BindingDB-show
Pyrrole Carboxamide Analog 6j23647172BindingDB-show
Pyrrole Carboxamide Analog 6k23647173BindingDB-show
Pyrrole Carboxamide Analog 6l23647174BindingDB-show
Pyrrole Carboxamide Analog 6m23647175BindingDB-show
Pyrrole Carboxamide Analog 6n23647176BindingDB-show
Pyrrole Carboxamide Analog 6q23647178BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB 203580176155BindingDB-show
SB-4315424521392BindingDB-show
SMR0001684859581780BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
STK8254887367149BindingDB-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-70210341154BindingDB-show
VX-7453038525BindingDB-show
ZINC000824272808202BindingDB-show
ZINC00135906290221BindingDB-show
ZINC00475678897877BindingDB-show
ZINC013848106096886BindingDB-show
ZINC013972521483690BindingDB-show
ZINC013972569559963BindingDB-show
ZINC028789982231029BindingDB-show
ZINC030638569581773BindingDB-show
ZINC030640759581779BindingDB-show
ZINC047446259614812BindingDB-show
Synonyms:
c-Jun N-terminal kinase 3
MAP kinase p49 3F12
Mitogen-activated protein kinase 10
Stress-activated protein kinase JNK3
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
MK12_HUMAN5236.8
MK14_HUMAN51.237
MK14_MOUSE51.237
Q499G7_HUMAN49.532.3
MK01_HUMAN49.532.6
Q1HBJ4_HUMAN49.532.6
MK01_MOUSE48.331.8
MK01_RAT48.331.8
MK03_MOUSE48.231.8
MK03_HUMAN48.131
MK03_RAT47.931.6
GSK3B_HUMAN42.124.4
GSK3B_MOUSE41.324
Q5KU03_MOUSE41.324
B5BUC0_HUMAN41.124.1
CDK8_HUMAN40.424.4
MSK1_TOBAC38.722.8
CDK7_HUMAN36.922.4
CSK21_HUMAN36.921.9
GSK3A_HUMAN36.621.6
CDK15_HUMAN36.223.2
CDK2_HUMAN36.124.9
CDK6_HUMAN36.124.4
A4D1G0_HUMAN36.124.4
CDK9_HUMAN34.821.3
CSK2A_MAIZE34.618.9
CDK1_HUMAN34.424.8
CDK5_HUMAN34.223.1
CDK5_MOUSE34.223.1
CDK4_RAT33.824.2
Protein-Protein Interactions: