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Target Details

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Name:Mitogen-activated protein kinase 3
Uniprot name:MK03_HUMAN
Accession Numbers:P27361
EC-Number:2.7.11.24
Organism:Homo sapiens
Human
PDB IDs:2ZOQ
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2′-Amino-3′-methoxyflavone4713PROMISCUOUSPMID 16982750show
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide6918454PROMISCUOUSPMID 12963734show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole4306515PROMISCUOUSPMID 18424914show
ABT-86911485656BindingDB-show
AMG 70611667893BindingDB-show
Arsentrioxide518740DrugBank-show
Arsentrioxide14888DrugBank-show
Arthrocine1548887PROMISCUOUSPMID 12566304show
AST-48711409972BindingDB-show
Benzylideneacetaldehyde637511PROMISCUOUSPMID 15964311show
Bio2_0004136610353BindingDB-show
Calpeptin73364PROMISCUOUSPMID 15331404show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL108215211560568BindingDB-show
CHEMBL108911946203864BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL124297746929544BindingDB-show
CHEMBL124320046929748BindingDB-show
CHEMBL124332646929857BindingDB-show
CHEMBL125400715949613BindingDB-show
CHEMBL129007250908681BindingDB-show
CHEMBL19472144401437BindingDB-show
CHEMBL19564144401410BindingDB-show
CHEMBL20914811467730BindingDB-show
CHEMBL21361816043304BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL31955623532567BindingDB-show
CHEMBL36493544401506BindingDB-show
CHEMBL37246444401556BindingDB-show
CHEMBL52049744582794BindingDB-show
CHEMBL55226544241614BindingDB-show
CHEMBL55851245273505BindingDB-show
CHEMBL56106644241613BindingDB-show
CHEMBL7715544315929BindingDB-show
CHIR-26511656518BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Dihydroxyphenylethanolisopropylamine3779DrugBank-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Exisulind5472495PROMISCUOUSPMID 11245463show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
GW40649893571PROMISCUOUSPMID 19085950show
Imatinib Methansulfonate5291BindingDB-show
Irofulven148189PROMISCUOUSPMID 12014623show
JNK Inhibitor V11422035BindingDB-show
Kinome_26559952773BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lapatinib ditosylate208908PROMISCUOUSPMID 16020981show
Lestaurtinib126565BindingDB-show
MLN805411712649BindingDB-show
Olomoucine4592BindingDB-show
Pazopanib10113978BindingDB-show
Phenylaethylsenfoel16741PROMISCUOUSPMID 14729592show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
PURVALANOL448991BindingDB-show
PURVALANOL448991DrugBank-show
Purvalanol A456214BindingDB-show
Roscovitine160355BindingDB-show
Roscovitine160355PROMISCUOUSPMID 9030781show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1363_Selleck11317348BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
Silibinin5213PROMISCUOUSPMID 11759294show
SIMVASTATIN54454DrugBank-show
SNS-0323025986BindingDB-show
Sodium Ursodeoxycholate31401PROMISCUOUSPMID 19085950show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine451705BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Succinonitrile, bis(amino(o-aminophenylthio)methylene)-3006531PROMISCUOUSPMID 12446589show
Sulindac5352DrugBank-show
Sulindac sulfide5352624PROMISCUOUSPMID 12566304show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
ERK-1
ERT2
Extracellular signal-regulated kinase 1
Insulin-stimulated MAP2 kinase
MAP kinase 1
MAPK 1
Microtubule-associated protein 2 kinase
Mitogen-activated protein kinase 3
p44-ERK1
p44-MAPK
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
MK03_RAT97.196.8
MK03_MOUSE96.896.6
Q1HBJ4_HUMAN88.182.6
MK01_HUMAN88.182.6
MK01_MOUSE88.182.3
MK01_RAT88.182.3
Q499G7_HUMAN87.982.1
MK14_HUMAN59.843.2
MK14_MOUSE59.843.2
MK12_HUMAN56.337.9
MK10_HUMAN48.131
CDK2_HUMAN45.130.2
MSK1_TOBAC44.227.5
CDK7_HUMAN44.130.7
CDK6_HUMAN43.830.5
A4D1G0_HUMAN43.830.5
CSK2A_MAIZE43.524.7
CDK1_HUMAN43.528.9
CDK5_HUMAN43.228.6
CDK5_MOUSE43.228.6
KAPCG_HUMAN42.423.2
CDC2H_PLAFK42.229.2
CSK21_HUMAN42.125.1
Q5KU03_MOUSE41.427.5
GSK3B_MOUSE41.427.5
GSK3B_HUMAN41.227.6
B5BUC0_HUMAN40.827.4
GSK3A_HUMAN40.626
C4R3V7_PICPG40.626
CDK15_HUMAN40.527.3
Protein-Protein Interactions:
Uniprot nameSource
ZNF7_HUMANPMID 9155018
VINEX_HUMAN2 PMIDs
V2R_HUMAN3 PMIDs
V2R_HUMAN4 PMIDs
TY3H_HUMAN5 PMIDs
TTYH3_HUMAN6 PMIDs
TSC2_HUMAN7 PMIDs
TPA_HUMAN8 PMIDs
TOP2B_HUMAN9 PMIDs
TNR16_HUMAN10 PMIDs
TNF11_HUMAN11 PMIDs
TGIF1_HUMAN12 PMIDs
TFE2_HUMAN13 PMIDs
TAL2_HUMAN14 PMIDs
TAL1_HUMAN15 PMIDs
TAF1C_HUMAN16 PMIDs
TAF1B_HUMAN17 PMIDs
TAF1A_HUMAN18 PMIDs
SYUG_HUMAN19 PMIDs
SYUA_HUMAN20 PMIDs
SYN1_HUMAN21 PMIDs
STMN2_HUMAN22 PMIDs
STMN1_HUMAN23 PMIDs
STAT3_HUMAN24 PMIDs
STA5A_HUMAN25 PMIDs
SRBP2_HUMAN26 PMIDs
SRBP1_HUMAN27 PMIDs
SPN90_HUMAN28 PMIDs
SPIB_HUMAN29 PMIDs
SP1_HUMAN30 PMIDs
SOS1_HUMAN31 PMIDs
SOMA_HUMAN32 PMIDs
SMAD2_HUMAN33 PMIDs
SHC1_HUMAN34 PMIDs
RET_HUMAN35 PMIDs
RCAN1_HUMAN36 PMIDs
RASN_HUMAN37 PMIDs
RASK_HUMAN38 PMIDs
RASH_HUMAN39 PMIDs
RAF1_HUMAN40 PMIDs
RAF1_HUMAN41 PMIDs
RAB4A_HUMAN42 PMIDs
Q86SR6_HUMAN43 PMIDs
PTPRR_HUMAN44 PMIDs
PTPRO_HUMAN45 PMIDs
PTPRK_HUMAN46 PMIDs
PTPRJ_HUMAN47 PMIDs
PTPRG_HUMAN48 PMIDs
PTPRE_HUMAN49 PMIDs
PTPRB_HUMAN50 PMIDs
PTN7_HUMAN51 PMIDs
PTN5_HUMAN52 PMIDs
PTN11_HUMAN53 PMIDs
PPARA_HUMAN54 PMIDs
PP2AA_HUMAN55 PMIDs
PP1A_HUMAN56 PMIDs
PLCB1_HUMAN57 PMIDs
PEBP4_HUMAN58 PMIDs
PEA15_HUMAN59 PMIDs
PAXI_HUMAN60 PMIDs
PAK2_HUMAN61 PMIDs
P53_HUMAN62 PMIDs
NTRK3_HUMAN63 PMIDs
NTRK1_HUMAN64 PMIDs
MYLK_HUMAN65 PMIDs
MYC_HUMAN66 PMIDs
MPKS1_HUMAN67 PMIDs
MP2K3_HUMAN68 PMIDs
MP2K2_HUMAN69 PMIDs
MP2K1_HUMAN70 PMIDs
MP2K1_HUMAN71 PMIDs
MKNK1_HUMAN72 PMIDs
MK14_HUMAN73 PMIDs
MK08_HUMAN74 PMIDs
MK03_HUMAN75 PMIDs
MK01_HUMAN76 PMIDs
MBP_HUMAN77 PMIDs
M3K1_HUMAN78 PMIDs
M3K14_HUMAN79 PMIDs
LYN_HUMAN80 PMIDs
LIPS_HUMAN81 PMIDs
LCK_HUMAN82 PMIDs
KSYK_HUMAN83 PMIDs
KSR2_HUMAN84 PMIDs
KS6B1_HUMAN85 PMIDs
KS6A4_HUMAN86 PMIDs
KS6A3_HUMAN87 PMIDs
KS6A2_HUMAN88 PMIDs
KS6A1_HUMAN89 PMIDs
KPCZ_HUMAN90 PMIDs
KPCE_HUMAN91 PMIDs
KPCD_HUMAN92 PMIDs
K6PF_HUMAN93 PMIDs
K2C8_HUMAN94 PMIDs
JUN_HUMAN95 PMIDs
JUND_HUMAN96 PMIDs
IRX2_HUMAN97 PMIDs
IRS2_HUMAN98 PMIDs
IRS1_HUMAN99 PMIDs
INSR_HUMAN100 PMIDs
IEX1_HUMAN101 PMIDs
ID2_HUMAN102 PMIDs
HSPB8_HUMAN103 PMIDs
HSF4_HUMAN104 PMIDs
HSF1_HUMAN105 PMIDs
HMMR_HUMAN106 PMIDs
HIF1A_HUMAN107 PMIDs
HDAC4_HUMAN108 PMIDs
GTF2I_HUMAN109 PMIDs
GRB2_HUMAN110 PMIDs
GNDS_HUMAN111 PMIDs
GMFB_HUMAN112 PMIDs
GATA4_HUMAN113 PMIDs
GATA1_HUMAN114 PMIDs
GAB2_HUMAN115 PMIDs
GAB1_HUMAN116 PMIDs
FKBP2_HUMAN117 PMIDs
FCG2B_HUMAN118 PMIDs
F261_HUMAN119 PMIDs
ETV1_HUMAN120 PMIDs
ETS1_HUMAN121 PMIDs
ESR1_HUMAN122 PMIDs
EPOR_HUMAN123 PMIDs
ELK4_HUMAN124 PMIDs
ELK1_HUMAN125 PMIDs
DUS9_HUMAN126 PMIDs
DUS6_HUMAN127 PMIDs
DUS5_HUMAN128 PMIDs
DUS4_HUMAN129 PMIDs
DUS3_HUMAN130 PMIDs
DUS1_HUMAN131 PMIDs
DUS10_HUMAN132 PMIDs
DCC_HUMAN133 PMIDs
DAPK1_HUMAN134 PMIDs
CXA1_HUMAN135 PMIDs
CSH_HUMAN136 PMIDs
CRP_HUMAN137 PMIDs
CRK_HUMAN138 PMIDs
CPXM1_HUMAN139 PMIDs
CNRG_HUMAN140 PMIDs
CEBPB_HUMAN141 PMIDs
CD45_HUMAN142 PMIDs
CCNT1_HUMAN143 PMIDs
CCDC6_HUMAN144 PMIDs
CAV1_HUMAN145 PMIDs
CASP9_HUMAN146 PMIDs
CASP8_HUMAN147 PMIDs
C2TA_HUMAN148 PMIDs
C1QBP_HUMAN149 PMIDs
BRAF1_HUMAN150 PMIDs
BIEA_HUMAN151 PMIDs
BCL3_HUMAN152 PMIDs
BCL2_HUMAN153 PMIDs
AT1A1_HUMAN154 PMIDs
ARRB2_HUMAN155 PMIDs
ARRB2_HUMAN156 PMIDs
ARRB1_HUMAN157 PMIDs
ARBK1_HUMAN158 PMIDs
AMRP_HUMAN159 PMIDs
AMPM2_HUMAN160 PMIDs
AK1C1_HUMAN161 PMIDs
AGTR1_HUMAN162 PMIDs