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Target Details

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Name:MAP kinase-activated protein kinase 2
Uniprot name:MAPK2_HUMAN
Accession Numbers:P49137 Q8IYD6
EC-Number:2.7.11.1
Organism:Homo sapiens
Human
PDB IDs:1KWP 1NXK 1NY3 2JBO 2JBP 2OKR 2ONL 2OZA 2P3G 2PZY 3FPM 3FYJ 3FYK
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
.beta.-Carboline, 1,2,3,4-tetrahydro-1-carboxy-6-methoxy-1-methyl-612268BindingDB-show
2e9n10050156BindingDB-show
2jbo10389239BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
5-Isoquinolinol30386BindingDB-show
ABT-86911485656BindingDB-show
AC1L42GM176962BindingDB-show
AC1LAERY512549BindingDB-show
AC1MMOZF3264448BindingDB-show
AC1MZJ9W3848929BindingDB-show
Adenosindiphosphorsaeure6022DrugBank-show
AIDS028464461195BindingDB-show
AIDS186989512561BindingDB-show
AIDS186989512562BindingDB-show
alpha-Hydroxynaphthalene7005BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEBI:69015014308007BindingDB-show
CHEMBL107821944478684BindingDB-show
CHEMBL107822044478950BindingDB-show
CHEMBL108099445375865BindingDB-show
CHEMBL108099545375866BindingDB-show
CHEMBL108739724884503BindingDB-show
CHEMBL108765046880136BindingDB-show
CHEMBL108908224822704BindingDB-show
CHEMBL108986525052767BindingDB-show
CHEMBL109119925118220BindingDB-show
CHEMBL109192825119291BindingDB-show
CHEMBL109275444541014BindingDB-show
CHEMBL109440824993189BindingDB-show
CHEMBL109562644605035BindingDB-show
CHEMBL109562744605037BindingDB-show
CHEMBL109587316223008BindingDB-show
CHEMBL120882349862001BindingDB-show
CHEMBL120882449862002BindingDB-show
CHEMBL120882549862003BindingDB-show
CHEMBL120882649862004BindingDB-show
CHEMBL120882749862005BindingDB-show
CHEMBL120888549862049BindingDB-show
CHEMBL120888649862050BindingDB-show
CHEMBL120888749862051BindingDB-show
CHEMBL120888849862052BindingDB-show
CHEMBL120894849862087BindingDB-show
CHEMBL120894949862088BindingDB-show
CHEMBL120895046927902BindingDB-show
CHEMBL120895111575548BindingDB-show
CHEMBL120900811517184BindingDB-show
CHEMBL120900949862123BindingDB-show
CHEMBL120901011719115BindingDB-show
CHEMBL120901149862124BindingDB-show
CHEMBL120906611525487BindingDB-show
CHEMBL120906711495655BindingDB-show
CHEMBL120906811654763BindingDB-show
CHEMBL120906949862167BindingDB-show
CHEMBL120911911554437BindingDB-show
CHEMBL120912011604613BindingDB-show
CHEMBL120912111718461BindingDB-show
CHEMBL120912211632886BindingDB-show
CHEMBL120975049862702BindingDB-show
CHEMBL120975149862703BindingDB-show
CHEMBL120975249862704BindingDB-show
CHEMBL120983249862778BindingDB-show
CHEMBL120983349862779BindingDB-show
CHEMBL120983449862780BindingDB-show
CHEMBL120983549862781BindingDB-show
CHEMBL120983649862782BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL125891311847343BindingDB-show
CHEMBL127023024809764BindingDB-show
CHEMBL127211649765254BindingDB-show
CHEMBL127217149840306BindingDB-show
CHEMBL129074649838879BindingDB-show
CHEMBL17841344390177BindingDB-show
CHEMBL17895210467496BindingDB-show
CHEMBL17933644390232BindingDB-show
CHEMBL17978444390213BindingDB-show
CHEMBL18005444390165BindingDB-show
CHEMBL18036244390195BindingDB-show
CHEMBL18049044390212BindingDB-show
CHEMBL18050544390254BindingDB-show
CHEMBL18051044390209BindingDB-show
CHEMBL1805749971229BindingDB-show
CHEMBL18069044390210BindingDB-show
CHEMBL18088444390153BindingDB-show
CHEMBL18095944390130BindingDB-show
CHEMBL18106944390149BindingDB-show
CHEMBL18121244390205BindingDB-show
CHEMBL18187044390143BindingDB-show
CHEMBL18208844390233BindingDB-show
CHEMBL18209044390139BindingDB-show
CHEMBL18209144390140BindingDB-show
CHEMBL18243944390133BindingDB-show
CHEMBL18328844390132BindingDB-show
CHEMBL19753844143344BindingDB-show
CHEMBL19792344406013BindingDB-show
CHEMBL19802244405988BindingDB-show
CHEMBL19921016085320BindingDB-show
CHEMBL19938344406014BindingDB-show
CHEMBL19952811645322BindingDB-show
CHEMBL19975544406074BindingDB-show
CHEMBL19995144405940BindingDB-show
CHEMBL20049911359538BindingDB-show
CHEMBL20065744405939BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL24151711281930BindingDB-show
CHEMBL2416829938299BindingDB-show
CHEMBL24529644441121BindingDB-show
CHEMBL24546144441146BindingDB-show
CHEMBL24550221399939BindingDB-show
CHEMBL24550344441123BindingDB-show
CHEMBL24550544441126BindingDB-show
CHEMBL24566144441152BindingDB-show
CHEMBL24566223661565BindingDB-show
CHEMBL24570444441130BindingDB-show
CHEMBL24570544441132BindingDB-show
CHEMBL24586244441155BindingDB-show
CHEMBL24610044441116BindingDB-show
CHEMBL24610244441118BindingDB-show
CHEMBL24630944441119BindingDB-show
CHEMBL24713817881612BindingDB-show
CHEMBL24734244441112BindingDB-show
CHEMBL24734344441114BindingDB-show
CHEMBL24734444441115BindingDB-show
CHEMBL24770744441140BindingDB-show
CHEMBL24791144441141BindingDB-show
CHEMBL24811044441136BindingDB-show
CHEMBL24816444441128BindingDB-show
CHEMBL24831244441133BindingDB-show
CHEMBL24831344441134BindingDB-show
CHEMBL24831644441137BindingDB-show
CHEMBL24831744441139BindingDB-show
CHEMBL24851244441135BindingDB-show
CHEMBL24852544441144BindingDB-show
CHEMBL25388121081523BindingDB-show
CHEMBL28022444269421BindingDB-show
CHEMBL2819579869943BindingDB-show
CHEMBL36027810106198BindingDB-show
CHEMBL36055144390178BindingDB-show
CHEMBL36076444390193BindingDB-show
CHEMBL36142544390129BindingDB-show
CHEMBL36933244390260BindingDB-show
CHEMBL37109544405504BindingDB-show
CHEMBL37123944406018BindingDB-show
CHEMBL37124244405938BindingDB-show
CHEMBL37165811496376BindingDB-show
CHEMBL37300144405941BindingDB-show
CHEMBL37773411632737BindingDB-show
CHEMBL39183012773710BindingDB-show
CHEMBL39266544441143BindingDB-show
CHEMBL39287623661564BindingDB-show
CHEMBL39412444441149BindingDB-show
CHEMBL39412544441151BindingDB-show
CHEMBL39513244441129BindingDB-show
CHEMBL39513344441131BindingDB-show
CHEMBL39535244441158BindingDB-show
CHEMBL39540944441113BindingDB-show
CHEMBL39616344441122BindingDB-show
CHEMBL39631444441120BindingDB-show
CHEMBL39733044441142BindingDB-show
CHEMBL39764944441124BindingDB-show
CHEMBL3978199821423BindingDB-show
CHEMBL4123679871380BindingDB-show
CHEMBL43755444441117BindingDB-show
CHEMBL43776644441127BindingDB-show
CHEMBL44693844390204BindingDB-show
CHEMBL44969244575074BindingDB-show
CHEMBL45269944574982BindingDB-show
CHEMBL45458211292790BindingDB-show
CHEMBL46600944574424BindingDB-show
CHEMBL46649615295578BindingDB-show
CHEMBL46670025205757BindingDB-show
CHEMBL46670125207355BindingDB-show
CHEMBL46706924825721BindingDB-show
CHEMBL46707825205591BindingDB-show
CHEMBL46707925206064BindingDB-show
CHEMBL46753244574933BindingDB-show
CHEMBL46772944574928BindingDB-show
CHEMBL46773044574929BindingDB-show
CHEMBL46773144574931BindingDB-show
CHEMBL46773244574932BindingDB-show
CHEMBL46791144575024BindingDB-show
CHEMBL46791225206065BindingDB-show
CHEMBL46791325207516BindingDB-show
CHEMBL46812544575073BindingDB-show
CHEMBL46829244574425BindingDB-show
CHEMBL46832125207353BindingDB-show
CHEMBL46832244574469BindingDB-show
CHEMBL46912444574422BindingDB-show
CHEMBL46949044575125BindingDB-show
CHEMBL47647921590534BindingDB-show
CHEMBL47781724766030BindingDB-show
CHEMBL47929044575124BindingDB-show
CHEMBL47983544570884BindingDB-show
CHEMBL48124844575127BindingDB-show
CHEMBL48124944575128BindingDB-show
CHEMBL48719111623773BindingDB-show
CHEMBL48905825211064BindingDB-show
CHEMBL50454742625986BindingDB-show
CHEMBL50483025207519BindingDB-show
CHEMBL50533544575025BindingDB-show
CHEMBL50724944591740BindingDB-show
CHEMBL51054510313607BindingDB-show
CHEMBL51121944574983BindingDB-show
CHEMBL51141025207521BindingDB-show
CHEMBL51141944575072BindingDB-show
CHEMBL51245425207350BindingDB-show
CHEMBL51278444574873BindingDB-show
CHEMBL51279125206391BindingDB-show
CHEMBL51315444574930BindingDB-show
CHEMBL51387044574421BindingDB-show
CHEMBL51594021590533BindingDB-show
CHEMBL51911344575126BindingDB-show
CHEMBL52358644592504BindingDB-show
CHEMBL52447225207352BindingDB-show
CHEMBL52592744574423BindingDB-show
CHEMBL53945045271878BindingDB-show
CHEMBL54144845269366BindingDB-show
CHEMBL54958545270159BindingDB-show
CHEMBL54991545271859BindingDB-show
CHEMBL55006045271022BindingDB-show
CHEMBL55026045271028BindingDB-show
CHEMBL55153445271889BindingDB-show
CHEMBL55233945271846BindingDB-show
CHEMBL55339745268500BindingDB-show
CHEMBL55428645271854BindingDB-show
CHEMBL55520545273683BindingDB-show
CHEMBL55639245267582BindingDB-show
CHEMBL55710145273358BindingDB-show
CHEMBL55731844517742BindingDB-show
CHEMBL55816245271890BindingDB-show
CHEMBL55941145269376BindingDB-show
CHEMBL55948745267633BindingDB-show
CHEMBL55978745269074BindingDB-show
CHEMBL55988145267641BindingDB-show
CHEMBL56007545267583BindingDB-show
CHEMBL56073745268501BindingDB-show
CHEMBL56133444517741BindingDB-show
CHEMBL56200245269365BindingDB-show
CHEMBL56213745268471BindingDB-show
CHEMBL56219445269319BindingDB-show
CHEMBL56260645272713BindingDB-show
CHEMBL56275445272705BindingDB-show
CHEMBL56330745269326BindingDB-show
CHEMBL56330844631900BindingDB-show
CHEMBL56367245268513BindingDB-show
CHEMBL56407645271845BindingDB-show
CHEMBL56494045267327BindingDB-show
CHEMBL56712445485083BindingDB-show
CHEMBL56907845486342BindingDB-show
CHEMBL57086545487634BindingDB-show
CHEMBL57158123627212BindingDB-show
CHEMBL57189745271879BindingDB-show
CHEMBL58442346224689BindingDB-show
CHEMBL58461746224694BindingDB-show
CHEMBL58464046224703BindingDB-show
CHEMBL58595846224686BindingDB-show
CHEMBL58962646224690BindingDB-show
CHEMBL58965046224666BindingDB-show
CHEMBL58985346224675BindingDB-show
CHEMBL59011044543658BindingDB-show
CHEMBL59049146231476BindingDB-show
CHEMBL59061246224704BindingDB-show
CHEMBL59083446224682BindingDB-show
CHEMBL59107146224671BindingDB-show
CHEMBL59130546224674BindingDB-show
CHEMBL59132846224700BindingDB-show
CHEMBL59132946224701BindingDB-show
CHEMBL59178346224679BindingDB-show
CHEMBL59179746224696BindingDB-show
CHEMBL59203146224698BindingDB-show
CHEMBL59228846224667BindingDB-show
CHEMBL59409046226047BindingDB-show
CHEMBL59593346226038BindingDB-show
CHEMBL59658846226037BindingDB-show
CHEMBL59762846231474BindingDB-show
CHEMBL59762946231475BindingDB-show
CHEMBL59764046231584BindingDB-show
CHEMBL59775446233287BindingDB-show
CHEMBL59783944593854BindingDB-show
CHEMBL59823746231473BindingDB-show
CHEMBL59832446231638BindingDB-show
CHEMBL59844915366651BindingDB-show
CHEMBL59850646231423BindingDB-show
CHEMBL59922445139989BindingDB-show
CHEMBL59942845139991BindingDB-show
CHEMBL59947846231531BindingDB-show
CHEMBL59947946231532BindingDB-show
CHEMBL59968246231534BindingDB-show
CHEMBL60008146224695BindingDB-show
CHEMBL60332246226048BindingDB-show
CHEMBL60348246228648BindingDB-show
CHEMBL60369446231533BindingDB-show
CHEMBL60451046231585BindingDB-show
CHEMBL60471210429593BindingDB-show
CHEMBL60512546231583BindingDB-show
CHEMBL60592246226031BindingDB-show
CHEMBL61078046231477BindingDB-show
ChemDiv1_0192594567175BindingDB-show
ChemDiv3_0148424274924BindingDB-show
CHIR-26511656518BindingDB-show
CID 1043124010621161BindingDB-show
CID 1163241211632412BindingDB-show
CID 99267919818231BindingDB-show
CID 995340011361892BindingDB-show
CP-7247149874913BindingDB-show
Cyanoquinoline, 1117759555BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
JNK Inhibitor V11422035BindingDB-show
K00599a9549300BindingDB-show
Kinome_248046224697BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_291844444843BindingDB-show
L2G9549184BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
MLN805411712649BindingDB-show
nchembio.90-comp111715767BindingDB-show
NSC629423145879BindingDB-show
Pazopanib10113978BindingDB-show
PHA-66575210461815BindingDB-show
Phaeochromycins A11602057BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Pyrrolo-pyrimidone, 1016119154BindingDB-show
Pyrrolo-pyrimidone, 1116119155BindingDB-show
Pyrrolo-pyrimidone, 1216119199BindingDB-show
Pyrrolo-pyrimidone, 1316119297BindingDB-show
Pyrrolo-pyrimidone, 1416119298BindingDB-show
Pyrrolo-pyrimidone, 1516119158BindingDB-show
Pyrrolo-pyrimidone, 1616119710BindingDB-show
Pyrrolo-pyrimidone, 1716119021BindingDB-show
Pyrrolo-pyrimidone, 1816119156BindingDB-show
Pyrrolo-pyrimidone, 216119153BindingDB-show
Pyrrolo-pyrimidone, 316119198BindingDB-show
Pyrrolo-pyrimidone, 444143569BindingDB-show
Pyrrolo-pyrimidone, 544143570BindingDB-show
Pyrrolo-pyrimidone, 616119200BindingDB-show
Pyrrolo-pyrimidone, 716119303BindingDB-show
Pyrrolo-pyrimidone, 816042899BindingDB-show
Pyrrolo-pyrimidone, 916119201BindingDB-show
Roscovitine160355BindingDB-show
rottlerin5281847BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
STAUROSPORINE44259DrugBank-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
MAP kinase-activated protein kinase 2
MAPK-activated protein kinase 2
MAPKAP kinase 2
MAPKAPK-2
MK2
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
MAPK2_CRILO8281
KAPCG_HUMAN4324.9
KAPCB_HUMAN41.924.5
KAPCA_HUMAN41.724.5
KAPCA_PIG41.524.7
KAPCA_BOVIN41.424.3
KAPCA_MOUSE41.124.1
KAPCA_RAT41.124.1
KAPCB_MOUSE39.723.3
KAPCB_RAT39.723.3
KAPA_YEAST39.324.4
CSK21_HUMAN38.122.4
MK12_HUMAN3821.8
MK14_HUMAN36.319.2
MK14_MOUSE36.319.2
MK03_HUMAN36.121
Q5KU03_MOUSE35.322.8
GSK3B_MOUSE35.222.9
CDK9_HUMAN35.118.8
STK6_HUMAN34.921.9
MK03_RAT34.420
CDK7_HUMAN34.422.7
MK03_MOUSE34.420
HEMAT_BACSU34.117.1
GSK3B_HUMAN34.123.2
MSK1_TOBAC3420.4
A4D1G0_HUMAN33.519
CDK6_HUMAN33.519
AKT1_HUMAN33.519.9
AKT1_MOUSE33.520.1
Protein-Protein Interactions: