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Target Details

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Name:5-lipoxygenase
Uniprot name:LOX5_RAT
Accession Numbers:P12527
EC-Number:1.13.11.34
Organism:Rat
Rattus norvegicus
PDB IDs:-
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(1-Ethyl-3(4-(4-(4-hydroxyphenyl)-1-piperazinyl)phenyl)-5-dimethyl)-2-thioxo-4-imidazolidinone132150BindingDB-show
(E)-3-(hydroxy-methyl-amino)-1-(4-phenylphenyl)prop-2-en-1-one10060825BindingDB-show
(Z)-1-(4-chlorophenyl)-3-(hydroxy-methyl-amino)prop-2-en-1-one10104592BindingDB-show
(Z)-1-(benzyl-hydroxy-amino)-4,4-dimethyl-pent-1-en-3-one10353940BindingDB-show
(Z)-3-(benzyl-hydroxy-amino)-1-(4-chlorophenyl)prop-2-en-1-one10085473BindingDB-show
(Z)-3-(benzyl-hydroxy-amino)-1-(4-nitrophenyl)prop-2-en-1-one10063258BindingDB-show
(Z)-3-(benzyl-hydroxy-amino)-1-(4-phenylphenyl)prop-2-en-1-one9973841BindingDB-show
(Z)-3-(hydroxy-methyl-amino)-1-(4-nitrophenyl)prop-2-en-1-one10036480BindingDB-show
(Z)-5-(3,5-Di-tert-butyl-4-hydroxybenzylidene)-2-thioxo-thiazolidin-4-one1514885BindingDB-show
1-benzyl-2-naphthol285915BindingDB-show
1-hydroxy-1-(5-phenylmethoxy-2,3-dihydro-1H-inden-1-yl)urea9948192BindingDB-show
1-hydroxy-1-[1-(6-methoxynaphthalen-2-yl)ethyl]urea10400378BindingDB-show
1-naphthaleneacetamide, n-hydroxy-289794BindingDB-show
1-Naphthohydroxamic acid23382BindingDB-show
15-Hpete6437084BindingDB-show
2',3,4-Trihydroxychalcone5709318BindingDB-show
2',5'-Dimethoxy-3,4-dihydroxychalcone6366723BindingDB-show
2,3,5-Trimethyl-6-(3-pyridylmethyl)-1,4-benzoquinone93543BindingDB-show
2,6-Dibenzylphenol259641BindingDB-show
2-((1-Naphthalenyloxy)methyl)quinoline176149BindingDB-show
2-(3-(2-Quinolylmethoxy)phenylamino)benzoic acid128355BindingDB-show
2-(4-chlorophenyl)-5-methyl-1,3-thiazol-4-ol3824241BindingDB-show
2-(4-Dimethylaminophenyl)-1,3-indandione622184BindingDB-show
2-(4-Hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole128480BindingDB-show
2-(Phenylmethyl)-1,4-naphthalenedione3015658BindingDB-show
2-Benzyl-1-hydroxynaphthalene160268BindingDB-show
2-benzyl-4-nitro-1-naphthol24971986BindingDB-show
2-Benzylphenol24216BindingDB-show
2-Methoxyphenothiazine74490BindingDB-show
2-Methyl-1-naphthol24055BindingDB-show
2-Naphthohydroximic acid25164BindingDB-show
2-prop-2-enylnaphthalen-1-ol10655090BindingDB-show
2-PROPEN-1-ONE, 1-(2-HYDROXYPHENYL)-3-(4-HYDROXYPHENYL)-5357218BindingDB-show
2-tert-butylnaphthalen-1-ol10910545BindingDB-show
3-benzylnaphthalen-1-ol11139055BindingDB-show
4'-Hydroxychalcone5282362BindingDB-show
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine47795BindingDB-show
4-amino-n-hydroxybenzamide245297BindingDB-show
4-Bromo-N-hydroxybenzamide603910BindingDB-show
4-cyano-N-hydroxybenzamide4128407BindingDB-show
5-Hete lactone6439592BindingDB-show
5-Hydroxyeicosatetraenoate5280733PROMISCUOUS2 PMIDsshow
6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole443292BindingDB-show
6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole443292PROMISCUOUSPMID 12023941show
7-Chloro-2-((4-methoxyphenyl)methyl)-3-methyl-5-propyl-4-benzofuranol128132BindingDB-show
9-Phenylnonanohydroxamic acid188382BindingDB-show
A 63162121876BindingDB-show
A 69412130007BindingDB-show
Abbott 7917571460BindingDB-show
AC1L2UXW129065BindingDB-show
AC1LC7BD570772BindingDB-show
AC1MUS5I3670955BindingDB-show
AC1N3TUW4118131BindingDB-show
AC1NCUYT4517796BindingDB-show
AC1NN3UO5061934BindingDB-show
AC1NR1OH5283169BindingDB-show
AC1NRTXN5272734BindingDB-show
AC1NXG0X5804842BindingDB-show
AC1O1KQO6099176BindingDB-show
AC1O6FK66474895BindingDB-show
AC1O6FK76474896BindingDB-show
AC1P0KCL8122281BindingDB-show
AC1PKXBL9067394BindingDB-show
AC1Q7DIT24689999BindingDB-show
ACRIDAN7106BindingDB-show
AG-690/154270865973690BindingDB-show
AIDS059274129723BindingDB-show
alpha-(3,5-di-tert-Butyl-4-hydroxybenzylidene)gamma-butyrolactone6438990BindingDB-show
alpha-Hydroxynaphthalene7005BindingDB-show
ANISINDIONE2197BindingDB-show
Arthrocine1548887BindingDB-show
Atreleuton3086671BindingDB-show
Baicalein5281605BindingDB-show
Benzamide, N,4-dihydroxy-269946BindingDB-show
Benzohydroxamate10313BindingDB-show
Bio2_0003926610350BindingDB-show
BRN 1979355200488BindingDB-show
BRN 354327153542BindingDB-show
BS 8983D84108BindingDB-show
BUDDLEDIN A5281514BindingDB-show
Buddledin B44593338BindingDB-show
Buddledin C5352042BindingDB-show
Buddleoflavonol5280442BindingDB-show
Butacortelone3672BindingDB-show
butein5281222BindingDB-show
caffeic acid689043BindingDB-show
Calythropsin5353470BindingDB-show
Chalconaringenin5280960BindingDB-show
CHEBI:155595280701BindingDB-show
CHEBI:21184913971335BindingDB-show
CHEBI:21187813971309BindingDB-show
CHEBI:21192413971312BindingDB-show
CHEBI:21193813971314BindingDB-show
CHEBI:21205413971326BindingDB-show
CHEBI:21208413971324BindingDB-show
CHEBI:21208513971322BindingDB-show
CHEBI:21210813971339BindingDB-show
CHEBI:21223013971328BindingDB-show
CHEBI:21226113971341BindingDB-show
CHEBI:21266113971318BindingDB-show
CHEBI:21266213971316BindingDB-show
CHEBI:21269213971320BindingDB-show
CHEBI:21269313971355BindingDB-show
CHEBI:21270413971332BindingDB-show
CHEBI:524495283159BindingDB-show
CHEBI:609439862886BindingDB-show
CHEBI:64639944334662BindingDB-show
CHEBI:64640044334909BindingDB-show
CHEBI:64651544334661BindingDB-show
CHEBI:64652144334866BindingDB-show
CHEBI:64653944334911BindingDB-show
CHEBI:64656944334701BindingDB-show
CHEBI:64691444347630BindingDB-show
CHEBI:64693344347632BindingDB-show
CHEBI:64694044347828BindingDB-show
CHEBI:64694444347833BindingDB-show
CHEBI:64696244347594BindingDB-show
CHEBI:64696744347610BindingDB-show
CHEBI:64698544347686BindingDB-show
CHEBI:65159344334892BindingDB-show
CHEBI:65179644334700BindingDB-show
CHEMBL10224310063338BindingDB-show
CHEMBL10415610042219BindingDB-show
CHEMBL10538610335738BindingDB-show
CHEMBL10558710425738BindingDB-show
CHEMBL10879514988708BindingDB-show
CHEMBL1095019998276BindingDB-show
CHEMBL1102244267382BindingDB-show
CHEMBL11045344337548BindingDB-show
CHEMBL11143810044750BindingDB-show
CHEMBL1127209998758BindingDB-show
CHEMBL11273310067948BindingDB-show
CHEMBL1130810061734BindingDB-show
CHEMBL1130910337734BindingDB-show
CHEMBL11313844340012BindingDB-show
CHEMBL11321110449393BindingDB-show
CHEMBL11352510247111BindingDB-show
CHEMBL1137009885218BindingDB-show
CHEMBL11376814986312BindingDB-show
CHEMBL11390810044272BindingDB-show
CHEMBL1139910352627BindingDB-show
CHEMBL11401314986315BindingDB-show
CHEMBL11451614986313BindingDB-show
CHEMBL1154110264418BindingDB-show
CHEMBL11581314986322BindingDB-show
CHEMBL1160789864367BindingDB-show
CHEMBL11620114986314BindingDB-show
CHEMBL11649614986311BindingDB-show
CHEMBL11661214986340BindingDB-show
CHEMBL11675514986310BindingDB-show
CHEMBL11720314986345BindingDB-show
CHEMBL1180710018456BindingDB-show
CHEMBL1185810424056BindingDB-show
CHEMBL1187110334122BindingDB-show
CHEMBL12010710477060BindingDB-show
CHEMBL12067210089979BindingDB-show
CHEMBL12088510337727BindingDB-show
CHEMBL12102510452722BindingDB-show
CHEMBL1213909948121BindingDB-show
CHEMBL12140710479877BindingDB-show
CHEMBL1215410424219BindingDB-show
CHEMBL12155510316276BindingDB-show
CHEMBL12217515617856BindingDB-show
CHEMBL1221910356827BindingDB-show
CHEMBL12219344347736BindingDB-show
CHEMBL12225544347761BindingDB-show
CHEMBL12225813701489BindingDB-show
CHEMBL12233544347842BindingDB-show
CHEMBL122349971422BindingDB-show
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CHEMBL12307915617914BindingDB-show
CHEMBL12308010243916BindingDB-show
CHEMBL12313415617869BindingDB-show
CHEMBL12313515617863BindingDB-show
CHEMBL12317420453515BindingDB-show
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CHEMBL12339610070583BindingDB-show
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CHEMBL12460115617847BindingDB-show
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CHEMBL12495644347555BindingDB-show
CHEMBL12504111778354BindingDB-show
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CHEMBL12515144349384BindingDB-show
CHEMBL12519744349371BindingDB-show
CHEMBL12537444349054BindingDB-show
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CHEMBL1257210403436BindingDB-show
CHEMBL12572744349373BindingDB-show
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CHEMBL12711010726964BindingDB-show
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CHEMBL12801214977360BindingDB-show
CHEMBL1280910313621BindingDB-show
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CHEMBL13188010357141BindingDB-show
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CHEMBL13222811777756BindingDB-show
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CHEMBL13331710404108BindingDB-show
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CHEMBL13548310334622BindingDB-show
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CHEMBL136239861661BindingDB-show
CHEMBL1366110493616BindingDB-show
CHEMBL1392015153337BindingDB-show
CHEMBL1398010516483BindingDB-show
CHEMBL141129885504BindingDB-show
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CHEMBL14593310752791BindingDB-show
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CHEMBL14609310733892BindingDB-show
CHEMBL14647744364373BindingDB-show
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CHEMBL14653710521556BindingDB-show
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CHEMBL14671510830117BindingDB-show
CHEMBL14678614695704BindingDB-show
CHEMBL14809610591996BindingDB-show
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CHEMBL14873910803103BindingDB-show
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CHEMBL14884410825611BindingDB-show
CHEMBL14884510612896BindingDB-show
CHEMBL14885014578555BindingDB-show
CHEMBL14892244366100BindingDB-show
CHEMBL14896219764711BindingDB-show
CHEMBL14927814578565BindingDB-show
CHEMBL14938410759377BindingDB-show
CHEMBL14944814578537BindingDB-show
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CHEMBL14992610177000BindingDB-show
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CHEMBL1501444269688BindingDB-show
CHEMBL15017014578549BindingDB-show
CHEMBL1505810568310BindingDB-show
CHEMBL15071744366087BindingDB-show
CHEMBL15078314578547BindingDB-show
CHEMBL15080414578591BindingDB-show
CHEMBL15130944366083BindingDB-show
CHEMBL15143314578546BindingDB-show
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CHEMBL15184714791272BindingDB-show
CHEMBL15198719764723BindingDB-show
CHEMBL15234644369472BindingDB-show
CHEMBL15400844369651BindingDB-show
CHEMBL15420016081869BindingDB-show
CHEMBL15451744369352BindingDB-show
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DEXIBUPROFEN39912BindingDB-show
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ENAZADREM PHOSPHATE60816BindingDB-show
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ethyl 1-hydroxy-2-naphthoate12388083BindingDB-show
Ethyl caffeate5317238BindingDB-show
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Fluindione68942BindingDB-show
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Fpl-55712105007BindingDB-show
Hydroxychalcone analog6474295BindingDB-show
ICI 211965164272BindingDB-show
ICI 216800131453BindingDB-show
IFLab1_005154589461BindingDB-show
Iminodibenzyl10308BindingDB-show
Indomethacinum3715BindingDB-show
Isoliquiritigenin638278BindingDB-show
Ketoconazole456201BindingDB-show
Kinome_34279841863BindingDB-show
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LMFA010600735283013BindingDB-show
LONAPALENE56237BindingDB-show
Lopac-R-55236603985BindingDB-show
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Methoxypropiocin156391BindingDB-show
Methyl 3-(2-quinolinylmethoxy)benzeneacetohydroxamate3081156BindingDB-show
Methylacetopyronone122903BindingDB-show
N-(4-Benzyloxybenzyl)acetohydroxamic acid129265BindingDB-show
N-(4-Benzyloxybenzyl)acetohydroxamic acid129265PROMISCUOUSPMID 3146394show
N-(m-(2-Quinolinylmethoxy)phenyl)succinamic acid methyl ester13626822BindingDB-show
N-Bhpp157806BindingDB-show
N-hydroxy arachidonoyl amine6439861BindingDB-show
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N-hydroxy-4-methylbenzamide426839BindingDB-show
N-Hydroxy-4-phenylbutanamide279980BindingDB-show
N-hydroxy-arachidonoylamide5283414BindingDB-show
N-Hydroxy-N-(m-(2-quinolinylmethoxy)phenyl)succinamic acid methyl ester129110BindingDB-show
N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one6438164BindingDB-show
N-Methyl-4-benzyloxyphenylacetohydroxamic acid129232BindingDB-show
NAFAZATROM42923BindingDB-show
NCGC00024705-016069552BindingDB-show
nchembio.83-comp124712BindingDB-show
NORDIHYDROGUAIARETIC ACID4534BindingDB-show
Nordihyolroguaiaretic acid71398BindingDB-show
NSC286663323817BindingDB-show
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NSC4014925376979BindingDB-show
NSC638023367858BindingDB-show
NSC646164371715BindingDB-show
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Oprea1_02109010829998BindingDB-show
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Oprea1_87573310679375BindingDB-show
Oxametacine33675BindingDB-show
p-Butoxyphenylacetohydroxamic acid2466BindingDB-show
p-Iodobenzohydroxamic acid615643BindingDB-show
p-Isobutylhydratropohydroxamic acid68704BindingDB-show
p-Nitrobenzhydroxamic acid5043691BindingDB-show
Phenazoxine67278BindingDB-show
Phenidone7090BindingDB-show
Phenylindanedione4760BindingDB-show
Piroxicam5280452BindingDB-show
Quiflapon60923BindingDB-show
Quinacrine Dihydrochloride237BindingDB-show
Rev 59015059BindingDB-show
RITOLUKAST60539BindingDB-show
salicylhydroxamate66644BindingDB-show
SB 203580176155BindingDB-show
sb2169955171BindingDB-show
SK&F 107649197400BindingDB-show
Sodium meclophenamate4038BindingDB-show
ST0843261510045BindingDB-show
STK110153645040BindingDB-show
Tebufelone60542BindingDB-show
TEPOXALIN59757BindingDB-show
Thiazole deriv.5228BindingDB-show
Ticolubant6441619BindingDB-show
Tmk 7776438911BindingDB-show
Tocris-13113651377BindingDB-show
Tomelukast3969BindingDB-show
UY06870005745169BindingDB-show
Wy 44329124623BindingDB-show
WY 493533081197BindingDB-show
WY 49451130030BindingDB-show
Wy-50295 tromethamine6918158BindingDB-show
Xanthaurine5280343BindingDB-show
ZILEUTON60490BindingDB-show
ZINC00007301667570BindingDB-show
ZINC001682962763636BindingDB-show
ZINC001682992763637BindingDB-show
ZINC001683012763638BindingDB-show
ZINC013857681474031BindingDB-show
ZINC031166293652331BindingDB-show
ZINC059159055708903BindingDB-show
ZINC077419636171844BindingDB-show
[2,2'-Biindan]-1,1',3,3'-tetrone246855BindingDB-show
Synonyms:
5-lipoxygenase
5-LO
Arachidonate 5-lipoxygenase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
LOX5_MOUSE98.497.6
LOX5_HUMAN96.992.9
LOX12_HUMAN60.140.4
LOX15_HUMAN59.839.1
B1ASX6_MOUSE58.540.5
LX12B_HUMAN57.939.3
LOX15_RABIT57.337
LOXE3_HUMAN55.838.2
AOSL_PLEHO38.925
LOX3_SOYBN37.824.1
PLCZ1_PIG32.619
ACE_DROME31.417.4
METE_THEMA31.116.4
SYFB_HUMAN31.117
LEF_BACAN3117
ENPL_CANFA30.116.8
AMYM_GEOSE30.116.6
TOP1_HUMAN30.115
HUTH_HUMAN3017
GCYB1_HUMAN29.916.7
KAR3_YEAST29.915.6
THSA_THEK129.817
KIF2C_MOUSE29.615.7
VCAM1_HUMAN29.415.6
CP4A2_RAT29.416.5
Q6L8F0_THETH29.317.2
HSP82_YEAST29.315.4
KPCT_HUMAN29.214.8
Q8CHM5_MOUSE29.117.3
PDE4C_HUMAN29.118.5
Protein-Protein Interactions:
No data available