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Name:Arachidonate 5-lipoxygenase
Uniprot name:LOX5_HUMAN
Accession Numbers:P09917 Q5JQ14
EC-Number:1.13.11.34
Organism:Homo sapiens
Human
PDB IDs:2ABV
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(-)-pinoresinol12309636BindingDB-show
1-(2-chlorophenyl)pyrazolidin-3-one3775015BindingDB-show
1-(3-chlorophenyl)pyrazolidin-3-one767605BindingDB-show
1-(3-fluorophenyl)diazinan-3-one5061725BindingDB-show
1-(4-(3-(4-(Bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl)propoxy)-3-methoxyphenyl)ethanone173727PROMISCUOUSPMID 2554366show
1-hydroxy-1-[1-(6-methoxynaphthalen-2-yl)ethyl]urea10400378BindingDB-show
1-[3-(hydroxymethyl)phenyl]diazinan-3-one5061930BindingDB-show
10H-phenoxazine-1-carboxylic Acid4556427BindingDB-show
11-keto-boswellic Acid9847548BindingDB-show
147030-01-123672584BindingDB-show
2,6-Di-tert-butyl-4-(2-(3-pyridinyl)ethenyl)phenol6439912BindingDB-show
2,6-Dimethyl-4-(2-(2,5-dimethylphenyl)ethenyl)phenol6366698BindingDB-show
2,6-Dimethyl-4-(2-(2-benzyloxyphenyl)ethenyl)phenol6366699BindingDB-show
2,6-Dimethyl-4-(2-(2-thienyl)ethenyl)phenol6439221BindingDB-show
2,6-Dimethyl-4-(2-phenylethenyl)phenol6365297BindingDB-show
2-(3,7-dimethylocta-2,6-dien-1-yl)-6-methylbenzo-1,4-quinone642530BindingDB-show
2-(4-Hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole128480BindingDB-show
2-amino-5-hydroxyindole, 1111637678BindingDB-show
2-amino-5-hydroxyindole, 3j11500329BindingDB-show
2-amino-5-hydroxyindole, 3k11602022BindingDB-show
2-amino-5-hydroxyindole, 3l11674232BindingDB-show
2-amino-5-hydroxyindole, 3m11500409BindingDB-show
2-amino-5-hydroxyindole, 3n11530031BindingDB-show
2-aminoindole, 9b11645226BindingDB-show
3-((N-(Aminocarbonyl)-N-hydroxyamino)methyl)-6-phenoxychromene131820BindingDB-show
3-Htbp127577BindingDB-show
4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine47795BindingDB-show
5-Htobt127576BindingDB-show
5-Hydroxyeicosatetraenoate5280733BindingDB-show
6-Hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole443292BindingDB-show
7-Chloro-2-((4-methoxyphenyl)methyl)-3-methyl-5-propyl-4-benzofuranol128132BindingDB-show
9-Phenylnonanohydroxamic acid188382BindingDB-show
A 69412130007BindingDB-show
AA 863133543PROMISCUOUSPMID 2117290show
AA-516/314090511206916BindingDB-show
Abbott 7917571460BindingDB-show
AC1L2UXW129065BindingDB-show
AC1LFIV1778729BindingDB-show
AC1LZ3RB1913485BindingDB-show
AC1MCVK72801550BindingDB-show
AC1MPHC93385224BindingDB-show
AC1MVKIX3684695BindingDB-show
AC1MVKJ33684697BindingDB-show
AC1MVKJ93684699BindingDB-show
AC1MVN2D3735492BindingDB-show
AC1MXGVN3765426BindingDB-show
AC1MYS113861394BindingDB-show
AC1NCUYT4517796BindingDB-show
AC1NFWOD4665555BindingDB-show
AC1O5RN56439421BindingDB-show
Acetylphenylhydrazine8247BindingDB-show
AIDS1153595997630BindingDB-show
AKbetaBA11168203BindingDB-show
alpha-(3,5-di-tert-Butyl-4-hydroxybenzylidene)gamma-butyrolactone6438990BindingDB-show
arachidonoylethanolamide5281969PROMISCUOUSPMID 11095952show
Atractylenolide I5321018BindingDB-show
Atractylenolide III155948BindingDB-show
ATRACTYLOCHROMENE10244247BindingDB-show
Atractylon3080635BindingDB-show
Atreleuton3086671BindingDB-show
Atreleuton3086671PROMISCUOUSPMID 7490726show
Benzoic acid, 4-((((3-fluorophenyl)methyl)(4-(2-quinolinylmethoxy)phenyl)amino)methyl)-131627BindingDB-show
Benzyl 2-naphthyl ether123080BindingDB-show
Butacortelone3672BindingDB-show
Butacortelone3672SuperTarget-show
BW A4C6438354BindingDB-show
BW B70C5353454BindingDB-show
caffeic acid689043BindingDB-show
Celecoxib2662BindingDB-show
CGS 24891195771BindingDB-show
CHEBI:25410921661037BindingDB-show
CHEBI:64566844316835BindingDB-show
CHEBI:64572644316784BindingDB-show
CHEBI:64573744316800BindingDB-show
CHEBI:64578744316822BindingDB-show
CHEBI:64606844321962BindingDB-show
CHEBI:65139344316945BindingDB-show
CHEBI:65140944316785BindingDB-show
CHEBI:65146844316810BindingDB-show
CHEMBL10620615005976BindingDB-show
CHEMBL10820415005943BindingDB-show
CHEMBL10853815005972BindingDB-show
CHEMBL10862415005946BindingDB-show
CHEMBL10885415005969BindingDB-show
CHEMBL108888746866298BindingDB-show
CHEMBL108984046866297BindingDB-show
CHEMBL11024215005948BindingDB-show
CHEMBL11032715005970BindingDB-show
CHEMBL11045344337548BindingDB-show
CHEMBL11051315005967BindingDB-show
CHEMBL11086315005977BindingDB-show
CHEMBL11092815005945BindingDB-show
CHEMBL116321946845032BindingDB-show
CHEMBL116322146906737BindingDB-show
CHEMBL116322246906741BindingDB-show
CHEMBL116322346845034BindingDB-show
CHEMBL116323746906729BindingDB-show
CHEMBL116323846906733BindingDB-show
CHEMBL116324346845030BindingDB-show
CHEMBL116393846907573BindingDB-show
CHEMBL116393946907574BindingDB-show
CHEMBL116436946907602BindingDB-show
CHEMBL116439646906739BindingDB-show
CHEMBL116494346906743BindingDB-show
CHEMBL116494946906731BindingDB-show
CHEMBL116495046906735BindingDB-show
CHEMBL116524344557858BindingDB-show
CHEMBL116557746907572BindingDB-show
CHEMBL11761510541466BindingDB-show
CHEMBL11791144344532BindingDB-show
CHEMBL11821214971256BindingDB-show
CHEMBL11837714971255BindingDB-show
CHEMBL11839314971281BindingDB-show
CHEMBL11843014971310BindingDB-show
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CHEMBL11917010517413BindingDB-show
CHEMBL11943310709447BindingDB-show
CHEMBL11949914971312BindingDB-show
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CHEMBL1253444268068BindingDB-show
CHEMBL12579244351458BindingDB-show
CHEMBL12613510492504BindingDB-show
CHEMBL12618144351407BindingDB-show
CHEMBL12661919756612BindingDB-show
CHEMBL12673310001795BindingDB-show
CHEMBL1268144268063BindingDB-show
CHEMBL12694910824904BindingDB-show
CHEMBL127011344460122BindingDB-show
CHEMBL127022044460123BindingDB-show
CHEMBL127031244460112BindingDB-show
CHEMBL127031449788946BindingDB-show
CHEMBL127060844460139BindingDB-show
CHEMBL127081044460130BindingDB-show
CHEMBL12710710702459BindingDB-show
CHEMBL12710910826834BindingDB-show
CHEMBL12711010726964BindingDB-show
CHEMBL127111644460128BindingDB-show
CHEMBL127122044460114BindingDB-show
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CHEMBL12809444351607BindingDB-show
CHEMBL12810544351794BindingDB-show
CHEMBL12814344351618BindingDB-show
CHEMBL1281617865655BindingDB-show
CHEMBL12823844351729BindingDB-show
CHEMBL12827144351758BindingDB-show
CHEMBL12830044351822BindingDB-show
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CHEMBL1294789847369BindingDB-show
CHEMBL12951744351742BindingDB-show
CHEMBL12954710317471BindingDB-show
CHEMBL12956644351870BindingDB-show
CHEMBL12958010475867BindingDB-show
CHEMBL12966610430807BindingDB-show
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CHEMBL12967310247254BindingDB-show
CHEMBL12969844351461BindingDB-show
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CHEMBL16322210600308BindingDB-show
CHEMBL1633410009283BindingDB-show
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CHEMBL16343410718706BindingDB-show
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CHEMBL16380610601569BindingDB-show
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CHEMBL16425110529020BindingDB-show
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CHEMBL1659010054908BindingDB-show
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CHEMBL18023344389292BindingDB-show
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Diaethylcarbamazinum3052DrugBank-show
Diaethylcarbamazinum3052SuperTargetPMID 9145114show
Enofelast6439222BindingDB-show
Fenleuton72059BindingDB-show
hiperforina441298DrugBank-show
Honokiol72303BindingDB-show
Hydrocorticosterone5754DrugBank-show
Hydrocorticosterone5754SuperTarget-show
Hydroxybenzopyridine1923SuperTarget-show
ICI 211965164272BindingDB-show
ICI 216800131453BindingDB-show
Ici 230487132998BindingDB-show
Ici D2138132306BindingDB-show
Indomethacinum3715BindingDB-show
isaindigotone10405595BindingDB-show
Isoscopoletin69894BindingDB-show
Justicidin B122805BindingDB-show
JUSTICIDIN E363128BindingDB-show
Ketotiphene3827BindingDB-show
Leflunomide3899DrugBank-show
Leflunomide3899SuperTarget-show
Leukotriene A45280383BindingDB-show
Licofelone133021BindingDB-show
Licofelone133021PROMISCUOUSPMID 18033773show
LMFA030200195283133BindingDB-show
LS-19180010386055BindingDB-show
Meclofenamate4037DrugBank-show
Mesalazinum4075SuperTargetPMID 011430933show
Methylesculetin5280460BindingDB-show
Minocycline Monohydrochloride5281021DrugBank-show
Mizolastine65906SuperTargetPMID 012359006show
MK-8864519262BindingDB-show
Montelukast5281040DrugBank-show
Montelukast5311297DrugBank-show
Montelukast5281040SuperTargetPMID 015474500show
Montelukast5311297SuperTargetPMID 015474500show
N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide4553BindingDB-show
N-(2-dimethylaminoethyl)-4-(naphthalen-2-yloxymethyl)benzamide4443437BindingDB-show
N-(4-Benzyloxybenzyl)acetohydroxamic acid129265BindingDB-show
N-Bhpp157806BindingDB-show
N-Methyl-4-benzyloxyphenylacetohydroxamic acid129232BindingDB-show
NAFAZATROM42923BindingDB-show
nchembio.188-comp4642609834BindingDB-show
nchembio.188-comp4710427847BindingDB-show
nchembio.281-comp814771920BindingDB-show
NCI60_008868363130BindingDB-show
NORDIHYDROGUAIARETIC ACID4534BindingDB-show
Nordihyolroguaiaretic acid71398BindingDB-show
Nordihyolroguaiaretic acid71398DrugBank-show
Nordihyolroguaiaretic acid71398SuperTargetPMID 015132836show
NSC286667323821BindingDB-show
NSC293101155160BindingDB-show
NSC293102325144BindingDB-show
NSC638023367858BindingDB-show
NSC692765392401BindingDB-show
Oprea1_01042415056539BindingDB-show
Oprea1_03599810776511BindingDB-show
Oprea1_03863915056515BindingDB-show
Oprea1_07841115056511BindingDB-show
Oprea1_13233210538130BindingDB-show
Oprea1_17077810845542BindingDB-show
Oprea1_28882315056516BindingDB-show
Oprea1_29477910822291BindingDB-show
Oprea1_32331310588079BindingDB-show
Oprea1_32726310847997BindingDB-show
Oprea1_3457859921059BindingDB-show
Oprea1_38875110755909BindingDB-show
Oprea1_41516515056509BindingDB-show
Oprea1_43077210729840BindingDB-show
Oprea1_43449610799877BindingDB-show
Oprea1_43615810821903BindingDB-show
Oprea1_48840210834926BindingDB-show
Oprea1_50501015056517BindingDB-show
Oprea1_5606464143121BindingDB-show
Oprea1_56497615056543BindingDB-show
Oprea1_56720910443576BindingDB-show
Oprea1_58587810660093BindingDB-show
Oprea1_59524910726930BindingDB-show
Oprea1_60708110845994BindingDB-show
Oprea1_60754514425906BindingDB-show
Oprea1_62072910726380BindingDB-show
Oprea1_63615424043496BindingDB-show
Oprea1_65488910822398BindingDB-show
Oprea1_68872810751689BindingDB-show
Oprea1_69815910059051BindingDB-show
Oprea1_75558510587216BindingDB-show
Oprea1_86840310655329BindingDB-show
Osthole10228BindingDB-show
Pelargidenolon5280863BindingDB-show
Phenazoxine67278BindingDB-show
Phenidone7090BindingDB-show
Phloroglucinol359PROMISCUOUSPMID 16787324show
Phthalhydroquinone289PROMISCUOUSPMID 12097654show
Phytogermine14985DrugBank-show
Piriprost6437373PROMISCUOUSPMID 2117290show
Prifelone71751BindingDB-show
Puupehedione460087BindingDB-show
puupehenone72536BindingDB-show
Quiflapon60923BindingDB-show
Quinacrine Dihydrochloride237DrugBank-show
Quinacrine Dihydrochloride237SuperTarget-show
Retrojusticidin B460888BindingDB-show
Rev 59015059BindingDB-show
Rofecoxib5090BindingDB-show
Rofecoxib5090PROMISCUOUSPMID 16904331show
Salicylazosulfapyridine5353980SuperTargetPMID 001357724show
Shogaol5281794BindingDB-show
SILYMARIN31553SuperTargetPMID 10782486show
SMR000035823663693BindingDB-show
substituted chalcone, 5c42618003BindingDB-show
Tagorizine6436051BindingDB-show
Taiwanin C363127BindingDB-show
Tebufelone60542BindingDB-show
TEPOXALIN59757BindingDB-show
Tocris-13113651377BindingDB-show
Tomelukast3969BindingDB-show
Veliflapon123723BindingDB-show
Wasserstoffperoxid784PROMISCUOUSPMID 1446663show
Wedelolactone5281813BindingDB-show
Wy-50295 tromethamine6918158BindingDB-show
Xanthaurine5280343BindingDB-show
YS121 cpd24816385BindingDB-show
ZILEUTON60490BindingDB-show
ZILEUTON60490DrugBank-show
ZILEUTON60490PROMISCUOUSPMID 14570767show
ZINC0000085010220327BindingDB-show
ZINC024007711998811BindingDB-show
ZINC038398983692652BindingDB-show
ZINC0383992311866208BindingDB-show
ZINC038399543684700BindingDB-show
ZINC038399673667020BindingDB-show
ZINC038456692750392BindingDB-show
ZINC051286177515046BindingDB-show
ZINC056766835466621BindingDB-show
Synonyms:
5-lipoxygenase
5-LO
Arachidonate 5-lipoxygenase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
LOX5_MOUSE97.293.5
LOX5_RAT96.992.9
LOX12_HUMAN60.441.8
LOX15_HUMAN60.239.7
B1ASX6_MOUSE58.140.4
LX12B_HUMAN58.139.7
LOX15_RABIT57.838.5
LOXE3_HUMAN56.438.8
AOSL_PLEHO3925.7
LOX3_SOYBN3824.2
PTN11_HUMAN32.518.2
HUTH_HUMAN32.418.7
PDE9A_HUMAN3217.1
GFPT2_HUMAN31.315.9
Q6I7E7_STAAU31.117.8
IF2P_METTH3116.8
AMYM_GEOSE30.616.5
THNS1_HUMAN30.618.1
SYFB_HUMAN30.416.5
RIR3_SALTY30.417.9
IMDH2_HUMAN3017.3
ACE_DROME29.917.5
PDE4C_HUMAN29.816.2
KAR3_YEAST29.815.3
TOP1_HUMAN29.714.9
THSA_THEK129.716.2
A3GFE9_PICST29.616.9
CACP_HUMAN29.617
LEF_BACAN29.515.3
Q8LPE0_CHLRE29.317.5
Protein-Protein Interactions: