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Target Details

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Name:Spleen tyrosine kinase
Uniprot name:KSYK_HUMAN
Accession Numbers:P43405
EC-Number:2.7.10.2
Organism:Homo sapiens
Human
PDB IDs:1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt44457722BindingDB-show
()-oxazepam hemisuccinate sodium salt44457583BindingDB-show
()-oxazepam hemisuccinate sodium salt44457581BindingDB-show
()-oxazepam hemisuccinate sodium salt44457582BindingDB-show
1,2,4-Oxadiazole Analogue 105329202BindingDB-show
1,2,4-Oxadiazole Analogue 12a5329204BindingDB-show
1,2,4-Oxadiazole Analogue 12b5329220BindingDB-show
1,2,4-Oxadiazole Analogue 12c5329221BindingDB-show
1,2,4-Oxadiazole Analogue 12g5329207BindingDB-show
1,2,4-Oxadiazole Analogue 13a5329223BindingDB-show
1,2,4-Oxadiazole Analogue 13b5329224BindingDB-show
1,2,4-Oxadiazole Analogue 13c5329225BindingDB-show
1,2,4-Oxadiazole Analogue 14c6326461BindingDB-show
1,2,4-Oxadiazole Analogue 14e5329212BindingDB-show
1,2,4-Oxadiazole Analogue 14f6326463BindingDB-show
1,2,4-Oxadiazole Analogue 15a5329226BindingDB-show
1,2,4-Oxadiazole Analogue 15c5329228BindingDB-show
1,2,4-Oxadiazole Analogue 4a5329214BindingDB-show
1,2,4-Oxadiazole Analogue 4b5329179BindingDB-show
1,2,4-Oxadiazole Analogue 4d5329181BindingDB-show
1,2,4-Oxadiazole Analogue 4f5329215BindingDB-show
1,2,4-Oxadiazole Analogue 4g5329183BindingDB-show
1,2,4-Oxadiazole Analogue 4i5329185BindingDB-show
1,2,4-Oxadiazole Analogue 4j5329216BindingDB-show
1,2,4-Oxadiazole Analogue 4k5329186BindingDB-show
1,2,4-Oxadiazole Analogue 5a6326454BindingDB-show
1,2,4-Oxadiazole Analogue 5c6326458BindingDB-show
1,2,4-Oxadiazole Analogue 5d5329217BindingDB-show
1,2,4-Oxadiazole Analogue 5f6326464BindingDB-show
1,2,4-Oxadiazole Analogue 5h6326456BindingDB-show
1,2,4-Oxadiazole Analogue 5i6326457BindingDB-show
1,2,4-Oxadiazole Analogue 5j6326459BindingDB-show
1,2,4-Oxadiazole Analogue 5m5329196BindingDB-show
1,2,4-Oxadiazole Analogue 5n5329197BindingDB-show
1,2,4-Oxadiazole Analogue 75329199BindingDB-show
1,2,4-Oxadiazole Analogue 85329200BindingDB-show
1,2,4-Oxadiazole Analogue 95329201BindingDB-show
2-methoxy-4-(2-nitrovinyl)phenol638439BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3emg25113172BindingDB-show
4-(Phosphonomethyl)phenylalanine383690BindingDB-show
ABT-86911485656BindingDB-show
AC1LRA051365090BindingDB-show
ACHP10451420BindingDB-show
AG 2135328803BindingDB-show
alpha-Carboxyphenylacetic acid75791BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Astringinine667639BindingDB-show
BAS 001148582063494BindingDB-show
Bio2_0004136610353BindingDB-show
Bosutinib5328940BindingDB-show
BSPBio_00152010930781BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:64960344422592BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL10276510347718BindingDB-show
CHEMBL10276610031003BindingDB-show
CHEMBL10433310000020BindingDB-show
CHEMBL10437344335802BindingDB-show
CHEMBL10451944335885BindingDB-show
CHEMBL10458344335771BindingDB-show
CHEMBL10465144335755BindingDB-show
CHEMBL10469144335780BindingDB-show
CHEMBL10481344336147BindingDB-show
CHEMBL10506144335756BindingDB-show
CHEMBL10542144335823BindingDB-show
CHEMBL10542744335776BindingDB-show
CHEMBL10543844335902BindingDB-show
CHEMBL10574044336163BindingDB-show
CHEMBL10609544336168BindingDB-show
CHEMBL10622644335865BindingDB-show
CHEMBL10706144336128BindingDB-show
CHEMBL107672122353185BindingDB-show
CHEMBL108090246865325BindingDB-show
CHEMBL108119811755812BindingDB-show
CHEMBL10825844335763BindingDB-show
CHEMBL108492625242324BindingDB-show
CHEMBL108517846180666BindingDB-show
CHEMBL108673646880951BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL124210052949496BindingDB-show
CHEMBL127023024809764BindingDB-show
CHEMBL128816049839481BindingDB-show
CHEMBL129074649838879BindingDB-show
CHEMBL13782810504027BindingDB-show
CHEMBL13782910740438BindingDB-show
CHEMBL13792410619651BindingDB-show
CHEMBL13834010343317BindingDB-show
CHEMBL13869810044189BindingDB-show
CHEMBL13983310452792BindingDB-show
CHEMBL14077410428841BindingDB-show
CHEMBL14127110620637BindingDB-show
CHEMBL14159710941165BindingDB-show
CHEMBL14213510787405BindingDB-show
CHEMBL14522810995725BindingDB-show
CHEMBL17305010295268BindingDB-show
CHEMBL1734849912932BindingDB-show
CHEMBL20914811467730BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL21594316086114BindingDB-show
CHEMBL2185444274560BindingDB-show
CHEMBL24579844442739BindingDB-show
CHEMBL24579944442740BindingDB-show
CHEMBL24580044442742BindingDB-show
CHEMBL24702444442744BindingDB-show
CHEMBL24804444442729BindingDB-show
CHEMBL24804544442730BindingDB-show
CHEMBL24822044442732BindingDB-show
CHEMBL24822144442734BindingDB-show
CHEMBL24822244442735BindingDB-show
CHEMBL24839144442736BindingDB-show
CHEMBL24839244442738BindingDB-show
CHEMBL24839323661662BindingDB-show
CHEMBL2708510248747BindingDB-show
CHEMBL28101544280109BindingDB-show
CHEMBL28107844280184BindingDB-show
CHEMBL28110810150080BindingDB-show
CHEMBL28169610214743BindingDB-show
CHEMBL2819579869943BindingDB-show
CHEMBL28196544280403BindingDB-show
CHEMBL28234210308737BindingDB-show
CHEMBL28318144280484BindingDB-show
CHEMBL28459010215165BindingDB-show
CHEMBL28467510149633BindingDB-show
CHEMBL28534610193693BindingDB-show
CHEMBL28588944280691BindingDB-show
CHEMBL28591610125658BindingDB-show
CHEMBL2874789820420BindingDB-show
CHEMBL3012310194027BindingDB-show
CHEMBL3024010286428BindingDB-show
CHEMBL3035510286667BindingDB-show
CHEMBL3038110286814BindingDB-show
CHEMBL3038844280317BindingDB-show
CHEMBL3051410236713BindingDB-show
CHEMBL3054810215299BindingDB-show
CHEMBL3056610171604BindingDB-show
CHEMBL3058810286183BindingDB-show
CHEMBL3063310172273BindingDB-show
CHEMBL3064010309216BindingDB-show
CHEMBL3064210126020BindingDB-show
CHEMBL3066110308373BindingDB-show
CHEMBL306789818573BindingDB-show
CHEMBL3070610125483BindingDB-show
CHEMBL3070810149940BindingDB-show
CHEMBL3071644280198BindingDB-show
CHEMBL3072344280098BindingDB-show
CHEMBL3077444280099BindingDB-show
CHEMBL3082310193837BindingDB-show
CHEMBL3082410308736BindingDB-show
CHEMBL3082610236571BindingDB-show
CHEMBL3087310125723BindingDB-show
CHEMBL3088510193068BindingDB-show
CHEMBL3094910309014BindingDB-show
CHEMBL3114144280048BindingDB-show
CHEMBL3166844280402BindingDB-show
CHEMBL31675644335826BindingDB-show
CHEMBL31719744336148BindingDB-show
CHEMBL3180799820317BindingDB-show
CHEMBL31917944332978BindingDB-show
CHEMBL31961344335920BindingDB-show
CHEMBL32037212968822BindingDB-show
CHEMBL32107944333009BindingDB-show
CHEMBL32195522978714BindingDB-show
CHEMBL32197644336073BindingDB-show
CHEMBL32215244335827BindingDB-show
CHEMBL32236844335815BindingDB-show
CHEMBL3300944280690BindingDB-show
CHEMBL3306910309119BindingDB-show
CHEMBL3317544280710BindingDB-show
CHEMBL3337344280462BindingDB-show
CHEMBL3346610286233BindingDB-show
CHEMBL3362610287337BindingDB-show
CHEMBL3410410236578BindingDB-show
CHEMBL34194610500718BindingDB-show
CHEMBL3421123467602BindingDB-show
CHEMBL34236010258706BindingDB-show
CHEMBL34307110593843BindingDB-show
CHEMBL34461410761144BindingDB-show
CHEMBL34802010995861BindingDB-show
CHEMBL35712544362038BindingDB-show
CHEMBL37773411632737BindingDB-show
CHEMBL38666116086104BindingDB-show
CHEMBL39943844442745BindingDB-show
CHEMBL40105444442733BindingDB-show
CHEMBL40125144442737BindingDB-show
CHEMBL40164444442731BindingDB-show
CHEMBL41935312968819BindingDB-show
CHEMBL4195399985193BindingDB-show
CHEMBL42010044335921BindingDB-show
CHEMBL42264310738302BindingDB-show
CHEMBL42373711016822BindingDB-show
CHEMBL43164544335814BindingDB-show
CHEMBL43524010084407BindingDB-show
CHEMBL44052910716388BindingDB-show
CHEMBL44079744280286BindingDB-show
CHEMBL44351444565579BindingDB-show
CHEMBL44788711500389BindingDB-show
CHEMBL4491810318571BindingDB-show
CHEMBL45052421106482BindingDB-show
CHEMBL45086744565660BindingDB-show
CHEMBL45145044589516BindingDB-show
CHEMBL45235511617275BindingDB-show
CHEMBL45321744593471BindingDB-show
CHEMBL45401244565782BindingDB-show
CHEMBL45751944589025BindingDB-show
CHEMBL45878844589023BindingDB-show
CHEMBL45880610457649BindingDB-show
CHEMBL45897344589050BindingDB-show
CHEMBL45914644589051BindingDB-show
CHEMBL47017544590150BindingDB-show
CHEMBL47052815458392BindingDB-show
CHEMBL4707169836081BindingDB-show
CHEMBL47071811551547BindingDB-show
CHEMBL47073611545405BindingDB-show
CHEMBL47078044590204BindingDB-show
CHEMBL47091010150032BindingDB-show
CHEMBL47091411688688BindingDB-show
CHEMBL47142444590109BindingDB-show
CHEMBL47157611501395BindingDB-show
CHEMBL47157718460827BindingDB-show
CHEMBL47158244565661BindingDB-show
CHEMBL47158544565780BindingDB-show
CHEMBL47172744593470BindingDB-show
CHEMBL47175344565662BindingDB-show
CHEMBL47177644593472BindingDB-show
CHEMBL47181920741385BindingDB-show
CHEMBL47194844565681BindingDB-show
CHEMBL47195044565802BindingDB-show
CHEMBL47247825169255BindingDB-show
CHEMBL47259022958832BindingDB-show
CHEMBL47260024753683BindingDB-show
CHEMBL47261111710403BindingDB-show
CHEMBL47298944565581BindingDB-show
CHEMBL4730219968856BindingDB-show
CHEMBL47321644565843BindingDB-show
CHEMBL47322944593475BindingDB-show
CHEMBL47436115458391BindingDB-show
CHEMBL47436244565578BindingDB-show
CHEMBL47436344565580BindingDB-show
CHEMBL47441944565735BindingDB-show
CHEMBL47442044565736BindingDB-show
CHEMBL47458210022152BindingDB-show
CHEMBL47465121106492BindingDB-show
CHEMBL47465244565804BindingDB-show
CHEMBL47465410455153BindingDB-show
CHEMBL47465544565696BindingDB-show
CHEMBL47483244565697BindingDB-show
CHEMBL47500124753585BindingDB-show
CHEMBL47501411523529BindingDB-show
CHEMBL47518044593467BindingDB-show
CHEMBL4751959965312BindingDB-show
CHEMBL47519611660668BindingDB-show
CHEMBL47524844565733BindingDB-show
CHEMBL47524944593469BindingDB-show
CHEMBL47525044565884BindingDB-show
CHEMBL47525244565886BindingDB-show
CHEMBL47525425169256BindingDB-show
CHEMBL47525524753686BindingDB-show
CHEMBL47525944565737BindingDB-show
CHEMBL47537112017518BindingDB-show
CHEMBL47540844565868BindingDB-show
CHEMBL47541644565734BindingDB-show
CHEMBL47542044565887BindingDB-show
CHEMBL47542144565888BindingDB-show
CHEMBL47556911624063BindingDB-show
CHEMBL47557044593468BindingDB-show
CHEMBL47557544589022BindingDB-show
CHEMBL47560944589002BindingDB-show
CHEMBL47577911565679BindingDB-show
CHEMBL47578044565711BindingDB-show
CHEMBL48197325138151BindingDB-show
CHEMBL48217525138153BindingDB-show
CHEMBL48435044588972BindingDB-show
CHEMBL48520444589001BindingDB-show
CHEMBL48573044589515BindingDB-show
CHEMBL48573144589517BindingDB-show
CHEMBL48675144589514BindingDB-show
CHEMBL49316944219632BindingDB-show
CHEMBL49422144219633BindingDB-show
CHEMBL50008644565801BindingDB-show
CHEMBL50415111602075BindingDB-show
CHEMBL50455844565867BindingDB-show
CHEMBL50644844565781BindingDB-show
CHEMBL50833911523166BindingDB-show
CHEMBL5091619856983BindingDB-show
CHEMBL51167011324412BindingDB-show
CHEMBL51181144590205BindingDB-show
CHEMBL51182910005715BindingDB-show
CHEMBL51215216744158BindingDB-show
CHEMBL5121909866765BindingDB-show
CHEMBL51231944590149BindingDB-show
CHEMBL51232844565756BindingDB-show
CHEMBL51234544590110BindingDB-show
CHEMBL51236211667007BindingDB-show
CHEMBL51236411493171BindingDB-show
CHEMBL51398510291291BindingDB-show
CHEMBL5140129979898BindingDB-show
CHEMBL5141909925060BindingDB-show
CHEMBL5143459902848BindingDB-show
CHEMBL51481144565698BindingDB-show
CHEMBL51505444589024BindingDB-show
CHEMBL5152719904854BindingDB-show
CHEMBL51575644565885BindingDB-show
CHEMBL5157579817349BindingDB-show
CHEMBL51586821106496BindingDB-show
CHEMBL51591044565682BindingDB-show
CHEMBL51606044565803BindingDB-show
CHEMBL51606144565695BindingDB-show
CHEMBL51623111667761BindingDB-show
CHEMBL51913125138152BindingDB-show
CHEMBL52066944588971BindingDB-show
CHEMBL52084244589000BindingDB-show
CHEMBL52358644592504BindingDB-show
CHEMBL52522244565783BindingDB-show
CHEMBL55102445270368BindingDB-show
CHEMBL55710145273358BindingDB-show
CHEMBL55978745269074BindingDB-show
CHEMBL56494045267327BindingDB-show
CHEMBL56892211723489BindingDB-show
CHEMBL57688723401001BindingDB-show
CHEMBL57698923400934BindingDB-show
CHEMBL57860110246246BindingDB-show
CHEMBL59775446233287BindingDB-show
CHEMBL59922445139989BindingDB-show
CHEMBL59942845139991BindingDB-show
CHIR-26511656518BindingDB-show
CID 1009754410097544BindingDB-show
CID 1009754410028975BindingDB-show
CID 98443209844320BindingDB-show
CP-7247149874913BindingDB-show
Cyclohexanemalonic acid348911BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
Genisterin5280961BindingDB-show
GW-258011617559BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
Imatinib Methansulfonate5291DrugBank-show
K00592a9549296BindingDB-show
Kinome_248146224684BindingDB-show
Krisolamine31420BindingDB-show
L2G9549184BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
MLN805411712649BindingDB-show
Pazopanib10113978BindingDB-show
Pelitinib6445562BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
R406(free base)11213558BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
ST030081718278BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
STAUROSPORINE44259DrugBank-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Syk Inhibitor6419747BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
Spleen tyrosine kinase
Tyrosine-protein kinase SYK
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
ZAP70_HUMAN69.452.5
FYN_HUMAN39.325
CSK_HUMAN38.327.9
SRC_RSVSE3824.8
LCK_HUMAN37.125.3
SRC_RAT36.924.1
SRC_HUMAN36.924.4
ITK_HUMAN35.822
HCK_HUMAN35.223.1
YES_HUMAN34.822.4
FGFR4_HUMAN34.521.2
BTK_HUMAN3420.7
BRAF_HUMAN33.820.9
Q99052_MOUSE33.621.8
FGFR2_HUMAN32.720.9
FGFR3_HUMAN32.621.4
DDR1_HUMAN32.319.4
NTRK1_HUMAN3220.9
PTN11_HUMAN31.819.1
SYDM_HUMAN31.817.8
GLMS_ECOLI31.618.8
KPCE_HUMAN31.517.9
AOFA_HUMAN31.218
ERO1_YEAST31.217.4
KPCB_HUMAN30.619.1
KPCB_BOVIN30.518.9
Q9Y780_COPCI30.518
PAPS1_HUMAN30.418.6
DPOL_BPR6930.417.3
VCAM1_HUMAN30.316
Protein-Protein Interactions: