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Target Details

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Name:c-kit
Uniprot name:KIT_HUMAN
Accession Numbers:P10721 Q9UM99
EC-Number:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2VIF 3G0E 3G0F
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
1-((3-(Diethylamino)propyl)amino)-5,6,11-trimethyl-6H-pyrido(4,3-b)carbazo3068873BindingDB-show
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 465327893BindingDB-show
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 505327897BindingDB-show
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 515327898BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3cp924812717BindingDB-show
3cpb24812718BindingDB-show
3cpc24812719BindingDB-show
3ds624941253BindingDB-show
4-Anilinoquinazoline 225329048BindingDB-show
4434904144349041BindingDB-show
6,7-Dimethoxy-2-phenylquinozaline2049PROMISCUOUSPMID 12357354show
7MP10062694BindingDB-show
9-Bromoellipticine97080BindingDB-show
ABT-86911485656BindingDB-show
Adenosindiphosphorsaeure6022DrugBank-show
AMG 70611667893BindingDB-show
Aminobenzoisothiazole, 1811223082BindingDB-show
Aminobenzoisothiazole, 1911281789BindingDB-show
Aminobenzoisoxazole, 1024768395BindingDB-show
Aminobenzoisoxazole, 1124768396BindingDB-show
Aminobenzoisoxazole, 1311406239BindingDB-show
Aminobenzoisoxazole, 1411235290BindingDB-show
Aminobenzoisoxazole, 2311462058BindingDB-show
Aminobenzoisoxazole, 2411337407BindingDB-show
Aminobenzoisoxazole, 2511856200BindingDB-show
Aminobenzoisoxazole, 2611177394BindingDB-show
Aminobenzoisoxazole, 279928737BindingDB-show
Aminobenzoisoxazole, 2811257328BindingDB-show
Aminobenzoisoxazole, 2911440661BindingDB-show
Aminobenzoisoxazole, 3011268446BindingDB-show
Aminobenzoisoxazole, 3111373591BindingDB-show
Aminobenzoisoxazole, 3211451774BindingDB-show
Aminobenzoisoxazole, 3311152545BindingDB-show
Aminobenzoisoxazole, 3411327388BindingDB-show
Aminobenzoisoxazole, 3511428773BindingDB-show
Aminobenzoisoxazole, 3611325920BindingDB-show
Aminobenzoisoxazole, 3711189551BindingDB-show
Aminobenzoisoxazole, 3911304968BindingDB-show
Aminobenzoisoxazole, 4011417521BindingDB-show
Aminobenzoisoxazole, 4111855937BindingDB-show
Aminobenzoisoxazole, 4211856199BindingDB-show
Aminobenzoisoxazole, 4311280431BindingDB-show
Aminobenzoisoxazole, 4511856201BindingDB-show
Aminobenzoisoxazole, 4911429654BindingDB-show
Aminobenzoisoxazole, 5011374110BindingDB-show
Aminobenzoisoxazole, 5111429729BindingDB-show
Aminobenzoisoxazole, 5311856467BindingDB-show
Aminobenzoisoxazole, 5411429321BindingDB-show
Aminobenzoisoxazole, 5511856735BindingDB-show
Aminobenzoisoxazole, 5611465676BindingDB-show
Aminobenzoisoxazole, 5711156401BindingDB-show
Aminobenzoisoxazole, 824768394BindingDB-show
Aminobenzoisoxazole, 911265647BindingDB-show
Aminopyrimidine amide, 10a24823426BindingDB-show
anthranyl amide derivative C6398883BindingDB-show
arylamide, 811654378BindingDB-show
AST-48711409972BindingDB-show
AZD-115211497983BindingDB-show
Bosutinib5328940BindingDB-show
BRN 0714636149478BindingDB-show
BRN 0717969149480BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:64767744359680BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL1016839797919BindingDB-show
CHEMBL1023019890746BindingDB-show
CHEMBL10234610907042BindingDB-show
CHEMBL10406711048367BindingDB-show
CHEMBL10696610905857BindingDB-show
CHEMBL10759910303591BindingDB-show
CHEMBL107911324897305BindingDB-show
CHEMBL107954511200284BindingDB-show
CHEMBL108102246879153BindingDB-show
CHEMBL108150911189588BindingDB-show
CHEMBL108183123654166BindingDB-show
CHEMBL108551124762205BindingDB-show
CHEMBL108879611848506BindingDB-show
CHEMBL109119925118220BindingDB-show
CHEMBL109201346197240BindingDB-show
CHEMBL109440824993189BindingDB-show
CHEMBL117281549799067BindingDB-show
CHEMBL117283749799372BindingDB-show
CHEMBL117288649799068BindingDB-show
CHEMBL117288749799069BindingDB-show
CHEMBL117295746898022BindingDB-show
CHEMBL117310749799374BindingDB-show
CHEMBL117314949799031BindingDB-show
CHEMBL117317449799375BindingDB-show
CHEMBL117341146898039BindingDB-show
CHEMBL117348246182735BindingDB-show
CHEMBL117354149799301BindingDB-show
CHEMBL11825810005638BindingDB-show
CHEMBL11841944345639BindingDB-show
CHEMBL1201859826083BindingDB-show
CHEMBL12140544346053BindingDB-show
CHEMBL121521846847552BindingDB-show
CHEMBL12403510117540BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL124297746929544BindingDB-show
CHEMBL125400715949613BindingDB-show
CHEMBL125860349800164BindingDB-show
CHEMBL125891311847343BindingDB-show
CHEMBL12589810231458BindingDB-show
CHEMBL12669910187285BindingDB-show
CHEMBL127023024809764BindingDB-show
CHEMBL127689024742584BindingDB-show
CHEMBL127689124742586BindingDB-show
CHEMBL127698025207322BindingDB-show
CHEMBL127698125113814BindingDB-show
CHEMBL127707125114266BindingDB-show
CHEMBL127707225116064BindingDB-show
CHEMBL127716149840467BindingDB-show
CHEMBL127814616662431BindingDB-show
CHEMBL127814724742411BindingDB-show
CHEMBL127823324742412BindingDB-show
CHEMBL127823449840391BindingDB-show
CHEMBL15089410275001BindingDB-show
CHEMBL18398744394665BindingDB-show
CHEMBL18408244394745BindingDB-show
CHEMBL18412944394865BindingDB-show
CHEMBL18418044394869BindingDB-show
CHEMBL1842279872659BindingDB-show
CHEMBL18423510120038BindingDB-show
CHEMBL18424444394619BindingDB-show
CHEMBL18475310187537BindingDB-show
CHEMBL18559744394899BindingDB-show
CHEMBL18668210187699BindingDB-show
CHEMBL18671844394847BindingDB-show
CHEMBL1868519894619BindingDB-show
CHEMBL1872809828619BindingDB-show
CHEMBL19582811662314BindingDB-show
CHEMBL19761012733993BindingDB-show
CHEMBL20151111530963BindingDB-show
CHEMBL20291911656170BindingDB-show
CHEMBL20322744409504BindingDB-show
CHEMBL20327944409484BindingDB-show
CHEMBL20412011655667BindingDB-show
CHEMBL20422511604829BindingDB-show
CHEMBL20440911496035BindingDB-show
CHEMBL20508911640405BindingDB-show
CHEMBL20537211525727BindingDB-show
CHEMBL20567411690679BindingDB-show
CHEMBL20595311539040BindingDB-show
CHEMBL20785811616255BindingDB-show
CHEMBL20942144414881BindingDB-show
CHEMBL20991944414666BindingDB-show
CHEMBL20992244414659BindingDB-show
CHEMBL20997144414371BindingDB-show
CHEMBL21007044414547BindingDB-show
CHEMBL21011344414460BindingDB-show
CHEMBL21146444414527BindingDB-show
CHEMBL21208444414322BindingDB-show
CHEMBL21276244414880BindingDB-show
CHEMBL21293244414597BindingDB-show
CHEMBL21298544414486BindingDB-show
CHEMBL21298644414867BindingDB-show
CHEMBL21298744414868BindingDB-show
CHEMBL21327044414395BindingDB-show
CHEMBL21343044414394BindingDB-show
CHEMBL21350444414679BindingDB-show
CHEMBL21350744414376BindingDB-show
CHEMBL21361816043304BindingDB-show
CHEMBL21374344414347BindingDB-show
CHEMBL21390944414596BindingDB-show
CHEMBL21391016043229BindingDB-show
CHEMBL21406344414621BindingDB-show
CHEMBL21410944414632BindingDB-show
CHEMBL21416144414348BindingDB-show
CHEMBL21425844414779BindingDB-show
CHEMBL21541744414847BindingDB-show
CHEMBL21594844414316BindingDB-show
CHEMBL21972711259128BindingDB-show
CHEMBL21977416125453BindingDB-show
CHEMBL21988716125380BindingDB-show
CHEMBL21999816125381BindingDB-show
CHEMBL22004911473904BindingDB-show
CHEMBL22031716125110BindingDB-show
CHEMBL22105311268741BindingDB-show
CHEMBL22231544420784BindingDB-show
CHEMBL22272811177668BindingDB-show
CHEMBL22277816125106BindingDB-show
CHEMBL22318516125109BindingDB-show
CHEMBL22322044421705BindingDB-show
CHEMBL22330416124775BindingDB-show
CHEMBL22336111407736BindingDB-show
CHEMBL22347811271710BindingDB-show
CHEMBL22352816124976BindingDB-show
CHEMBL22357211465254BindingDB-show
CHEMBL22358311417108BindingDB-show
CHEMBL22379016124975BindingDB-show
CHEMBL22397111590078BindingDB-show
CHEMBL22524844421704BindingDB-show
CHEMBL23757024180608BindingDB-show
CHEMBL24536244440245BindingDB-show
CHEMBL24537716747696BindingDB-show
CHEMBL24573444440232BindingDB-show
CHEMBL24576844440253BindingDB-show
CHEMBL24576944440254BindingDB-show
CHEMBL24580444442392BindingDB-show
CHEMBL24580511605467BindingDB-show
CHEMBL24593444440233BindingDB-show
CHEMBL24596844440256BindingDB-show
CHEMBL24616644440259BindingDB-show
CHEMBL24634244440242BindingDB-show
CHEMBL24634344440243BindingDB-show
CHEMBL24635617748275BindingDB-show
CHEMBL24642344442400BindingDB-show
CHEMBL24642411697289BindingDB-show
CHEMBL24654644440244BindingDB-show
CHEMBL24660844442394BindingDB-show
CHEMBL24703044442393BindingDB-show
CHEMBL24724811561411BindingDB-show
CHEMBL24725044442418BindingDB-show
CHEMBL24738844440249BindingDB-show
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CHEMBL24742344442407BindingDB-show
CHEMBL24742444442408BindingDB-show
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CHEMBL24743516101466BindingDB-show
CHEMBL24743711704845BindingDB-show
CHEMBL24758544440252BindingDB-show
CHEMBL24759144442405BindingDB-show
CHEMBL24761811597486BindingDB-show
CHEMBL24761944442415BindingDB-show
CHEMBL24779244442409BindingDB-show
CHEMBL24779311705461BindingDB-show
CHEMBL24779744442416BindingDB-show
CHEMBL24779844442417BindingDB-show
CHEMBL24805144442388BindingDB-show
CHEMBL24822611604883BindingDB-show
CHEMBL24822744442389BindingDB-show
CHEMBL24825644442396BindingDB-show
CHEMBL24825744442397BindingDB-show
CHEMBL24825844442398BindingDB-show
CHEMBL24839744442390BindingDB-show
CHEMBL24839811634109BindingDB-show
CHEMBL24886044442403BindingDB-show
CHEMBL25329224882503BindingDB-show
CHEMBL25924724824046BindingDB-show
CHEMBL26959412004372BindingDB-show
CHEMBL31989411729539BindingDB-show
CHEMBL32333610457505BindingDB-show
CHEMBL33086310231813BindingDB-show
CHEMBL34753744368815BindingDB-show
CHEMBL3523089850161BindingDB-show
CHEMBL36460144394635BindingDB-show
CHEMBL37384511178869BindingDB-show
CHEMBL37433016125232BindingDB-show
CHEMBL37475211245809BindingDB-show
CHEMBL37567011337894BindingDB-show
CHEMBL37607716124774BindingDB-show
CHEMBL37624511340683BindingDB-show
CHEMBL37630711371508BindingDB-show
CHEMBL37695116043241BindingDB-show
CHEMBL37740044414595BindingDB-show
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CHEMBL37848911583439BindingDB-show
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CHEMBL37908844414647BindingDB-show
CHEMBL38006844414419BindingDB-show
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CHEMBL38039744414816BindingDB-show
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CHEMBL38239911583287BindingDB-show
CHEMBL38429444414648BindingDB-show
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CHEMBL39015616220354BindingDB-show
CHEMBL39178144442419BindingDB-show
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CHEMBL39386244440231BindingDB-show
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CHEMBL39508044427518BindingDB-show
CHEMBL39542744440261BindingDB-show
CHEMBL39569444440248BindingDB-show
CHEMBL39569544440251BindingDB-show
CHEMBL39570044442406BindingDB-show
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CHEMBL39658644440247BindingDB-show
CHEMBL39734544442410BindingDB-show
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CHEMBL39887244442391BindingDB-show
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CHEMBL39957144442411BindingDB-show
CHEMBL40005744442401BindingDB-show
CHEMBL40010944442395BindingDB-show
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CHEMBL41504744414695BindingDB-show
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CHEMBL42504311690947BindingDB-show
CHEMBL42526244414848BindingDB-show
CHEMBL42561544414683BindingDB-show
CHEMBL42593511525218BindingDB-show
CHEMBL42600416124831BindingDB-show
CHEMBL42688711404903BindingDB-show
CHEMBL43509844394571BindingDB-show
CHEMBL43865316124974BindingDB-show
CHEMBL44227344440246BindingDB-show
CHEMBL44390244560590BindingDB-show
CHEMBL4440649828962BindingDB-show
CHEMBL44563610302519BindingDB-show
CHEMBL45305744560803BindingDB-show
CHEMBL46988244560546BindingDB-show
CHEMBL46988344593407BindingDB-show
CHEMBL47048344560547BindingDB-show
CHEMBL47614144578709BindingDB-show
CHEMBL48296816041424BindingDB-show
CHEMBL48488325068516BindingDB-show
CHEMBL48488425069340BindingDB-show
CHEMBL48488525068569BindingDB-show
CHEMBL48786344560587BindingDB-show
CHEMBL48786444560588BindingDB-show
CHEMBL48786544560589BindingDB-show
CHEMBL48883344560639BindingDB-show
CHEMBL48883444560640BindingDB-show
CHEMBL48884025065806BindingDB-show
CHEMBL48898425068620BindingDB-show
CHEMBL48898525068624BindingDB-show
CHEMBL48919625068623BindingDB-show
CHEMBL48957925069284BindingDB-show
CHEMBL48978625068566BindingDB-show
CHEMBL49040725069339BindingDB-show
CHEMBL49040825069336BindingDB-show
CHEMBL49082325068622BindingDB-show
CHEMBL49123825068675BindingDB-show
CHEMBL49141825068568BindingDB-show
CHEMBL49142923658582BindingDB-show
CHEMBL49162825068511BindingDB-show
CHEMBL49226625130181BindingDB-show
CHEMBL49367011848309BindingDB-show
CHEMBL49367124854903BindingDB-show
CHEMBL49370824854902BindingDB-show
CHEMBL49407224963046BindingDB-show
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CHEMBL49427225129830BindingDB-show
CHEMBL49446911848825BindingDB-show
CHEMBL49447025129831BindingDB-show
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CHEMBL49533011848567BindingDB-show
CHEMBL49649424879307BindingDB-show
CHEMBL49650524879366BindingDB-show
CHEMBL49671324879244BindingDB-show
CHEMBL49691624879310BindingDB-show
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CHEMBL49855724879308BindingDB-show
CHEMBL50539444560642BindingDB-show
CHEMBL50603324879309BindingDB-show
CHEMBL51133744588220BindingDB-show
CHEMBL51284044560451BindingDB-show
CHEMBL51952025069338BindingDB-show
CHEMBL52071844560641BindingDB-show
CHEMBL52178825068567BindingDB-show
CHEMBL52290524879184BindingDB-show
CHEMBL52337425181502BindingDB-show
CHEMBL52374124879306BindingDB-show
CHEMBL52381625068621BindingDB-show
CHEMBL52574424879367BindingDB-show
CHEMBL52589324879368BindingDB-show
CHEMBL55870845273507BindingDB-show
CHEMBL56536610006987BindingDB-show
CHEMBL56537210071040BindingDB-show
CHEMBL56558710458235BindingDB-show
CHEMBL56560945487959BindingDB-show
CHEMBL56580110095463BindingDB-show
CHEMBL56663510345191BindingDB-show
CHEMBL56663610070245BindingDB-show
CHEMBL56683410413666BindingDB-show
CHEMBL56685010366675BindingDB-show
CHEMBL5670689805421BindingDB-show
CHEMBL56988024883334BindingDB-show
CHEMBL57017510029735BindingDB-show
CHEMBL57104024883287BindingDB-show
CHEMBL57458845482700BindingDB-show
CHEMBL57461345482750BindingDB-show
CHEMBL57592544622967BindingDB-show
CHEMBL57621845487992BindingDB-show
CHEMBL57726910454329BindingDB-show
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CHEMBL58566645487997BindingDB-show
CHEMBL59749246231220BindingDB-show
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CHEMBL59862646228822BindingDB-show
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CHEMBL60471210429593BindingDB-show
CHEMBL60595746231221BindingDB-show
CHEMBL60616846231219BindingDB-show
CHEMBL997439911005BindingDB-show
CHIR-2589886808BindingDB-show
CHIR-26511656518BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Dasatinib3062316DrugBank-show
Doramapimod156422BindingDB-show
Ellipticine3213BindingDB-show
Elliptinium42723BindingDB-show
epihematoxylol24949852BindingDB-show
Erlotinib176870BindingDB-show
Flt-3 Inhibitor II11601743BindingDB-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
Haematoxylin442514BindingDB-show
hematoxylene24949856BindingDB-show
hematoxylone44578561BindingDB-show
Hydroxyellipticine91643BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
Imatinib Methansulfonate5291DrugBank-show
Imatinib Methansulfonate5291SuperTarget2 PMIDsshow
Kinome_219911407183BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_291844444843BindingDB-show
Kinome_46111749082BindingDB-show
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lfm-a139549280BindingDB-show
Methoxyellipticine72512BindingDB-show
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nchembio.90-comp111715767BindingDB-show
Neuro_00015872035BindingDB-show
Nilotinib644241BindingDB-show
NSC735424447700BindingDB-show
NVP-AEW54145270897BindingDB-show
NVP-TAE68416038120BindingDB-show
Pazopanib10113978BindingDB-show
PD1739565330524BindingDB-show
Phosphonotyrosine30819DrugBank-show
PI-1039884685BindingDB-show
PKC-41224202429BindingDB-show
PKC-4129829523BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1363_Selleck11317348BindingDB-show
S1526_Selleck24889392BindingDB-show
Saracatinib10302451BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
Semaxinib5329098BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
sorafenibum216239DrugBank-show
STAUROSPORINE44259BindingDB-show
staurosporine451705BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Sunitinib5329102DrugBank-show
Tandutinib3038522BindingDB-show
Thienopyrimidine deriv. 106539988BindingDB-show
Thienopyrimidine deriv. 116539972BindingDB-show
Thienopyrimidine deriv. 136539990BindingDB-show
Thienopyrimidine deriv. 146539991BindingDB-show
Thienopyrimidine deriv. 156539992BindingDB-show
Thienopyrimidine deriv. 186539995BindingDB-show
Thienopyrimidine deriv. 196539996BindingDB-show
Thienopyrimidine deriv. 206539997BindingDB-show
Thienopyrimidine deriv. 216539998BindingDB-show
Thienopyrimidine deriv. 236540000BindingDB-show
Thienopyrimidine deriv. 246540001BindingDB-show
Thienopyrimidine deriv. 266540003BindingDB-show
Thienopyrimidine deriv. 276540004BindingDB-show
Thienopyrimidine deriv. 286540005BindingDB-show
Thienopyrimidine deriv. 516540006BindingDB-show
Thienopyrimidine deriv. 526540007BindingDB-show
Thienopyrimidine deriv. 536540008BindingDB-show
Thienopyrimidine deriv. 596540009BindingDB-show
Thienopyrimidine deriv. 606540010BindingDB-show
Thienopyrimidine deriv. 766539985BindingDB-show
Thienopyrimidine deriv. 796540012BindingDB-show
Thienopyrimidine deriv. 836540016BindingDB-show
Thienopyrimidine deriv. 856540018BindingDB-show
Thienopyrimidine deriv. 876540020BindingDB-show
Thienopyrimidine deriv. 886540021BindingDB-show
Thienopyrimidine deriv. 906540023BindingDB-show
Thienopyrimidine deriv. 916540024BindingDB-show
Thienopyrimidine deriv. 926540025BindingDB-show
Thienopyrimidine deriv. 936540026BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
Vatalanib succinate151193BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
c-kit
CD117
Mast/stem cell growth factor receptor
Proto-oncogene tyrosine-protein kinase Kit
SCFR
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
Q6IQ28_HUMAN99.999.8
CSF1R_HUMAN54.139.5
FLT3_HUMAN46.930.8
PGFRA_HUMAN4531.4
PGFRB_HUMAN44.130.6
FGFR1_HUMAN39.926.4
FGFR1_MOUSE39.626.4
FGFR2_HUMAN39.425.2
Q99052_MOUSE3924.9
FGFR3_HUMAN38.424.7
VGFR1_HUMAN38.224.7
FGFR4_HUMAN37.725.8
VGFR3_HUMAN37.524.7
VGFR2_HUMAN35.723.3
RET_HUMAN34.823
NTRK1_HUMAN34.723.3
Q6P4H5_HUMAN33.622.4
BRAF_HUMAN32.719.5
Q59F04_HUMAN32.423.2
SYI1_STAAU31.917.8
TYRO3_HUMAN31.419.3
HYSA_STRA33117.4
SYMC_HUMAN30.716.7
Q68DE6_HUMAN30.317.1
PDE5A_HUMAN30.117.2
PPDK_CLOSY29.716.1
Q59GM9_HUMAN29.416.3
PDE5A_BOVIN29.317
NMD3A_HUMAN29.316.5
DDR1_HUMAN29.218.4
Protein-Protein Interactions: