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Target Details

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Name:JAK-2
Uniprot name:JAK2_HUMAN
Accession Numbers:O14636 O60674 O75297
EC-Number:2.7.10.2
Organism:Homo sapiens
Human
PDB IDs:2B7A 2W1I 3E62 3E63 3E64 3FUP
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
5-bromo-1H-indazol-3-amine817910BindingDB-show
5-phenyl-1H-indazol-3-amine11492186BindingDB-show
6-bromo-1H-indazol-3-amine2786631BindingDB-show
6-phenyl-1H-indazol-3-amine11658542BindingDB-show
7PY11957393BindingDB-show
ABT-86911485656BindingDB-show
AC1NV8WC5473838BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Bio2_0004136610353BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:65304644419562BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEBI:67937245486164BindingDB-show
CHEMBL1040749796455BindingDB-show
CHEMBL107622146879483BindingDB-show
CHEMBL107670046880785BindingDB-show
CHEMBL107672122353185BindingDB-show
CHEMBL107743146882362BindingDB-show
CHEMBL107745824877326BindingDB-show
CHEMBL107757525062228BindingDB-show
CHEMBL107784146882802BindingDB-show
CHEMBL107784225063021BindingDB-show
CHEMBL107800525059112BindingDB-show
CHEMBL107815925062765BindingDB-show
CHEMBL107816525062226BindingDB-show
CHEMBL107816625060146BindingDB-show
CHEMBL107822825059626BindingDB-show
CHEMBL107822925061949BindingDB-show
CHEMBL107827425061685BindingDB-show
CHEMBL107827546882470BindingDB-show
CHEMBL107827646882471BindingDB-show
CHEMBL107827746882472BindingDB-show
CHEMBL107836325062498BindingDB-show
CHEMBL107836425060927BindingDB-show
CHEMBL107837025063023BindingDB-show
CHEMBL107845325061950BindingDB-show
CHEMBL107868846882539BindingDB-show
CHEMBL107868946882540BindingDB-show
CHEMBL107872025063025BindingDB-show
CHEMBL107872125061435BindingDB-show
CHEMBL107876746882541BindingDB-show
CHEMBL107886646882542BindingDB-show
CHEMBL107888946882590BindingDB-show
CHEMBL107893346882803BindingDB-show
CHEMBL107893425060922BindingDB-show
CHEMBL107897146882589BindingDB-show
CHEMBL107898425062767BindingDB-show
CHEMBL107907746882591BindingDB-show
CHEMBL107907846882592BindingDB-show
CHEMBL107912025060677BindingDB-show
CHEMBL107912125059891BindingDB-show
CHEMBL107952346879420BindingDB-show
CHEMBL107952446879421BindingDB-show
CHEMBL107952546879422BindingDB-show
CHEMBL107952646879423BindingDB-show
CHEMBL107959345375955BindingDB-show
CHEMBL107959445375956BindingDB-show
CHEMBL107968946882360BindingDB-show
CHEMBL107969046882361BindingDB-show
CHEMBL108011046879484BindingDB-show
CHEMBL108011146879485BindingDB-show
CHEMBL108015946865431BindingDB-show
CHEMBL108032246880193BindingDB-show
CHEMBL108032346880194BindingDB-show
CHEMBL108033246880196BindingDB-show
CHEMBL108033346880197BindingDB-show
CHEMBL108039446882359BindingDB-show
CHEMBL108039525061438BindingDB-show
CHEMBL108041146882412BindingDB-show
CHEMBL108090246865325BindingDB-show
CHEMBL108095446882409BindingDB-show
CHEMBL108095546882410BindingDB-show
CHEMBL108113846882411BindingDB-show
CHEMBL108119011951225BindingDB-show
CHEMBL108129024800423BindingDB-show
CHEMBL108129124800604BindingDB-show
CHEMBL108129224800602BindingDB-show
CHEMBL108137646879545BindingDB-show
CHEMBL108137711844913BindingDB-show
CHEMBL108137846879546BindingDB-show
CHEMBL108137945375954BindingDB-show
CHEMBL108144324801650BindingDB-show
CHEMBL108148546880738BindingDB-show
CHEMBL108166346880739BindingDB-show
CHEMBL108166446865657BindingDB-show
CHEMBL108184646880195BindingDB-show
CHEMBL108197524800776BindingDB-show
CHEMBL108197646880686BindingDB-show
CHEMBL108197724801129BindingDB-show
CHEMBL108197846880687BindingDB-show
CHEMBL108202246865430BindingDB-show
CHEMBL108202346880784BindingDB-show
CHEMBL108551124762205BindingDB-show
CHEMBL108673646880951BindingDB-show
CHEMBL108723546880119BindingDB-show
CHEMBL108723646880120BindingDB-show
CHEMBL108726925102935BindingDB-show
CHEMBL108789825171662BindingDB-show
CHEMBL108803025104741BindingDB-show
CHEMBL108842346880121BindingDB-show
CHEMBL108842446880122BindingDB-show
CHEMBL108885625123475BindingDB-show
CHEMBL108885725123807BindingDB-show
CHEMBL108977346865529BindingDB-show
CHEMBL108981346885231BindingDB-show
CHEMBL108981446885232BindingDB-show
CHEMBL108981546885234BindingDB-show
CHEMBL108983325123806BindingDB-show
CHEMBL109119046885052BindingDB-show
CHEMBL109119146885053BindingDB-show
CHEMBL109156525123154BindingDB-show
CHEMBL109206346885233BindingDB-show
CHEMBL109258825123474BindingDB-show
CHEMBL109284046885289BindingDB-show
CHEMBL109292546865530BindingDB-show
CHEMBL109292646398810BindingDB-show
CHEMBL109311946885290BindingDB-show
CHEMBL109319125123155BindingDB-show
CHEMBL109345425123808BindingDB-show
CHEMBL109346825123472BindingDB-show
CHEMBL109374925128110BindingDB-show
CHEMBL122163346934144BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL124297746929544BindingDB-show
CHEMBL124320046929748BindingDB-show
CHEMBL124332646929857BindingDB-show
CHEMBL125891311847343BindingDB-show
CHEMBL127023024809764BindingDB-show
CHEMBL127039946868971BindingDB-show
CHEMBL128781252944839BindingDB-show
CHEMBL128785450878566BindingDB-show
CHEMBL128788352947304BindingDB-show
CHEMBL128791052942437BindingDB-show
CHEMBL128794052941228BindingDB-show
CHEMBL128794152948526BindingDB-show
CHEMBL128800152943663BindingDB-show
CHEMBL128800252948550BindingDB-show
CHEMBL128803252948562BindingDB-show
CHEMBL128806252943672BindingDB-show
CHEMBL128872052944434BindingDB-show
CHEMBL128909525096020BindingDB-show
CHEMBL128909625096279BindingDB-show
CHEMBL128909750925513BindingDB-show
CHEMBL128921652942701BindingDB-show
CHEMBL128921752942702BindingDB-show
CHEMBL128921825096016BindingDB-show
CHEMBL128999152941200BindingDB-show
CHEMBL128999252948490BindingDB-show
CHEMBL129008952949754BindingDB-show
CHEMBL129009052942449BindingDB-show
CHEMBL129019652949761BindingDB-show
CHEMBL129019752947324BindingDB-show
CHEMBL129030852941284BindingDB-show
CHEMBL129030952949798BindingDB-show
CHEMBL129031052946111BindingDB-show
CHEMBL129042352947390BindingDB-show
CHEMBL129042425096277BindingDB-show
CHEMBL129053325096276BindingDB-show
CHEMBL129053425097027BindingDB-show
CHEMBL129065025096532BindingDB-show
CHEMBL129065152948678BindingDB-show
CHEMBL129076752946313BindingDB-show
CHEMBL129076852947547BindingDB-show
CHEMBL129076925096019BindingDB-show
CHEMBL18514016723801BindingDB-show
CHEMBL21793744419532BindingDB-show
CHEMBL21843944419475BindingDB-show
CHEMBL21857944419559BindingDB-show
CHEMBL21860244419499BindingDB-show
CHEMBL21874644419498BindingDB-show
CHEMBL22048344419524BindingDB-show
CHEMBL22048444419547BindingDB-show
CHEMBL22058544419523BindingDB-show
CHEMBL22096944419544BindingDB-show
CHEMBL22102944419491BindingDB-show
CHEMBL22103744419485BindingDB-show
CHEMBL22103844419522BindingDB-show
CHEMBL22137644419528BindingDB-show
CHEMBL22137844419556BindingDB-show
CHEMBL22191216126645BindingDB-show
CHEMBL22197644419492BindingDB-show
CHEMBL22202744419493BindingDB-show
CHEMBL22202844419527BindingDB-show
CHEMBL23173344432185BindingDB-show
CHEMBL23192544432193BindingDB-show
CHEMBL23194844432187BindingDB-show
CHEMBL23194944432188BindingDB-show
CHEMBL23214716664854BindingDB-show
CHEMBL23214944432191BindingDB-show
CHEMBL23315144432177BindingDB-show
CHEMBL23355544432180BindingDB-show
CHEMBL23396944432183BindingDB-show
CHEMBL24635617748275BindingDB-show
CHEMBL24746811684933BindingDB-show
CHEMBL24786611626406BindingDB-show
CHEMBL25329224882503BindingDB-show
CHEMBL31955623532567BindingDB-show
CHEMBL3239949947841BindingDB-show
CHEMBL37352344419516BindingDB-show
CHEMBL37432144419533BindingDB-show
CHEMBL37485444419515BindingDB-show
CHEMBL37507644419526BindingDB-show
CHEMBL37520544419548BindingDB-show
CHEMBL37529644419474BindingDB-show
CHEMBL37688544419481BindingDB-show
CHEMBL38482044419502BindingDB-show
CHEMBL38511444419478BindingDB-show
CHEMBL39109644432184BindingDB-show
CHEMBL39149244432179BindingDB-show
CHEMBL39237144432192BindingDB-show
CHEMBL39299844432190BindingDB-show
CHEMBL39337544432189BindingDB-show
CHEMBL39417444432182BindingDB-show
CHEMBL44767044570436BindingDB-show
CHEMBL45542811675054BindingDB-show
CHEMBL45787125180101BindingDB-show
CHEMBL45976920111936BindingDB-show
CHEMBL46216811398307BindingDB-show
CHEMBL47581711626920BindingDB-show
CHEMBL47961944570386BindingDB-show
CHEMBL47962044570387BindingDB-show
CHEMBL47983044570474BindingDB-show
CHEMBL48041124963047BindingDB-show
CHEMBL48041244570437BindingDB-show
CHEMBL48060644570438BindingDB-show
CHEMBL48099844570435BindingDB-show
CHEMBL48158344570391BindingDB-show
CHEMBL48158444570388BindingDB-show
CHEMBL48158544570392BindingDB-show
CHEMBL48198511601868BindingDB-show
CHEMBL48218744570476BindingDB-show
CHEMBL48218844570477BindingDB-show
CHEMBL48218925181422BindingDB-show
CHEMBL49316944219632BindingDB-show
CHEMBL49422144219633BindingDB-show
CHEMBL49885944570390BindingDB-show
CHEMBL51064144570389BindingDB-show
CHEMBL51927944570434BindingDB-show
CHEMBL52094744570475BindingDB-show
CHEMBL55157045272300BindingDB-show
CHEMBL56024545267171BindingDB-show
CHEMBL56308045273165BindingDB-show
CHEMBL56325745273175BindingDB-show
CHEMBL56355545272290BindingDB-show
CHEMBL56436545267176BindingDB-show
CHEMBL56879045486163BindingDB-show
CHEMBL56881544158660BindingDB-show
CHEMBL56881644159594BindingDB-show
CHEMBL56886645486119BindingDB-show
CHEMBL56901244159711BindingDB-show
CHEMBL56909145486120BindingDB-show
CHEMBL56909245486121BindingDB-show
CHEMBL56972045375974BindingDB-show
CHEMBL56972145486136BindingDB-show
CHEMBL56973745486106BindingDB-show
CHEMBL56973825171663BindingDB-show
CHEMBL56973944160079BindingDB-show
CHEMBL56975745486113BindingDB-show
CHEMBL56994845486138BindingDB-show
CHEMBL56995745486139BindingDB-show
CHEMBL56996645486142BindingDB-show
CHEMBL57000225171665BindingDB-show
CHEMBL57019245486168BindingDB-show
CHEMBL57020644158549BindingDB-show
CHEMBL57021744159001BindingDB-show
CHEMBL57022944158886BindingDB-show
CHEMBL57023045486157BindingDB-show
CHEMBL57023145486158BindingDB-show
CHEMBL57045645486159BindingDB-show
CHEMBL57046245486130BindingDB-show
CHEMBL57046425171664BindingDB-show
CHEMBL57066845486109BindingDB-show
CHEMBL57068644159590BindingDB-show
CHEMBL57089042641406BindingDB-show
CHEMBL57089925171661BindingDB-show
CHEMBL57111845486147BindingDB-show
CHEMBL57111945486148BindingDB-show
CHEMBL57152645486169BindingDB-show
CHEMBL57606825172086BindingDB-show
CHEMBL57625725171666BindingDB-show
CHEMBL57627245486137BindingDB-show
CHEMBL57628625171877BindingDB-show
CHEMBL57647544159959BindingDB-show
CHEMBL57647644158553BindingDB-show
CHEMBL57648645486124BindingDB-show
CHEMBL57686245486170BindingDB-show
CHEMBL57794445486118BindingDB-show
CHEMBL57819425171876BindingDB-show
CHEMBL57820145486156BindingDB-show
CHEMBL57897445483929BindingDB-show
CHEMBL58280844158658BindingDB-show
CHEMBL58303044159962BindingDB-show
CHEMBL58310545483928BindingDB-show
CHEMBL58389544160207BindingDB-show
CHEMBL58405244605611BindingDB-show
CHEMBL58432244159839BindingDB-show
CHEMBL58494444159000BindingDB-show
CHEMBL58552745486129BindingDB-show
CHEMBL58592744622837BindingDB-show
CHEMBL58914546224911BindingDB-show
CHEMBL58914646224939BindingDB-show
CHEMBL58938546224940BindingDB-show
CHEMBL58938746224971BindingDB-show
CHEMBL58963244605608BindingDB-show
CHEMBL58963346224997BindingDB-show
CHEMBL58963446224998BindingDB-show
CHEMBL58986946224936BindingDB-show
CHEMBL59085425132023BindingDB-show
CHEMBL59109525132384BindingDB-show
CHEMBL59109646224796BindingDB-show
CHEMBL59180025130693BindingDB-show
CHEMBL59203325129655BindingDB-show
CHEMBL59203446224837BindingDB-show
CHEMBL59203525129311BindingDB-show
CHEMBL59226925128955BindingDB-show
CHEMBL59227025130695BindingDB-show
CHEMBL59252025132389BindingDB-show
CHEMBL59468625130691BindingDB-show
CHEMBL59468746225316BindingDB-show
CHEMBL59530525132390BindingDB-show
CHEMBL59539646225269BindingDB-show
CHEMBL59539746225270BindingDB-show
CHEMBL59562646225315BindingDB-show
CHEMBL59991146224835BindingDB-show
CHEMBL59991225128956BindingDB-show
CHEMBL60056225131681BindingDB-show
CHEMBL60087425132021BindingDB-show
CHEMBL60087525128951BindingDB-show
CHEMBL60126846224970BindingDB-show
CHEMBL60130325131017BindingDB-show
CHEMBL60171825131018BindingDB-show
CHEMBL60192525132729BindingDB-show
CHEMBL60210046224972BindingDB-show
CHEMBL60218346224797BindingDB-show
CHEMBL60264825132733BindingDB-show
CHEMBL60278825131021BindingDB-show
CHEMBL60284246224910BindingDB-show
CHEMBL60304846224937BindingDB-show
CHEMBL60343225132387BindingDB-show
CHEMBL60348246228648BindingDB-show
CHEMBL60403746224912BindingDB-show
CHEMBL60403846224913BindingDB-show
CHEMBL60424546224836BindingDB-show
CHEMBL60424646224876BindingDB-show
CHEMBL60427425132388BindingDB-show
CHEMBL60448125132730BindingDB-show
CHEMBL60457846224938BindingDB-show
CHEMBL60469525132025BindingDB-show
CHEMBL60471210429593BindingDB-show
CHEMBL60635525133399BindingDB-show
CHEMBL60899925130358BindingDB-show
CHIR-26511656518BindingDB-show
CID 1149662911696609BindingDB-show
CID 99267919818231BindingDB-show
CID 99267919966538BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
IKK-2 Inhibitor IV9903786BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
JAK Inhibitor I5494425BindingDB-show
JAK Inhibitor I5494425DrugBank-show
JAK3 Inhibitor I3794BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_291844444843BindingDB-show
Kinome_71446886323BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
MASTPROM3795BindingDB-show
MLN805411712649BindingDB-show
nchembio.117-comp91400BindingDB-show
NVP-TAE68416038120BindingDB-show
Pazopanib10113978BindingDB-show
Pelitinib6445562BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
S2219_Selleck25062766BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Tg-10134816722836BindingDB-show
Tyrphostin B425328779BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
JAK-2
Janus kinase 2
Tyrosine-protein kinase JAK2
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
JAK2_RAT97.394.6
JAK3_HUMAN65.948.1
JAK3_MOUSE6447
JAK3_RAT63.347.1
P93098_CERPU33.719.5
KINH_NEUCR31.317.6
PK3CD_MOUSE30.918.3
IGF1R_HUMAN30.817.5
PK3CD_HUMAN30.518.5
SYI1_STAAU30.415
EPHA2_HUMAN30.318.4
VGFR1_HUMAN30.118
PLD1_HUMAN29.916.2
MET_HUMAN29.918.5
RAD50_PYRFU29.818.2
TETX_CLOTE29.817.5
SYIM_HUMAN29.516.7
SYI_THET829.517
PK3CB_HUMAN29.116.6
PK3CB_MOUSE28.816.4
SYI_ECOLI28.715.8
DPOD_CANAL28.616
MYOE_DICDI28.416
ODO1_HUMAN28.315.9
HXK1_HUMAN28.316
AASS_HUMAN2816.3
FLT3_HUMAN2817.2
NTRK1_HUMAN2817.9
AMD_HUMAN2815.6
TRI_THEAC2816.9
Protein-Protein Interactions: