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Target Details

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Name:I-kappa-B kinase 2
Uniprot name:IKKB_HUMAN
Accession Numbers:O14920 O75327
EC-Number:2.7.11.10
Organism:Homo sapiens
Human
PDB IDs:3BRT 3BRV
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2-amino-5-phenyl-benzamide11600944BindingDB-show
2-aminoquinoline-3-carboxamide5200228BindingDB-show
3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide613528BindingDB-show
3-amino-6-methylthieno[2,3-b]pyridine-2-carboxamide765847BindingDB-show
3-aminothieno[2,3-b]pyridine-2-carboxamide359052BindingDB-show
4-(2′-Aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline9813758BindingDB-show
4622461146224611BindingDB-show
4622461246224612BindingDB-show
5-amino-2-(2-methylphenyl)-1,3-oxazole-4-carboxamide11672971BindingDB-show
5-amino-2-(4-methylphenyl)-1,3-oxazole-4-carboxamide11543063BindingDB-show
63339016333901DrugBank-show
7-alkoxyisoquinoline, 1642618139BindingDB-show
7-alkoxyisoquinoline, 1742618140BindingDB-show
7-alkoxyisoquinoline, 1842618141BindingDB-show
7-alkoxyisoquinoline, 1942618142BindingDB-show
7-alkoxyisoquinoline, 2042618143BindingDB-show
7-alkoxyisoquinoline, 2142618144BindingDB-show
7-alkoxyisoquinoline, 2242618145BindingDB-show
7-alkoxyisoquinoline, 2342618146BindingDB-show
7-alkoxyisoquinoline, 2442618147BindingDB-show
7-alkoxyisoquinoline, 2542618148BindingDB-show
7-alkoxyisoquinoline, 2642618149BindingDB-show
7-alkoxyisoquinoline, 2742618150BindingDB-show
7-alkoxyisoquinoline, 2842618151BindingDB-show
7-alkoxyisoquinoline, 2942618152BindingDB-show
7-alkoxyisoquinoline, 3042618153BindingDB-show
7-alkoxyisoquinoline, 3142618154BindingDB-show
7-alkoxyisoquinoline, 3242618155BindingDB-show
7-alkoxyisoquinoline, 3342618156BindingDB-show
7-alkoxyisoquinoline, 3442618157BindingDB-show
7-alkoxyisoquinoline, 3542618158BindingDB-show
7-alkoxyisoquinoline, 3642618159BindingDB-show
7-alkoxyisoquinoline, 3742618160BindingDB-show
7-alkoxyisoquinoline, 3842618161BindingDB-show
7-alkoxyisoquinoline, 3942618162BindingDB-show
AC1LGIJV821974BindingDB-show
AC1MZJ9W3848929BindingDB-show
AC1O0KUY6043769BindingDB-show
ACHP10451420BindingDB-show
Amino-substituted diarylbenzamide, 8t16047973BindingDB-show
Amino-substituted diarylbenzamide, 8u16047852BindingDB-show
Amino-substituted diarylbenzamide, 8v16047740BindingDB-show
Amino-substituted diarylbenzamide, 8w16047851BindingDB-show
Amino-substituted diarylbenzamide, 8x16047853BindingDB-show
Amino-substituted diarylbenzamide, 8y16047743BindingDB-show
Arsentrioxide518740DrugBank-show
Arsentrioxide14888DrugBank-show
Arthrocine1548887SuperTargetPMID 015033733show
BAS 003973715720657BindingDB-show
benzyloxyisoquinoline, 642618163BindingDB-show
benzyloxyisoquinoline, 742618164BindingDB-show
CHEBI:64872244382921BindingDB-show
CHEBI:64879044384500BindingDB-show
CHEBI:64879944383679BindingDB-show
CHEBI:64880544384373BindingDB-show
CHEBI:64881044382917BindingDB-show
CHEBI:65268144383045BindingDB-show
CHEBI:65295344384426BindingDB-show
CHEMBL108251111667571BindingDB-show
CHEMBL108251246871628BindingDB-show
CHEMBL108283446890183BindingDB-show
CHEMBL108317546890284BindingDB-show
CHEMBL108317646890285BindingDB-show
CHEMBL108348246890286BindingDB-show
CHEMBL108348346890287BindingDB-show
CHEMBL108408846890256BindingDB-show
CHEMBL108408946890257BindingDB-show
CHEMBL108417411568801BindingDB-show
CHEMBL108434546890182BindingDB-show
CHEMBL108434611559659BindingDB-show
CHEMBL108436146871625BindingDB-show
CHEMBL108462846890255BindingDB-show
CHEMBL108486311558904BindingDB-show
CHEMBL108497046890318BindingDB-show
CHEMBL108512146890213BindingDB-show
CHEMBL108512211719652BindingDB-show
CHEMBL108530846890388BindingDB-show
CHEMBL108530946890389BindingDB-show
CHEMBL108531046890390BindingDB-show
CHEMBL108565446890319BindingDB-show
CHEMBL108571046890387BindingDB-show
CHEMBL108588046890320BindingDB-show
CHEMBL108588146871627BindingDB-show
CHEMBL108608746890212BindingDB-show
CHEMBL108635746890317BindingDB-show
CHEMBL108739724884503BindingDB-show
CHEMBL108765046880136BindingDB-show
CHEMBL108870446222244BindingDB-show
CHEMBL108908224822704BindingDB-show
CHEMBL109014346865419BindingDB-show
CHEMBL109440824993189BindingDB-show
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CHEMBL122247449864785BindingDB-show
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CHEMBL122263549864894BindingDB-show
CHEMBL122263649864895BindingDB-show
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CHEMBL122285149865034BindingDB-show
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CHEMBL122328649865383BindingDB-show
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CHEMBL17305010295268BindingDB-show
CHEMBL17311144383504BindingDB-show
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CHEMBL19360125138000BindingDB-show
CHEMBL19393925137993BindingDB-show
CHEMBL19396625137999BindingDB-show
CHEMBL19411025137997BindingDB-show
CHEMBL19494125137988BindingDB-show
CHEMBL19578025137990BindingDB-show
CHEMBL19665325138002BindingDB-show
CHEMBL19665925138006BindingDB-show
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CHEMBL19720725138005BindingDB-show
CHEMBL19725225138001BindingDB-show
CHEMBL19735825137991BindingDB-show
CHEMBL19740525137996BindingDB-show
CHEMBL19741411438476BindingDB-show
CHEMBL19983744406565BindingDB-show
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CHEMBL20689611507891BindingDB-show
CHEMBL20696111579568BindingDB-show
CHEMBL20698511608384BindingDB-show
CHEMBL20703411658697BindingDB-show
CHEMBL20711311702815BindingDB-show
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CHEMBL20717311651984BindingDB-show
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CHEMBL21971125190913BindingDB-show
CHEMBL21989925190912BindingDB-show
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CHEMBL37191125138004BindingDB-show
CHEMBL37196744406386BindingDB-show
CHEMBL37216044406581BindingDB-show
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CHEMBL37273644406634BindingDB-show
CHEMBL37375111626927BindingDB-show
CHEMBL37578711625181BindingDB-show
CHEMBL37792811608743BindingDB-show
CHEMBL37932711615418BindingDB-show
CHEMBL38007311680280BindingDB-show
CHEMBL38104144406549BindingDB-show
CHEMBL38119325137998BindingDB-show
CHEMBL38190711631150BindingDB-show
CHEMBL38193211499932BindingDB-show
CHEMBL38242111658724BindingDB-show
CHEMBL38275244406468BindingDB-show
CHEMBL38276511701554BindingDB-show
CHEMBL38294544406586BindingDB-show
CHEMBL38306111702259BindingDB-show
CHEMBL38348211507173BindingDB-show
CHEMBL38362011550651BindingDB-show
CHEMBL38372311651993BindingDB-show
CHEMBL38803325190920BindingDB-show
CHEMBL38908625190928BindingDB-show
CHEMBL38974544427519BindingDB-show
CHEMBL39020120767724BindingDB-show
CHEMBL39287623661564BindingDB-show
CHEMBL39700816048085BindingDB-show
CHEMBL39700916047968BindingDB-show
CHEMBL39766825190925BindingDB-show
CHEMBL41165944353885BindingDB-show
CHEMBL42400044383296BindingDB-show
CHEMBL42406944353954BindingDB-show
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CHEMBL42534620585251BindingDB-show
CHEMBL42588344393011BindingDB-show
CHEMBL42640310203693BindingDB-show
CHEMBL42700825138003BindingDB-show
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CHEMBL43356520585286BindingDB-show
CHEMBL43469144383461BindingDB-show
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CHEMBL44434544383326BindingDB-show
CHEMBL44593125137994BindingDB-show
CHEMBL44760321083902BindingDB-show
CHEMBL45083525263293BindingDB-show
CHEMBL45447025263284BindingDB-show
CHEMBL45497321083895BindingDB-show
CHEMBL4621349826896BindingDB-show
CHEMBL47361911348603BindingDB-show
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CHEMBL47781724766030BindingDB-show
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CID 1000796011757505BindingDB-show
CID 1000796010007960BindingDB-show
CID 29137335733794BindingDB-show
CID 98443209844320BindingDB-show
CID 998555010257503BindingDB-show
CID 99855509985550BindingDB-show
Cyanoquinoline, 1117759555BindingDB-show
Doramapimod156422BindingDB-show
Ertiprotafib157049BindingDB-show
IKK-2 Inhibitor IV9903786BindingDB-show
Imidazole salicylate37425SuperTarget2 PMIDsshow
imidazothienopyrazine, 13a10126159BindingDB-show
imidazothienopyrazine, 13b10215156BindingDB-show
imidazothienopyrazine, 13c25093427BindingDB-show
imidazothienopyrazine, 13d25093428BindingDB-show
imidazothienopyrazine, 13e25093429BindingDB-show
imidazothienopyrazine, 13f25093430BindingDB-show
imidazothienopyrazine, 13g25093431BindingDB-show
imidazothienopyrazine, 13h25093432BindingDB-show
imidazothienopyrazine, 13i25093433BindingDB-show
imidazothienopyrazine, 13j25093434BindingDB-show
imidazothienopyrazine, 14a25093435BindingDB-show
imidazothienopyrazine, 14b25093436BindingDB-show
imidazothienopyrazine, 14c25093437BindingDB-show
imidazothienopyrazine, 14d25093438BindingDB-show
imidazothienopyrazine, 14e25093439BindingDB-show
imidazothienopyrazine, 14f25093440BindingDB-show
imidazothienopyrazine, 14g25093441BindingDB-show
imidazothienopyrazine, 1820823998BindingDB-show
imidazothienopyrazine, 20a20823960BindingDB-show
imidazothienopyrazine, 20b20823959BindingDB-show
imidazothienopyrazine, 20c20824060BindingDB-show
imidazothienopyrazine, 20d20823982BindingDB-show
imidazothienopyrazine, 20e20823995BindingDB-show
imidazothienopyrazine, 20f25093442BindingDB-show
imidazothienopyrazine, 20g20823986BindingDB-show
imidazothienopyrazine, 20h20823975BindingDB-show
imidazothienopyrazine, 20i20823993BindingDB-show
imidazothienopyrazine, 21a20824041BindingDB-show
imidazothienopyrazine, 21b20823920BindingDB-show
imidazothienopyrazine, 22a25093443BindingDB-show
imidazothienopyrazine, 22b25093444BindingDB-show
imidazothienopyrazine, 22c25093445BindingDB-show
imidazothienopyrazine, 22d25093446BindingDB-show
imidazothienopyrazine, 22e25093447BindingDB-show
imidazothienopyrazine, 22f25093448BindingDB-show
imidazothienopyrazine, 22g25093449BindingDB-show
imidazothienopyrazine, 22h25093450BindingDB-show
imidazothienopyrazine, 22i25093451BindingDB-show
imidazothienopyrazine, 22j23657350BindingDB-show
imidazothienopyrazine, 22k25093452BindingDB-show
imidazothienopyrazine, 22l20823956BindingDB-show
imidazothienopyrazine, 22m20823952BindingDB-show
imidazothienopyrazine, 22n25093453BindingDB-show
imidazothienopyrazine, 22o25093454BindingDB-show
imidazothienopyrazine, 22p25093455BindingDB-show
imidazothienopyrazine, 22q25093456BindingDB-show
imidazothienopyrazine, 22r25093457BindingDB-show
imidazothienopyrazine, 22s25093458BindingDB-show
imidazothienopyrazine, 22t25093459BindingDB-show
imidazothienopyrazine, 22u25093460BindingDB-show
InSolution™ IKK-2 Inhibitor, SC-5142807869BindingDB-show
JAK Inhibitor I5494425BindingDB-show
JNK Inhibitor V11422035BindingDB-show
K00596a9549298BindingDB-show
Kinome_26559952773BindingDB-show
Kinome_291844444843BindingDB-show
L2G9549184BindingDB-show
Lestaurtinib126565BindingDB-show
Maybridge1_0039374278270BindingDB-show
methyl 3-amino-5-phenylthiophene-2-carboxylate700562BindingDB-show
MLS000036657661437BindingDB-show
Morpholinium salicylate120183SuperTarget2 PMIDsshow
NCGC00165873-019949093BindingDB-show
nchembio.90-comp111715767BindingDB-show
O-substituted diarylbenzamide, 12c16047146BindingDB-show
Oprea1_46434013297340BindingDB-show
Orthohydroxybenzoic acid338SuperTarget2 PMIDsshow
PKC-4129829523BindingDB-show
pyrazolopurine, 3b25263282BindingDB-show
S1526_Selleck24889392BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
tetrahydro-benzodipyrazole deriv. 7a5331009BindingDB-show
trihydroxidoarsenic545SuperTarget-show
ZINC00087504703965BindingDB-show
ZINC00106876613585BindingDB-show
ZINC025397642756534BindingDB-show
ZINC025561192756390BindingDB-show
ZINC025650732782903BindingDB-show
Synonyms:
I-kappa-B kinase 2
I-kappa-B-kinase beta
IkBKB
IKK-B
IKK-beta
IKK2
Inhibitor of nuclear factor kappa-B kinase subunit beta
NFKBIKB
Nuclear factor NF-kappa-B inhibitor kinase beta
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
IKKA_HUMAN67.150.1
Q59GL9_HUMAN58.858.2
IKKE_HUMAN37.422.9
ENPL_HUMAN33.218.4
P85A_HUMAN33.117.5
LEF_BACAN32.819.2
RAD50_PYRFU32.217.4
Q9H4D1_HUMAN31.718.5
P5CS_HUMAN31.716.1
PFLB_ECOLI31.618.3
CTNA1_MOUSE31.416.5
Q8CHM5_MOUSE31.217.4
CAN1_HUMAN31.118.2
PERM_HUMAN30.917.5
KS6A5_HUMAN30.817.6
GCYB2_HUMAN30.817.7
DNLJ_ENTFA30.617.9
ABCB8_HUMAN30.617.9
KIF11_HUMAN30.615.9
LOX12_HUMAN30.518.9
KAT2B_HUMAN30.316.5
B5RQL8_BORRA3017.3
KCNH5_HUMAN29.915.8
Q59F19_HUMAN29.917.4
A3LMT4_PICST29.917.5
CAN1_RAT29.818.3
GSHR_PLAFK29.816.3
MASZ_ECOLI29.816.7
TRFE_ANAPL29.717.9
PHSM_ECOLI29.715.9
Protein-Protein Interactions:
Uniprot nameSource
TSC1_HUMANPMID 17693255
TRAF2_HUMAN2 PMIDs
TP4AP_HUMAN3 PMIDs
TNR1A_HUMAN4 PMIDs
TNAP3_HUMAN5 PMIDs
TLR3_HUMAN6 PMIDs
TIM50_HUMAN7 PMIDs
TGFR1_HUMAN8 PMIDs
TF65_HUMAN9 PMIDs
TCAM1_HUMAN10 PMIDs
TBK1_HUMAN11 PMIDs
TBB5_HUMAN12 PMIDs
TBB4_HUMAN13 PMIDs
TBB2B_HUMAN14 PMIDs
TBA3C_HUMAN15 PMIDs
TANK_HUMAN16 PMIDs
TAB1_HUMAN17 PMIDs
SYEP_HUMAN18 PMIDs
STAP2_HUMAN19 PMIDs
STAP2_HUMAN20 PMIDs
SMRC1_HUMAN21 PMIDs
RIPK1_HUMAN22 PMIDs
Q9UQC1_HUMAN23 PMIDs
Q96RR5_HUMAN24 PMIDs
PRKDC_HUMAN25 PMIDs
PRDX3_HUMAN26 PMIDs
PPM1B_HUMAN27 PMIDs
PEBP1_HUMAN28 PMIDs
PARP1_HUMAN29 PMIDs
NR2C2_HUMAN30 PMIDs
NFKB2_HUMAN31 PMIDs
NFKB1_HUMAN32 PMIDs
NEMO_HUMAN33 PMIDs
NEMO_HUMAN34 PMIDs
NCOA3_HUMAN35 PMIDs
MYH10_HUMAN36 PMIDs
MYD88_HUMAN37 PMIDs
MAVS_HUMAN38 PMIDs
MARK3_HUMAN39 PMIDs
M3K3_HUMAN40 PMIDs
M3K1_HUMAN41 PMIDs
M3K14_HUMAN42 PMIDs
M3K13_HUMAN43 PMIDs
M3K11_HUMAN44 PMIDs
LYSC_HUMAN45 PMIDs
KPCZ_HUMAN46 PMIDs
KPCB_HUMAN47 PMIDs
K1967_HUMAN48 PMIDs
IRS1_HUMAN49 PMIDs
IRAK1_HUMAN50 PMIDs
IQGA1_HUMAN51 PMIDs
IKKB_HUMAN52 PMIDs
IKBB_HUMAN53 PMIDs
IKBA_HUMAN54 PMIDs
IKBA_HUMAN55 PMIDs
HSP7C_HUMAN56 PMIDs
HSP71_HUMAN57 PMIDs
HS90B_HUMAN58 PMIDs
HS90A_HUMAN59 PMIDs
HS71L_HUMAN60 PMIDs
HNRPU_HUMAN61 PMIDs
GRP78_HUMAN62 PMIDs
GRP75_HUMAN63 PMIDs
FLNA_HUMAN64 PMIDs
FANCA_HUMAN65 PMIDs
ELP1_HUMAN66 PMIDs
E2AK3_HUMAN67 PMIDs
E2AK2_HUMAN68 PMIDs
CTNB1_HUMAN69 PMIDs
CSF2R_HUMAN70 PMIDs
CNTN2_HUMAN71 PMIDs
CLH1_HUMAN72 PMIDs
CIKS_HUMAN73 PMIDs
CFLAR_HUMAN74 PMIDs
CDC37_HUMAN75 PMIDs
CBP_HUMAN76 PMIDs
CASP8_HUMAN77 PMIDs
CALM_HUMAN78 PMIDs
C1QBP_HUMAN79 PMIDs
ARRB2_HUMAN80 PMIDs
ACVR1_HUMAN81 PMIDs
ACTG_HUMAN82 PMIDs
ACTB_HUMAN83 PMIDs
1433B_HUMAN84 PMIDs