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Name:Conserved helix-loop-helix ubiquitous kinase
Uniprot name:IKKA_HUMAN
Accession Numbers:O14666 O15111 Q13132 Q5W0I4 Q92467
EC-Number:2.7.11.10
Organism:Homo sapiens
Human
PDB IDs:3BRT
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2-amino-5-phenyl-benzamide11600944BindingDB-show
3-Amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide613528BindingDB-show
3-aminothieno[2,3-b]pyridine-2-carboxamide359052BindingDB-show
4-(2′-Aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline9813758BindingDB-show
6-Methoxy-9H-beta-carboline607775BindingDB-show
7-alkoxyisoquinoline, 1642618139BindingDB-show
7-alkoxyisoquinoline, 1742618140BindingDB-show
7-alkoxyisoquinoline, 1842618141BindingDB-show
7-alkoxyisoquinoline, 1942618142BindingDB-show
7-alkoxyisoquinoline, 2042618143BindingDB-show
7-alkoxyisoquinoline, 2142618144BindingDB-show
7-alkoxyisoquinoline, 2242618145BindingDB-show
7-alkoxyisoquinoline, 2342618146BindingDB-show
7-alkoxyisoquinoline, 2442618147BindingDB-show
7-alkoxyisoquinoline, 2542618148BindingDB-show
7-alkoxyisoquinoline, 2642618149BindingDB-show
7-alkoxyisoquinoline, 2742618150BindingDB-show
7-alkoxyisoquinoline, 2842618151BindingDB-show
7-alkoxyisoquinoline, 2942618152BindingDB-show
7-alkoxyisoquinoline, 3042618153BindingDB-show
7-alkoxyisoquinoline, 3142618154BindingDB-show
7-alkoxyisoquinoline, 3242618155BindingDB-show
7-alkoxyisoquinoline, 3342618156BindingDB-show
7-alkoxyisoquinoline, 3442618157BindingDB-show
7-alkoxyisoquinoline, 3542618158BindingDB-show
7-alkoxyisoquinoline, 3642618159BindingDB-show
7-alkoxyisoquinoline, 3742618160BindingDB-show
7-alkoxyisoquinoline, 3842618161BindingDB-show
7-alkoxyisoquinoline, 3942618162BindingDB-show
ACHP10451420BindingDB-show
Amino-substituted diarylbenzamide, 8t16047973BindingDB-show
Amino-substituted diarylbenzamide, 8u16047852BindingDB-show
Amino-substituted diarylbenzamide, 8v16047740BindingDB-show
Amino-substituted diarylbenzamide, 8w16047851BindingDB-show
Amino-substituted diarylbenzamide, 8x16047853BindingDB-show
Amino-substituted diarylbenzamide, 8y16047743BindingDB-show
benzyloxyisoquinoline, 642618163BindingDB-show
benzyloxyisoquinoline, 742618164BindingDB-show
Carbazoline64961BindingDB-show
CHEMBL108765046880136BindingDB-show
CHEMBL109275444541014BindingDB-show
CHEMBL109562644605035BindingDB-show
CHEMBL109562744605037BindingDB-show
CHEMBL122247449864785BindingDB-show
CHEMBL122256549864850BindingDB-show
CHEMBL122299046933384BindingDB-show
CHEMBL122299249865153BindingDB-show
CHEMBL122320324959046BindingDB-show
CHEMBL122320449865328BindingDB-show
CHEMBL122320749865330BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL12998144353955BindingDB-show
CHEMBL13051144353967BindingDB-show
CHEMBL13063144353953BindingDB-show
CHEMBL13086644353969BindingDB-show
CHEMBL13169344353995BindingDB-show
CHEMBL13241644354030BindingDB-show
CHEMBL13294244353987BindingDB-show
CHEMBL13347144354009BindingDB-show
CHEMBL13354844353996BindingDB-show
CHEMBL13382344354029BindingDB-show
CHEMBL13392844354000BindingDB-show
CHEMBL13394144353890BindingDB-show
CHEMBL13401044354001BindingDB-show
CHEMBL17305010295268BindingDB-show
CHEMBL1734849912932BindingDB-show
CHEMBL19983744406565BindingDB-show
CHEMBL19998044406564BindingDB-show
CHEMBL20010644406635BindingDB-show
CHEMBL20022944406419BindingDB-show
CHEMBL20046244406636BindingDB-show
CHEMBL20083244406379BindingDB-show
CHEMBL20094644406486BindingDB-show
CHEMBL20798711708263BindingDB-show
CHEMBL21580316046126BindingDB-show
CHEMBL23005516048084BindingDB-show
CHEMBL2301849922100BindingDB-show
CHEMBL23018510109125BindingDB-show
CHEMBL23027616047856BindingDB-show
CHEMBL23048815979284BindingDB-show
CHEMBL23059225190921BindingDB-show
CHEMBL23059516048308BindingDB-show
CHEMBL23059716048194BindingDB-show
CHEMBL23069916048543BindingDB-show
CHEMBL23080816048544BindingDB-show
CHEMBL23080916048414BindingDB-show
CHEMBL23081025190923BindingDB-show
CHEMBL23091116048415BindingDB-show
CHEMBL23091216047031BindingDB-show
CHEMBL23091316047033BindingDB-show
CHEMBL23101325190924BindingDB-show
CHEMBL2310369813880BindingDB-show
CHEMBL2310379900652BindingDB-show
CHEMBL23110816047147BindingDB-show
CHEMBL23112625190927BindingDB-show
CHEMBL23121116047150BindingDB-show
CHEMBL23152125190922BindingDB-show
CHEMBL23153016663529BindingDB-show
CHEMBL23162316048303BindingDB-show
CHEMBL2498999796523BindingDB-show
CHEMBL26888525190926BindingDB-show
CHEMBL2819579869943BindingDB-show
CHEMBL30926544317538BindingDB-show
CHEMBL30995321362698BindingDB-show
CHEMBL31017921362749BindingDB-show
CHEMBL31097511414735BindingDB-show
CHEMBL31130644317865BindingDB-show
CHEMBL31217021362697BindingDB-show
CHEMBL31232021362735BindingDB-show
CHEMBL31264844317768BindingDB-show
CHEMBL31265121362741BindingDB-show
CHEMBL31267621362756BindingDB-show
CHEMBL31269821362754BindingDB-show
CHEMBL33450644353891BindingDB-show
CHEMBL33475810410982BindingDB-show
CHEMBL33594944353870BindingDB-show
CHEMBL33659444353968BindingDB-show
CHEMBL33723644353923BindingDB-show
CHEMBL33884844353966BindingDB-show
CHEMBL34143244353999BindingDB-show
CHEMBL36007710266458BindingDB-show
CHEMBL37016644406470BindingDB-show
CHEMBL37154344406614BindingDB-show
CHEMBL37196744406386BindingDB-show
CHEMBL37216044406581BindingDB-show
CHEMBL37234544406506BindingDB-show
CHEMBL37273644406634BindingDB-show
CHEMBL37375111626927BindingDB-show
CHEMBL37773411632737BindingDB-show
CHEMBL37792811608743BindingDB-show
CHEMBL38104144406549BindingDB-show
CHEMBL38275244406468BindingDB-show
CHEMBL38294544406586BindingDB-show
CHEMBL38803325190920BindingDB-show
CHEMBL38908625190928BindingDB-show
CHEMBL39020120767724BindingDB-show
CHEMBL39700816048085BindingDB-show
CHEMBL39700916047968BindingDB-show
CHEMBL39766825190925BindingDB-show
CHEMBL41165944353885BindingDB-show
CHEMBL42406944353954BindingDB-show
CHEMBL44760321083902BindingDB-show
CHEMBL45083525263293BindingDB-show
CHEMBL45447025263284BindingDB-show
CHEMBL45497321083895BindingDB-show
CHEMBL46649615295578BindingDB-show
CHEMBL46707925206064BindingDB-show
CHEMBL46812544575073BindingDB-show
CHEMBL47781724766030BindingDB-show
CHEMBL48124844575127BindingDB-show
CHEMBL49233125263287BindingDB-show
CHEMBL49233221083898BindingDB-show
CHEMBL49252725263289BindingDB-show
CHEMBL49316121083906BindingDB-show
CHEMBL49394011161778BindingDB-show
CHEMBL49397421083896BindingDB-show
CHEMBL49415321083893BindingDB-show
CHEMBL49415421083894BindingDB-show
CHEMBL49416225263295BindingDB-show
CHEMBL50472725263288BindingDB-show
CHEMBL50594311448486BindingDB-show
CHEMBL51141025207521BindingDB-show
CHEMBL51911344575126BindingDB-show
CHEMBL52164311173949BindingDB-show
CHEMBL52167925263294BindingDB-show
CHEMBL52201125263283BindingDB-show
CHEMBL52201425263296BindingDB-show
CHEMBL52233121083789BindingDB-show
CHEMBL52300221083908BindingDB-show
CHEMBL52343524825779BindingDB-show
CHEMBL52369225263292BindingDB-show
CHEMBL53891021083790BindingDB-show
CHEMBL54947844187181BindingDB-show
CHEMBL54947945271427BindingDB-show
CHEMBL55102445270368BindingDB-show
CHEMBL55177345272329BindingDB-show
CHEMBL55218345269780BindingDB-show
CHEMBL55680645273193BindingDB-show
CHEMBL55849144187182BindingDB-show
CHEMBL56070845268050BindingDB-show
CHEMBL56144745267192BindingDB-show
CHEMBL56237045268940BindingDB-show
CHEMBL56272045270611BindingDB-show
CHEMBL56297144187183BindingDB-show
CHEMBL56355445270614BindingDB-show
CHEMBL56507611954411BindingDB-show
CHEMBL56892211723489BindingDB-show
CHEMBL57688723401001BindingDB-show
CHEMBL57698923400934BindingDB-show
CHEMBL57860110246246BindingDB-show
CHEMBL59289322291652BindingDB-show
CHEMBL59775446233287BindingDB-show
CHEMBL59922445139989BindingDB-show
CHEMBL59942845139991BindingDB-show
CHEMBL7846411075446BindingDB-show
CHEMBL7861814929458BindingDB-show
CHEMBL7886221362674BindingDB-show
CHEMBL7887921362736BindingDB-show
CHEMBL7888521362748BindingDB-show
CHEMBL7891721362689BindingDB-show
CHEMBL8012121362732BindingDB-show
CHEMBL8079344317844BindingDB-show
CHEMBL8084310448840BindingDB-show
CHEMBL8117013441298BindingDB-show
CHEMBL8121421362669BindingDB-show
CHEMBL8122921362727BindingDB-show
CHEMBL8131544317866BindingDB-show
CHEMBL8160321362696BindingDB-show
CHEMBL8178121362701BindingDB-show
CHEMBL8180921362699BindingDB-show
CHEMBL8213621362687BindingDB-show
CHEMBL8213744317726BindingDB-show
CID 1122224811164332BindingDB-show
CID 1128715311287153BindingDB-show
CID 98443209844320BindingDB-show
Dasatinib3062316BindingDB-show
Eudistomin N162883BindingDB-show
imidazothienopyrazine, 13a10126159BindingDB-show
imidazothienopyrazine, 13b10215156BindingDB-show
imidazothienopyrazine, 13c25093427BindingDB-show
imidazothienopyrazine, 13d25093428BindingDB-show
imidazothienopyrazine, 13e25093429BindingDB-show
imidazothienopyrazine, 13f25093430BindingDB-show
imidazothienopyrazine, 13g25093431BindingDB-show
imidazothienopyrazine, 13h25093432BindingDB-show
imidazothienopyrazine, 13i25093433BindingDB-show
imidazothienopyrazine, 13j25093434BindingDB-show
imidazothienopyrazine, 14a25093435BindingDB-show
imidazothienopyrazine, 14b25093436BindingDB-show
imidazothienopyrazine, 14c25093437BindingDB-show
imidazothienopyrazine, 14d25093438BindingDB-show
imidazothienopyrazine, 14e25093439BindingDB-show
imidazothienopyrazine, 14f25093440BindingDB-show
imidazothienopyrazine, 14g25093441BindingDB-show
imidazothienopyrazine, 1820823998BindingDB-show
imidazothienopyrazine, 20a20823960BindingDB-show
imidazothienopyrazine, 20b20823959BindingDB-show
imidazothienopyrazine, 20c20824060BindingDB-show
imidazothienopyrazine, 20d20823982BindingDB-show
imidazothienopyrazine, 20e20823995BindingDB-show
imidazothienopyrazine, 20f25093442BindingDB-show
imidazothienopyrazine, 20g20823986BindingDB-show
imidazothienopyrazine, 20h20823975BindingDB-show
imidazothienopyrazine, 20i20823993BindingDB-show
imidazothienopyrazine, 21a20824041BindingDB-show
imidazothienopyrazine, 21b20823920BindingDB-show
imidazothienopyrazine, 22a25093443BindingDB-show
imidazothienopyrazine, 22b25093444BindingDB-show
imidazothienopyrazine, 22c25093445BindingDB-show
imidazothienopyrazine, 22d25093446BindingDB-show
imidazothienopyrazine, 22e25093447BindingDB-show
imidazothienopyrazine, 22f25093448BindingDB-show
imidazothienopyrazine, 22g25093449BindingDB-show
imidazothienopyrazine, 22h25093450BindingDB-show
imidazothienopyrazine, 22i25093451BindingDB-show
imidazothienopyrazine, 22j23657350BindingDB-show
imidazothienopyrazine, 22k25093452BindingDB-show
imidazothienopyrazine, 22l20823956BindingDB-show
imidazothienopyrazine, 22m20823952BindingDB-show
imidazothienopyrazine, 22n25093453BindingDB-show
imidazothienopyrazine, 22o25093454BindingDB-show
imidazothienopyrazine, 22p25093455BindingDB-show
imidazothienopyrazine, 22q25093456BindingDB-show
imidazothienopyrazine, 22r25093457BindingDB-show
imidazothienopyrazine, 22s25093458BindingDB-show
imidazothienopyrazine, 22t25093459BindingDB-show
imidazothienopyrazine, 22u25093460BindingDB-show
K00596a9549298BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_291844444843BindingDB-show
L2G9549184BindingDB-show
Lestaurtinib126565BindingDB-show
NCGC00165873-019949093BindingDB-show
O-substituted diarylbenzamide, 12c16047146BindingDB-show
PKC-4129829523BindingDB-show
pyrazolopurine, 3b25263282BindingDB-show
S1526_Selleck24889392BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
trihydroxidoarsenic545SuperTarget-show
ZINC025397642756534BindingDB-show
ZINC025650732782903BindingDB-show
Synonyms:
Conserved helix-loop-helix ubiquitous kinase
I kappa-B kinase alpha
I-kappa-B kinase 1
IkappaB kinase
IkBKA
IKK-A
IKK-alpha
IKK1
Inhibitor of nuclear factor kappa-B kinase subunit alpha
NFKBIKA
Nuclear factor NF-kappa-B inhibitor kinase alpha
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
IKKB_HUMAN67.150.1
Q59GL9_HUMAN45.335.5
IKKE_HUMAN35.520.7
KS6A5_HUMAN3418.9
PDE5A_CANFA32.518.3
Q9H4D1_HUMAN32.520.6
KAT2B_HUMAN32.417
Q8CHM5_MOUSE31.918.9
P85A_HUMAN31.817
PDE5A_HUMAN31.617.1
PCCA_HUMAN31.317.1
Q9WYA5_THEMA31.315.3
Q8NHA5_HUMAN31.117.4
PDE1B_HUMAN3116.7
CLAT_RAT30.918.3
Q59F19_HUMAN30.817.6
GAL10_YEAST30.616.7
O75555_HUMAN30.617.4
MTP_HUMAN30.617.3
CPT2_HUMAN30.617.2
NCBP1_HUMAN30.515.8
CHK1_USTMA30.318
PFLB_ECOLI30.317.7
LEF_BACAN30.317.1
CLAT_HUMAN30.216.9
AAPK1_HUMAN3018.7
PLOD2_HUMAN29.916.5
CHK1_YEAST29.817.8
MTRR_HUMAN29.816.9
CLAT_MOUSE29.717
Protein-Protein Interactions:
Uniprot nameSource
USP9X_HUMANPMID 14743216
UBE2N_HUMAN2 PMIDs
UBC9_HUMAN3 PMIDs
UB2E3_HUMAN4 PMIDs
TRAF2_HUMAN5 PMIDs
TPM3_HUMAN6 PMIDs
TP4AP_HUMAN7 PMIDs
TNR1A_HUMAN8 PMIDs
TNIP2_HUMAN9 PMIDs
TNIP2_HUMAN10 PMIDs
TNIP2_HUMAN11 PMIDs
TNIP2_HUMAN12 PMIDs
TNIP1_HUMAN13 PMIDs
TNAP3_HUMAN14 PMIDs
TLR3_HUMAN15 PMIDs
TGFR1_HUMAN16 PMIDs
TF65_HUMAN17 PMIDs
TF65_HUMAN18 PMIDs
TF65_HUMAN19 PMIDs
TF65_HUMAN20 PMIDs
TF65_HUMAN21 PMIDs
TF65_HUMAN22 PMIDs
TCAM1_HUMAN23 PMIDs
TBB5_HUMAN24 PMIDs
TBB4_HUMAN25 PMIDs
TBA3C_HUMAN26 PMIDs
TANK_HUMAN27 PMIDs
TAB1_HUMAN28 PMIDs
STAP2_HUMAN29 PMIDs
STAP2_HUMAN30 PMIDs
SMAD3_HUMAN31 PMIDs
SMAD2_HUMAN32 PMIDs
SC16A_HUMAN33 PMIDs
RS13_HUMAN34 PMIDs
RS13_HUMAN35 PMIDs
RS13_HUMAN36 PMIDs
RS11_HUMAN37 PMIDs
RS11_HUMAN38 PMIDs
ROCK2_HUMAN39 PMIDs
ROCK2_HUMAN40 PMIDs
RO52_HUMAN41 PMIDs
RL8_HUMAN42 PMIDs
RL8_HUMAN43 PMIDs
RL6_HUMAN44 PMIDs
RL6_HUMAN45 PMIDs
RL6_HUMAN46 PMIDs
RL4_HUMAN47 PMIDs
RL4_HUMAN48 PMIDs
RL30_HUMAN49 PMIDs
RL30_HUMAN50 PMIDs
RL30_HUMAN51 PMIDs
RIPK1_HUMAN52 PMIDs
REL_HUMAN53 PMIDs
REL_HUMAN54 PMIDs
REL_HUMAN55 PMIDs
REL_HUMAN56 PMIDs
RELB_HUMAN57 PMIDs
RELB_HUMAN58 PMIDs
RELB_HUMAN59 PMIDs
Q9UQC1_HUMAN60 PMIDs
Q96RR5_HUMAN61 PMIDs
PRKDC_HUMAN62 PMIDs
PPM1B_HUMAN63 PMIDs
PIAS1_HUMAN64 PMIDs
PEBP1_HUMAN65 PMIDs
P53_HUMAN66 PMIDs
NR2C2_HUMAN67 PMIDs
NFKB2_HUMAN68 PMIDs
NFKB2_HUMAN69 PMIDs
NFKB2_HUMAN70 PMIDs
NFKB2_HUMAN71 PMIDs
NFKB2_HUMAN72 PMIDs
NFKB1_HUMAN73 PMIDs
NFKB1_HUMAN74 PMIDs
NFKB1_HUMAN75 PMIDs
NFKB1_HUMAN76 PMIDs
NEMO_HUMAN77 PMIDs
NEMO_HUMAN78 PMIDs
NEMO_HUMAN79 PMIDs
NEMO_HUMAN80 PMIDs
NEMO_HUMAN81 PMIDs
NEMO_HUMAN82 PMIDs
NEMO_HUMAN83 PMIDs
NEMO_HUMAN84 PMIDs
NEMO_HUMAN85 PMIDs
NEMO_HUMAN86 PMIDs
NEMO_HUMAN87 PMIDs
NCOR2_HUMAN88 PMIDs
NCOA3_HUMAN89 PMIDs
NCOA3_HUMAN90 PMIDs
NCOA2_HUMAN91 PMIDs
NALP4_HUMAN92 PMIDs
MYO1D_HUMAN93 PMIDs
MYL6_HUMAN94 PMIDs
MYH9_HUMAN95 PMIDs
MYH14_HUMAN96 PMIDs
MYH10_HUMAN97 PMIDs
MAVS_HUMAN98 PMIDs
M3K8_HUMAN99 PMIDs
M3K8_HUMAN100 PMIDs
M3K3_HUMAN101 PMIDs
M3K14_HUMAN102 PMIDs
M3K14_HUMAN103 PMIDs
M3K14_HUMAN104 PMIDs
M3K14_HUMAN105 PMIDs
M3K14_HUMAN106 PMIDs
M3K11_HUMAN107 PMIDs
KPCI_HUMAN108 PMIDs
KPCB_HUMAN109 PMIDs
JIP4_HUMAN110 PMIDs
IRS1_HUMAN111 PMIDs
IRS1_HUMAN112 PMIDs
IRAK1_HUMAN113 PMIDs
IQGA2_HUMAN114 PMIDs
IMA3_HUMAN115 PMIDs
IKKB_HUMAN116 PMIDs
IKKB_HUMAN117 PMIDs
IKKB_HUMAN118 PMIDs
IKKB_HUMAN119 PMIDs
IKKB_HUMAN120 PMIDs
IKKB_HUMAN121 PMIDs
IKKB_HUMAN122 PMIDs
IKKB_HUMAN123 PMIDs
IKKB_HUMAN124 PMIDs
IKKB_HUMAN125 PMIDs
IKKA_HUMAN126 PMIDs
IKBE_HUMAN127 PMIDs
IKBE_HUMAN128 PMIDs
IKBE_HUMAN129 PMIDs
IKBB_HUMAN130 PMIDs
IKBB_HUMAN131 PMIDs
IKBB_HUMAN132 PMIDs
IKBA_HUMAN133 PMIDs
IKBA_HUMAN134 PMIDs
IKBA_HUMAN135 PMIDs
IKBA_HUMAN136 PMIDs
IKBA_HUMAN137 PMIDs
HSP71_HUMAN138 PMIDs
HS90B_HUMAN139 PMIDs
HS90B_HUMAN140 PMIDs
HS90B_HUMAN141 PMIDs
HS90A_HUMAN142 PMIDs
HS90A_HUMAN143 PMIDs
HS90A_HUMAN144 PMIDs
HS90A_HUMAN145 PMIDs
H31T_HUMAN146 PMIDs
GTF2I_HUMAN147 PMIDs
GSLG1_HUMAN148 PMIDs
GRP75_HUMAN149 PMIDs
FKBP5_HUMAN150 PMIDs
FBXW7_HUMAN151 PMIDs
FBRL_HUMAN152 PMIDs
FBRL_HUMAN153 PMIDs
FANCA_HUMAN154 PMIDs
ESR1_HUMAN155 PMIDs
ELP1_HUMAN156 PMIDs
EF1A2_HUMAN157 PMIDs
E2AK2_HUMAN158 PMIDs
DDX3X_HUMAN159 PMIDs
CTNB1_HUMAN160 PMIDs
CSF2R_HUMAN161 PMIDs
COPB2_HUMAN162 PMIDs
CNTN2_HUMAN163 PMIDs
CLH1_HUMAN164 PMIDs
CIKS_HUMAN165 PMIDs
CDC37_HUMAN166 PMIDs
CDC37_HUMAN167 PMIDs
CDC37_HUMAN168 PMIDs
CDC37_HUMAN169 PMIDs
CBP_HUMAN170 PMIDs
CBP_HUMAN171 PMIDs
CAZA1_HUMAN172 PMIDs
CASP8_HUMAN173 PMIDs
CALM_HUMAN174 PMIDs
ARRB2_HUMAN175 PMIDs
ARRB2_HUMAN176 PMIDs
ARRB1_HUMAN177 PMIDs
ARRB1_HUMAN178 PMIDs
AKP8L_HUMAN179 PMIDs
ACTG_HUMAN180 PMIDs
ACTB_HUMAN181 PMIDs