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Target Details

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Name:Histamine H1 receptor
Uniprot name:HRH1_HUMAN
Accession Numbers:P35367 Q6P9E5
EC-Number:-
Organism:Homo sapiens
Human
PDB IDs:-
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(1R,2S)-2-(3H-imidazol-4-yl)cyclopropan-1-amine10986211BindingDB-show
(1R,2S)-2-(3H-imidazol-4-yl)cyclopropan-1-amine10374457BindingDB-show
(1R,2S)-2-(3H-imidazol-4-yl)cyclopropan-1-amine11804748BindingDB-show
(1R,2S)-2-(3H-imidazol-4-yl)cyclopropan-1-amine10103168BindingDB-show
(5-chloro-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone4908365BindingDB-show
1-(4-(3-(4-(Bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl)propoxy)-3-methoxyphenyl)ethanone173727BindingDB-show
1H-Imidazole-4-ethanamine, alpha-methyl-, (alphaR)-156615BindingDB-show
2,2-Diphenylethylamine77575BindingDB-show
2-[(1S,2R)-2-(3H-imidazol-4-yl)cyclopropyl]ethanamine11829635BindingDB-show
2-[(1S,2R)-2-(3H-imidazol-4-yl)cyclopropyl]ethanamine10154137BindingDB-show
2-[1-[2-(2-pyrrolidin-1-ylethyl)benzothiophen-3-yl]ethyl]pyridine11508317BindingDB-show
2-[4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,511948707BindingDB-show
2-[4-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]butyl]-4-methyl-1,2,4-tri11676174BindingDB-show
3,3-Diphenylpropylamine79698BindingDB-show
3-[(2R)-4-propylmorpholin-2-yl]phenol9794475BindingDB-show
3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1H-quinazoline-2,4-dione122065BindingDB-show
4-DESMETHYLOLANZAPINE9948206BindingDB-show
9,10-Didehydro-N,N-diethyl-6-methylergoline-8-carboxamide (8alpha)-3083747BindingDB-show
9-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-5,7-diazabicyclo[4.3.0]nona-210267394BindingDB-show
A-98730625109291BindingDB-show
AC1L1H5P29298BindingDB-show
AC1L35TO83632BindingDB-show
AC1L3QT1120445BindingDB-show
AC1METN62860933BindingDB-show
AC1MFI302872050BindingDB-show
AC1MS68C3529324BindingDB-show
Acepromethazine26035DrugBank-show
Amitriprolidine2160BindingDB-show
Astemizole2247BindingDB-show
Astemizole2247DrugBank-show
Astemizole2247SuperTarget2 PMIDsshow
Azacyclonol15723BindingDB-show
Azatadine19861DrugBank-show
Azatadine19861SuperTargetPMID 11291777show
Azelastine2267DrugBank-show
Azelastine2267SuperTarget2 PMIDsshow
Benzchinamidum2342DrugBank-show
beta-Dimethylaminoethylbenzhydrylether3100DrugBank-show
beta-Dimethylaminoethylbenzhydrylether3100SuperTarget2 PMIDsshow
Betahistine Methanesulphonate2366SuperTargetPMID 15729086show
Betotastine2350DrugBank-show
Bromdiphenhydraminum2444DrugBank-show
Carboxyterfenadine3348BindingDB-show
Carboxyterfenadine3348DrugBank-show
Carboxyterfenadine3348SuperTarget2 PMIDsshow
CBMicro_0278084440380BindingDB-show
Cetirizine2678BindingDB-show
Cetirizine2678DrugBank-show
Cetirizine2678SuperTargetPMID 008741162show
CHEBI:26136614984034BindingDB-show
CHEBI:26158914984032BindingDB-show
CHEBI:26159214984031BindingDB-show
CHEBI:26162314984030BindingDB-show
CHEBI:26230110423703BindingDB-show
CHEBI:64355844271729BindingDB-show
CHEBI:64722344352701BindingDB-show
CHEBI:65284144387805BindingDB-show
CHEMBL1004549840400BindingDB-show
CHEMBL10163444334037BindingDB-show
CHEMBL10169144334430BindingDB-show
CHEMBL10174844334038BindingDB-show
CHEMBL10233144333988BindingDB-show
CHEMBL10238444334025BindingDB-show
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CHEMBL10250744334193BindingDB-show
CHEMBL10284044334214BindingDB-show
CHEMBL10292544334212BindingDB-show
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CHEMBL10302710003483BindingDB-show
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CHEMBL9673244326298BindingDB-show
CHEMBL9724010284042BindingDB-show
CHEMBL9735710190770BindingDB-show
CHEMBL9807644328187BindingDB-show
CHEMBL9807910212223BindingDB-show
ChemDiv2_003208126624BindingDB-show
CHLOPHEDIANOL2795DrugBank-show
Chloroprophenpyridamine2725BindingDB-show
Chloroprophenpyridamine2725DrugBank-show
Chloroprophenpyridamine2725SuperTarget2 PMIDsshow
Chloroprothixene2729DrugBank-show
Chloroprothixene667467DrugBank-show
Chloropyribenzamine25295SuperTargetPMID 6114483show
CHLORPROTHIXENE667466BindingDB-show
CID 1032417810744393BindingDB-show
CID 1047214310947658BindingDB-show
CID 1047214311121216BindingDB-show
CID 1047214310472143BindingDB-show
CID 1055538310326069BindingDB-show
CID 1126748811186523BindingDB-show
CID 153996153996BindingDB-show
CID 98307419830741BindingDB-show
CID 98390509839050BindingDB-show
CID 98390819839081BindingDB-show
CID 98946659894665BindingDB-show
Cidoxepinum667477DrugBank-show
Cidoxepinum667477SuperTarget-show
Cinnarizine2761DrugBank-show
Cinnarizine2761SuperTargetPMID 6399658show
ciproxifan6422124BindingDB-show
Claratyne Decongestant3957BindingDB-show
Claratyne Decongestant3957DrugBank-show
Claratyne Decongestant3957SuperTargetPMID 015942272show
Clozapine2818BindingDB-show
Clozapine2818DrugBank-show
Clozapine2818SuperTarget-show
Conessinum441082BindingDB-show
CPMPP-35311200BindingDB-show
Cyclizine Hydrochloride6726DrugBank-show
Cyclizine hydrochloride6420019DrugBank-show
Cyclizine Hydrochloride6726SuperTargetPMID 1676005show
Cyclizine hydrochloride6420019SuperTargetPMID 1676005show
Cyproheptadine2913BindingDB-show
Cyproheptadine2913DrugBank-show
Cyproheptadine13770DrugBank-show
DC 0155487531BindingDB-show
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Descarboethoxyloratadine124087SuperTarget2 PMIDsshow
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Dexchlorpheniramine33036SuperTarget2 PMIDsshow
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Dimeboline197033BindingDB-show
Dimethpyrindene21855SuperTarget-show
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Diphenhydrinate10660DrugBank-show
diphenylalkylamine (DPA), 6b20293994BindingDB-show
Diphenylpyralamine3103DrugBank-show
Diphenylpyralamine3103SuperTarget-show
Dossilamina3162DrugBank-show
Dossilamina3162SuperTarget-show
EBASTINE3191BindingDB-show
EBASTINE3191SuperTarget2 PMIDsshow
EINECS 253-194-63015863BindingDB-show
Emedastine3219DrugBank-show
Emedastine3219SuperTargetPMID 11057344show
Epinastine3241DrugBank-show
Epinastine3241SuperTarget-show
Eprozinol122553SuperTargetPMID 21982show
Fenspiride hydrochloride3344SuperTargetPMID 9652346show
Fenspiride hydrochloride68626SuperTargetPMID 9652346show
flunarizine dihydrochloride941361DrugBank-show
FLUNARIZINE DIHYDROCHLORIDE6365505DrugBank-show
Fluorophenazine3372BindingDB-show
GR 127935 hydrochloride107780BindingDB-show
Haloperidol3559BindingDB-show
Histabutyzine dihydrochloride6729DrugBank-show
Histabutyzine dihydrochloride6729SuperTarget-show
Histamethizine4034DrugBank-show
Histamethizine4034SuperTarget-show
histamine774BindingDB-show
Histamine biphosphate65513DrugBank-show
Hydroxizinum3658DrugBank-show
Hydroxizinum3658SuperTargetPMID 012815318show
Ifenprodil [DCF:INN]6604117BindingDB-show
Isopromethazine4927DrugBank-show
Isopromethazine4927SuperTarget-show
KETOTIFEN FUMARATE5282408BindingDB-show
Ketotiphene3827BindingDB-show
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Ketotiphene3827SuperTargetPMID 12431041show
KF-A644566054BindingDB-show
KW 409923666701BindingDB-show
Largactilothiazine2726BindingDB-show
LEVOCABASTINE54385DrugBank-show
LEVOCABASTINE54385SuperTargetPMID 009627096show
Levocetirizine1549000SuperTargetPMID 008741162show
Lopac-O-1116603950BindingDB-show
Mecloprodin26987DrugBank-show
mequitazine hydrochloride4066DrugBank-show
mequitazine hydrochloride4066SuperTarget-show
Methdilazine Monohydrochloride14677DrugBank-show
Methdilazine Monohydrochloride14677SuperTarget-show
Methotrimeprazine72287DrugBank-show
Methylaminopropyliminodibenzyl2995DrugBank-show
Methylaminopropyliminodibenzyl2995SuperTarget-show
Methyldiphenylhydramine4601DrugBank-show
Methyldiphenylhydramine4601SuperTarget-show
Methylpromazine5574DrugBank-show
Methylpromazine5574SuperTarget-show
Mianserin Monohydrochloride4184BindingDB-show
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Mirtazapin4205BindingDB-show
Mirtazapin4205DrugBank-show
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N-Methyl-3,3-diphenylpropylamine119812BindingDB-show
NCGC00165717-019934033BindingDB-show
Nedocromil50294DrugBank-show
Nedocromil50294SuperTarget-show
NITD60944469321BindingDB-show
Octoclothepine1238BindingDB-show
Olanzapine4585BindingDB-show
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Olanzapine4585SuperTarget-show
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OLOPATADINE HYDROCHLORIDE5282402DrugBank-show
OLOPATADINE HYDROCHLORIDE5281071SuperTargetPMID 015942272show
OLOPATADINE HYDROCHLORIDE5282402SuperTargetPMID 015942272show
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Oprea1_31423511357157BindingDB-show
Oprea1_75324214984033BindingDB-show
OXATOMIDE4615BindingDB-show
Parabromdylamine6834DrugBank-show
Parabromdylamine6834SuperTarget-show
Paracarbinoxamine2564DrugBank-show
Paracarbinoxamine2564SuperTargetPMID 7513381show
Pemirolast57697DrugBank-show
Phenindiamine11291DrugBank-show
Phenothiazine4926DrugBank-show
Phenothiazine4926SuperTarget-show
Prochlorpermazine4917DrugBank-show
Prochlorpermazine4917SuperTargetPMID 1361536show
Prophenpyridamine4761DrugBank-show
Prophenpyridamine4761SuperTargetPMID 9795048show
Propionylpromethazine4940DrugBank-show
Propionylpromethazine4940SuperTarget-show
Pyranisamine4992BindingDB-show
Pyranisamine4992PROMISCUOUSPMID 8590995show
Pyranisamine4992SuperTargetPMID 015680274show
Quetiapine5002BindingDB-show
Quetiapine5002DrugBank-show
Quinupramine93154SuperTargetPMID 6098759show
RESPATADINE60680BindingDB-show
Risperidonum5073BindingDB-show
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Ritanserinum5074BindingDB-show
Rupatadine133017BindingDB-show
sertindole hydrochloride60149BindingDB-show
SMR0001180403201696BindingDB-show
STK3765422860026BindingDB-show
STK3765432861786BindingDB-show
STK3867552861271BindingDB-show
STK3867562861590BindingDB-show
STK3867582861042BindingDB-show
Terestigmine5405BindingDB-show
Terestigmine5405DrugBank-show
Terestigmine5405SuperTargetPMID 008880073show
Thiethylpipezazine5440DrugBank-show
Thiethylpipezazine5440SuperTargetPMID 2947734show
Thioperamide3035905BindingDB-show
Trazodone Hydrochloride5533DrugBank-show
Trazodone hydrochloride62935DrugBank-show
Trazodone Hydrochloride5533SuperTarget-show
Trazodone hydrochloride62935SuperTarget-show
Tripelennamine5587DrugBank-show
Tripelennamine5587SuperTarget-show
Triprolidine hydrochloride5282443BindingDB-show
Triprolidine hydrochloride5282443DrugBank-show
Triprolidine hydrochloride5282443SuperTarget-show
Zafirlukast5717BindingDB-show
Ziprasidone hydrochloride60854BindingDB-show
Ziprasidone hydrochloride60854DrugBank-show
Ziprasidone hydrochloride219099DrugBank-show
Ziprasidone hydrochloride60854SuperTarget-show
Ziprasidone hydrochloride219099SuperTarget-show
Zotepine5736BindingDB-show
[2-(3H-imidazol-4-yl)cyclopropyl]methanamine11116130BindingDB-show
[2-(3H-imidazol-4-yl)cyclopropyl]methanamine10942498BindingDB-show
[2-(3H-imidazol-4-yl)cyclopropyl]methanamine11126319BindingDB-show
[2-(3H-imidazol-4-yl)cyclopropyl]methanamine11094685BindingDB-show
Synonyms:
Histamine H1 receptor
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
HRH1_BOVIN8881.9
ACM2_HUMAN44.627.8
DRD2_RAT43.626.6
DRD2_MOUSE43.626.6
ACM4_HUMAN4328.8
DRD2_HUMAN42.926.3
5HT1A_HUMAN42.826.5
Q5ZGX3_HUMAN42.826.5
ADA2C_HUMAN42.625.9
Q59EH9_HUMAN42.426.1
5HT1F_HUMAN42.227.8
Q9P2Q4_HUMAN42.227.8
HRH3_HUMAN4224
5HT1E_HUMAN41.727.7
ADA2A_HUMAN41.525.7
ADA2B_HUMAN40.522.6
5HT1B_HUMAN40.225.5
ACM1_HUMAN4027.5
5HT1D_HUMAN4026.5
DRD3_HUMAN4025.7
ACM5_HUMAN39.826.8
DRD4_MOUSE39.625.2
ACM3_HUMAN39.524.6
HRH4_HUMAN39.121.6
DRD4_HUMAN3826.4
5HT5A_HUMAN35.322.7
5HT2C_HUMAN33.718.1
ADRB2_HUMAN33.419.9
Q9BYZ0_HUMAN32.920.3
GASR_HUMAN32.918.8
Protein-Protein Interactions:
Uniprot nameSource
IL6_HUMANPMID 11238657