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Target Details

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Name:3-hydroxy-3-methylglutaryl-coenzyme A reductase
Uniprot name:HMDH_HUMAN
Accession Numbers:P04035 Q8N190
EC-Number:1.1.1.34
Organism:Homo sapiens
Human
PDB IDs:1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A5288565DrugBank-show
9-Octadecynoic acid68167BindingDB-show
AC1O4WI36420024BindingDB-show
Adenosindiphosphorsaeure6022DrugBank-show
Aluzime87642DrugBank-show
Atorvastatin60823DrugBank-show
Atorvastatin60823SuperTarget2 PMIDsshow
Cerivastatin446156BindingDB-show
Cerivastatin446156DrugBank-show
cerivastatin23663992DrugBank-show
Cerivastatin446156SuperTarget2 PMIDsshow
cerivastatin23663992SuperTarget2 PMIDsshow
CHEBI:13060223697631BindingDB-show
CHEBI:40560144392454BindingDB-show
CHEBI:40560544392458BindingDB-show
CHEBI:40560844392461BindingDB-show
CHEBI:40560944392462BindingDB-show
CHEBI:40561644392468BindingDB-show
CHEBI:40562144392474BindingDB-show
CHEBI:40562244392475BindingDB-show
CHEBI:40562444392478BindingDB-show
CHEBI:40563044392484BindingDB-show
CHEBI:40563144392486BindingDB-show
CHEBI:40563544392489BindingDB-show
CHEBI:40564144392492BindingDB-show
CHEBI:40564444392494BindingDB-show
CHEBI:40564544392495BindingDB-show
CHEBI:40565544392501BindingDB-show
CHEBI:40565744392502BindingDB-show
CHEBI:40566244392504BindingDB-show
CHEBI:40566344392506BindingDB-show
CHEBI:40566944392511BindingDB-show
CHEBI:40567144392513BindingDB-show
CHEBI:40567744392515BindingDB-show
CHEBI:40568244392520BindingDB-show
CHEBI:40568444392521BindingDB-show
CHEBI:40568944392524BindingDB-show
CHEBI:40569244392528BindingDB-show
CHEBI:40569544392530BindingDB-show
CHEBI:40569744392531BindingDB-show
CHEBI:40570744392540BindingDB-show
CHEBI:40605916760227BindingDB-show
CHEBI:5069017589822BindingDB-show
CHEBI:58741444306810BindingDB-show
CHEMBL10016544331994BindingDB-show
CHEMBL10149744331999BindingDB-show
CHEMBL10160044331627BindingDB-show
CHEMBL10182444331886BindingDB-show
CHEMBL10183144331896BindingDB-show
CHEMBL10211244331510BindingDB-show
CHEMBL10216844332132BindingDB-show
CHEMBL10219944332134BindingDB-show
CHEMBL10313944332018BindingDB-show
CHEMBL10821244335616BindingDB-show
CHEMBL11530715931922BindingDB-show
CHEMBL116314546906162BindingDB-show
CHEMBL116314646906165BindingDB-show
CHEMBL116314946906166BindingDB-show
CHEMBL116315046906169BindingDB-show
CHEMBL116319846906528BindingDB-show
CHEMBL116372346906164BindingDB-show
CHEMBL116380446906168BindingDB-show
CHEMBL116415746906130BindingDB-show
CHEMBL116454646906129BindingDB-show
CHEMBL116502446906167BindingDB-show
CHEMBL116509946906558BindingDB-show
CHEMBL116525946906163BindingDB-show
CHEMBL1180423665944BindingDB-show
CHEMBL1189144267551BindingDB-show
CHEMBL12386644349994BindingDB-show
CHEMBL13343444354270BindingDB-show
CHEMBL13383444354271BindingDB-show
CHEMBL15433544370303BindingDB-show
CHEMBL15469844370438BindingDB-show
CHEMBL15469944370439BindingDB-show
CHEMBL15493444370307BindingDB-show
CHEMBL15497044370321BindingDB-show
CHEMBL15546444370426BindingDB-show
CHEMBL15561044370131BindingDB-show
CHEMBL15564244370417BindingDB-show
CHEMBL15669544370459BindingDB-show
CHEMBL15716844370302BindingDB-show
CHEMBL15772444370471BindingDB-show
CHEMBL15788244370314BindingDB-show
CHEMBL15910344375049BindingDB-show
CHEMBL15995144374825BindingDB-show
CHEMBL16010244374884BindingDB-show
CHEMBL16108044374843BindingDB-show
CHEMBL16182944374879BindingDB-show
CHEMBL16212544374881BindingDB-show
CHEMBL16264244374900BindingDB-show
CHEMBL16327744374861BindingDB-show
CHEMBL17754544387497BindingDB-show
CHEMBL22852844426473BindingDB-show
CHEMBL22858344426486BindingDB-show
CHEMBL22866744426467BindingDB-show
CHEMBL22895444426490BindingDB-show
CHEMBL22895525048338BindingDB-show
CHEMBL24927344442240BindingDB-show
CHEMBL24972424763877BindingDB-show
CHEMBL24988424944096BindingDB-show
CHEMBL24990644442216BindingDB-show
CHEMBL25008844442190BindingDB-show
CHEMBL25009044442253BindingDB-show
CHEMBL25031744442196BindingDB-show
CHEMBL25050044442258BindingDB-show
CHEMBL25070744442260BindingDB-show
CHEMBL25074944442208BindingDB-show
CHEMBL25095344442202BindingDB-show
CHEMBL25149944442219BindingDB-show
CHEMBL25858344452269BindingDB-show
CHEMBL25899925254902BindingDB-show
CHEMBL25924025166691BindingDB-show
CHEMBL26051044451948BindingDB-show
CHEMBL26133425254901BindingDB-show
CHEMBL26162124873519BindingDB-show
CHEMBL26162224873518BindingDB-show
CHEMBL26174825166903BindingDB-show
CHEMBL27380044349660BindingDB-show
CHEMBL27671744267525BindingDB-show
CHEMBL29346144306807BindingDB-show
CHEMBL30059644298247BindingDB-show
CHEMBL30351544306551BindingDB-show
CHEMBL30352344306910BindingDB-show
CHEMBL30674244315574BindingDB-show
CHEMBL30955211166019BindingDB-show
CHEMBL31714244331901BindingDB-show
CHEMBL31777744332036BindingDB-show
CHEMBL31870744331923BindingDB-show
CHEMBL32107644331955BindingDB-show
CHEMBL32171344331887BindingDB-show
CHEMBL32176844332020BindingDB-show
CHEMBL32334444331644BindingDB-show
CHEMBL32388044342306BindingDB-show
CHEMBL32930744332034BindingDB-show
CHEMBL33161044349689BindingDB-show
CHEMBL33191344349993BindingDB-show
CHEMBL34537544375051BindingDB-show
CHEMBL34576544370427BindingDB-show
CHEMBL34613944370401BindingDB-show
CHEMBL34644644370305BindingDB-show
CHEMBL34879844374858BindingDB-show
CHEMBL34972544374776BindingDB-show
CHEMBL35067044370712BindingDB-show
CHEMBL36017244392689BindingDB-show
CHEMBL38751444426492BindingDB-show
CHEMBL38900211753476BindingDB-show
CHEMBL38921644426476BindingDB-show
CHEMBL38921744426479BindingDB-show
CHEMBL38944144426482BindingDB-show
CHEMBL38944244426484BindingDB-show
CHEMBL38944344426488BindingDB-show
CHEMBL39100244426494BindingDB-show
CHEMBL3910244285652BindingDB-show
CHEMBL3931244285668BindingDB-show
CHEMBL39823944442223BindingDB-show
CHEMBL39824044442226BindingDB-show
CHEMBL39855144442232BindingDB-show
CHEMBL39931344442205BindingDB-show
CHEMBL39931544442211BindingDB-show
CHEMBL39936044442191BindingDB-show
CHEMBL39977144442247BindingDB-show
CHEMBL39977344442195BindingDB-show
CHEMBL40056044442237BindingDB-show
CHEMBL40074744442192BindingDB-show
CHEMBL40087444442213BindingDB-show
CHEMBL40097344442193BindingDB-show
CHEMBL40129344442221BindingDB-show
CHEMBL40312744442199BindingDB-show
CHEMBL40984125166692BindingDB-show
CHEMBL41063944452214BindingDB-show
CHEMBL41144325166904BindingDB-show
CHEMBL41206044451976BindingDB-show
CHEMBL41229544452237BindingDB-show
CHEMBL41773944306399BindingDB-show
CHEMBL43777444442203BindingDB-show
CHEMBL43866223708976BindingDB-show
CHEMBL43869444442243BindingDB-show
CHEMBL44846214309408BindingDB-show
CHEMBL48260114309405BindingDB-show
CHEMBL48280314309404BindingDB-show
CHEMBL48381914309407BindingDB-show
CHEMBL50130714309406BindingDB-show
CHEMBL5047819543637BindingDB-show
CHEMBL59368646227488BindingDB-show
CHEMBL59386246227489BindingDB-show
CHEMBL59457846227471BindingDB-show
CHEMBL59481346196548BindingDB-show
CHEMBL59575446227475BindingDB-show
CHEMBL59598446227476BindingDB-show
CHEMBL59598846227441BindingDB-show
CHEMBL60551446227470BindingDB-show
CHEMBL60635946227447BindingDB-show
CHEMBL60681346196547BindingDB-show
CHEMBL60898646196560BindingDB-show
CHEMBL6320444306923BindingDB-show
CHEMBL6326544307031BindingDB-show
CHEMBL6496244306438BindingDB-show
CHEMBL6503744306815BindingDB-show
CHEMBL6636844306430BindingDB-show
CHEMBL7466710065248BindingDB-show
CHEMBL7958344462116BindingDB-show
CHEMBL9983844331598BindingDB-show
dihydrodiphosphopyridine nucleotide439153DrugBank-show
Dithiothreitol446094DrugBank-show
Fluindostatin1548972DrugBank-show
fluindostatin446155DrugBank-show
fluindostatin446155SuperTarget2 PMIDsshow
Fluindostatin1548972SuperTarget2 PMIDsshow
Lipoglutaren1662BindingDB-show
Lipoglutaren1662DrugBank-show
Lipoglutaren1662SuperTarget-show
LMFA010305325312662BindingDB-show
LMFA010307379543636BindingDB-show
Lovastatin53232BindingDB-show
Lovastatin53232DrugBank-show
Lovastatin3962DrugBank-show
Lovastatin53232SuperTarget2 PMIDsshow
Lovastatin3962SuperTarget2 PMIDsshow
Pravastatin54687BindingDB-show
Pravastatin54687DrugBank-show
Pravastatin54687SuperTarget2 PMIDsshow
PRAVASTATIN SODIUM16759173BindingDB-show
Pyrrole-based compound, 3023708535BindingDB-show
Rosuvastatin446157BindingDB-show
Rosuvastatin6439133BindingDB-show
Rosuvastatin6439133DrugBank-show
Rosuvastatin6439133SuperTarget-show
SIMVASTATIN54454BindingDB-show
SIMVASTATIN54454DrugBank-show
SIMVASTATIN54454SuperTargetPMID 015503655show
Sklerofibrat39042DrugBank-show
Triphosphopyridine nucleotide5886DrugBank-show
Triphosphopyridine nucleotide5885DrugBank-show
Vytorin6419910BindingDB-show
ZINC015351019869776BindingDB-show
ZINC0188661737888681BindingDB-show
Synonyms:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
HMG-CoA reductase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
GUC2C_PIG31.117.3
O77690_BOVIN30.816.4
GRIK2_HUMAN30.715.1
ENPL_CANFA30.616.2
FOL1_PNECA30.416.1
GRIK2_RAT30.314.8
DPP4_RAT3017.2
SYMC_HUMAN3017.2
NAC1_HUMAN29.817.1
DPP4_MOUSE29.816.5
ACSL4_HUMAN29.616.8
ECHA_HUMAN29.416
IKKA_HUMAN29.416.9
GRIA2_RAT29.217.5
Q9XSW7_PIG29.216.7
Q8IVZ4_HUMAN2916.1
GRIK1_HUMAN2915.5
QHED_COMTE28.916
GRIA2_HUMAN28.917.5
GRIA1_HUMAN28.816.9
STAT1_HUMAN28.715
INLA_LISMO28.716.1
PABS_YEAST28.415.1
Q59F93_HUMAN28.316.8
PLCL1_HUMAN28.317
Q9WYA5_THEMA28.116.1
PDE5A_HUMAN28.116.8
SYAM_HUMAN2817.3
AT2A1_RABIT2816.7
HXK1_RAT2815.8
Protein-Protein Interactions: