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Target Details

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Name:Glycogen synthase kinase-3 alpha
Uniprot name:GSK3A_HUMAN
Accession Numbers:O14959 P49840
EC-Number:2.7.11.26
Organism:Homo sapiens
Human
PDB IDs:2DFM
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine449054BindingDB-show
2-chloro-5-[[4-(3-chlorophenyl)-2,5-dioxopyrrol-3-yl]amino]benzoic acid448008BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
4-arylmaleimide deriv. 6-a6539477BindingDB-show
4-arylmaleimide deriv. 6-c6539478BindingDB-show
4-arylmaleimide deriv. 6-d6539479BindingDB-show
4-arylmaleimide deriv. 6-e6539480BindingDB-show
4-arylmaleimide deriv. 6-f6539481BindingDB-show
4-arylmaleimide deriv. 6-g6539482BindingDB-show
4-arylmaleimide deriv. 6-h6539483BindingDB-show
4-arylmaleimide deriv. 6-i6539484BindingDB-show
4-arylmaleimide deriv. 6-j6539485BindingDB-show
4-arylmaleimide deriv. 6-k6539486BindingDB-show
4-arylmaleimide deriv. 6-l6539487BindingDB-show
4-arylmaleimide deriv. 6-m6539488BindingDB-show
4-arylmaleimide deriv. 6-n6539489BindingDB-show
4-arylmaleimide deriv. 6-o6539490BindingDB-show
4-arylmaleimide deriv. 6-p6539491BindingDB-show
4-arylmaleimide deriv. 6-q6539492BindingDB-show
4-arylmaleimide deriv. 6-r6539493BindingDB-show
4-arylmaleimide deriv. 6-s6539494BindingDB-show
4-arylmaleimide deriv. 6-t6539495BindingDB-show
4-arylmaleimide deriv. 6-u6539496BindingDB-show
4-arylmaleimide deriv. 6-v6539497BindingDB-show
4-arylmaleimide deriv. 6-w6539498BindingDB-show
4-arylmaleimide deriv. 6-x6539499BindingDB-show
4-arylmaleimide deriv. 6-y6539500BindingDB-show
4-arylmaleimide deriv. 6a6539451BindingDB-show
4-arylmaleimide deriv. 6aa6539501BindingDB-show
4-arylmaleimide deriv. 6b6539452BindingDB-show
4-arylmaleimide deriv. 6bb3513BindingDB-show
4-arylmaleimide deriv. 6c6539453BindingDB-show
4-arylmaleimide deriv. 6cc6539502BindingDB-show
4-arylmaleimide deriv. 6d6539454BindingDB-show
4-arylmaleimide deriv. 6dd6539503BindingDB-show
4-arylmaleimide deriv. 6e6539455BindingDB-show
4-arylmaleimide deriv. 6ee6539504BindingDB-show
4-arylmaleimide deriv. 6f6539456BindingDB-show
4-arylmaleimide deriv. 6ff6539505BindingDB-show
4-arylmaleimide deriv. 6g6539457BindingDB-show
4-arylmaleimide deriv. 6gg6539506BindingDB-show
4-arylmaleimide deriv. 6h6539458BindingDB-show
4-arylmaleimide deriv. 6hh6539507BindingDB-show
4-arylmaleimide deriv. 6i6539459BindingDB-show
4-arylmaleimide deriv. 6ii6539508BindingDB-show
4-arylmaleimide deriv. 6j6539460BindingDB-show
4-arylmaleimide deriv. 6jj6539509BindingDB-show
4-arylmaleimide deriv. 6k6539461BindingDB-show
4-arylmaleimide deriv. 6kk6539510BindingDB-show
4-arylmaleimide deriv. 6l6539462BindingDB-show
4-arylmaleimide deriv. 6ll6539511BindingDB-show
4-arylmaleimide deriv. 6m6539463BindingDB-show
4-arylmaleimide deriv. 6n6539464BindingDB-show
4-arylmaleimide deriv. 6o6539465BindingDB-show
4-arylmaleimide deriv. 6p6539466BindingDB-show
4-arylmaleimide deriv. 6q6539467BindingDB-show
4-arylmaleimide deriv. 6r6539468BindingDB-show
4-arylmaleimide deriv. 6s6539469BindingDB-show
4-arylmaleimide deriv. 6t6539470BindingDB-show
4-arylmaleimide deriv. 6u6539471BindingDB-show
4-arylmaleimide deriv. 6v6539472BindingDB-show
4-arylmaleimide deriv. 6w6539473BindingDB-show
4-arylmaleimide deriv. 6x6539474BindingDB-show
4-arylmaleimide deriv. 6y6539475BindingDB-show
4-arylmaleimide deriv. 6z6539476BindingDB-show
4-arylmaleimide deriv. 7a6539512BindingDB-show
4-arylmaleimide deriv. 7b6539513BindingDB-show
4-arylmaleimide deriv. 7c6539514BindingDB-show
4-arylmaleimide deriv. 7d6539515BindingDB-show
4-arylmaleimide deriv. 8a6539516BindingDB-show
4-arylmaleimide deriv. 8b6539517BindingDB-show
4-arylmaleimide deriv. 8c6539518BindingDB-show
4-arylmaleimide deriv. 8d6539519BindingDB-show
4-arylmaleimide deriv. 8e6539520BindingDB-show
4-arylmaleimide deriv. 8f6539521BindingDB-show
4-arylmaleimide deriv. 8g6539522BindingDB-show
4-arylmaleimide deriv. 9a6539523BindingDB-show
4-arylmaleimide deriv. 9b6539524BindingDB-show
4-arylmaleimide deriv. 9c6539525BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 106539571BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 116539572BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 126539573BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 136539574BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 146539575BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 156539576BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 166539577BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 176539578BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 186539579BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 196539580BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 206539581BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 226539583BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 236539584BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 246539585BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 46539565BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 56539566BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 66539567BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 76539568BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 86539569BindingDB-show
6-aryl-pyrazolo[3,4-b]pyridine analogue 96539570BindingDB-show
7-bromo-indirubin-3'-oxime11846148BindingDB-show
ABT-86911485656BindingDB-show
AC1M5WRE2337532BindingDB-show
AIDS0228376509753BindingDB-show
Alsterpaullone5005498BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:45344644413883BindingDB-show
CHEBI:45347844413893BindingDB-show
CHEBI:45348044413894BindingDB-show
CHEBI:45350644413897BindingDB-show
CHEBI:45353544413900BindingDB-show
CHEBI:45357944413922BindingDB-show
CHEBI:45372144413950BindingDB-show
CHEBI:45374244413951BindingDB-show
CHEBI:45377144413958BindingDB-show
CHEBI:45379344413964BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL10809019957049BindingDB-show
CHEMBL108215211560568BindingDB-show
CHEMBL109275444541014BindingDB-show
CHEMBL10962211162136BindingDB-show
CHEMBL1114339795578BindingDB-show
CHEMBL11162411220045BindingDB-show
CHEMBL11439611151410BindingDB-show
CHEMBL11930910017795BindingDB-show
CHEMBL1200779797370BindingDB-show
CHEMBL124070352945601BindingDB-show
CHEMBL124255623641602BindingDB-show
CHEMBL1762489966101BindingDB-show
CHEMBL17823744389527BindingDB-show
CHEMBL17826411208863BindingDB-show
CHEMBL17830611632139BindingDB-show
CHEMBL17848811689490BindingDB-show
CHEMBL17864544389398BindingDB-show
CHEMBL17864644389399BindingDB-show
CHEMBL17876644389387BindingDB-show
CHEMBL17882044389360BindingDB-show
CHEMBL17885044389438BindingDB-show
CHEMBL17885144389439BindingDB-show
CHEMBL17895311493632BindingDB-show
CHEMBL17922411595868BindingDB-show
CHEMBL17934110236668BindingDB-show
CHEMBL1794209814443BindingDB-show
CHEMBL17972544389394BindingDB-show
CHEMBL18077944389371BindingDB-show
CHEMBL18101544389435BindingDB-show
CHEMBL18102911645981BindingDB-show
CHEMBL18103111283328BindingDB-show
CHEMBL18111244389548BindingDB-show
CHEMBL18129644389420BindingDB-show
CHEMBL18133944389381BindingDB-show
CHEMBL18137144389443BindingDB-show
CHEMBL18146444389424BindingDB-show
CHEMBL18151844389357BindingDB-show
CHEMBL18177444389370BindingDB-show
CHEMBL18204844389365BindingDB-show
CHEMBL20293511543980BindingDB-show
CHEMBL20854011846972BindingDB-show
CHEMBL20874124970388BindingDB-show
CHEMBL20883211846484BindingDB-show
CHEMBL20933644412652BindingDB-show
CHEMBL20964811846149BindingDB-show
CHEMBL20996811846483BindingDB-show
CHEMBL21000144412747BindingDB-show
CHEMBL21007311846322BindingDB-show
CHEMBL21010411846822BindingDB-show
CHEMBL21010544412748BindingDB-show
CHEMBL21010644412749BindingDB-show
CHEMBL21016111845974BindingDB-show
CHEMBL21022916007031BindingDB-show
CHEMBL21023644412671BindingDB-show
CHEMBL21033044412637BindingDB-show
CHEMBL21038544412638BindingDB-show
CHEMBL21044611847138BindingDB-show
CHEMBL21047444412585BindingDB-show
CHEMBL21091844412669BindingDB-show
CHEMBL21091944412670BindingDB-show
CHEMBL21120511846155BindingDB-show
CHEMBL21140911846648BindingDB-show
CHEMBL21142911846647BindingDB-show
CHEMBL21144511846150BindingDB-show
CHEMBL21156244412575BindingDB-show
CHEMBL21159311846154BindingDB-show
CHEMBL21180344412576BindingDB-show
CHEMBL21205711846318BindingDB-show
CHEMBL21217411845975BindingDB-show
CHEMBL21246511846319BindingDB-show
CHEMBL21258111846651BindingDB-show
CHEMBL21312811846317BindingDB-show
CHEMBL21340111846649BindingDB-show
CHEMBL21345411846152BindingDB-show
CHEMBL21350611846320BindingDB-show
CHEMBL21361816043304BindingDB-show
CHEMBL21374211846479BindingDB-show
CHEMBL21417311845789BindingDB-show
CHEMBL23534516739279BindingDB-show
CHEMBL24355611846316BindingDB-show
CHEMBL24377711847137BindingDB-show
CHEMBL30453344307734BindingDB-show
CHEMBL32119211460544BindingDB-show
CHEMBL32119411771622BindingDB-show
CHEMBL32691911737463BindingDB-show
CHEMBL35953744389517BindingDB-show
CHEMBL35983011544306BindingDB-show
CHEMBL35987144389400BindingDB-show
CHEMBL36100744389373BindingDB-show
CHEMBL36112544389414BindingDB-show
CHEMBL36112711196978BindingDB-show
CHEMBL36120444389455BindingDB-show
CHEMBL36163544389367BindingDB-show
CHEMBL36174644389463BindingDB-show
CHEMBL36176544389388BindingDB-show
CHEMBL36194844389453BindingDB-show
CHEMBL36199644389426BindingDB-show
CHEMBL36222144389477BindingDB-show
CHEMBL36225944389423BindingDB-show
CHEMBL36258744389445BindingDB-show
CHEMBL36258811294864BindingDB-show
CHEMBL36281411316975BindingDB-show
CHEMBL36283044389433BindingDB-show
CHEMBL36824644389363BindingDB-show
CHEMBL36824844389448BindingDB-show
CHEMBL36842644389356BindingDB-show
CHEMBL36909044389409BindingDB-show
CHEMBL36909944389386BindingDB-show
CHEMBL36910844389431BindingDB-show
CHEMBL36931644389389BindingDB-show
CHEMBL36957244389457BindingDB-show
CHEMBL37400611846153BindingDB-show
CHEMBL37587011845973BindingDB-show
CHEMBL37741011846485BindingDB-show
CHEMBL37753611847136BindingDB-show
CHEMBL37773411632737BindingDB-show
CHEMBL37805911847139BindingDB-show
CHEMBL37819024970434BindingDB-show
CHEMBL37820511846151BindingDB-show
CHEMBL37830744412651BindingDB-show
CHEMBL37831611846321BindingDB-show
CHEMBL37848511847135BindingDB-show
CHEMBL37878711845971BindingDB-show
CHEMBL37884911846482BindingDB-show
CHEMBL37893711846480BindingDB-show
CHEMBL37916011845790BindingDB-show
CHEMBL37937811846481BindingDB-show
CHEMBL37953044412639BindingDB-show
CHEMBL37985811846650BindingDB-show
CHEMBL37987811846652BindingDB-show
CHEMBL38005311846323BindingDB-show
CHEMBL38024111845972BindingDB-show
CHEMBL38415911846486BindingDB-show
CHEMBL39392911631681BindingDB-show
CHEMBL42108711161961BindingDB-show
CHEMBL42624344389407BindingDB-show
CHEMBL42669311846823BindingDB-show
CHEMBL43879111846970BindingDB-show
CHEMBL43950244412653BindingDB-show
CHEMBL44564944389456BindingDB-show
CHEMBL45312824970433BindingDB-show
CHEMBL45312924970438BindingDB-show
CHEMBL45313024970385BindingDB-show
CHEMBL45313124970386BindingDB-show
CHEMBL45313224970436BindingDB-show
CHEMBL45313324970387BindingDB-show
CHEMBL45412624970437BindingDB-show
CHEMBL45413024970495BindingDB-show
CHEMBL46173924970435BindingDB-show
CHEMBL50666944563897BindingDB-show
CHEMBL51086324970432BindingDB-show
CHEMBL659449884977BindingDB-show
CHEMBL6607210092260BindingDB-show
CHEMBL6686010248678BindingDB-show
CHEMBL6968710432939BindingDB-show
CHIR-26511656518BindingDB-show
CP-7247149874913BindingDB-show
Cystoceva5318432BindingDB-show
Dasatinib3062316BindingDB-show
Dipropylacetate3121SuperTarget-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Gefitinib123631BindingDB-show
GSK-3 Inhibitor XIII6419766BindingDB-show
GW-258011617559BindingDB-show
heterocyclic pyrimidyl hydrazone 19604911BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
indazole analog 46539551BindingDB-show
indazole analogue 116539593BindingDB-show
indazole analogue 126539594BindingDB-show
indazole analogue 136539595BindingDB-show
indazole analogue 146539596BindingDB-show
indazole analogue 156539597BindingDB-show
indazole analogue 166539598BindingDB-show
indazole analogue 176539599BindingDB-show
indazole analogue 186539600BindingDB-show
indazole analogue 196539601BindingDB-show
indazole analogue 206539602BindingDB-show
indazole analogue 216539603BindingDB-show
indazole analogue 226539604BindingDB-show
indazole analogue 236539605BindingDB-show
indazole analogue 246539606BindingDB-show
indazole analogue 256539607BindingDB-show
indazole analogue 266539608BindingDB-show
indazole analogue 276539609BindingDB-show
indazole analogue 286539610BindingDB-show
indazole analogue 296539586BindingDB-show
indazole analogue 306539587BindingDB-show
Indirubin5318433BindingDB-show
INDIRUBIN 224205929BindingDB-show
indirubin deriv. 13d6538834BindingDB-show
indirubin deriv. 8h6538812BindingDB-show
indirubin deriv. 9b6538813BindingDB-show
Indirubin-3monoxime5326739BindingDB-show
InSolution™ GSK-3 Inhibitor IX5287844BindingDB-show
isoxazolopyridine deriv. 76539531BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_291844444843BindingDB-show
Kinome_368211248978BindingDB-show
Kinome_6366420138BindingDB-show
Kinome_71446886323BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
Lithium monohydride3028194SuperTargetPMID 14550568show
MLN805411712649BindingDB-show
NSC7178115472297BindingDB-show
Pazopanib10113978BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Pyrazolopyridazine 1a6263849BindingDB-show
Pyrazolopyridazine 1n6538884BindingDB-show
pyrazolopyridazine 56539527BindingDB-show
pyrazolopyridazine deriv. 106539555BindingDB-show
pyrazolopyridazine deriv. 116539556BindingDB-show
pyrazolopyridazine deriv. 126539557BindingDB-show
pyrazolopyridazine deriv. 136539558BindingDB-show
pyrazolopyridazine deriv. 146539559BindingDB-show
pyrazolopyridazine deriv. 156539560BindingDB-show
pyrazolopyridazine deriv. 166539561BindingDB-show
pyrazolopyridazine deriv. 176539562BindingDB-show
pyrazolopyridazine deriv. 186539563BindingDB-show
pyrazolopyridazine deriv. 196539564BindingDB-show
pyrazolopyridazine deriv. 86539553BindingDB-show
pyrazolopyridazine deriv. 96539554BindingDB-show
pyrazolopyridine deriv. 106539534BindingDB-show
pyrazolopyridine deriv. 116539535BindingDB-show
pyrazolopyridine deriv. 126539536BindingDB-show
pyrazolopyridine deriv. 136539537BindingDB-show
pyrazolopyridine deriv. 146539538BindingDB-show
pyrazolopyridine deriv. 156539539BindingDB-show
pyrazolopyridine deriv. 166539540BindingDB-show
pyrazolopyridine deriv. 176539541BindingDB-show
pyrazolopyridine deriv. 186539542BindingDB-show
pyrazolopyridine deriv. 196539543BindingDB-show
pyrazolopyridine deriv. 206539544BindingDB-show
pyrazolopyridine deriv. 216539545BindingDB-show
pyrazolopyridine deriv. 226539546BindingDB-show
pyrazolopyridine deriv. 236539547BindingDB-show
pyrazolopyridine deriv. 246539548BindingDB-show
pyrazolopyridine deriv. 256539549BindingDB-show
pyrazolopyridine deriv. 266539550BindingDB-show
pyrazolopyridine deriv. 36539528BindingDB-show
pyrazolopyridine deriv. 56539529BindingDB-show
pyrazolopyridine deriv. 66539530BindingDB-show
pyrazolopyridine deriv. 66539526BindingDB-show
pyrazolopyridine deriv. 96539533BindingDB-show
pyrazolopyrimidine deriv. 76539552BindingDB-show
pyrazolopyrimidine derivative 409604948BindingDB-show
pyrazolopyrimidine derivative 549604961BindingDB-show
pyrazolopyrimidine derivative 559604962BindingDB-show
pyrazolopyrimidine derivative 89604917BindingDB-show
pyrazolo[3,4-b]pyridine analogue 316539588BindingDB-show
pyrazolo[3,4-b]pyridine analogue 326539591BindingDB-show
pyrazolo[3,4-b]pyridine analogue 336539592BindingDB-show
pyrazolo[3,4-b]pyridine analogue 346539611BindingDB-show
pyrazolo[3,4-b]pyridine analogue 356539612BindingDB-show
pyrazolo[3,4-b]pyridine analogue 366539613BindingDB-show
pyrazolo[3,4-b]pyridine analogue 376539614BindingDB-show
pyrazolo[3,4-b]pyridine analogue 386539615BindingDB-show
pyrazolo[3,4-b]pyridine analogue 66539589BindingDB-show
pyrazolo[3,4-b]pyridine analogue 76539590BindingDB-show
pyrazolo[3,4-b]pyridine analogue 96539582BindingDB-show
pyrrolopyridine deriv. 86539532BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1263_Selleck9956119BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Tocris-1616176158BindingDB-show
Tocris-16174210951BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
ZINC001697752764173BindingDB-show
Synonyms:
Glycogen synthase kinase-3 alpha
GSK-3 alpha
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
GSK3B_MOUSE73.466.5
Q5KU03_MOUSE73.466.5
GSK3B_HUMAN73.366.5
B5BUC0_HUMAN72.966.1
MSK1_TOBAC59.247.7
MK03_RAT40.825
MK03_HUMAN40.626
MK03_MOUSE40.524.6
MK14_MOUSE38.222.4
MK14_HUMAN38.222.4
CDK15_HUMAN38.124
CDK2_HUMAN37.423.4
MK01_HUMAN36.822.4
MK01_MOUSE36.822.2
MK01_RAT36.822.2
CDK7_HUMAN36.825.3
Q499G7_HUMAN36.822.2
Q1HBJ4_HUMAN36.822.4
MK10_HUMAN36.621.6
CDK5_MOUSE34.322.8
CDK5_HUMAN34.322.8
MP2K4_HUMAN34.220.3
KAPA_YEAST33.920
CSK21_HUMAN33.820.7
CDC2H_PLAFK33.720.1
PIM1_HUMAN33.620.9
MK12_HUMAN33.520.6
CDK9_HUMAN33.521.8
A4D1G0_HUMAN33.121.4
CDK6_HUMAN33.121.4
Protein-Protein Interactions: