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Target Details

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Name:Glutathione reductase, mitochondrial
Uniprot name:GSHR_HUMAN
Accession Numbers:P00390 Q7Z5C9 Q9NP63
EC-Number:1.8.1.7
Organism:Homo sapiens
Human
PDB IDs:1ALG 1BWC 1DNC 1GRA 1GRB 1GRE 1GRF 1GRG 1GRH 1GRT 1GSN 1K4Q 1XAN 2AAQ 2GH5 2GRT 3DJG 3DJJ 3DK4 3DK8 3DK9 3GRS 3GRT 4GR1 4GRT 5GRT
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
10-Cpmf128254BindingDB-show
2-oxido-4-phenyl-1-oxa-5-aza-2-azoniacyclopenta-2,4-diene-3-carbaldehyde10352496BindingDB-show
3,6-DIHYDROXY-XANTHENE-9-PROPIONIC ACID449159DrugBank-show
3-(PROP-2-ENE-1-SULFINYL)-PROPENE-1-THIOL9543424DrugBank-show
3-Hydroxybenzyldimethylamine hydrochloride21025BindingDB-show
439154439154DrugBank-show
A0720/00335811712537BindingDB-show
AC1NRY8Y5325382BindingDB-show
AC1NRY9A5325386BindingDB-show
AE-848/420258924362773BindingDB-show
BAS 013653572881754BindingDB-show
Bischloroethylnitrosourea2578DrugBank-show
Bischloroethylnitrosourea2578SuperTarget2 PMIDsshow
CBMicro_037469877340BindingDB-show
CHEBI:438304139BindingDB-show
CHEBI:64970144432448BindingDB-show
CHEBI:65039144432443BindingDB-show
CHEBI:65330944432446BindingDB-show
CHEMBL10576911798906BindingDB-show
CHEMBL10610810791392BindingDB-show
CHEMBL12014711595259BindingDB-show
CHEMBL13461510683588BindingDB-show
CHEMBL13528710708341BindingDB-show
CHEMBL13550410708472BindingDB-show
CHEMBL13553610851879BindingDB-show
CHEMBL13913010489510BindingDB-show
CHEMBL18778811416788BindingDB-show
CHEMBL19059211290283BindingDB-show
CHEMBL20691644411997BindingDB-show
CHEMBL20716344412016BindingDB-show
CHEMBL20739616047388BindingDB-show
CHEMBL20829016048003BindingDB-show
CHEMBL20903916047279BindingDB-show
CHEMBL20983416047278BindingDB-show
CHEMBL21037016047175BindingDB-show
CHEMBL21037116047281BindingDB-show
CHEMBL22497611665560BindingDB-show
CHEMBL27784044323190BindingDB-show
CHEMBL28781615192337BindingDB-show
CHEMBL28784914860354BindingDB-show
CHEMBL28795513989170BindingDB-show
CHEMBL28826914016406BindingDB-show
CHEMBL28911710026610BindingDB-show
CHEMBL28920510475024BindingDB-show
CHEMBL29001915192343BindingDB-show
CHEMBL29023215192344BindingDB-show
CHEMBL29042210317614BindingDB-show
CHEMBL31558310072380BindingDB-show
CHEMBL34352410847727BindingDB-show
CHEMBL37194144404033BindingDB-show
CHEMBL37813616047389BindingDB-show
CHEMBL37890016047280BindingDB-show
CHEMBL37970144412091BindingDB-show
CHEMBL38085716047174BindingDB-show
CHEMBL38243444412123BindingDB-show
CHEMBL3835515192342BindingDB-show
CHEMBL3856315192341BindingDB-show
CHEMBL3889944285823BindingDB-show
CHEMBL3905110429818BindingDB-show
CHEMBL3908412247627BindingDB-show
CHEMBL3913715192395BindingDB-show
CHEMBL3914114016404BindingDB-show
CHEMBL3922515192338BindingDB-show
CHEMBL3944915192339BindingDB-show
CHEMBL3982915192393BindingDB-show
CHEMBL412099979274BindingDB-show
CHEMBL41417610387232BindingDB-show
CHEMBL41587015192340BindingDB-show
CHEMBL41825010319412BindingDB-show
CHEMBL43952015605637BindingDB-show
CHEMBL44639444286066BindingDB-show
CHEMBL55572145268767BindingDB-show
CHEMBL55625645273021BindingDB-show
CHEMBL55667145273032BindingDB-show
CHEMBL55679145272169BindingDB-show
CHEMBL55961545266944BindingDB-show
CHEMBL56122045269616BindingDB-show
CHEMBL56190145267883BindingDB-show
CHEMBL56190245267884BindingDB-show
CHEMBL56235945268768BindingDB-show
CHEMBL56361945273020BindingDB-show
CHEMBL56524245484008BindingDB-show
CHEMBL56740825269395BindingDB-show
CHEMBL56896125269392BindingDB-show
CHEMBL56918825269738BindingDB-show
CHEMBL57013025269388BindingDB-show
CHEMBL57013225269734BindingDB-show
CHEMBL57034625269736BindingDB-show
CHEMBL57171025269389BindingDB-show
CHEMBL57171225269732BindingDB-show
CHEMBL57436012219475BindingDB-show
CHEMBL57457925269737BindingDB-show
CHEMBL57480125269039BindingDB-show
CHEMBL57501325270069BindingDB-show
CHEMBL57611825269394BindingDB-show
CHEMBL57881025269733BindingDB-show
CHEMBL58519025269740BindingDB-show
CHEMBL58536825269037BindingDB-show
CHEMBL7699444315802BindingDB-show
CHEMBL8930344322851BindingDB-show
CHEMBL8936844323177BindingDB-show
CHEMBL9082044322860BindingDB-show
CHEMBL9130910253825BindingDB-show
CHEMBL9215544323235BindingDB-show
chlorhexidine9552079BindingDB-show
Cysteine sulfinate109DrugBank-show
dihydrodiphosphopyridine nucleotide439153DrugBank-show
dihydroquercetin471BindingDB-show
Fotemustine104799SuperTargetPMID 1841712show
Furoxan1756BindingDB-show
gamma-Glutamylcysteinylglycine124886DrugBank-show
gamma-Glutamylcysteinylglycine124886SuperTarget-show
GLUTATHIONYLSPERMIDINE DISULFIDE449555DrugBank-show
HMS519K1144432442BindingDB-show
methylene blue6099BindingDB-show
Methylnaphthoquinone4055BindingDB-show
NAD449328DrugBank-show
Nifurtimox6842999SuperTargetPMID 1505781show
NSC627989363243BindingDB-show
NSC688494390735BindingDB-show
Oprea1_24203416193441BindingDB-show
Oxiglutatione65359DrugBank-show
Peakdale1_000585214232BindingDB-show
Quinacrine Dihydrochloride237BindingDB-show
ST038052723918BindingDB-show
Tripelennamine5587SuperTarget2 PMIDsshow
Xanthaurine5280343BindingDB-show
ZINC00059752580286BindingDB-show
ZINC00354323831028BindingDB-show
ZINC00446424877450BindingDB-show
ZINC028702172223018BindingDB-show
[(1S,2S)-2-hydroxycyclohexyl] Nitrate10964817BindingDB-show
Synonyms:
Glutathione reductase, mitochondrial
GR
GRase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
GSHR_RAT75.169.6
GSHR_ECOLI60.648.1
TRXR2_RAT54.437
TRXR2_MOUSE53.737.9
TRXR2_HUMAN52.636.6
GSHR_PLAFK51.835.4
TRXR1_RAT4730.6
DLDH_PEA46.826.1
TRXR1_MOUSE46.130.2
TYTR_TRYCR44.730.1
Q03504_HUMAN44.144.1
TYTR_CRIFA43.429.9
DLDH_HUMAN4328
DLDH_AZOVI42.723.7
DLDH_PSEFL42.624.9
Q51225_NEIME41.325.2
DLDH_YEAST4126
TRXR1_HUMAN39.926.4
DLDH1_PSEPU39.423.3
TRXR3_HUMAN38.425.4
XECC_XANP237.823.1
TRXR3_MOUSE37.225.8
Q91Y95_MOUSE33.321.3
LPDA_MYCTU33.220.1
NFS1_HUMAN32.920.3
FUMC_ECOLI32.718.5
Q6LEN0_HUMAN32.519
KPYK1_YEAST32.519.2
VSM2_TRYBB32.518.9
Q6LEN2_HUMAN32.318.8
Protein-Protein Interactions: