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Name:Liver carboxylesterase 1
Uniprot name:EST1_HUMAN
Accession Numbers:A8K3K8 A8K844 P23141 P82127 Q00015 Q13657 Q14062 Q16737 Q16788 Q549X7 Q549X8 Q86UK2 Q96EE8 Q9UC52 Q9UK77 Q9ULY2
EC-Number:3.1.1.1
Organism:Homo sapiens
Human
PDB IDs:1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(4-(Bromomethyl)phenyl)phenylethanedione87502BindingDB-show
1,1,1-trifluoro-3-phenylacetone222958BindingDB-show
1,1,1-trifluorononan-2-one176443BindingDB-show
1,10-Phenanthroline-5,6-dione72810BindingDB-show
1,2-Aceanthrylenedione316765BindingDB-show
1,2-bis(4-bromo-3-nitrophenyl)ethane-1,2-dione5038499BindingDB-show
1,2-bis(4-ethoxyphenyl)ethane-1,2-dione4369935BindingDB-show
1,2-bis(4-fluorophenyl)-2-hydroxyethanone103786BindingDB-show
1,2-bis(4-nitrophenyl)ethane-1,2-dione1812008BindingDB-show
1,2-Bis(4-trifluoromethylphenyl)-ethan-1,2-dione599378BindingDB-show
1,2-dinaphthalen-2-ylethane-1,2-dione3274712BindingDB-show
1,2-Indandione123358BindingDB-show
1,3-Cyclohexanedione10434BindingDB-show
1,3-dimethylcycloadipic ketone70945BindingDB-show
1,4-Bis(phenylglyoxaloyl)benzene137905BindingDB-show
1-(2,3,4,5,6-pentachlorophenyl)-2-(2,3,4,5,6-pentafluorophenyl)ethane-1,2-3527426BindingDB-show
1-(2-iodoethyl)indole-2,3-dione4135273BindingDB-show
1-(3,4-dimethylphenyl)-2-phenylethane-1,2-dione2427416BindingDB-show
1-(Hydroxymethyl)indole-2,3-dione39834BindingDB-show
1-(thiomorpholin-4-ylmethyl)indole-2,3-dione3531512BindingDB-show
1-Benzyl-1H-indole-2,3-dione264734BindingDB-show
1-Chloro-2,3-indoledione137777BindingDB-show
1-Dodecyl-1H-indole-2,3-dione1897797BindingDB-show
1-hexadecylindole-2,3-dione3772674BindingDB-show
1-Morpholin-4-ylmethyl-1H-indole-2,3-dione262696BindingDB-show
1-Phenyl-1,4-pentanedione136371BindingDB-show
1-Phenylisatin12884BindingDB-show
1-Piperidin-1-ylmethyl-1H-indole-2,3-dione262695BindingDB-show
2,2',4,4'-Tetrahydroxybenzil219592BindingDB-show
2,2'-Dichlorobenzil89076BindingDB-show
2,2'-Thenil275005BindingDB-show
2,2,2-TRIFLUOROACETOPHENONE9905BindingDB-show
2,2-Dimethoxy-2-phenylacetophenone90571BindingDB-show
2,3-Dioxo-1-indolineacetic acid43402BindingDB-show
2,3-dioxoindoline-7-carboxylic acid2779383BindingDB-show
2,3-HEPTANEDIONE60983BindingDB-show
2,5-dichloro-N-[4-[(2,5-dichlorophenyl)sulfonylamino]phenyl]benzenesulfona4118889BindingDB-show
2-(2,3-dioxoindol-1-yl)-N-(4-hydroxyphenyl)acetamide3329233BindingDB-show
2-Chloro-3',4'-dimethoxybenzil92036BindingDB-show
2-METHYL-1,3-CYCLOPENTANEDIONE13005BindingDB-show
2-nitrophenanthrene-9,10-dione94860BindingDB-show
2-Nonadecanone, 1,1,1-trifluoro-157730BindingDB-show
3,3'-Dimethoxybenzil123493BindingDB-show
3,3'-Dinitrobenzil101375BindingDB-show
3,5,5-Trimethyl-1,2-cyclohexanedione93772BindingDB-show
3,5-Ditert-butylbenzo-1,2-quinone76915BindingDB-show
3-Methyl-1,2-cyclohexanedione3321360BindingDB-show
3-Methyl-1,2-cyclopentanedione61209BindingDB-show
4,4'-Dibromobenzil96430BindingDB-show
4,4'-Dichlorobenzil18946BindingDB-show
4,4'-Difluorobenzil123072BindingDB-show
4,4'-Dihydroxybenzil458204BindingDB-show
4,4'-Dimethoxybenzil71043BindingDB-show
4,4'-Dimethylbenzil76996BindingDB-show
4,5-dichloro-1H-indole-2,3-dione5139980BindingDB-show
4,6-Dichloro-1H-indole-2,3-dione251908BindingDB-show
4,7-Dichloroisatin2734793BindingDB-show
4,7-dimethyl-1H-indole-2,3-dione3264931BindingDB-show
4-Benzoylbenzoic acid69147BindingDB-show
4-bromo-N-(4-phenoxyphenyl)benzenesulfonamide4381638BindingDB-show
4-bromo-N-[4-[(4-bromophenyl)sulfonylamino]phenyl]benzenesulfonamide5235003BindingDB-show
4-Chloro-7-methyl-1H-indole-2,3-dione1810509BindingDB-show
4-chloro-N-(4-ethoxyphenyl)benzenesulfonamide306215BindingDB-show
4-Chlorodibenzoyl89801BindingDB-show
4-Chloroisatin96047BindingDB-show
4-Ethyl isatin13827082BindingDB-show
4-Nitrobenzil283893BindingDB-show
4290-72-62786143BindingDB-show
5,6-dichloro-1H-indole-2,3-dione11009341BindingDB-show
5,6-dimethylmorpholine-2,3-dione3469206BindingDB-show
5,7-Dichloroisatin80771BindingDB-show
5,7-Dimethylisatin38296BindingDB-show
5-(Trifluoromethoxy)isatin2732752BindingDB-show
5-Bromoisatin6889BindingDB-show
5-Chloro-7-methylisatin366710BindingDB-show
5-Chloroisatin87203BindingDB-show
5-Fluoroisatin236566BindingDB-show
5-Iodoisatin88695BindingDB-show
5-Methoxyisatin38333BindingDB-show
5-Methylisatin11840BindingDB-show
5-Nitroisatin4669250BindingDB-show
6-bromo-5-methyl-1H-indole-2,3-dione1718647BindingDB-show
6-Chloro-2-methoxyacridine-9-ylamine19080BindingDB-show
6-chloro-7-methyl-1H-indole-2,3-dione4513067BindingDB-show
6-Chloroisatin241331BindingDB-show
6-Ethyl isatin13827083BindingDB-show
7-Chloroisatin344135BindingDB-show
7-Fluoroisatin586418BindingDB-show
7-methoxyindoline-2,3-dione4088910BindingDB-show
7-Methylisatin14313BindingDB-show
7-Trifluoromethylisatin604575BindingDB-show
AC1LBXCL590628BindingDB-show
AC1M5V1J2385968BindingDB-show
AC1MBTQK2731127BindingDB-show
AC1MBV042731732BindingDB-show
AC1MBVDR2731902BindingDB-show
AC1MD6UA2784639BindingDB-show
AC1N9FPX4384851BindingDB-show
AC1NMC2C5004413BindingDB-show
AC1NO1465080545BindingDB-show
AC1NS4MT5353845BindingDB-show
AC1Q3HQA16786802BindingDB-show
Acenaphthenequinone6724BindingDB-show
Acetoacetaldehyde650BindingDB-show
Acetylacetone31261BindingDB-show
Acetylbenzoyl11363BindingDB-show
Acetylpropionyl11747BindingDB-show
AE-848/012910443477013BindingDB-show
Aethacridinum2017BindingDB-show
Avasimibe166558BindingDB-show
BAS 001171152305233BindingDB-show
BAS 011232233126152BindingDB-show
Benzil-based compound, 1211437501BindingDB-show
Benzil-based compound, 1311392969BindingDB-show
Benzil-based compound, 3324825630BindingDB-show
Benzoylphenylcarbinol8400BindingDB-show
Benzyl phenyl sulfone76561BindingDB-show
Benzyl sulfoxide12116BindingDB-show
Bipicolinoyl68115BindingDB-show
CBDivE_0120922835143BindingDB-show
CHEMBL17399211279040BindingDB-show
CHEMBL17439711441196BindingDB-show
CHEMBL1755809977214BindingDB-show
CHEMBL17585410085812BindingDB-show
CHEMBL17721610044204BindingDB-show
CHEMBL17735611278743BindingDB-show
CHEMBL17770811393923BindingDB-show
CHEMBL17807111739291BindingDB-show
CHEMBL17811511709766BindingDB-show
CHEMBL17839811484453BindingDB-show
CHEMBL17856344389973BindingDB-show
CHEMBL17976022486206BindingDB-show
CHEMBL18062511631387BindingDB-show
CHEMBL18219944389776BindingDB-show
CHEMBL18220611695972BindingDB-show
CHEMBL19067211245953BindingDB-show
CHEMBL19259211280423BindingDB-show
CHEMBL21963316110652BindingDB-show
CHEMBL21965816110708BindingDB-show
CHEMBL21967511991810BindingDB-show
CHEMBL21981816110717BindingDB-show
CHEMBL21988016110656BindingDB-show
CHEMBL21994216110715BindingDB-show
CHEMBL21995316110658BindingDB-show
CHEMBL22012511991808BindingDB-show
CHEMBL22037916110655BindingDB-show
CHEMBL22044924748349BindingDB-show
CHEMBL22055616110710BindingDB-show
CHEMBL22062916110651BindingDB-show
CHEMBL22067916110654BindingDB-show
CHEMBL22068616110711BindingDB-show
CHEMBL22068716110666BindingDB-show
CHEMBL22072911991892BindingDB-show
CHEMBL22073116110723BindingDB-show
CHEMBL22077011991895BindingDB-show
CHEMBL22078411991809BindingDB-show
CHEMBL22340616110641BindingDB-show
CHEMBL23528711806279BindingDB-show
CHEMBL24206722574214BindingDB-show
CHEMBL24228719377173BindingDB-show
CHEMBL24228844428837BindingDB-show
CHEMBL24229644428842BindingDB-show
CHEMBL24250644428843BindingDB-show
CHEMBL24272122574258BindingDB-show
CHEMBL24272244428839BindingDB-show
CHEMBL24276819971657BindingDB-show
CHEMBL24293044428840BindingDB-show
CHEMBL24293144428841BindingDB-show
CHEMBL24442544428828BindingDB-show
CHEMBL24442644428829BindingDB-show
CHEMBL24442744428831BindingDB-show
CHEMBL24442844428832BindingDB-show
CHEMBL24463044428834BindingDB-show
CHEMBL24463116745302BindingDB-show
CHEMBL24463244428836BindingDB-show
CHEMBL24463311043027BindingDB-show
CHEMBL28567810293363BindingDB-show
CHEMBL359259821458BindingDB-show
CHEMBL36117011674428BindingDB-show
CHEMBL36152911696246BindingDB-show
CHEMBL36270544389963BindingDB-show
CHEMBL36690744387731BindingDB-show
CHEMBL3669599905153BindingDB-show
CHEMBL37271611322015BindingDB-show
CHEMBL37355511991988BindingDB-show
CHEMBL37360611991896BindingDB-show
CHEMBL37423516110653BindingDB-show
CHEMBL37489516110701BindingDB-show
CHEMBL37620124748380BindingDB-show
CHEMBL37641716110722BindingDB-show
CHEMBL38888344428844BindingDB-show
CHEMBL3941244285344BindingDB-show
CHEMBL39455744428830BindingDB-show
CHEMBL39480644428835BindingDB-show
CHEMBL39480715044210BindingDB-show
CHEMBL39501822574224BindingDB-show
CHEMBL39501922574246BindingDB-show
CHEMBL39697710868634BindingDB-show
CHEMBL39773944428838BindingDB-show
CHEMBL4137279878121BindingDB-show
CHEMBL4220649840659BindingDB-show
CHEMBL42497611652690BindingDB-show
CHEMBL42623011327355BindingDB-show
CHEMBL42641011154099BindingDB-show
CHEMBL42696744391726BindingDB-show
CHEMBL43737344428833BindingDB-show
CHEMBL44155616110699BindingDB-show
CHEMBL44892224951000BindingDB-show
CHEMBL45015824950526BindingDB-show
CHEMBL45555624951319BindingDB-show
CHEMBL45645024950683BindingDB-show
CHEMBL46031744554615BindingDB-show
CHEMBL46116324950844BindingDB-show
CHEMBL46154144554611BindingDB-show
CHEMBL46154444554787BindingDB-show
CHEMBL46242325147546BindingDB-show
CHEMBL46696124951005BindingDB-show
CHEMBL46718224949227BindingDB-show
CHEMBL46736824948914BindingDB-show
CHEMBL46779624950841BindingDB-show
CHEMBL46781724950843BindingDB-show
CHEMBL46818824949075BindingDB-show
CHEMBL46818924949076BindingDB-show
CHEMBL46822024950363BindingDB-show
CHEMBL46822124951160BindingDB-show
CHEMBL46822224950364BindingDB-show
CHEMBL46905024951006BindingDB-show
CHEMBL46905124951156BindingDB-show
CHEMBL46919824951001BindingDB-show
CHEMBL47651124950525BindingDB-show
CHEMBL47651224951320BindingDB-show
CHEMBL47716724950523BindingDB-show
CHEMBL47737124951315BindingDB-show
CHEMBL47737224951316BindingDB-show
CHEMBL47801424950875BindingDB-show
CHEMBL47801524950722BindingDB-show
CHEMBL47818724950528BindingDB-show
CHEMBL47842424951162BindingDB-show
CHEMBL47906215895570BindingDB-show
CHEMBL48244144157296BindingDB-show
CHEMBL48244224319385BindingDB-show
CHEMBL48264044157218BindingDB-show
CHEMBL48284744157219BindingDB-show
CHEMBL48285422772980BindingDB-show
CHEMBL48307122772981BindingDB-show
CHEMBL48307244583159BindingDB-show
CHEMBL48346744157372BindingDB-show
CHEMBL48346844157373BindingDB-show
CHEMBL48347111226329BindingDB-show
CHEMBL48367544157144BindingDB-show
CHEMBL48367644157145BindingDB-show
CHEMBL48368344157295BindingDB-show
CHEMBL48469844157220BindingDB-show
CHEMBL48510644157293BindingDB-show
CHEMBL48510744157294BindingDB-show
CHEMBL48524416307342BindingDB-show
CHEMBL48524517479504BindingDB-show
CHEMBL48607244157512BindingDB-show
CHEMBL48627744157513BindingDB-show
CHEMBL4871021167776BindingDB-show
CHEMBL48729944157441BindingDB-show
CHEMBL48730044157443BindingDB-show
CHEMBL48811122109309BindingDB-show
CHEMBL48833544583034BindingDB-show
CHEMBL48900544157439BindingDB-show
CHEMBL48900644157440BindingDB-show
CHEMBL48965244157370BindingDB-show
CHEMBL49126244157442BindingDB-show
CHEMBL49206644157374BindingDB-show
CHEMBL49206744157375BindingDB-show
CHEMBL50433024951318BindingDB-show
CHEMBL51210724951159BindingDB-show
CHEMBL51296524951004BindingDB-show
CHEMBL51378744554613BindingDB-show
CHEMBL5138929975693BindingDB-show
CHEMBL51404324950876BindingDB-show
CHEMBL51549024948911BindingDB-show
CHEMBL51782724950720BindingDB-show
CHEMBL51907244157298BindingDB-show
CHEMBL51932617485200BindingDB-show
CHEMBL52037125325634BindingDB-show
CHEMBL52107224445964BindingDB-show
CHEMBL52129216324698BindingDB-show
CHEMBL52144744157297BindingDB-show
CHEMBL52146444157371BindingDB-show
CHEMBL52149944157221BindingDB-show
CHEMBL9025810609180BindingDB-show
CHEMBL9030815353606BindingDB-show
CHEMBL914169813810BindingDB-show
CHEMBL914179795477BindingDB-show
Cyclohexadienedione4650BindingDB-show
DCQX1845BindingDB-show
Dibenzoylmethane8433BindingDB-show
Dibenzyl sulfone69282BindingDB-show
Dibromosalicil10662BindingDB-show
Diphenylethanedione8651BindingDB-show
Diphenylmethanone3102BindingDB-show
Ethandione, bis[4-(dimethylamino)phenyl]-222570BindingDB-show
Furil68119BindingDB-show
FUROIN11100BindingDB-show
HOMOTROPINE447234DrugBank-show
Isatin-based compound, 254338240BindingDB-show
meso-Hydrobenzoin95447BindingDB-show
N,N-Diphenylbenzenesulfonamide597830BindingDB-show
N-Acetylisatin11321BindingDB-show
N-Acetylneuraminic acid444885DrugBank-show
N-Methylisatin16358BindingDB-show
N-METHYLNALOXONIUM6323452DrugBank-show
NM18903001906162BindingDB-show
NSC127077277990BindingDB-show
NSC156842291540BindingDB-show
NSC29006232004BindingDB-show
NSC94807261836BindingDB-show
o-Anisil222475BindingDB-show
o-Chloranil73252BindingDB-show
OL-13510427006BindingDB-show
OL-9211150976BindingDB-show
ortho-naphthoquinone10667BindingDB-show
p-Anisoin95415BindingDB-show
p-Methoxybenzil31494BindingDB-show
p-Methylbenzil75511BindingDB-show
Pactimibe3081927BindingDB-show
Phenanthrenequinone6763BindingDB-show
Pseudoisatin7054BindingDB-show
ST0780894427802BindingDB-show
ST0949552734800BindingDB-show
STK3686924350924BindingDB-show
STK3700403794313BindingDB-show
Tetrachloroparabenzoquinone8371BindingDB-show
Tetrahydroaminoacridine1935BindingDB-show
Tetrahydroaminoacridine1935SuperTarget-show
Tropinmandelsaeureester3623SuperTarget-show
ZINC00638542988563BindingDB-show
ZINC006697931009717BindingDB-show
ZINC008289241103353BindingDB-show
ZINC008743051133380BindingDB-show
ZINC008797181137588BindingDB-show
ZINC009986521222869BindingDB-show
ZINC020257881713189BindingDB-show
ZINC020285823821945BindingDB-show
ZINC020997871755771BindingDB-show
ZINC022761101901244BindingDB-show
ZINC023598361972026BindingDB-show
ZINC025102452777298BindingDB-show
ZINC026686913542734BindingDB-show
ZINC027094432147394BindingDB-show
ZINC030708502731733BindingDB-show
ZINC03086180589576BindingDB-show
ZINC031302653114312BindingDB-show
ZINC043614572731126BindingDB-show
ZINC043618892731904BindingDB-show
Synonyms:
ACAT
Acyl coenzyme A:cholesterol acyltransferase
Brain carboxylesterase hBr1
Egasyn
HMSE
Liver carboxylesterase 1
Monocyte/macrophage serine esterase
REH
Retinyl ester hydrolase
Serine esterase 1
TGH
Triacylglycerol hydrolase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
EST1_RABIT90.781.1
EST1_PIG86.876.6
EST2_HUMAN61.345.7
O35535_RAT61.145.8
O70177_RAT59.342.9
Q53H57_HUMAN59.144.1
Q6IPK9_HUMAN56.141.8
Q4G0E9_HUMAN5641.7
ACES_TORCA47.932.1
Q9JKC1_RAT4531.9
ACES_HUMAN43.529.6
ACES_RAT43.329
ACES_MOUSE43.230
CEL_BOVIN42.829.3
CHLE_HUMAN42.629.9
Q6ED33_ASPNG41.526.8
ACES_DROME39.224.8
LIP1_CANRU3827.2
LIP3_CANRU37.825.4
ACES_CHICK37.325.4
GGT_ECOLI33.321
MCCB_HUMAN32.318
NRFA_WOLSU32.117.9
KCNA1_HUMAN32.118.1
ESR2_RAT31.818.2
DNPEP_HUMAN31.516.8
CP51_CANAL31.516.9
GGT7_MOUSE31.219.9
SGPL1_HUMAN31.118.1
ARLY2_ANAPL30.717.4
Protein-Protein Interactions: