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Target Details

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Name:Receptor tyrosine-protein kinase erbB-2
Uniprot name:ERBB2_HUMAN
Accession Numbers:P04626 Q14256 Q6LDV1 Q9UMK4
EC-Number:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 3BE1
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt16149965BindingDB-show
()-oxazepam hemisuccinate sodium salt16148913BindingDB-show
()-oxazepam hemisuccinate sodium salt16157462BindingDB-show
()-oxazepam hemisuccinate sodium salt16151138BindingDB-show
()-oxazepam hemisuccinate sodium salt16150666BindingDB-show
()-oxazepam hemisuccinate sodium salt16151367BindingDB-show
()-oxazepam hemisuccinate sodium salt16148480BindingDB-show
()-oxazepam hemisuccinate sodium salt16149502BindingDB-show
(3Z)-3-[(4-pyrrolidin-1-ylphenyl)methylidene]-1H-indol-2-one5427216BindingDB-show
(3Z)-3-[[4-(1-piperidyl)phenyl]methylidene]-1H-indol-2-one9948410BindingDB-show
2-Cyano-3-(4-hydroxy-3-methoxy-5-((phenylthio)methyl)phenyl)-2-propenamide6447926BindingDB-show
2rgp24897276BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone5941540BindingDB-show
4-Anilinopyrido[3,4-d]pyrimidine 35329069BindingDB-show
4-anilinoquinazoline deriv. 12776BindingDB-show
4-anilinoquinazoline deriv. 10n5328967BindingDB-show
4-anilinoquinazoline deriv. 24708BindingDB-show
4-Hydroxy-3-methoxy-5-(benzothiazolylthiomethyl)benzylidenecyanoacetamide6091659BindingDB-show
4440504844405048BindingDB-show
5-(4-bromophenyl)-2H-triazole-4-carbonitrile6411478BindingDB-show
5-(4-methoxyphenyl)-2H-triazole-4-carbonitrile5076757BindingDB-show
6,7-diethoxy-N-(3-iodophenyl)quinazolin-4-amine10048580BindingDB-show
6-Thiazolylquinazoline 65329480BindingDB-show
ABT-86911485656BindingDB-show
AC1LD2U9611097BindingDB-show
AC1LDYS1727518BindingDB-show
AC1LFCRF800888BindingDB-show
AC1LIXJS964113BindingDB-show
AC1M5Q2K2358462BindingDB-show
AC1M62TH2365265BindingDB-show
AC1MDY7A2844935BindingDB-show
AC1NUOY85509091BindingDB-show
AC1NUTV85512733BindingDB-show
AC1NWVF05713379BindingDB-show
AC1NXZ1Z5820127BindingDB-show
AC1NZ3T85874584BindingDB-show
AC1NZWNU5919167BindingDB-show
AC1O0CK76036100BindingDB-show
AC1O6VYY6536705BindingDB-show
AC1OC8CQ6896871BindingDB-show
AG 2135328803BindingDB-show
alkynyl thienopyrimidine, 15a11284937BindingDB-show
Ambcb60411929604669BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
BAS 003165925718913BindingDB-show
BAS 003425816862734BindingDB-show
Bio1_0004293139BindingDB-show
BMS-53692410390396BindingDB-show
Canertinib156414BindingDB-show
CFPQA cpd9974694BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:47452911703562BindingDB-show
CHEBI:54742944560357BindingDB-show
CHEBI:64749644358270BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEBI:68198345487386BindingDB-show
CHEMBL10300544426287BindingDB-show
CHEMBL107624111679357BindingDB-show
CHEMBL107726946881850BindingDB-show
CHEMBL107730546881918BindingDB-show
CHEMBL108027146879473BindingDB-show
CHEMBL108027246879474BindingDB-show
CHEMBL108050624782374BindingDB-show
CHEMBL108081246879471BindingDB-show
CHEMBL108099046879472BindingDB-show
CHEMBL108184924782622BindingDB-show
CHEMBL108201224782621BindingDB-show
CHEMBL108551124762205BindingDB-show
CHEMBL108736824786207BindingDB-show
CHEMBL108893146886320BindingDB-show
CHEMBL109035046886313BindingDB-show
CHEMBL109035146886314BindingDB-show
CHEMBL109035246886315BindingDB-show
CHEMBL109035346886316BindingDB-show
CHEMBL109035446886317BindingDB-show
CHEMBL109035546886318BindingDB-show
CHEMBL109035746865992BindingDB-show
CHEMBL109035846886321BindingDB-show
CHEMBL109035946886322BindingDB-show
CHEMBL109036146886324BindingDB-show
CHEMBL109036246886325BindingDB-show
CHEMBL109036446886327BindingDB-show
CHEMBL109161346886245BindingDB-show
CHEMBL109323446886311BindingDB-show
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CHEMBL109381546886310BindingDB-show
CHEMBL11390010973186BindingDB-show
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CHEMBL11390211037303BindingDB-show
CHEMBL11398510029703BindingDB-show
CHEMBL1139969891993BindingDB-show
CHEMBL11407310918242BindingDB-show
CHEMBL11439210885120BindingDB-show
CHEMBL1144909890154BindingDB-show
CHEMBL11459310884588BindingDB-show
CHEMBL1147289913648BindingDB-show
CHEMBL11518711733863BindingDB-show
CHEMBL11551944345396BindingDB-show
CHEMBL11589544345439BindingDB-show
CHEMBL1160129984664BindingDB-show
CHEMBL116374946906826BindingDB-show
CHEMBL1164239899125BindingDB-show
CHEMBL1165259803006BindingDB-show
CHEMBL116546846846074BindingDB-show
CHEMBL11654744345182BindingDB-show
CHEMBL11685310906920BindingDB-show
CHEMBL11685711102890BindingDB-show
CHEMBL117027849798860BindingDB-show
CHEMBL117045949798861BindingDB-show
CHEMBL117127349799785BindingDB-show
CHEMBL117280249799777BindingDB-show
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CHEMBL117287749799781BindingDB-show
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CHEMBL117294749799783BindingDB-show
CHEMBL117295049799786BindingDB-show
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CHEMBL11800010983483BindingDB-show
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CHEMBL1315779927718BindingDB-show
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CHEMBL1432610085225BindingDB-show
CHEMBL15376344388499BindingDB-show
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CHEMBL17549211249881BindingDB-show
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CHEMBL18051611398999BindingDB-show
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CHEMBL19009421080010BindingDB-show
CHEMBL19065110385997BindingDB-show
CHEMBL19065444399994BindingDB-show
CHEMBL19336823646550BindingDB-show
CHEMBL19354410288761BindingDB-show
CHEMBL19357844403429BindingDB-show
CHEMBL19368121945968BindingDB-show
CHEMBL19416023646549BindingDB-show
CHEMBL19433744403435BindingDB-show
CHEMBL19434923646539BindingDB-show
CHEMBL19438944403436BindingDB-show
CHEMBL19449810073832BindingDB-show
CHEMBL19495823646544BindingDB-show
CHEMBL19520410162954BindingDB-show
CHEMBL1952189893493BindingDB-show
CHEMBL19590311432911BindingDB-show
CHEMBL19601823646535BindingDB-show
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CHEMBL19768923646545BindingDB-show
CHEMBL20151111530963BindingDB-show
CHEMBL2023609907221BindingDB-show
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CHEMBL21858616108948BindingDB-show
CHEMBL21910416108940BindingDB-show
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CHEMBL22892544426286BindingDB-show
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CHEMBL22897644426289BindingDB-show
CHEMBL22897744426291BindingDB-show
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CHEMBL23025544426277BindingDB-show
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CHEMBL23057444426258BindingDB-show
CHEMBL23057544426260BindingDB-show
CHEMBL23067944426261BindingDB-show
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CHEMBL23078544426265BindingDB-show
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Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
ZINC000169785329009BindingDB-show
ZINC001369421538822BindingDB-show
ZINC005750645427224BindingDB-show
ZINC005861935293755BindingDB-show
ZINC006817212883337BindingDB-show
ZINC010938906871170BindingDB-show
ZINC012035135334065BindingDB-show
ZINC019586489591259BindingDB-show
ZINC032806632396126BindingDB-show
ZINC040383565707304BindingDB-show
Synonyms:
C-erbB-2
CD340
MLN 19
NEU proto-oncogene
p185erbB2
Receptor tyrosine-protein kinase erbB-2
Tyrosine kinase-type cell surface receptor HER2
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
EGFR_HUMAN62.748.9
EGFR_MOUSE61.848.7
ERBB4_HUMAN5844.8
Q59FL8_HUMAN56.443.9
EGFR_DROME4230.2
EPHB1_HUMAN3220
FAK1_MOUSE31.419.7
RET_HUMAN30.920.1
PGFRB_HUMAN30.819.3
INSR_HUMAN30.820.7
Q68GS6_HUMAN30.822.3
IGF1R_HUMAN30.420
EPHB2_MOUSE3018.2
TYRO3_HUMAN29.920.1
GUC2C_PIG29.618.2
O32393_SPIPL28.917.6
GRM1_HUMAN28.818.2
KCNH7_HUMAN28.516.7
ANPRB_HUMAN28.518.1
FGFR2_HUMAN28.418.4
DDR1_HUMAN28.218.3
PGFRA_HUMAN2816.9
VGFR2_HUMAN2817.8
TOP2A_RAT2816.7
GRM1_RAT27.917
MA2B1_CAVPO27.918.2
ACLY_RAT27.815.5
GRM5_MOUSE27.816.6
Q14TE9_RAT27.715.6
O77690_BOVIN27.718
Protein-Protein Interactions:
Uniprot nameSource
WASL_HUMANPMID 17092940
TXK_HUMAN2 PMIDs
TOB1_HUMAN3 PMIDs
TGFA_HUMAN4 PMIDs
TENS3_HUMAN5 PMIDs
TENC1_HUMAN6 PMIDs
TEC_HUMAN7 PMIDs
STUB1_HUMAN8 PMIDs
SPT6H_HUMAN9 PMIDs
SOCS1_HUMAN10 PMIDs
SLAP2_HUMAN11 PMIDs
SLAP1_HUMAN12 PMIDs
SH3L3_HUMAN13 PMIDs
SH3L1_HUMAN14 PMIDs
SH2D5_HUMAN15 PMIDs
SH2B3_HUMAN16 PMIDs
SH2B2_HUMAN17 PMIDs
SH23A_HUMAN18 PMIDs
SH22A_HUMAN19 PMIDs
SH21B_HUMAN20 PMIDs
RIN2_HUMAN21 PMIDs
RIN1_HUMAN22 PMIDs
Q96D37_HUMAN23 PMIDs
Q5TEW3_HUMAN24 PMIDs
Q3ZCU5_HUMAN25 PMIDs
PTPRZ_HUMAN26 PMIDs
PTPRO_HUMAN27 PMIDs
PTPRK_HUMAN28 PMIDs
PTPRJ_HUMAN29 PMIDs
PTPRG_HUMAN30 PMIDs
PTPRB_HUMAN31 PMIDs
PTN3_HUMAN32 PMIDs
PTN22_HUMAN33 PMIDs
PTN18_HUMAN34 PMIDs
PTN12_HUMAN35 PMIDs
PPAP_HUMAN36 PMIDs
P55G_HUMAN37 PMIDs
P3C2B_HUMAN38 PMIDs
P3C2B_HUMAN39 PMIDs
P3C2A_HUMAN40 PMIDs
P3C2A_HUMAN41 PMIDs
OSMR_HUMAN42 PMIDs
O14909_HUMAN43 PMIDs
NRG1_HUMAN44 PMIDs
NRG1_HUMAN45 PMIDs
MUC1_HUMAN46 PMIDs
MERL_HUMAN47 PMIDs
MATK_HUMAN48 PMIDs
LAP2_HUMAN49 PMIDs
L2GL1_HUMAN50 PMIDs
JIP2_HUMAN51 PMIDs
JIP1_HUMAN52 PMIDs
JAK2_HUMAN53 PMIDs
JAK1_HUMAN54 PMIDs
ITK_HUMAN55 PMIDs
ITB4_HUMAN56 PMIDs
ITA5_HUMAN57 PMIDs
IRS4_HUMAN58 PMIDs
IRS1_HUMAN59 PMIDs
IL6RB_HUMAN60 PMIDs
FGR_HUMAN61 PMIDs
FER_HUMAN62 PMIDs
FAK2_HUMAN63 PMIDs
ESR1_HUMAN64 PMIDs
ERRFI_HUMAN65 PMIDs
ERBB4_HUMAN66 PMIDs
ERBB3_HUMAN67 PMIDs
ERBB3_HUMAN68 PMIDs
ERBB2_HUMAN69 PMIDs
ENPL_HUMAN70 PMIDs
ELF3_HUMAN71 PMIDs
DOK6_HUMAN72 PMIDs
DOK4_HUMAN73 PMIDs
DOK1_HUMAN74 PMIDs
DLG4_HUMAN75 PMIDs
DAB1_HUMAN76 PMIDs
CISH_HUMAN77 PMIDs
CHIN_HUMAN78 PMIDs
CD82_HUMAN79 PMIDs
CD44_HUMAN80 PMIDs
CD44_HUMAN81 PMIDs
BTC_HUMAN82 PMIDs
BMX_HUMAN83 PMIDs
BLNK_HUMAN84 PMIDs
BLK_HUMAN85 PMIDs
APBB3_HUMAN86 PMIDs
APBB1_HUMAN87 PMIDs
ANS1B_HUMAN88 PMIDs
ANS1A_HUMAN89 PMIDs
ABL2_HUMAN90 PMIDs
ABL1_HUMAN91 PMIDs
AACT_HUMAN92 PMIDs
3BP2_HUMAN93 PMIDs
1A68_HUMAN94 PMIDs