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Target Details

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Name:Dihydrofolate reductase
Uniprot name:DYR_PNECA
Accession Numbers:P16184
EC-Number:1.5.1.3
Organism:Pneumocystis carinii
PDB IDs:1CD2 1DAJ 1DYR 1E26 1KLK 1LY3 1LY4 1S3Y 1VJ3 2CD2 2FZH 2FZI 3CD2 4CD2
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
156698-69-0462085BindingDB-show
175411-14-0457744BindingDB-show
2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine327404BindingDB-show
2,4-Diamino-5-methyl-6-[N(2,5-dimethoxyphenyl)methylamino]-pyrido[272468BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 244246319BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 444246321BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 544246322BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 644246323BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 744246324BindingDB-show
2,6-Diamino-8-(2',4',5'-trimethoxyphenyl)purine473569BindingDB-show
2,6-Diamino-8-phenylpurine99545BindingDB-show
6-(10H,11H-Dibenzo[b,f]azepin-5-ylmethyl)pteridine-2,4-diamine481460BindingDB-show
6-(Anilinomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine457773BindingDB-show
6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE5289495DrugBank-show
6-[3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyph6481075BindingDB-show
8-Azatrimetrexate456204BindingDB-show
AC1L1FXT3439BindingDB-show
AC1L8GGA380969BindingDB-show
AC1L9TO1475795BindingDB-show
AC1L9TO4475796BindingDB-show
AC1L9U5D476025BindingDB-show
AC1L9U5G476026BindingDB-show
AC1L9U5J476027BindingDB-show
AC1L9U5M476028BindingDB-show
AC1L9U5P476029BindingDB-show
AC1L9U5S476030BindingDB-show
AC1L9U5V476031BindingDB-show
AC1L9U5Y476032BindingDB-show
AC1L9U61476033BindingDB-show
AC1L9U64476034BindingDB-show
AC1L9U67476035BindingDB-show
AC1L9U6A476036BindingDB-show
AC1L9U6D476037BindingDB-show
AC1L9U6G476038BindingDB-show
AC1L9U6J476039BindingDB-show
AC1L9U6S476042BindingDB-show
AC1L9U6V476043BindingDB-show
AC1L9U6Y476044BindingDB-show
AC1L9U74476046BindingDB-show
AC1L9UGF456205BindingDB-show
AC1L9UH9456216BindingDB-show
AC1L9UHC456217BindingDB-show
AC1L9VOT456893BindingDB-show
AC1L9VOW456894BindingDB-show
AC1L9VOZ456895BindingDB-show
AC1L9VP2456896BindingDB-show
AC1L9VP5456897BindingDB-show
AC1L9W0N457122BindingDB-show
AC1L9W0Z457126BindingDB-show
AC1L9W3Z457174BindingDB-show
AC1L9W42457175BindingDB-show
AC1L9WES457345BindingDB-show
AC1L9WF4457350BindingDB-show
AC1L9WF7457351BindingDB-show
AC1L9WFA457352BindingDB-show
AC1L9WFG457354BindingDB-show
AC1L9WFJ457355BindingDB-show
AC1L9X3A457717BindingDB-show
AC1L9X3D457718BindingDB-show
AC1L9X3G457719BindingDB-show
AC1L9X4P457735BindingDB-show
AC1L9X4S457736BindingDB-show
AC1L9X4V457738BindingDB-show
AC1L9X4Y457739BindingDB-show
AC1L9X51457740BindingDB-show
AC1L9X54457741BindingDB-show
AC1L9X5A457743BindingDB-show
AC1L9X5G457745BindingDB-show
AC1L9X5J457746BindingDB-show
AC1L9X5M457747BindingDB-show
AC1L9X5P457748BindingDB-show
AC1L9X5S457749BindingDB-show
AC1L9X5V457750BindingDB-show
AC1L9X5Y457751BindingDB-show
AC1L9X61457752BindingDB-show
AC1L9X64457754BindingDB-show
AC1L9X67457757BindingDB-show
AC1L9X6A457763BindingDB-show
AC1L9X6D457764BindingDB-show
AC1L9X7A457775BindingDB-show
AC1L9X7D457776BindingDB-show
AC1L9X7G457777BindingDB-show
AC1L9X7J457778BindingDB-show
AC1L9X7M457779BindingDB-show
AC1L9YB8504022BindingDB-show
AC1L9YBB504023BindingDB-show
AC1L9YBH504025BindingDB-show
AC1L9YBN504027BindingDB-show
AC1L9YBQ504028BindingDB-show
AC1L9YBT504029BindingDB-show
AC1L9YBW504030BindingDB-show
AC1L9YBZ504031BindingDB-show
AC1L9ZJP478874BindingDB-show
AC1L9ZJY478877BindingDB-show
AC1L9ZMG478945BindingDB-show
AC1L9ZMJ478946BindingDB-show
AC1L9ZMM478947BindingDB-show
AC1L9ZMP478948BindingDB-show
AC1LA0CE479281BindingDB-show
AC1LA0CH479282BindingDB-show
AC1LA0CQ479285BindingDB-show
AC1LA0CT479286BindingDB-show
AC1LA0CW479287BindingDB-show
AC1LA0CZ479288BindingDB-show
AC1LA0D2479289BindingDB-show
AC1LA0D5479290BindingDB-show
AC1LA0D8479291BindingDB-show
AC1LA0DB479292BindingDB-show
AC1LA0DE479293BindingDB-show
AC1LA0DH479294BindingDB-show
AC1LA0DK479295BindingDB-show
AC1LA0DN479296BindingDB-show
AC1LA0KZ479407BindingDB-show
AC1LA0L5479410BindingDB-show
AC1LA0L8479411BindingDB-show
AC1LA0LB479412BindingDB-show
AC1LA0LE479413BindingDB-show
AC1LA0LH479414BindingDB-show
AC1LA0LK479415BindingDB-show
AC1LA0LN479416BindingDB-show
AC1LA0LQ479417BindingDB-show
AC1LA0LT479418BindingDB-show
AC1LA0LW479419BindingDB-show
AC1LA0LZ479420BindingDB-show
AC1LA0M2479421BindingDB-show
AC1LA0M5479422BindingDB-show
AC1LA0M8479423BindingDB-show
AC1LA0MB479424BindingDB-show
AC1LA0ME479425BindingDB-show
AC1LA0MH479426BindingDB-show
AC1LA0MT479430BindingDB-show
AC1LA53L461918BindingDB-show
AC1LA53R461920BindingDB-show
AC1LA53U461921BindingDB-show
AC1LA53X461922BindingDB-show
AC1LA540461923BindingDB-show
AC1LA543461924BindingDB-show
AC1LA546461925BindingDB-show
AC1LA549461926BindingDB-show
AC1LA5DU462086BindingDB-show
AC1LA5DX462087BindingDB-show
AC1LA5EI462094BindingDB-show
AC1LA5EO462096BindingDB-show
AC1LA5ER462097BindingDB-show
AC1LA5EU462098BindingDB-show
AC1LA5EX462099BindingDB-show
AC1LA5F0462100BindingDB-show
AC1LA5F3462101BindingDB-show
AC1LA5F6462102BindingDB-show
AC1LA5F9462103BindingDB-show
AC1LA5FC462104BindingDB-show
AC1LA5FF462105BindingDB-show
AC1LA5FI462106BindingDB-show
AC1LA5FL462107BindingDB-show
AC1LA5FO462108BindingDB-show
AC1LA5FR462109BindingDB-show
AC1LA5FX462111BindingDB-show
AC1LA5GI462118BindingDB-show
AC1LA5GL462119BindingDB-show
AC1LA5GO462120BindingDB-show
AC1LA5GR462121BindingDB-show
AC1LA5GU462122BindingDB-show
AC1LA5GX462123BindingDB-show
AC1LA5H3462125BindingDB-show
AC1LA5H6462126BindingDB-show
AC1LA5H9462127BindingDB-show
AC1LA5HC462128BindingDB-show
AC1LA5HF462129BindingDB-show
AC1LA6DS462574BindingDB-show
AC1LA6DV462575BindingDB-show
AC1LA6DY462576BindingDB-show
AC1LA6E1462577BindingDB-show
AC1LA7YU483227BindingDB-show
AC1LA7YX483228BindingDB-show
AC1LA7Z0483229BindingDB-show
AC1LAARC464889BindingDB-show
AC1LAAVA464992BindingDB-show
AC1LABB5484953BindingDB-show
AC1LABB8484954BindingDB-show
AC1LABBB484955BindingDB-show
AC1LABBE484956BindingDB-show
AC1LABBH484957BindingDB-show
AC1LABBK484958BindingDB-show
AC1LABBN484959BindingDB-show
AC1LABBW484962BindingDB-show
AC1LABBZ484963BindingDB-show
AC1LABC2484964BindingDB-show
AC1LABC5484965BindingDB-show
AC1LABC8484966BindingDB-show
AC1LABCB484967BindingDB-show
AC1LABGU485021BindingDB-show
AC1LACV5466050BindingDB-show
AC1LACV8466051BindingDB-show
AC1LACVB466052BindingDB-show
AC1LACVE466053BindingDB-show
AC1LACVH466054BindingDB-show
AC1LACVK466055BindingDB-show
AC1LAHT8468709BindingDB-show
AC1LAHTB468710BindingDB-show
AC1LAHTE468711BindingDB-show
AC1LAHTH468712BindingDB-show
AC1LAJ7L469405BindingDB-show
AC1LAJ7O469406BindingDB-show
AC1LAJ83469411BindingDB-show
AC1LAJ86469412BindingDB-show
AC1LAJ89469413BindingDB-show
AC1LAJ8C469414BindingDB-show
AC1LAJ9C469427BindingDB-show
AC1LAJ9F469428BindingDB-show
AC1LAJ9I469429BindingDB-show
AC1LAJ9L469430BindingDB-show
AC1LAJ9O469431BindingDB-show
AC1LAJ9R469432BindingDB-show
AC1LAJ9U469433BindingDB-show
AC1LAJ9X469434BindingDB-show
AC1LAJA0469435BindingDB-show
AC1LAJK9469605BindingDB-show
AC1LAJKL469609BindingDB-show
AC1LAK1Y469853BindingDB-show
AC1LAK21469854BindingDB-show
AC1LAKT7470264BindingDB-show
AC1LALFL490662BindingDB-show
AC1LALFO490663BindingDB-show
AC1LALFR490664BindingDB-show
AC1LALFU490665BindingDB-show
AC1LALFX490666BindingDB-show
AC1LALG0490667BindingDB-show
AC1LALG3490668BindingDB-show
AC1LAPYO472903BindingDB-show
AC1LAPYR472904BindingDB-show
AC1LAPZ0472907BindingDB-show
AC1LAPZ3472908BindingDB-show
AC1LAR8R473566BindingDB-show
AC1LAR8U473567BindingDB-show
AC1LAR8X473568BindingDB-show
AC1LAR93473570BindingDB-show
AC1LAR96473571BindingDB-show
AC1LAR99473572BindingDB-show
AC1LAR9C473573BindingDB-show
AC1LAR9F473574BindingDB-show
AC1LARKO473734BindingDB-show
AC1MNPHU3331411BindingDB-show
AC1NUILK5479794BindingDB-show
AC1NUILN5479795BindingDB-show
AC1NUILQ5479796BindingDB-show
AC1NUILT5479797BindingDB-show
AC1NUILW5479798BindingDB-show
AC1NUILZ5479799BindingDB-show
AC1NUIM25479800BindingDB-show
AC1NUIM55479801BindingDB-show
AC1NUJ9R5480465BindingDB-show
AC1NUJ9U5480466BindingDB-show
AC1NUJ9X5480467BindingDB-show
AC1NUJA35480469BindingDB-show
AC1NUJA65480470BindingDB-show
AC1NUJA95480471BindingDB-show
AC1NUJAC5480472BindingDB-show
AC1NUK3C5481064BindingDB-show
AC1NUK3F5481065BindingDB-show
AC1NUK3I5481066BindingDB-show
AC1NUKJP5481386BindingDB-show
AC1NUKJS5481387BindingDB-show
AC1NX3NU5742589BindingDB-show
AC1NX3O85742599BindingDB-show
AC1NX3OA5742600BindingDB-show
AC1NX3OC5742601BindingDB-show
AC1NX3OY5742617BindingDB-show
AC1NX3P05742618BindingDB-show
AC1NX3P25742619BindingDB-show
AC1NX3P45742620BindingDB-show
AC1NX3P65742621BindingDB-show
AC1NX3P85742622BindingDB-show
AC1NX3PA5742623BindingDB-show
AC1NX3PC5742624BindingDB-show
AC1O5APL6481077BindingDB-show
AC1O5APO6481078BindingDB-show
AC1O5APR6481079BindingDB-show
AC1O5APU6481080BindingDB-show
AC1O5APX6481081BindingDB-show
AC1O5AQ96481085BindingDB-show
AC1O5AQO6481090BindingDB-show
AC1O5AQR6481091BindingDB-show
AC1O5AQU6481092BindingDB-show
AC1O6FM36474985BindingDB-show
AC1O6FM46474986BindingDB-show
AIDS007470447815BindingDB-show
AIDS0115185479802BindingDB-show
AIDS05982711396216BindingDB-show
AIDS0788176477203BindingDB-show
AIDS07881711687971BindingDB-show
AIDS093885479284BindingDB-show
AIDS094330447229BindingDB-show
AIDS1046386532431BindingDB-show
CHEMBL10308611979618BindingDB-show
CHEMBL10310810805204BindingDB-show
CHEMBL10449544333886BindingDB-show
CHEMBL123205844246320BindingDB-show
CHEMBL13841910590469BindingDB-show
CHEMBL14154844362450BindingDB-show
CHEMBL14506044362532BindingDB-show
CHEMBL14557944362381BindingDB-show
CHEMBL14562844362786BindingDB-show
CHEMBL14692511099765BindingDB-show
CHEMBL14859911783065BindingDB-show
CHEMBL14902711047021BindingDB-show
CHEMBL16222023583141BindingDB-show
CHEMBL16231210403719BindingDB-show
CHEMBL1728744271419BindingDB-show
CHEMBL17811944388463BindingDB-show
CHEMBL17851244388457BindingDB-show
CHEMBL17868444388478BindingDB-show
CHEMBL17888844388476BindingDB-show
CHEMBL17890444388477BindingDB-show
CHEMBL17913144388481BindingDB-show
CHEMBL17931944388480BindingDB-show
CHEMBL18047644388464BindingDB-show
CHEMBL22695216732891BindingDB-show
CHEMBL22695316732892BindingDB-show
CHEMBL22695416733029BindingDB-show
CHEMBL22695516733031BindingDB-show
CHEMBL22700816733033BindingDB-show
CHEMBL22700916733034BindingDB-show
CHEMBL22701016733035BindingDB-show
CHEMBL22706316733036BindingDB-show
CHEMBL22706416733165BindingDB-show
CHEMBL22706523647976BindingDB-show
CHEMBL29325844303114BindingDB-show
CHEMBL29341511792794BindingDB-show
CHEMBL2941319883365BindingDB-show
CHEMBL29992710068729BindingDB-show
CHEMBL3026339948789BindingDB-show
CHEMBL3031029840204BindingDB-show
CHEMBL30403457742BindingDB-show
CHEMBL33129244345035BindingDB-show
CHEMBL3335744281405BindingDB-show
CHEMBL33445610663211BindingDB-show
CHEMBL34255510691405BindingDB-show
CHEMBL34363014642750BindingDB-show
CHEMBL3491499973530BindingDB-show
CHEMBL35757344362565BindingDB-show
CHEMBL35797310883066BindingDB-show
CHEMBL38790116733030BindingDB-show
CHEMBL38812016733162BindingDB-show
CHEMBL38812116733163BindingDB-show
CHEMBL38968616733164BindingDB-show
CHEMBL38988716732893BindingDB-show
CHEMBL4185029818659BindingDB-show
CHEMBL42195910902858BindingDB-show
CHEMBL42393944362354BindingDB-show
CHEMBL4398169976735BindingDB-show
CHEMBL44270223647977BindingDB-show
CHEMBL45501244569106BindingDB-show
CHEMBL49289525131855BindingDB-show
CHEMBL49289625132198BindingDB-show
CHEMBL49371725132195BindingDB-show
CHEMBL49371825131854BindingDB-show
CHEMBL52167225099170BindingDB-show
CHEMBL52254325132197BindingDB-show
CHEMBL52267825132196BindingDB-show
CHEMBL52300444569105BindingDB-show
CHEMBL53420457774BindingDB-show
CHEMBL59433944246330BindingDB-show
CHEMBL59479044246328BindingDB-show
CHEMBL59575744246326BindingDB-show
CHEMBL59667246231368BindingDB-show
CHEMBL59667346231370BindingDB-show
CHEMBL59668046231372BindingDB-show
CHEMBL59668146231373BindingDB-show
CHEMBL59788546231409BindingDB-show
CHEMBL59809046231411BindingDB-show
CHEMBL59829246231412BindingDB-show
CHEMBL59829346231413BindingDB-show
CHEMBL60210446231369BindingDB-show
CHEMBL60319844246327BindingDB-show
CHEMBL60472246231410BindingDB-show
CHEMBL60541344246325BindingDB-show
CHEMBL60636244246329BindingDB-show
CHEMBL60989646231371BindingDB-show
CHEMBL611089883700BindingDB-show
CHEMBL611109926004BindingDB-show
CHEMBL61198446231414BindingDB-show
CHEMBL6141510687788BindingDB-show
CHEMBL6192710806235BindingDB-show
CHEMBL647299819553BindingDB-show
CHEMBL647859796929BindingDB-show
CHEMBL6936310450058BindingDB-show
chlorcycloguanil9049BindingDB-show
CID 1025404910624126BindingDB-show
CID 1096183110961831BindingDB-show
D2K6481086BindingDB-show
D2N6481088BindingDB-show
Deazapteridine der.457349BindingDB-show
DH1490573BindingDB-show
Diaminodiphenylsulfone2955BindingDB-show
Diaminopyrimidine analogue, 323647975BindingDB-show
Diaminopyrimidine, 21504024BindingDB-show
Diaminopyrimidine, 23504026BindingDB-show
Diaminopyritamin4993BindingDB-show
Dpmmabg158376DrugBank-show
Epiroprim68916BindingDB-show
Ethodichlorophen29142BindingDB-show
Iclaprim213043BindingDB-show
Isotrimethoprim452507BindingDB-show
L-Aspartic acid der.421299BindingDB-show
Methylaminopterin4112BindingDB-show
Methylaminopterinum126941BindingDB-show
Methylaminopterinum72440BindingDB-show
Methylbenzoprim72438BindingDB-show
n-(4-{[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]amino}benzoyl)glutamic468708BindingDB-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine444617BindingDB-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylquinazoline-2,4,6-triamine447021BindingDB-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylquinazoline-2,4,6-triamine447021DrugBank-show
N6-[(3,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine447022BindingDB-show
N6-[(3,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine447022DrugBank-show
NSC156246291270BindingDB-show
NSC341077434006BindingDB-show
Piritrexim analogue, 66481073BindingDB-show
Piritrexim analogue, 76481074BindingDB-show
Piritrexim analogue, 96481076BindingDB-show
Piritrexim analogue,316481087BindingDB-show
Piritrexim analogue,386481089BindingDB-show
Piritrexim Isethionate54369BindingDB-show
Pteridine analogue, 1911396736BindingDB-show
Pteridine analogue, 2011190448BindingDB-show
Pteridine analogue, 2111431512BindingDB-show
PY 896484960BindingDB-show
PY 898484952BindingDB-show
PY 899484961BindingDB-show
PY802456227BindingDB-show
PY839457374BindingDB-show
PY856461917BindingDB-show
PY860461919BindingDB-show
Pyrimidine analog382165BindingDB-show
Pyrimidine analog72934BindingDB-show
Pyrrolo[2, 3-d]pyrimidine analogue, 916733032BindingDB-show
Sulfamethoprim5578BindingDB-show
Tetroxoprim65450BindingDB-show
Trimetrexate5583BindingDB-show
Triphosphopyridine nucleotide5886DrugBank-show
Triphosphopyridine nucleotide5885DrugBank-show
Synonyms:
Dihydrofolate reductase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
DYR_HUMAN55.536.4
DYR_CANAL53.934.6
DYR_CHICK53.335.8
DYR_ECOLI44.227.2
DYR_MYCTU42.226.1
DYR_LACCA38.121.9
AZR_BACSU35.619.6
COMB_CLOAB35.517.9
GLTP_HUMAN35.418.5
CYCL_METEA35.317.7
RIFK_SCHPO35.116.2
BLAB1_FLAME34.917.6
FABI_ECOLI34.821
Q8YWS4_NOSS134.720
Q19774_CAEEL3417.5
DCTD_BPT433.518.7
Q8DW21_STRMU33.117.3
A7UKY0_HUMAN32.718.3
A7UKX8_HUMAN32.618.1
YPT7_YEAST32.418.5
DMA_BPT432.417.8
CFI1_MEDSA32.218
Q970Z7_SULTO32.115.4
PDXJ_ECOLI32.114.7
Q9KQN0_VIBCH31.913.8
ERM_BACSU31.913.5
Q9ADS9_STAAU31.516.9
NTPA_METJA31.514.5
AZRB_BACOY31.517
PH4H_CHRVO31.417.6
Protein-Protein Interactions:
No data available