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Target Details

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Name:Dihydrofolate reductase
Uniprot name:DYR_HUMAN
Accession Numbers:P00374 Q14130 Q6IRW8
EC-Number:1.5.1.3
Organism:Homo sapiens
Human
PDB IDs:1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(2,4-Diaminopteridin-6-yl)methyl benzoate487405BindingDB-show
(2,4-Diaminoquinazolin-6-yl)methyl 2,3,4-trimethoxybenzoate487407BindingDB-show
(2,4-Diaminoquinazolin-6-yl)methyl 2-phenylacetate487410BindingDB-show
(2,4-Diaminoquinazolin-6-yl)methyl 3,4,5-trimethoxybenzoate487406BindingDB-show
(2,4-Diaminoquinazolin-6-yl)methyl 3,4-dimethoxybenzoate487408BindingDB-show
(3-hydrazinylquinoxalin-2-yl)hydrazine155947BindingDB-show
1,3,5-Triazine-2,4-diamine, 1,6-dihydro-6,6-dimethyl-1-phenyl-19931BindingDB-show
1-ynyl]-6-methylpyrimidine25093367BindingDB-show
10-EdAM54586BindingDB-show
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID443388BindingDB-show
11-Oxahomoaminopterin100056BindingDB-show
159210-74-9464984BindingDB-show
174654-73-0464021BindingDB-show
174654-74-1464020BindingDB-show
174654-76-3464019BindingDB-show
174654-78-5464015BindingDB-show
174654-88-7464975BindingDB-show
174654-91-2464980BindingDB-show
2,4-Diamino-25093363BindingDB-show
2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine327404BindingDB-show
2,4-Diamino-5-(3-methoxybenzyl)pyrimidine101067BindingDB-show
2,4-Diamino-5-methyl-6-[N(2,5-dimethoxyphenyl)methylamino]-pyrido[272468BindingDB-show
2,4-Diamino-6,7-dimethylpteridine74023BindingDB-show
2,4-Diamino-6-benzyl-5-methylthieno[2,3-d]pyrimidine457382BindingDB-show
2,4-Diamino-6-ethyl-5-(4-chloro-3-dimethylaminoazophenyl)pyrimidine332598BindingDB-show
2,4-Diamino-6-phenylthiomethyl-pteridine314604BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 244246319BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 444246321BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 544246322BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 644246323BindingDB-show
2,4-diaminofuro[2,3-d]pyrimidine, 744246324BindingDB-show
2,4-Diaminopteridine der.456306BindingDB-show
2,4-Pteridinediamine, 6-[(1-naphthalenylamino)-methyl]-314924BindingDB-show
2,4-Pyrimidinediamine der.343098BindingDB-show
2-({4-carboxy-4-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}benzoyl)amino360682BindingDB-show
3,4-dichloro-N-[5-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]-1,3,4-thiadia2799782BindingDB-show
3bla24778299BindingDB-show
4-(p-Bromophenylazo)phenol5492867BindingDB-show
5-(4-methylphenoxy)quinazoline-2,4-diamine4106338BindingDB-show
5-(4-methylphenyl)sulfanylquinazoline-2,4-diamine446245BindingDB-show
5-(4-morpholin-4-ylphenyl)sulfanylquinazoline-2,4-diamine3534BindingDB-show
5-Benzyl-6-methylthieno[2,3-d]pyrimidine-2,4-diamine457384BindingDB-show
5-Methyl-6-phenylthieno[2,3-d]pyrimidine-2,4-diamine457380BindingDB-show
5-Monobutyl methotrexate100477BindingDB-show
5-PHENYLSULFANYL-2,4-QUINAZOLINEDIAMINE446244BindingDB-show
5-[4-TERT-BUTYLPHENYLSULFANYL]-2,4-QUINAZOLINEDIAMINE3537BindingDB-show
5-[[4-(trifluoromethyl)phenyl]methoxy]quinazoline-2,4-diamine4047882BindingDB-show
53R25093369BindingDB-show
54798-36-6464014BindingDB-show
6-(10H,11H-Dibenzo[b,f]azepin-5-ylmethyl)pteridine-2,4-diamine481460BindingDB-show
6-(Carbazol-9-ylmethyl)pteridine-2,4-diamine486244BindingDB-show
6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE5289495DrugBank-show
6-(Phenothiazin-10-ylmethyl)pteridine-2,4-diamine486243BindingDB-show
6-(Phenoxazin-10-ylmethyl)pteridine-2,4-diamine486241BindingDB-show
6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE446752BindingDB-show
6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE446752DrugBank-show
6-[(4-Chloroanilino)methyl]pyrido[2,3-d]pyrimidine-2,4-diamine464994BindingDB-show
8-Azatrimetrexate456204BindingDB-show
A156448780BindingDB-show
AC1L1FXT3439BindingDB-show
AC1L1I3Y4412BindingDB-show
AC1L1TU035510BindingDB-show
AC1L1TU335511BindingDB-show
AC1L71HI353015BindingDB-show
AC1L74LG329367BindingDB-show
AC1L7FUM309795BindingDB-show
AC1L8GGA380969BindingDB-show
AC1L8VI2433474BindingDB-show
AC1L9UGF456205BindingDB-show
AC1L9UH9456216BindingDB-show
AC1L9UIC456229BindingDB-show
AC1L9UIF456230BindingDB-show
AC1L9UII456231BindingDB-show
AC1L9UIL456232BindingDB-show
AC1L9UIO456233BindingDB-show
AC1L9UIR456234BindingDB-show
AC1L9UIU456235BindingDB-show
AC1L9UIX456236BindingDB-show
AC1L9UJ0456237BindingDB-show
AC1L9UJ3456238BindingDB-show
AC1L9UJ6456239BindingDB-show
AC1L9UJ9456240BindingDB-show
AC1L9UJF456242BindingDB-show
AC1L9UJL456244BindingDB-show
AC1L9UK3456250BindingDB-show
AC1L9UWF456430BindingDB-show
AC1L9UWI456431BindingDB-show
AC1L9UWL456432BindingDB-show
AC1L9VOT456893BindingDB-show
AC1L9VOZ456895BindingDB-show
AC1L9VP2456896BindingDB-show
AC1L9VP5456897BindingDB-show
AC1L9W0N457122BindingDB-show
AC1L9W9P457258BindingDB-show
AC1L9WDV457334BindingDB-show
AC1L9WDY457335BindingDB-show
AC1L9WE4457337BindingDB-show
AC1L9WE7457338BindingDB-show
AC1L9WEA457339BindingDB-show
AC1L9WED457340BindingDB-show
AC1L9WEG457341BindingDB-show
AC1L9WEJ457342BindingDB-show
AC1L9WEM457343BindingDB-show
AC1L9WEP457344BindingDB-show
AC1L9WES457345BindingDB-show
AC1L9WEV457346BindingDB-show
AC1L9WF4457350BindingDB-show
AC1L9WF7457351BindingDB-show
AC1L9WFA457352BindingDB-show
AC1L9WFD457353BindingDB-show
AC1L9WFG457354BindingDB-show
AC1L9WFJ457355BindingDB-show
AC1L9WGM457369BindingDB-show
AC1L9WGP457370BindingDB-show
AC1L9WGS457371BindingDB-show
AC1L9WGV457372BindingDB-show
AC1L9WGY457373BindingDB-show
AC1L9WHA457377BindingDB-show
AC1L9X3A457717BindingDB-show
AC1L9X3D457718BindingDB-show
AC1L9X3G457719BindingDB-show
AC1L9X5A457743BindingDB-show
AC1L9X5Y457751BindingDB-show
AC1L9X6A457763BindingDB-show
AC1L9X6D457764BindingDB-show
AC1L9X6G457765BindingDB-show
AC1L9X7J457778BindingDB-show
AC1L9X7P457780BindingDB-show
AC1L9YB8504022BindingDB-show
AC1L9YBB504023BindingDB-show
AC1L9YBN504027BindingDB-show
AC1L9YBQ504028BindingDB-show
AC1L9YBT504029BindingDB-show
AC1L9YBW504030BindingDB-show
AC1L9YBZ504031BindingDB-show
AC1L9ZJM478873BindingDB-show
AC1L9ZJP478874BindingDB-show
AC1L9ZJS478875BindingDB-show
AC1L9ZJV478876BindingDB-show
AC1L9ZJY478877BindingDB-show
AC1L9ZK1478878BindingDB-show
AC1L9ZMG478945BindingDB-show
AC1L9ZMJ478946BindingDB-show
AC1L9ZMM478947BindingDB-show
AC1L9ZMP478948BindingDB-show
AC1LA0CE479281BindingDB-show
AC1LA0CK479283BindingDB-show
AC1LA0LB479412BindingDB-show
AC1LA0LE479413BindingDB-show
AC1LA0LN479416BindingDB-show
AC1LA0LT479418BindingDB-show
AC1LA0M2479421BindingDB-show
AC1LA1E0459880BindingDB-show
AC1LA1E3459881BindingDB-show
AC1LA1NF460024BindingDB-show
AC1LA4KH481401BindingDB-show
AC1LA53L461918BindingDB-show
AC1LA53R461920BindingDB-show
AC1LA5EI462094BindingDB-show
AC1LA5EL462095BindingDB-show
AC1LA5F6462102BindingDB-show
AC1LA5FX462111BindingDB-show
AC1LA5G3462113BindingDB-show
AC1LA5GF462117BindingDB-show
AC1LA5GI462118BindingDB-show
AC1LA5GL462119BindingDB-show
AC1LA5GO462120BindingDB-show
AC1LA5GR462121BindingDB-show
AC1LA5GU462122BindingDB-show
AC1LA5GX462123BindingDB-show
AC1LA5H0462124BindingDB-show
AC1LA5H3462125BindingDB-show
AC1LA5H9462127BindingDB-show
AC1LA5HF462129BindingDB-show
AC1LA5HI462130BindingDB-show
AC1LA5HL462131BindingDB-show
AC1LA5HU462134BindingDB-show
AC1LA6DS462574BindingDB-show
AC1LA6DV462575BindingDB-show
AC1LA6DY462576BindingDB-show
AC1LA6E1462577BindingDB-show
AC1LA6F1462589BindingDB-show
AC1LA7YR483225BindingDB-show
AC1LA8L2463731BindingDB-show
AC1LA8UE463890BindingDB-show
AC1LA8UH463891BindingDB-show
AC1LA8UJ483687BindingDB-show
AC1LA8VK463908BindingDB-show
AC1LA8Z3464018BindingDB-show
AC1LA8ZF464022BindingDB-show
AC1LA8ZX464028BindingDB-show
AC1LA90I464035BindingDB-show
AC1LA90U464040BindingDB-show
AC1LAARC464889BindingDB-show
AC1LAARF464890BindingDB-show
AC1LAARI464891BindingDB-show
AC1LAAUP464985BindingDB-show
AC1LAAVA464992BindingDB-show
AC1LABDF484980BindingDB-show
AC1LABGU485021BindingDB-show
AC1LAD75466230BindingDB-show
AC1LAD78466231BindingDB-show
AC1LADWQ486242BindingDB-show
AC1LAFYY487329BindingDB-show
AC1LAFZ4487331BindingDB-show
AC1LAFZ7487332BindingDB-show
AC1LAFZA487333BindingDB-show
AC1LAFZD487334BindingDB-show
AC1LAFZG487335BindingDB-show
AC1LAFZJ487336BindingDB-show
AC1LAFZM487337BindingDB-show
AC1LAFZP487338BindingDB-show
AC1LAFZS487339BindingDB-show
AC1LAFZV487340BindingDB-show
AC1LAFZY487341BindingDB-show
AC1LAG01487342BindingDB-show
AC1LAG04487343BindingDB-show
AC1LAG07487344BindingDB-show
AC1LAG0A487345BindingDB-show
AC1LAG0D487346BindingDB-show
AC1LAG0G487347BindingDB-show
AC1LAG0J487348BindingDB-show
AC1LAG0M487349BindingDB-show
AC1LAG0P487350BindingDB-show
AC1LAG0S487351BindingDB-show
AC1LAG0V487352BindingDB-show
AC1LAG4P487401BindingDB-show
AC1LAG4V487403BindingDB-show
AC1LAG4Y487404BindingDB-show
AC1LAG5D487409BindingDB-show
AC1LAG5J487412BindingDB-show
AC1LAG5M487413BindingDB-show
AC1LAG5S487415BindingDB-show
AC1LAG5Y487417BindingDB-show
AC1LAG62467889BindingDB-show
AC1LAG65467890BindingDB-show
AC1LAG68467891BindingDB-show
AC1LAG6B467892BindingDB-show
AC1LAG6E467893BindingDB-show
AC1LAG6H467894BindingDB-show
AC1LAG6K467895BindingDB-show
AC1LAG6N467896BindingDB-show
AC1LAG6Q467897BindingDB-show
AC1LAG6T467898BindingDB-show
AC1LAG6W467899BindingDB-show
AC1LAG6Z467900BindingDB-show
AC1LAG72467901BindingDB-show
AC1LAG75467902BindingDB-show
AC1LAG78467903BindingDB-show
AC1LAG7B467904BindingDB-show
AC1LAG7E467905BindingDB-show
AC1LAG9V487466BindingDB-show
AC1LAG9Y487467BindingDB-show
AC1LAHT8468709BindingDB-show
AC1LAHTB468710BindingDB-show
AC1LAHTE468711BindingDB-show
AC1LAHTH468712BindingDB-show
AC1LAJ7L469405BindingDB-show
AC1LAJ7O469406BindingDB-show
AC1LAJ83469411BindingDB-show
AC1LAJ86469412BindingDB-show
AC1LAJ89469413BindingDB-show
AC1LAJ8C469414BindingDB-show
AC1LAJ8F469415BindingDB-show
AC1LAJK3469603BindingDB-show
AC1LAJK6469604BindingDB-show
AC1LAJK9469605BindingDB-show
AC1LAJKI469608BindingDB-show
AC1LAJKO469612BindingDB-show
AC1LAJKR469613BindingDB-show
AC1LAJKU469614BindingDB-show
AC1LAJKX469615BindingDB-show
AC1LAJL0469616BindingDB-show
AC1LAJL6469618BindingDB-show
AC1LAJL9469619BindingDB-show
AC1LAJLC469620BindingDB-show
AC1LAKPG470175BindingDB-show
AC1LAKPJ470176BindingDB-show
AC1LAKPM470177BindingDB-show
AC1LAKPS470179BindingDB-show
AC1LAKQF470200BindingDB-show
AC1LAKQI470201BindingDB-show
AC1LAKQL470202BindingDB-show
AC1LAKT7470264BindingDB-show
AC1LAKTA470265BindingDB-show
AC1LAKTD470266BindingDB-show
AC1LAKUJ470281BindingDB-show
AC1LAKUS470284BindingDB-show
AC1LAKUV470285BindingDB-show
AC1LAKUY470286BindingDB-show
AC1LAKV1470287BindingDB-show
AC1LAKV4470288BindingDB-show
AC1LAKWS470317BindingDB-show
AC1LAKWV470318BindingDB-show
AC1LAKXY470332BindingDB-show
AC1LAKY1470333BindingDB-show
AC1LAL9L490567BindingDB-show
AC1LAL9O490568BindingDB-show
AC1LAL9R490569BindingDB-show
AC1LAL9U490570BindingDB-show
AC1LAL9X490571BindingDB-show
AC1LALA0490572BindingDB-show
AC1LALA6490574BindingDB-show
AC1LALA9490575BindingDB-show
AC1LALAC490576BindingDB-show
AC1LALAF490577BindingDB-show
AC1LALFL490662BindingDB-show
AC1LALFO490663BindingDB-show
AC1LALFR490664BindingDB-show
AC1LALFU490665BindingDB-show
AC1LALFX490666BindingDB-show
AC1LALG0490667BindingDB-show
AC1LALG3490668BindingDB-show
AC1LAPUU472826BindingDB-show
AC1LAPVR472845BindingDB-show
AC1LAPVU472846BindingDB-show
AC1LAPVX472847BindingDB-show
AC1LAPW0472848BindingDB-show
AC1LAPW3472849BindingDB-show
AC1LAPW6472850BindingDB-show
AC1LAPWC472852BindingDB-show
AC1LAPWF472853BindingDB-show
AC1LAPYO472903BindingDB-show
AC1LAPYR472904BindingDB-show
AC1LAPYU472905BindingDB-show
AC1LAPYX472906BindingDB-show
AC1LAPZ0472907BindingDB-show
AC1LAPZ3472908BindingDB-show
AC1LAPZ6472909BindingDB-show
AC1LARKR473735BindingDB-show
AC1LARKU473736BindingDB-show
AC1LARKX473737BindingDB-show
AC1LARL0473738BindingDB-show
AC1LARL3473739BindingDB-show
AC1LATK9474750BindingDB-show
AC1MBSH52730570BindingDB-show
AC1MDQO22794241BindingDB-show
AC1MHDBT3000709BindingDB-show
AC1MJ80Y3132813BindingDB-show
AC1MXRD93770186BindingDB-show
AC1NBM3Y4470180BindingDB-show
AC1NQ6BI5190983BindingDB-show
AC1NRRAN5271419BindingDB-show
AC1NRRAQ5271420BindingDB-show
AC1NRRAT5271421BindingDB-show
AC1NRRAW5271422BindingDB-show
AC1NRRAZ5271423BindingDB-show
AC1NRRB25271424BindingDB-show
AC1NRRCA5271440BindingDB-show
AC1NRRCD5271441BindingDB-show
AC1NUK5F5481094BindingDB-show
AC1NWE6S5703862BindingDB-show
AC1NWF7S5704385BindingDB-show
AC1NX3OY5742617BindingDB-show
AC1NX3P05742618BindingDB-show
AC1NX3P25742619BindingDB-show
AC1NX3P45742620BindingDB-show
AC1NX3P65742621BindingDB-show
AC1NX3P85742622BindingDB-show
AC1NX3PA5742623BindingDB-show
AC1NX3PC5742624BindingDB-show
AC1NZH755933236BindingDB-show
AC1O52OO6476138BindingDB-show
AC1O5DNO6482470BindingDB-show
AC1O6FM26474984BindingDB-show
AC1O6FM36474985BindingDB-show
AC1O6FM46474986BindingDB-show
Acetylsulfanilamide5320BindingDB-show
AIDS007470447815BindingDB-show
AIDS007470447815DrugBank-show
AIDS010493457375BindingDB-show
AIDS0788176477203BindingDB-show
AIDS07881711687971BindingDB-show
AIDS090598477890BindingDB-show
AIDS094330447229DrugBank-show
AIDS1046386532431BindingDB-show
AIDS107819485848BindingDB-show
aminopterin2154BindingDB-show
BRL 6231hydrochloride121750BindingDB-show
Bromdimoprim68760BindingDB-show
CB 37171405BindingDB-show
CHEBI:17121244292607BindingDB-show
CHEBI:17528944294491BindingDB-show
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CHEBI:17564044294633BindingDB-show
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CHEBI:23335944462180BindingDB-show
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CHEBI:47155444283692BindingDB-show
CHEMBL10592329597BindingDB-show
CHEMBL1066999889551BindingDB-show
CHEMBL108922946886122BindingDB-show
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CHEMBL109089646886145BindingDB-show
CHEMBL109089746886146BindingDB-show
CHEMBL109124446886489BindingDB-show
CHEMBL109125546886469BindingDB-show
CHEMBL109160346886490BindingDB-show
CHEMBL109245146886486BindingDB-show
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CHEMBL109268346886125BindingDB-show
CHEMBL109309925181586BindingDB-show
CHEMBL109310025218207BindingDB-show
CHEMBL109323046861681BindingDB-show
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CHEMBL1113344266987BindingDB-show
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CHEMBL13604244355913BindingDB-show
CHEMBL1363612996853BindingDB-show
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CHEMBL13744810634047BindingDB-show
CHEMBL13764110246793BindingDB-show
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CHEMBL13823010544281BindingDB-show
CHEMBL13850044359486BindingDB-show
CHEMBL1387744269050BindingDB-show
CHEMBL1390844269121BindingDB-show
CHEMBL13943010710507BindingDB-show
CHEMBL1400121064600BindingDB-show
CHEMBL1400244269062BindingDB-show
CHEMBL14032310782798BindingDB-show
CHEMBL1420144269104BindingDB-show
CHEMBL14217610566619BindingDB-show
CHEMBL1459479931657BindingDB-show
CHEMBL14692511099765BindingDB-show
CHEMBL14713744366400BindingDB-show
CHEMBL14859911783065BindingDB-show
CHEMBL14902711047021BindingDB-show
CHEMBL14916444366301BindingDB-show
CHEMBL15415244370886BindingDB-show
CHEMBL15502314801660BindingDB-show
CHEMBL15708344370807BindingDB-show
CHEMBL15711714801666BindingDB-show
CHEMBL15790444370870BindingDB-show
CHEMBL16069915021215BindingDB-show
CHEMBL16231210403719BindingDB-show
CHEMBL1624769980556BindingDB-show
CHEMBL16730444378321BindingDB-show
CHEMBL16806944378322BindingDB-show
CHEMBL19263224737646BindingDB-show
CHEMBL19327510456691BindingDB-show
CHEMBL19522144402301BindingDB-show
CHEMBL19578244401979BindingDB-show
CHEMBL19586744401859BindingDB-show
CHEMBL19587444402132BindingDB-show
CHEMBL19670644402113BindingDB-show
CHEMBL20161711659960BindingDB-show
CHEMBL20161811515277BindingDB-show
CHEMBL20194111552140BindingDB-show
CHEMBL20209811507922BindingDB-show
CHEMBL20217611717558BindingDB-show
CHEMBL20249011589874BindingDB-show
CHEMBL20328011538533BindingDB-show
CHEMBL20939411846625BindingDB-show
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CHEMBL21126511349789BindingDB-show
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CHEMBL21513316086913BindingDB-show
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CHEMBL21722716086919BindingDB-show
CHEMBL21776016086916BindingDB-show
CHEMBL21776510478775BindingDB-show
CHEMBL21962416110323BindingDB-show
CHEMBL21988916110338BindingDB-show
CHEMBL22015916110337BindingDB-show
CHEMBL22093616110329BindingDB-show
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CHEMBL25007525002412BindingDB-show
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CHEMBL28086414083105BindingDB-show
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CHEMBL28494344282953BindingDB-show
CHEMBL28520910805231BindingDB-show
CHEMBL28547415523786BindingDB-show
CHEMBL28753214840934BindingDB-show
CHEMBL29497344287188BindingDB-show
CHEMBL29585944292014BindingDB-show
CHEMBL29654544291963BindingDB-show
CHEMBL29755844292015BindingDB-show
CHEMBL29992710068729BindingDB-show
CHEMBL30103014570150BindingDB-show
CHEMBL30123614570149BindingDB-show
CHEMBL30206814503207BindingDB-show
CHEMBL30266914650023BindingDB-show
CHEMBL30403457742BindingDB-show
CHEMBL30440714650018BindingDB-show
CHEMBL30565611102571BindingDB-show
CHEMBL30713715616238BindingDB-show
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CHEMBL3074869846618BindingDB-show
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CHEMBL3123510019413BindingDB-show
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CHEMBL3154710518330BindingDB-show
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CHEMBL38644216086911BindingDB-show
CHEMBL38668516086910BindingDB-show
CHEMBL38700723648075BindingDB-show
CHEMBL38790116733030BindingDB-show
CHEMBL38812016733162BindingDB-show
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CHEMBL38834011248241BindingDB-show
CHEMBL38850144421498BindingDB-show
CHEMBL38887944428667BindingDB-show
CHEMBL3890215747121BindingDB-show
CHEMBL38964310433577BindingDB-show
CHEMBL38968616733164BindingDB-show
CHEMBL38988716732893BindingDB-show
CHEMBL39099011247965BindingDB-show
CHEMBL3917544287510BindingDB-show
CHEMBL39629616216218BindingDB-show
CHEMBL39841611645349BindingDB-show
CHEMBL40030424754609BindingDB-show
CHEMBL40036410471067BindingDB-show
CHEMBL40048510065888BindingDB-show
CHEMBL40107324754976BindingDB-show
CHEMBL40107424754978BindingDB-show
CHEMBL4085015747112BindingDB-show
CHEMBL41187116086917BindingDB-show
CHEMBL41399025007788BindingDB-show
CHEMBL4145915747123BindingDB-show
CHEMBL41468916086915BindingDB-show
CHEMBL4165529881905BindingDB-show
CHEMBL41756214650010BindingDB-show
CHEMBL41769644287458BindingDB-show
CHEMBL41834744269024BindingDB-show
CHEMBL41908714776619BindingDB-show
CHEMBL42195910902858BindingDB-show
CHEMBL42197314801655BindingDB-show
CHEMBL4239859805576BindingDB-show
CHEMBL42464744356150BindingDB-show
CHEMBL42504811282247BindingDB-show
CHEMBL42930824754979BindingDB-show
CHEMBL43079715616236BindingDB-show
CHEMBL43082111442756BindingDB-show
CHEMBL4308729911146BindingDB-show
CHEMBL43135914503206BindingDB-show
CHEMBL43305914650009BindingDB-show
CHEMBL43320444325439BindingDB-show
CHEMBL43618444356153BindingDB-show
CHEMBL43866410072852BindingDB-show
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CHEMBL45790525093365BindingDB-show
CHEMBL45790625093366BindingDB-show
CHEMBL45882925093368BindingDB-show
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CHEMBL49406725107577BindingDB-show
CHEMBL49512425107645BindingDB-show
CHEMBL49512525107643BindingDB-show
CHEMBL51421924950538BindingDB-show
CHEMBL51531224950693BindingDB-show
CHEMBL51612824950699BindingDB-show
CHEMBL51689124950540BindingDB-show
CHEMBL52035825093361BindingDB-show
CHEMBL52236344568860BindingDB-show
CHEMBL52251725107640BindingDB-show
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CHEMBL55198544221147BindingDB-show
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CHEMBL56321244221539BindingDB-show
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CHEMBL5994614570168BindingDB-show
CHEMBL6006914570167BindingDB-show
CHEMBL60210446231369BindingDB-show
CHEMBL60319844246327BindingDB-show
CHEMBL60472246231410BindingDB-show
CHEMBL60541344246325BindingDB-show
CHEMBL60636244246329BindingDB-show
CHEMBL6063944300964BindingDB-show
CHEMBL60989646231371BindingDB-show
CHEMBL61198446231414BindingDB-show
CHEMBL6170810477651BindingDB-show
CHEMBL6259914650017BindingDB-show
CHEMBL6267514650012BindingDB-show
CHEMBL6421514650007BindingDB-show
CHEMBL6561614776576BindingDB-show
CHEMBL6562014776583BindingDB-show
CHEMBL6571114776579BindingDB-show
CHEMBL7326714776590BindingDB-show
CHEMBL7442214776615BindingDB-show
CHEMBL7459211003295BindingDB-show
CHEMBL7478110991113BindingDB-show
CHEMBL7478223161237BindingDB-show
CHEMBL7594411822511BindingDB-show
CHEMBL7758210860015BindingDB-show
CHEMBL7760844314297BindingDB-show
CHEMBL7775811058970BindingDB-show
CHEMBL7810410884015BindingDB-show
CHEMBL7946411168298BindingDB-show
CHEMBL8199511773511BindingDB-show
CHEMBL8282544462183BindingDB-show
CHEMBL8293611317679BindingDB-show
CHEMBL8298544462345BindingDB-show
CHEMBL8364410457642BindingDB-show
CHEMBL8427311155280BindingDB-show
CHEMBL8557611071072BindingDB-show
CHEMBL8995944325252BindingDB-show
CHEMBL900189877881BindingDB-show
CHEMBL9029244325103BindingDB-show
CHEMBL9035844325237BindingDB-show
CHEMBL9046144325107BindingDB-show
CHEMBL9070344325106BindingDB-show
CHEMBL9218244325272BindingDB-show
CHEMBL9284644325327BindingDB-show
CHEMBL9300144325367BindingDB-show
CHEMBL9374844325118BindingDB-show
CHEMBL9388844325296BindingDB-show
CHEMBL9389312148065BindingDB-show
CHEMBL9397410404620BindingDB-show
CHEMBL9428144325300BindingDB-show
CHEMBL944709679790BindingDB-show
CHEMBL952749583359BindingDB-show
chlorcycloguanil9049BindingDB-show
CID 1003094710030947BindingDB-show
CID 1025404910624126BindingDB-show
CID 1032632210326322BindingDB-show
CID 1060341111478803BindingDB-show
CID 1084083210053803BindingDB-show
CID 1096183110961831BindingDB-show
CID 1099387010993870BindingDB-show
CID 1107842111078421BindingDB-show
CID 1107842110405166BindingDB-show
CID 1182653311826533BindingDB-show
CID 986792110478474BindingDB-show
CID 99322769932276BindingDB-show
Deazapteridine der.457349BindingDB-show
Deazapteridine der.457336BindingDB-show
Deazapteridine der.72509BindingDB-show
DH1490573BindingDB-show
Diaminodiphenylsulfone2955DrugBank-show
Diaminodiphenylsulfone2955SuperTargetPMID 7978638show
Diaminopyritamin4993BindingDB-show
Diaminopyritamin4993DrugBank-show
Diaminopyritamin4993SuperTargetPMID 11295178show
Diaminopyrrolo[3,2-f]quinazoline der.177894BindingDB-show
dihydrodiphosphopyridine nucleotide439153DrugBank-show
DIHYDROFOLATE98792BindingDB-show
DM624456183BindingDB-show
DMDP derivative482165BindingDB-show
Dpmabg158351BindingDB-show
Dpmmabg158376BindingDB-show
EKB25138225BindingDB-show
Epiroprim68916BindingDB-show
FMTX125843BindingDB-show
GHC44201386BindingDB-show
GHW11248226BindingDB-show
GPB5288461BindingDB-show
GW3451881BindingDB-show
Iclaprim213043BindingDB-show
LAMOTRIGINE3878DrugBank-show
Leucovorin6006BindingDB-show
Methylaminopterin4112BindingDB-show
Methylaminopterinum126941BindingDB-show
Methylaminopterinum72440BindingDB-show
Methylaminopterinum126941DrugBank-show
Methylaminopterinum72440DrugBank-show
Methylaminopterinum72440SuperTarget-show
Methylaminopterinum126941SuperTarget-show
Methylbenzoprim72438BindingDB-show
Methylsulfinylmethane679DrugBank-show
Methylsulfinylmethane679SuperTarget-show
MGN103487402BindingDB-show
MLS0003275152764922BindingDB-show
n-(4-{[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl]amino}benzoyl)glutamic468708BindingDB-show
n-(4-{[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]amino}benzoyl)glutam269323BindingDB-show
N2225058133BindingDB-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine444617BindingDB-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine444617DrugBank-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylquinazoline-2,4,6-triamine447021BindingDB-show
N6-[(3,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine447022BindingDB-show
Nair # 7456302BindingDB-show
nchembio.65-comp136508446BindingDB-show
NCI60_023541381233BindingDB-show
NSC 2675711036BindingDB-show
NSC137193421645BindingDB-show
NSC156246291270BindingDB-show
NSC174121425430BindingDB-show
NSC211275427350BindingDB-show
NSC211939427454BindingDB-show
NSC232964314603BindingDB-show
NSC245428429008BindingDB-show
NSC248859317332BindingDB-show
NSC25082230335BindingDB-show
NSC3077 (HYDROCHLORIDE SALT)25889BindingDB-show
NSC330464332597BindingDB-show
NSC3395785384532BindingDB-show
NSC372950341268BindingDB-show
NSC654830375312BindingDB-show
NSC667641381234BindingDB-show
NSC695788393599BindingDB-show
NSC719487403898BindingDB-show
NSC720934404585BindingDB-show
NSC722174405137BindingDB-show
NSC722177405140BindingDB-show
NSC79142416460BindingDB-show
Olomoucine4592PROMISCUOUSPMID 14653808show
PD 13088363348BindingDB-show
Pemetrexed446556BindingDB-show
Pemetrexed394493BindingDB-show
Pemetrexed446556BindingDB-show
Pemetrexed60843DrugBank-show
Piritrexim Isethionate54369BindingDB-show
Piritrexim Isethionate54369DrugBank-show
PIRITREXIM ISETHIONATE54368DrugBank-show
Proguanil4923DrugBank-show
Proguanil4923SuperTarget-show
Propargyl inhibitor, 1525138222BindingDB-show
Propargyl inhibitor, 1625138223BindingDB-show
Propargyl inhibitor, 1825138224BindingDB-show
Propargyl inhibitor, 2225138226BindingDB-show
Propargyl inhibitor, 2425138227BindingDB-show
Pteridine compound, 17446744BindingDB-show
Pteroylmonoglutamate3405BindingDB-show
Pteroylmonoglutamate6037SuperTarget-show
Pteroylmonoglutamate3405SuperTarget-show
PY 821457381BindingDB-show
PY 826457383BindingDB-show
PY 842457376BindingDB-show
PY831456251BindingDB-show
PY839457374BindingDB-show
PY856461917BindingDB-show
PY860461919BindingDB-show
Pyrimidine analog382165BindingDB-show
Pyrimidine analog72934BindingDB-show
Pyrimidine der.1987BindingDB-show
Pyrrolo[2, 3-d]pyrimidine analogue, 916733032BindingDB-show
Raltitrexed104758BindingDB-show
Riboflavin710BindingDB-show
SMR0001805161473299BindingDB-show
SoRI 7747456245BindingDB-show
SoRI 7843456341BindingDB-show
SoRI 7896456272BindingDB-show
SoRI 8226317602BindingDB-show
SRI 8451464023BindingDB-show
SRI 8453464024BindingDB-show
SRI 8455464033BindingDB-show
SRI 8573464034BindingDB-show
SRI 8708459887BindingDB-show
SRI-9662446753DrugBank-show
STK3966453834960BindingDB-show
STK5655551714014BindingDB-show
Sulfamethoprim5578BindingDB-show
Sulfamethoprim5578DrugBank-show
Sulfamethoprim5578SuperTargetPMID 14632594show
Sulphamethylisoxazole5329BindingDB-show
Tetrahydropteroylglutamate91443BindingDB-show
Trimetrexate5583BindingDB-show
Trimetrexate5583DrugBank-show
TRIMETREXATE5582DrugBank-show
Trimetrexate5583SuperTargetPMID 9479873show
TRIMETREXATE5582SuperTargetPMID 9479873show
Triphosphopyridine nucleotide5886DrugBank-show
Triphosphopyridine nucleotide5885DrugBank-show
X 48407233BindingDB-show
ZINC001280652747162BindingDB-show
ZINC001369421538822BindingDB-show
ZINC00146421732267BindingDB-show
ZINC00289771789778BindingDB-show
ZINC043446369584159BindingDB-show
ZINC047101939581136BindingDB-show
Synonyms:
Dihydrofolate reductase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
DYR_CHICK85.873.2
DYR_PNECA55.536.4
DYR_CANAL50.231.9
DYR_ECOLI46.827.4
DYR_LACCA45.526.5
DYR_MYCTU45.329.4
CBIT_METTH35.619.4
RRF_THEMA35.420.6
FRIL_HORSE34.418.9
Q8U3I1_PYRFU33.718.6
QACR_STAAM33.616.6
QACR_STAAU33.616.6
QACR_STAHA33.616.6
CYB5B_RAT33.320.4
LACB_BOVIN3318.7
Q9UEH3_HUMAN32.718
O59257_PYRHO32.418.2
OBP_PIG32.118.2
RIB4_SCHPO32.114.7
COAC_HUMAN3216.2
TNNI3_HUMAN31.915.7
NOS1_SHEEP31.818.6
SUHB_ARCFU31.715.5
Q9QWF6_CRILO31.619.3
MUP2_MOUSE31.618.7
SAMP_HUMAN31.513.4
KADC_MAIZE31.518.5
TXD12_HUMAN31.417.7
RET4_HUMAN31.317.2
LACB_PIG31.318.1
Protein-Protein Interactions: