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Target Details

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Name:Dihydrofolate reductase
Uniprot name:DYR_ECOLI
Accession Numbers:P00379 P0ABQ4
EC-Number:1.5.1.3
Organism:Escherichia coli
strain K12
PDB IDs:1DDR 1DDS 1DHI 1DHJ 1DRA 1DRB 1DRE 1DRH 1DYH 1DYI 1DYJ 1JOL 1JOM 1RA1 1RA2 1RA3 1RA8 1RA9 1RB2 1RB3 1RC4 1RD7 1RE7 1RF7 1RG7 1RH3 1RX1 1RX2 1RX3 1RX4 1RX5 1RX6 1RX7 1RX8 1RX9 1TDR 2ANO 2ANQ 2D0K 2DRC 2INQ 3DAU 3DRC 4DFR 5DFR 6DFR 7DFR
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID443388BindingDB-show
2,4-Diamino-6,7-dimethylpteridine74023BindingDB-show
2,4-Diamino-6-benzyl-5-methylthieno[2,3-d]pyrimidine457382BindingDB-show
2-Phospho-adenosine diphosphate165230DrugBank-show
3-(TRIFLUOROMETHYL)BENZYL N-[(E)-AMINO(IMINO)METHYL]IMIDOTHIOCARBAMATE9543472BindingDB-show
5-(4-methylphenoxy)quinazoline-2,4-diamine4106338BindingDB-show
5-(4-methylphenyl)sulfanylquinazoline-2,4-diamine446245BindingDB-show
5-Benzyl-6-methylthieno[2,3-d]pyrimidine-2,4-diamine457384BindingDB-show
5-FORMYL-6-HYDROFOLIC ACID6323313DrugBank-show
5-Methyl-6-phenylthieno[2,3-d]pyrimidine-2,4-diamine457380BindingDB-show
5-[2-(2,5-Dimethoxyphenyl)ethyl]thieno[2,3-D]pyrimidine-2,4-Diamine457378BindingDB-show
6-{[(2,5-Dichlorophenyl)amino]methyl}pyrido[2,3-D]pyrimidine-2,4-Diamine472910BindingDB-show
8-Azatrimetrexate456204BindingDB-show
AC1L9UH9456216BindingDB-show
AC1L9UI3456226BindingDB-show
AC1L9UI9456228BindingDB-show
AC1L9UIR456234BindingDB-show
AC1L9UK3456250BindingDB-show
AC1L9WGV457372BindingDB-show
AC1L9WGY457373BindingDB-show
AC1L9WHA457377BindingDB-show
AC1L9WHG457379BindingDB-show
AC1L9X3A457717BindingDB-show
AC1L9X6A457763BindingDB-show
AC1LA0LB479412BindingDB-show
AC1LA0LE479413BindingDB-show
AC1LA0LT479418BindingDB-show
AC1LA5G0462112BindingDB-show
AC1LA6F1462589BindingDB-show
AC1LABDF484980BindingDB-show
AC1LADD4511804BindingDB-show
AC1LADD7511805BindingDB-show
AC1LADDA511806BindingDB-show
AC1LADDD511807BindingDB-show
AC1LADDG511808BindingDB-show
AC1LADDJ511809BindingDB-show
AC1LADDM511810BindingDB-show
AC1LAJ7L469405BindingDB-show
AC1LAL9L490567BindingDB-show
AC1LAL9O490568BindingDB-show
AC1LAL9R490569BindingDB-show
AC1LAL9U490570BindingDB-show
AC1LAL9X490571BindingDB-show
AC1LALA0490572BindingDB-show
AC1LALA6490574BindingDB-show
AC1LALA9490575BindingDB-show
AC1LALAC490576BindingDB-show
AC1LALAF490577BindingDB-show
AC1LAPZF472912BindingDB-show
AC1LAPZI472913BindingDB-show
AC1LAR9C473573BindingDB-show
AIDS007470447815BindingDB-show
AIDS010493457375BindingDB-show
amidinothiouronium, 1011995626BindingDB-show
amidinothiouronium, 1111995526BindingDB-show
amidinothiouronium, 1211995627BindingDB-show
amidinothiouronium, 1311995527BindingDB-show
amidinothiouronium, 1411995628BindingDB-show
amidinothiouronium, 1511995528BindingDB-show
amidinothiouronium, 1611995629BindingDB-show
amidinothiouronium, 1711995529BindingDB-show
amidinothiouronium, 1811995630BindingDB-show
amidinothiouronium, 1911995530BindingDB-show
amidinothiouronium, 2011995624BindingDB-show
amidinothiouronium, 2111995631BindingDB-show
amidinothiouronium, 2211995625BindingDB-show
amidinothiouronium, 611995523BindingDB-show
amidinothiouronium, 811995524BindingDB-show
amidinothiouronium, 911995525BindingDB-show
C1A9543473BindingDB-show
Carbonyldiamide1176DrugBank-show
Carbonyldiamide1176SuperTarget-show
CHEMBL1390844269121BindingDB-show
CHEMBL1420144269104BindingDB-show
CHEMBL14692511099765BindingDB-show
CHEMBL14859911783065BindingDB-show
CHEMBL14902711047021BindingDB-show
CHEMBL19263224737646BindingDB-show
CHEMBL19327510456691BindingDB-show
CHEMBL19522144402301BindingDB-show
CHEMBL19535511668389BindingDB-show
CHEMBL19557844401729BindingDB-show
CHEMBL19578244401979BindingDB-show
CHEMBL19586744401859BindingDB-show
CHEMBL19587444402132BindingDB-show
CHEMBL19623544402320BindingDB-show
CHEMBL19670644402113BindingDB-show
CHEMBL22327911744008BindingDB-show
CHEMBL22497410433635BindingDB-show
CHEMBL22695216732891BindingDB-show
CHEMBL22695316732892BindingDB-show
CHEMBL22695416733029BindingDB-show
CHEMBL22700916733034BindingDB-show
CHEMBL22701016733035BindingDB-show
CHEMBL22706316733036BindingDB-show
CHEMBL22706416733165BindingDB-show
CHEMBL2333813953685BindingDB-show
CHEMBL2360913953688BindingDB-show
CHEMBL25213224742034BindingDB-show
CHEMBL25213324754835BindingDB-show
CHEMBL25213424754909BindingDB-show
CHEMBL25233824754676BindingDB-show
CHEMBL25358124754977BindingDB-show
CHEMBL25379524754677BindingDB-show
CHEMBL25379624754678BindingDB-show
CHEMBL32138844336792BindingDB-show
CHEMBL3304544281305BindingDB-show
CHEMBL3381544281312BindingDB-show
CHEMBL35797310883066BindingDB-show
CHEMBL36445344401858BindingDB-show
CHEMBL36497544401747BindingDB-show
CHEMBL36530744398808BindingDB-show
CHEMBL37010644402238BindingDB-show
CHEMBL3706399994380BindingDB-show
CHEMBL37099244401890BindingDB-show
CHEMBL37100544402319BindingDB-show
CHEMBL37169844401730BindingDB-show
CHEMBL37186010366939BindingDB-show
CHEMBL37191344402257BindingDB-show
CHEMBL37237111639604BindingDB-show
CHEMBL38141344401770BindingDB-show
CHEMBL38790116733030BindingDB-show
CHEMBL38812016733162BindingDB-show
CHEMBL38812116733163BindingDB-show
CHEMBL38964310433577BindingDB-show
CHEMBL38968616733164BindingDB-show
CHEMBL38988716732893BindingDB-show
CHEMBL40030424754609BindingDB-show
CHEMBL40107324754976BindingDB-show
CHEMBL40107424754978BindingDB-show
CHEMBL42195910902858BindingDB-show
CHEMBL42930824754979BindingDB-show
CHEMBL4308729911146BindingDB-show
CHEMBL43866410072852BindingDB-show
CHEMBL4398169976735BindingDB-show
CHEMBL44671424754675BindingDB-show
CHEMBL53814344221146BindingDB-show
CHEMBL55029644221346BindingDB-show
CHEMBL55076944221343BindingDB-show
CHEMBL55084244221347BindingDB-show
CHEMBL55176844221340BindingDB-show
CHEMBL55198544221147BindingDB-show
CHEMBL55609144221345BindingDB-show
CHEMBL56091244221145BindingDB-show
CHEMBL56321244221539BindingDB-show
CHEMBL56400444221144BindingDB-show
CHEMBL56427744221143BindingDB-show
CHEMBL56493744221344BindingDB-show
CHEMBL56517944221538BindingDB-show
CHEMBL5697744300967BindingDB-show
CHEMBL6006914570167BindingDB-show
CHEMBL6063944300964BindingDB-show
CHEMBL6170810477651BindingDB-show
CID 1096183110961831BindingDB-show
CID 1099387010993870BindingDB-show
CID 1182653311826533BindingDB-show
CID 986792110478474BindingDB-show
DH1490573BindingDB-show
DIHYDROFOLATE98792DrugBank-show
Epiroprim68916BindingDB-show
GHC44201386BindingDB-show
GHW11248226BindingDB-show
GPB5288461BindingDB-show
Iclaprim213043BindingDB-show
Lometrexol148138DrugBank-show
Methylaminopterin4112BindingDB-show
Methylaminopterinum126941BindingDB-show
Methylaminopterinum72440BindingDB-show
Monothioethyleneglycol1567DrugBank-show
N6-[(2,5-dimethoxyphenyl)methyl]-N6-methylpyrido[5,6-e]pyrimidine-2,4,6-triamine444617BindingDB-show
Pemetrexed446556BindingDB-show
Pemetrexed394493BindingDB-show
Pemetrexed446556BindingDB-show
Piritrexim Isethionate54369BindingDB-show
Pteridine compound, 17446744BindingDB-show
PY 821457381BindingDB-show
PY 826457383BindingDB-show
PY 842457376BindingDB-show
PY831456251BindingDB-show
PY839457374BindingDB-show
Pyrimidine der.1987BindingDB-show
Pyrrolo[2, 3-d]pyrimidine analogue, 916733032BindingDB-show
Raltitrexed104758BindingDB-show
SoRI 7747456245BindingDB-show
SoRI 7843456341BindingDB-show
Sulfamethoprim5578BindingDB-show
Trimetrexate5583BindingDB-show
Triphosphopyridine nucleotide5886DrugBank-show
Triphosphopyridine nucleotide5885DrugBank-show
Synonyms:
Dihydrofolate reductase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
DYR_LACCA49.729.7
DYR_CHICK47.728.5
DYR_HUMAN46.827.4
DYR_MYCTU44.931.9
DYR_CANAL44.328.9
DYR_PNECA44.227.2
FMM1_NEIGO35.916.8
CYCA_METME35.716.5
ACPM_HUMAN35.322.5
Q08124_HUMAN34.419.6
FABP7_HUMAN33.719.6
VPS21_YEAST33.319.6
GCSH_HUMAN3319.5
A7UKX7_HUMAN32.917.1
Q81F54_BACCR32.817.7
ACPS_STRR632.417.1
IPYR_ECOLI32.417.4
RMLC_SALTY31.917.8
RET1_HUMAN31.720.4
P93114_CALSE31.718
SAP3_HUMAN31.619.5
O75780_HUMAN31.418.8
NTPA_PYRHO31.216.7
MUP6_MOUSE31.116.3
HBB_HORSE31.119.4
LOLB_SHIFL31.118.2
Q8GIQ0_STRSU31.117.1
MUP2_MOUSE31.116.7
Q59GH6_HUMAN3115.7
O52646_9ACTO30.816.9
Protein-Protein Interactions:
No data available