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Target Details

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Name:Corticosteroid 11-beta-dehydrogenase isozyme 1
Uniprot name:DHI1_HUMAN
Accession Numbers:B2R9Z1 P28845
EC-Number:1.1.1.146
Organism:Homo sapiens
Human
PDB IDs:1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FRJ
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
1-(4-Chlorophenyl)-2-(phenylsulfonyl)ethanone586971BindingDB-show
1-adamantyl-(4-ethylpiperazin-1-yl)methanone4348598BindingDB-show
1-adamantyl-(4-phenethylpiperazin-1-yl)methanone9114624BindingDB-show
2-(benzenesulfonyl)-1-(4-methoxyphenyl)ethanone4271571BindingDB-show
2-(N-morpholiniumyl)ethanesulfonate4478249DrugBank-show
2-Benzylamine analog 216105494BindingDB-show
2-Benzylamine analog 316105485BindingDB-show
2-Benzylamine analog 416105486BindingDB-show
3-chloro-N-[[4-(4-methylpiperazine-1-carbonyl)phenyl]methyl]benzenesulfona984493BindingDB-show
3-cyclohexyl-1-(4-ethylpiperazin-1-yl)propan-1-one4432326BindingDB-show
A4071/01734222998753BindingDB-show
AC1LK3OL984541BindingDB-show
AC1LSEGH1437824BindingDB-show
AC1LSF5S1438157BindingDB-show
AC1MNIR93328378BindingDB-show
AC1N3XNV4119853BindingDB-show
AC1ND6JA4570352BindingDB-show
AC1NLIXT4982676BindingDB-show
AC1NN1MB5060832BindingDB-show
AC1NT9A35349980BindingDB-show
AC1NTQV35386622BindingDB-show
AC1NZWYH5946474BindingDB-show
AC1O2I0F6227694BindingDB-show
Acetylglycyrrhetinic acid94320BindingDB-show
Adamantan-1-yl-piperidin-1-yl-methanone584509BindingDB-show
adamantane ether 1023646484BindingDB-show
adamantane ether 1523646485BindingDB-show
adamantane ether 1623646486BindingDB-show
adamantane ether 1723646487BindingDB-show
adamantane ether 1823646488BindingDB-show
adamantane ether 1923646489BindingDB-show
adamantane ether 2023646490BindingDB-show
adamantane ether 2123646491BindingDB-show
adamantane ether 2223646492BindingDB-show
adamantane ether 2323646493BindingDB-show
adamantane ether 2423646494BindingDB-show
adamantane ether 2523646495BindingDB-show
adamantane ether 2623646496BindingDB-show
adamantane ether 2723646497BindingDB-show
adamantane ether 2823646498BindingDB-show
adamantane ether 523646479BindingDB-show
adamantane ether 623646480BindingDB-show
adamantane ether 723646481BindingDB-show
adamantane ether 823646482BindingDB-show
adamantane ether 923646483BindingDB-show
AE-848/153414071418612BindingDB-show
AF-399/420190163432649BindingDB-show
AF-399/421771682950639BindingDB-show
AG-205/3691713411835998BindingDB-show
AK-968/403897056874186BindingDB-show
Ambpe101708816371051BindingDB-show
Ambpe101717916371339BindingDB-show
Ambpe101720724735746BindingDB-show
AO-548/4319681411841377BindingDB-show
arylsulfonylpiperazine, 244237012BindingDB-show
arylsulfonylpiperazine, 4524812720BindingDB-show
ASN 065822111437062BindingDB-show
ASN 065822221437818BindingDB-show
ASN 065822661437832BindingDB-show
ASN 065822991437841BindingDB-show
ASN 065839491438163BindingDB-show
ASN 06584004655951BindingDB-show
ASN 065876891438312BindingDB-show
BAS 006664422999452BindingDB-show
BAS 008474842827468BindingDB-show
BAS 034510922903292BindingDB-show
BVT-142256918663BindingDB-show
carbenoxolone21913BindingDB-show
CARBENOXOLONE636403BindingDB-show
CARBENOXOLONE636403DrugBank-show
CARBENOXOLONE636403PROMISCUOUSPMID 7631800show
CARBENOXOLONE636403SuperTargetPMID 14973125show
Cerep_0005932741412BindingDB-show
CHEBI:16404111253BindingDB-show
CHEBI:64704044349499BindingDB-show
CHEMBL107658025192961BindingDB-show
CHEMBL107659446880490BindingDB-show
CHEMBL107660025192963BindingDB-show
CHEMBL107668346880710BindingDB-show
CHEMBL107997546880555BindingDB-show
CHEMBL108015846880556BindingDB-show
CHEMBL108031546880557BindingDB-show
CHEMBL108055746880663BindingDB-show
CHEMBL108075246880402BindingDB-show
CHEMBL108088516724456BindingDB-show
CHEMBL108088646880662BindingDB-show
CHEMBL108088746880617BindingDB-show
CHEMBL108088846880618BindingDB-show
CHEMBL108092225192962BindingDB-show
CHEMBL108093525192964BindingDB-show
CHEMBL108107846880711BindingDB-show
CHEMBL108125125192959BindingDB-show
CHEMBL108129725193102BindingDB-show
CHEMBL108129846880491BindingDB-show
CHEMBL108129946880492BindingDB-show
CHEMBL108145225192965BindingDB-show
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CHEMBL108180325193101BindingDB-show
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CHEMBL108249046890465BindingDB-show
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CHEMBL108249946890246BindingDB-show
CHEMBL108276846890514BindingDB-show
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CHEMBL108277046890516BindingDB-show
CHEMBL108281346890466BindingDB-show
CHEMBL108281446890467BindingDB-show
CHEMBL108293846890076BindingDB-show
CHEMBL108312546890426BindingDB-show
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CHEMBL60553846231390BindingDB-show
CHEMBL60554446231440BindingDB-show
CHEMBL60575625065024BindingDB-show
CHEMBL60576646230565BindingDB-show
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CHEMBL60642046231721BindingDB-show
CID 1154791511555218BindingDB-show
CID 1160564411504178BindingDB-show
CID 1161309211649095BindingDB-show
CID 1164170811627334BindingDB-show
CID 1167043511670435BindingDB-show
CID 1168415211634114BindingDB-show
CID 1170587211705872BindingDB-show
CID 382920411478969BindingDB-show
CID 410511711853305BindingDB-show
Compound 5443630776BindingDB-show
Corosolic acid6918774BindingDB-show
Corticosterone222786SuperTarget-show
Corticosterone5753SuperTarget-show
Cyclohexyl-(4-ethylpiperazin-1-yl)methanone798754BindingDB-show
Cyclopropyl-(4-ethylpiperazin-1-yl)methanone5151632BindingDB-show
Deltahydrocortisone5755PROMISCUOUSPMID 2384181show
dihydrodiphosphopyridine nucleotide439153DrugBank-show
Dihydroflumethiazide3440BindingDB-show
FIG 110193044BindingDB-show
Glycyrrhetinate10114BindingDB-show
Glycyrrhetinate10114PROMISCUOUSPMID 17459698show
Glycyrrhizinate14982PROMISCUOUSPMID 2384181show
N-(2-adamantyl)-1-(2-hydroxyethyl)pyrrolidine-2-carboxamide11609013BindingDB-show
N-(2-adamantyl)-1-(cyclohexylmethyl)pyrrolidine-2-carboxamide11695884BindingDB-show
N-(2-adamantyl)-1-(cyclopentylmethyl)pyrrolidine-2-carboxamide11667087BindingDB-show
N-(2-adamantyl)-1-ethyl-pyrrolidine-2-carboxamide11601544BindingDB-show
N-(2-adamantyl)-1-propyl-pyrrolidine-2-carboxamide11565519BindingDB-show
N-(5-hydroxy-2-adamantyl)-2-methyl-2-(3-methylphenyl)propanamide10065028BindingDB-show
N-(6-methylpyridin-2-yl)-4-(trifluoromethyl)benzenesulfonamide3812801BindingDB-show
N-benzoyl-4-methylbenzenesulfonamide81439BindingDB-show
N-Benzoyl-benzenesulfonamide229604BindingDB-show
NSC144078286220BindingDB-show
NSC33403234102BindingDB-show
NSC86473257864BindingDB-show
Oprea1_03338424072323BindingDB-show
Oprea1_41938723794291BindingDB-show
SMR000013476656335BindingDB-show
SMR0001229905436342BindingDB-show
spiro-carboxamide scaffold, 244143288BindingDB-show
spiro-carboxamide scaffold, 344143289BindingDB-show
spiro-carboxamide scaffold, 444143290BindingDB-show
spiro-carboxamide scaffold, 544143291BindingDB-show
spiro-carboxamide scaffold, 644143292BindingDB-show
spiro-carboxamide scaffold, 744143293BindingDB-show
spiro-carboxamide scaffold, 844143294BindingDB-show
spiro-carboxamide scaffold, 944143295BindingDB-show
spiro-chromanone scaffold, 144143287BindingDB-show
ST07204417233943BindingDB-show
ST08112911835767BindingDB-show
STK0718462851184BindingDB-show
STK0970184332595BindingDB-show
thiazolone analog 123644674BindingDB-show
Triphosphopyridine nucleotide5886DrugBank-show
Triphosphopyridine nucleotide5885DrugBank-show
Ursolic acid64945BindingDB-show
ZINC00209687755284BindingDB-show
ZINC00267737777284BindingDB-show
ZINC003951464592745BindingDB-show
ZINC00630910984480BindingDB-show
ZINC00630913984483BindingDB-show
ZINC009720171203924BindingDB-show
ZINC0102133111835626BindingDB-show
ZINC013363201437837BindingDB-show
ZINC013366051438038BindingDB-show
ZINC013969181483401BindingDB-show
ZINC013969611483443BindingDB-show
ZINC028615372214845BindingDB-show
ZINC040318452741656BindingDB-show
ZINC046608577312225BindingDB-show
ZINC046942035373089BindingDB-show
ZINC050435302953793BindingDB-show
ZINC053925743502039BindingDB-show
ZINC084332935735094BindingDB-show
[3-(4-methylphenyl)-1-adamantyl]-(4-methylpiperazin-1-yl)methanone2882437BindingDB-show
Synonyms:
11-beta-HSD1
11-beta-hydroxysteroid dehydrogenase 1
11-DH
Corticosteroid 11-beta-dehydrogenase isozyme 1
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
DHI1_SHEEP92.178.1
DHI1_MOUSE87.778.4
DHI1_RAT87.375.7
DHB11_HUMAN44.527.7
DHRS4_HUMAN43.926.3
FABG_ECOLI39.624.4
C6EHC1_ECOBD39.324.4
Q94KL8_PODPE39.223.1
TRN1_DATST38.624.6
Q9HFV6_MAGGR37.921.4
RDH12_HUMAN37.524.1
DHR11_HUMAN37.321
H17B6_HUMAN36.921.9
T4HR_MAGO736.722.8
RDH14_HUMAN36.621.2
RDH1_HUMAN36.521.2
HSD_STREX36.123.4
DHG_BACME36.118.7
DHB3_HUMAN36.120.3
BUDC_KLEPN35.823.3
SPRE_HUMAN35.420.6
FABG3_BRANA35.419.3
DHRS3_HUMAN35.422.2
Q9X0Q1_THEMA35.317.8
Q19774_CAEEL35.321.5
RDH8_HUMAN35.321.2
TRN2_DATST34.620.2
Q9WYS2_THEMA34.319.9
DCXR_HUMAN34.319.8
Q4R0Z5_HUMAN34.318
Protein-Protein Interactions: