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Name:CYPIIC8
Uniprot name:CP2C8_HUMAN
Accession Numbers:A8K9N8 B0AZN2 P10632 Q5VX93 Q8WWB1 Q9UCZ9
EC-Number:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:1PQ2 2NNH 2NNI 2NNJ 2VN0
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt44475943BindingDB-show
37672-04-1181536BindingDB-show
52885375288537DrugBank-show
860642-69-923653789BindingDB-show
Acetylsalicylsaeure2244SuperCyp-show
Aformoterol6437070SuperCyp-show
aformoterol3034756SuperCyp-show
Alitretinoin444795SuperCyp-show
ALITRETINOIN449171SuperCyp-show
Amfebutamone444SuperCyp-show
Amiodarone Hydrochloride2157SuperCyp3 PMIDsshow
AMIODARONE HYDROCHLORIDE441325SuperCyp3 PMIDsshow
Amitriprolidine2160SuperCypPMID 11136296show
Amlodipine Benzenesulfonate2162SuperCyp-show
Amodiachinum2165BindingDB-show
Amodiachinum2165SuperCyp5 PMIDsshow
Amprenavir65016PROMISCUOUS2 PMIDsshow
Amprenavir65016SuperCyp-show
Androsteston5995SuperCypPMID 11996015show
ApoGemfibrozil3463PROMISCUOUS3 PMIDsshow
ApoGemfibrozil3463SuperCyp5 PMIDsshow
ApoGemfibrozil3463SuperTarget2 PMIDsshow
ApoMefenamic4044SuperCyp-show
Atorvastatin60823SuperCypPMID 15998357show
azidodeoxythymidine35370SuperCyp2 PMIDsshow
Benzoylmethylecgonine5760SuperCypPMID 16188404show
Benzoylmethylecgonine446220SuperCypPMID 16188404show
BMS-68745316725047BindingDB-show
Bortezomib93860SuperCyp-show
Bortezomib387447SuperCyp-show
Bromochlorotrifluoroethane3562SuperCyp-show
BUPRENORPHINE40400SuperCyp2 PMIDsshow
Buprenorphine5311033SuperCyp2 PMIDsshow
Butacortelone3672SuperCyp3 PMIDsshow
Carbamazapine2756SuperCyp-show
Carbamazepine2554SuperCyp2 PMIDsshow
Carbamazepine2554SuperTargetPMID 015915352show
Cephaloridinum5773SuperCypPMID 15194707show
Cerivastatin446156SuperCyp6 PMIDsshow
cerivastatin23663992SuperCyp6 PMIDsshow
Cerivastatin446156SuperTargetPMID 012433802show
cerivastatin23663992SuperTargetPMID 012433802show
CHEMBL107925642646199BindingDB-show
CHEMBL108561646890301BindingDB-show
CHEMBL108610411516424BindingDB-show
CHEMBL108656746890163BindingDB-show
CHEMBL108665715987030BindingDB-show
CHEMBL109135646866604BindingDB-show
CHEMBL109618224871527BindingDB-show
CHEMBL12018310861208BindingDB-show
CHEMBL12042610938696BindingDB-show
CHEMBL12079710894740BindingDB-show
CHEMBL12082510861641BindingDB-show
CHEMBL12104044346781BindingDB-show
CHEMBL12104811123454BindingDB-show
CHEMBL12124111732429BindingDB-show
CHEMBL12132311100382BindingDB-show
CHEMBL12142011103028BindingDB-show
CHEMBL12150310950401BindingDB-show
CHEMBL12152211070834BindingDB-show
CHEMBL125851746947264BindingDB-show
CHEMBL127767749836293BindingDB-show
CHEMBL128931311647548BindingDB-show
CHEMBL14682611450263BindingDB-show
CHEMBL14780610316203BindingDB-show
CHEMBL20783111612187BindingDB-show
CHEMBL20852811641076BindingDB-show
CHEMBL21858316099923BindingDB-show
CHEMBL23616324741307BindingDB-show
CHEMBL24298316745311BindingDB-show
CHEMBL24423916072099BindingDB-show
CHEMBL2444039799417BindingDB-show
CHEMBL26621244428924BindingDB-show
CHEMBL26721016099905BindingDB-show
CHEMBL33087111078396BindingDB-show
CHEMBL33143111133137BindingDB-show
CHEMBL33148511046887BindingDB-show
CHEMBL33269010895263BindingDB-show
CHEMBL33299411013215BindingDB-show
CHEMBL33310810916150BindingDB-show
CHEMBL33321010938153BindingDB-show
CHEMBL33370410948187BindingDB-show
CHEMBL41423810045582BindingDB-show
CHEMBL43238610245060BindingDB-show
CHEMBL44354210925491BindingDB-show
CHEMBL4533849820134BindingDB-show
CHEMBL48248044586237BindingDB-show
CHEMBL48276811494579BindingDB-show
CHEMBL48298042625381BindingDB-show
CHEMBL48335211516324BindingDB-show
CHEMBL48335311523725BindingDB-show
CHEMBL48393444586212BindingDB-show
CHEMBL48519615986837BindingDB-show
CHEMBL48532615986758BindingDB-show
CHEMBL52013611639448BindingDB-show
CHEMBL52921342626024BindingDB-show
CHEMBL52922024796588BindingDB-show
CHEMBL54121411786814BindingDB-show
CHEMBL55196444192200BindingDB-show
CHEMBL56484044189732BindingDB-show
Chloramphenicolum5959PROMISCUOUSPMID 14576103show
Chloramphenicolum5959SuperCyp-show
Chloroquinium2719SuperCyp4 PMIDsshow
Chlorperphenazine4748SuperCyp-show
Chlotrimazole2812SuperCyp2 PMIDsshow
Cholecalciferol6221SuperCypPMID 10219964show
Claratyne Decongestant3957PROMISCUOUSPMID 11502723show
Claratyne Decongestant3957SuperCypPMID 15601807show
Clorazolam5556PROMISCUOUSPMID 12814972show
Clorazolam5556SuperCypPMID 11136296show
Clozapine2818SuperCypPMID 9840430show
Colchicinum6167SuperCypPMID 12815172show
Conquinine5953SuperCyp-show
Cyamepromazine62865SuperCypPMID 17951033show
cyanoguanidine, 344249821BindingDB-show
Cyclopentylrifampicin6323497SuperCypPMID 9402947show
Cyclophosphoramide2907SuperCyp3 PMIDsshow
CYCLOSPORINE6435893SuperCyp-show
Delavirdine5625PROMISCUOUSPMID 11124228show
Delavirdine5625SuperCyp-show
Demethyl Epipodophyllotoxin Ethylidine Glucoside36462SuperCypPMID 9842986show
Desoxyphenobarbitone4909SuperCyp-show
dexlansoprazole3883PROMISCUOUSPMID 12612455show
dexlansoprazole3883SuperCyp2 PMIDsshow
Dextromethadone4095SuperCypPMID 8839037show
Dextromethadone643985SuperCypPMID 8839037show
DEXTROMETHORPHAN5360696SuperCyp-show
Dextropropoxyphene10100SuperCyp-show
Dextropropoxyphene15330SuperCyp-show
Diacetylmorphine hydrochloride5288826SuperCyp2 PMIDsshow
Diaminodiphenylsulfone2955SuperCypPMID 10901692show
Diaminopyritamin4993SuperCyp-show
Dichlofenac3033PROMISCUOUS3 PMIDsshow
Dichlofenac3033SuperCyp2 PMIDsshow
Dichlofenac3033SuperTarget2 PMIDsshow
diethylcarbamothioylsulfanyl diethylaminomethanedithioate3117SuperCyp-show
Diethylparaoxon9395SuperCypPMID 12669189show
Diethylparaoxon9395SuperTarget-show
Dihydrofolliculin5757SuperCypPMID 11741520show
Diisopropylphenol4943PROMISCUOUSPMID 9764927show
Diisopropylphenol4943SuperCypPMID 9771309show
Diltiazem hydrochloride39186PROMISCUOUS2 PMIDsshow
Diltiazem hydrochloride39186SuperCypPMID 9223567show
Dimethylaminophenyldimethylpyrazolone6009PROMISCUOUSPMID 11853173show
Dimethylaminophenyldimethylpyrazolone6009SuperCypPMID 10199594show
Dimethyloxyquinazine2206SuperCypPMID 8681486show
Diphenylhydatanoin1775PROMISCUOUS2 PMIDsshow
Diphenylhydatanoin1775SuperCyp6 PMIDsshow
Dipropylacetate3121SuperCypPMID 9606477show
DL-tetrahydronicotyrine942SuperCypPMID 10350185show
DMZ447297BindingDB-show
Dolasetron3148SuperCyp-show
Dolasetron60654SuperCyp-show
Domperidone Monohydrochloride3151SuperCypPMID 15327587show
DORZOLAMIDE92087SuperCyp-show
Dorzolamide3154SuperCyp-show
Dorzolamide5284549SuperCyp-show
Efavirenz64139SuperCyp-show
EFAVIRENZ3203SuperCyp-show
Entacapone5281081SuperCyp-show
Enteropride2769SuperCypPMID 10859153show
Eprosartan5281037SuperCyp-show
Eprosartan60879SuperCyp-show
Esomeprazole4594SuperCypPMID 8894508show
eszopiclone5735SuperCypPMID 10460808show
Eszopiclone969472SuperCypPMID 10460808show
FELODIPINE3333PROMISCUOUSPMID 9153299show
Felodipine636806PROMISCUOUSPMID 9153299show
FELODIPINE3333SuperCypPMID 15601807show
Felodipine636806SuperCypPMID 15601807show
FLUCONAZOLE3365PROMISCUOUS3 PMIDsshow
FLUCONAZOLE3365SuperCyp-show
fluindostatin446155PROMISCUOUSPMID 10952477show
Fluindostatin1548972PROMISCUOUSPMID 10952477show
fluindostatin446155SuperCyp2 PMIDsshow
Fluindostatin1548972SuperCyp2 PMIDsshow
fluindostatin446155SuperTarget2 PMIDsshow
Fluindostatin1548972SuperTarget2 PMIDsshow
Fluormethylprednisolone5743SuperCyp2 PMIDsshow
Fluorophenazine3372SuperCyp-show
Fluorouracilum3385SuperCypPMID 11095583show
Fluoxetine Hydrochloride3386SuperCyp-show
FLURBIPROFEN3394SuperCyp-show
Fluvoxamine3404PROMISCUOUS7 PMIDsshow
Fluvoxamine5361192PROMISCUOUS7 PMIDsshow
Fluvoxamine3404SuperCyp-show
Fluvoxamine5361192SuperCyp-show
Fosamprenavir131536SuperCyp-show
Fosphenytoin56339SuperCyp-show
Furofutran5386SuperCypPMID 11095583show
Gelbkoerperhormon5994SuperCyp-show
Glimepiridum3476PROMISCUOUSPMID 11309547show
Glimepiridum3476SuperCyp-show
Glydiazinamide3478SuperCyp-show
Griseofulvinum441140SuperCyp-show
Halofantrinum72454SuperCypPMID 10385214show
Hydrocorticosterone5754SuperCypPMID 12031713show
Hydroxyacetanilide1983SuperCyp-show
Hydroxydiazepam5391SuperCypPMID 8948091show
hydroxyethylrutoside5280805SuperCypPMID 11911845show
Hydroxymethoxybenzyl pelargonamide2998SuperCypPMID 12641434show
Hydroxymethylprogesterone10631SuperCypPMID 15601807show
Ibrolipim131601PROMISCUOUSPMID 11854149show
Imatinib Methansulfonate5291PROMISCUOUSPMID 16286749show
Imatinib Methansulfonate5291SuperCyp-show
Indinavir60944PROMISCUOUS2 PMIDsshow
Indinavir5362440PROMISCUOUS2 PMIDsshow
Indinavir5462355PROMISCUOUS2 PMIDsshow
Indinavir60944SuperCyp-show
Indinavir5362440SuperCyp-show
Indinavir5462355SuperCyp-show
Indomethacinum3715SuperCyp-show
Ipriflavone3747SuperCypPMID 17624023show
Iproveratril2520SuperCyp3 PMIDsshow
Iproveratril2520SuperTarget2 PMIDsshow
Irbesartan3749SuperCypPMID 15601807show
Isonicotinoylhydrazine3767PROMISCUOUS2 PMIDsshow
Isonicotinoylhydrazine3767SuperCypPMID 15304522show
Isophosphamide3690SuperCyp4 PMIDsshow
Ketamine3821SuperCyp-show
Ketobemidonum10101SuperCypPMID 16278191show
KETOCONAZOLE47576SuperCyp4 PMIDsshow
Ketoconazole3823SuperCyp4 PMIDsshow
Ketoconazole456201SuperCyp4 PMIDsshow
Ketoprophene3825SuperCyp-show
Leflunomide3899SuperCyp-show
Lidocaine Monohydrochloride3676PROMISCUOUSPMID 15845683show
Lidocaine Monohydrochloride3676SuperCyp2 PMIDsshow
Loperamide Monohydrochloride3955PROMISCUOUSPMID 16758263show
Loperamide Monohydrochloride3955SuperCypPMID 15365656show
Losartan3961SuperCyp-show
Lovastatin53232SuperCyp2 PMIDsshow
Lovastatin3962SuperCyp2 PMIDsshow
Meloxicam5281106SuperCyp-show
Methoxypropiocin156391SuperCypPMID 9248768show
Methyldiazepinone3016SuperCypPMID 10771285show
Methyltheobromide2519SuperCyp-show
Metronidazole Monohydrochloride4173SuperCyp-show
Minoaleuiatin5576SuperCypPMID 9879636show
Mirtazapin4205SuperCyp2 PMIDsshow
Mometasone123620SuperCypPMID 15601807show
Monodesethylamodiaquine122068BindingDB-show
Montelukast5281040SuperCyp4 PMIDsshow
Montelukast5311297SuperCyp4 PMIDsshow
n-Allylnoroxymorphone5284596SuperCypPMID 16010532show
Nicardipine hydrochloride4474PROMISCUOUSPMID 15377640show
Nicardipine hydrochloride4474SuperCyp2 PMIDsshow
Nifedipine Monohydrochloride4485SuperCypPMID 15601807show
Nilutamide4493SuperCypPMID 1785203show
NILVADIPINE4494SuperCypPMID 14993813show
Nonylphenol1752PROMISCUOUSPMID 11853173show
Oxibutyninum4634SuperCypPMID 15601807show
Paclitaxel36314SuperCyp10 PMIDsshow
Palmitinsaeure985DrugBank-show
Parabromdylamine6834SuperCyp-show
Paracarbinoxamine2564SuperCyp-show
Paroxetine43815SuperCypPMID 12756206show
PENTACARINAT359323SuperCypPMID 12920490show
Pentacarinat4735SuperCypPMID 12920490show
PF-0086855416099590BindingDB-show
Phenethylhydrazine3675PROMISCUOUSPMID 16669850show
Phenethylhydrazine3675SuperCypPMID 15304522show
Phenofibrate3339PROMISCUOUSPMID 16176562show
Phenofibrate3339SuperCypPMID 15601807show
Phenylaethylbarbitursaeure4763SuperCyp3 PMIDsshow
Phenylethylmethylhydantoin4060PROMISCUOUSPMID 12597994show
Phenylethylmethylhydantoin4060SuperCypPMID 8110777show
Phenylpropylhydroxycumarinum9908SuperCypPMID 15054565show
Pioglitazone Hydrochloride4829PROMISCUOUSPMID 15860655show
Pioglitazone Hydrochloride4829SuperCyp3 PMIDsshow
Pioglitazone Hydrochloride4829SuperTargetPMID 016299161show
Piroxicam5280452SuperCyp-show
Pravastatin54687SuperCyp-show
Probampacin4911SuperCypPMID 15915352show
Propafenone hydrochloride4932SuperCyp-show
Pseudotheophylline2153SuperCyp-show
Quinalbarbitone5193SuperCyp-show
Quinineanhydrous8549SuperCypPMID 11136296show
Raloxifene Hydrochloride5035SuperCypPMID 15601807show
RALOXIFENE HYDROCHLORIDE54900SuperCypPMID 15601807show
Rattentraenke6691SuperCyp2 PMIDsshow
Repaglinide65981PROMISCUOUSPMID 16176562show
Repaglinide65981SuperCyp7 PMIDsshow
Repaglinide65981SuperTargetPMID 016372821show
Retinol1071SuperCyp2 PMIDsshow
Rifampicinum5381226SuperCyp7 PMIDsshow
Ritonavir392622PROMISCUOUS2 PMIDsshow
Ritonavir392622SuperCypPMID 15601807show
Rofecoxib5090SuperCyp-show
Rosigilitazone77999PROMISCUOUSPMID 15860655show
Rosigilitazone77999SuperCyp6 PMIDsshow
Rosigilitazone77999SuperTargetPMID 016027405show
Salmeterol5152SuperCypPMID 15601807show
SAQUINAVIR60787SuperCyp-show
Selegiline hydrochloride26757SuperCypPMID 12920164show
SERATRODAST2449SuperCypPMID 9010637show
SIMVASTATIN54454SuperCyp3 PMIDsshow
Sitagliptan4369359PROMISCUOUSPMID 17220239show
Sklerofibrat39042PROMISCUOUSPMID 16176562show
Sklerofibrat39042SuperCypPMID 16176562show
Spectrum_0000462166BindingDB-show
SPIRONOLACTONE/HYDROCHLOROTHIAZIDE5833SuperCypPMID 15601807show
Sulfamethoprim5578SuperCyp9 PMIDsshow
Sulfanilamidopyrimidine5215SuperCyp4 PMIDsshow
Sulfaphenylpyrazole5335BindingDB-show
Sulfaphenylpyrazole5335PROMISCUOUS6 PMIDsshow
Sulfaphenylpyrazole5335SuperCypPMID 7640150show
Sulfoxyphenylpyrazolidine5342SuperCypPMID 11996015show
Sulphadimethylisoxazole5344SuperCyp-show
Sulphamethylisoxazole5329SuperCypPMID 12019187show
tariquidarth148201BindingDB-show
TAZAROTENE5381SuperCyp-show
Tegaserod5487301SuperCypPMID 11560869show
Terbinafine hydrochloride5402SuperCypPMID 10460803show
Terbinafine hydrochloride5282481SuperCypPMID 10460803show
Terestigmine5405PROMISCUOUSPMID 9562230show
Terestigmine5405SuperCyp2 PMIDsshow
Tetrabenazine6018SuperCypPMID 15232626show
Thioridazine Hydrochloride5452SuperCyp-show
TICLOPIDINE HYDROCHLORIDE5472SuperCyp-show
Ticlopidine hydrochloride65335SuperCyp-show
Tioconazole5482SuperCyp-show
Tolylsulfonylbutylurea5505PROMISCUOUSPMID 14973304show
Tolylsulfonylbutylurea5505SuperCyp7 PMIDsshow
Tolylsulfonylbutylurea5505SuperTarget2 PMIDsshow
Tomaxithen2733526SuperCypPMID 15601807show
Torasemide41781SuperCyp2 PMIDsshow
Triacetyloleandomycin202225PROMISCUOUS4 PMIDsshow
Triacetyloleandomycin202225SuperCypPMID 15054565show
Trichloraethylenum6575SuperTarget-show
TROGLITAZONE5591PROMISCUOUS2 PMIDsshow
TROGLITAZONE5591SuperCyp3 PMIDsshow
Zafirlukast5717SuperCyp3 PMIDsshow
Synonyms:
CYPIIC8
Cytochrome P450 2C8
P450 form 1
P450 IIC2
P450 MP-12/MP-20
S-mephenytoin 4-hydroxylase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
CP2CJ_HUMAN87.878
CP2CI_HUMAN87.677.1
Q5VX92_HUMAN86.778
CP2C9_HUMAN86.778
CP2C5_RABIT83.973.3
CP2C6_RAT83.571.2
CP2CB_RAT82.472.2
Q3YA63_HUMAN73.156.1
CP2E1_HUMAN73.156.1
Q6NWT7_HUMAN72.955.9
Q6NWT9_HUMAN72.755.7
CP2B4_RABIT71.752.5
CP2B1_RAT70.153.4
CP2F1_HUMAN69.550.1
CP2B6_HUMAN68.850.3
CP2A5_MOUSE67.849.8
CP2A6_HUMAN67.448.6
CP2AD_HUMAN67.350.2
Q16743_HUMAN67.163.9
CP2A7_HUMAN66.548.2
CP2S1_HUMAN60.942.1
Q38LG2_HUMAN58.240.6
Q6NWU0_HUMAN58.240.8
CP2D6_HUMAN58.241
Q38LG0_HUMAN5840.6
CP2W1_HUMAN57.536.8
CP2J2_HUMAN56.938.7
CP2D1_RAT56.437.5
Q6XP50_HUMAN55.638.7
CP2R1_HUMAN55.134.4
Protein-Protein Interactions:
No data available