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Target Details

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Name:Cytochrome P450 2A6
Uniprot name:CP2A6_HUMAN
Accession Numbers:A7YAE5 B2R7F6 P00190 P10890 P11509 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48
EC-Number:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:1Z10 1Z11 2FDU 2FDV 2FDW 2FDY 3EBS
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(NE)-N-[(5-pyridin-3-yl-2-furyl)methylidene]hydroxylamine11389855BindingDB-show
(NE)-N-[(5-pyridin-3-yl-2-furyl)methylidene]hydroxylamine11355925BindingDB-show
(NZ)-N-[(5-pyridin-3-ylthiophen-2-yl)methylidene]hydroxylamine11264173BindingDB-show
1,2-DICHLORONAPHTHALENE16309BindingDB-show
1,2-DIMETHYLNAPHTHALENE11317BindingDB-show
1,3-DIMETHYLNAPHTHALENE11327BindingDB-show
1,4-Dibromobenzene7804BindingDB-show
1,4-DICHLORONAPHTHALENE15769BindingDB-show
1,5-DICHLORONAPHTHALENE15768BindingDB-show
1,5-DIMETHYLNAPHTHALENE11306BindingDB-show
1,6-DIMETHYLNAPHTHALENE11328BindingDB-show
1,7-DIMETHYLNAPHTHALENE11326BindingDB-show
1-METHYLNAPHTHALENE7002BindingDB-show
2,3'-Bipyridyl11389BindingDB-show
2,3-DICHLORONAPHTHALENE16312BindingDB-show
2,4-DIMETHYLQUINOLINE14536BindingDB-show
2,6-DIMETHYLNAPHTHALENE11387BindingDB-show
2,7-DICHLORONAPHTHALENE16619BindingDB-show
2,7-DIMETHYLNAPHTHALENE11396BindingDB-show
2-(p-Tolyl)ethylamine76751BindingDB-show
2-BROMONAPHTHALENE11372BindingDB-show
2-CHLOROBIPHENYL249266BindingDB-show
2-CHLORONAPHTHALENE7056BindingDB-show
2-ETHYLNAPHTHALENE13652BindingDB-show
2-Fluoronaphthalene67583BindingDB-show
2-METHYLNAPHTHALENE7055BindingDB-show
3,3'-Bipyridine68487BindingDB-show
3-(1H-Imidazol-4-yl)pyridine3040177BindingDB-show
3-(2H-tetrazol-5-yl)pyridine151091BindingDB-show
3-(3-Thienyl)pyridine595254BindingDB-show
3-Methylisoquinoline14306BindingDB-show
3-METHYLQUINOLINE11926BindingDB-show
3-pyridin-3-ylquinoline11701255BindingDB-show
4-CHLOROBIPHENYL16323BindingDB-show
6,7-Dimethoxy-2-tetralone609844BindingDB-show
Adsorbocarpine5910SuperCyp3 PMIDsshow
Adsorbocarpine5909SuperCyp3 PMIDsshow
Aformoterol6437070SuperCyp-show
aformoterol3034756SuperCyp-show
AI-942/25034651595145BindingDB-show
Alitretinoin444795SuperCyp-show
ALITRETINOIN449171SuperCyp-show
alpha-Chloronaphthalene7003BindingDB-show
alpha-Hydroxynaphthalene7005BindingDB-show
alpha-Tetralone10724BindingDB-show
Amfebutamone444SuperCyp-show
Amlodipine Benzenesulfonate2162SuperCyp-show
Amylobarbitone2164SuperCyp-show
Azelastine2267SuperCypPMID 10383922show
azidodeoxythymidine35370SuperCyp2 PMIDsshow
Azithramycine55185SuperCypPMID 11978200show
Benzenecarboxaldehyde240BindingDB-show
Benzopyrone323DrugBank-show
beta-Methoxynaphthalene7119BindingDB-show
beta-Tetralone68266BindingDB-show
Betanaphthol8663BindingDB-show
Bromochlorotrifluoroethane3562SuperCyp2 PMIDsshow
BUPRENORPHINE40400SuperCyp-show
Buprenorphine5311033SuperCyp-show
CHEBI:4180411332763BindingDB-show
CHEBI:68185721907BindingDB-show
CHEMBL108657946889932BindingDB-show
CHEMBL109135646866604BindingDB-show
CHEMBL125851746947264BindingDB-show
CHEMBL14980810510985BindingDB-show
CHEMBL15667910081254BindingDB-show
CHEMBL17819611311338BindingDB-show
CHEMBL17852711276492BindingDB-show
CHEMBL17868144388657BindingDB-show
CHEMBL17871111210706BindingDB-show
CHEMBL17878011207072BindingDB-show
CHEMBL17878144388612BindingDB-show
CHEMBL17887813349629BindingDB-show
CHEMBL17894616244360BindingDB-show
CHEMBL17900511389737BindingDB-show
CHEMBL17920016037176BindingDB-show
CHEMBL17939810899427BindingDB-show
CHEMBL17939944388606BindingDB-show
CHEMBL17952944388719BindingDB-show
CHEMBL17954444388586BindingDB-show
CHEMBL17956611290471BindingDB-show
CHEMBL17958915543761BindingDB-show
CHEMBL17961025817326BindingDB-show
CHEMBL17962111148236BindingDB-show
CHEMBL17962844388593BindingDB-show
CHEMBL17966923646069BindingDB-show
CHEMBL17970411378800BindingDB-show
CHEMBL17976216654683BindingDB-show
CHEMBL17996244388702BindingDB-show
CHEMBL18027010654534BindingDB-show
CHEMBL18052411816351BindingDB-show
CHEMBL21858316099923BindingDB-show
CHEMBL24423916072099BindingDB-show
CHEMBL26621244428924BindingDB-show
CHEMBL26721016099905BindingDB-show
CHEMBL35965711206290BindingDB-show
CHEMBL35973613349626BindingDB-show
CHEMBL36006811446630BindingDB-show
CHEMBL36054111263510BindingDB-show
CHEMBL36077916654687BindingDB-show
CHEMBL36099911344157BindingDB-show
CHEMBL36136411480732BindingDB-show
CHEMBL36196911310529BindingDB-show
CHEMBL36206244388718BindingDB-show
CHEMBL36223111785088BindingDB-show
CHEMBL36270215778480BindingDB-show
CHEMBL36804814345241BindingDB-show
CHEMBL36843411182787BindingDB-show
CHEMBL36888316654686BindingDB-show
CHEMBL36928511321674BindingDB-show
CHEMBL42551911389927BindingDB-show
CHEMBL44748115563485BindingDB-show
CHEMBL47632311697697BindingDB-show
CHEMBL54121411786814BindingDB-show
Chlormethiazole10783SuperCypPMID 11996015show
Chlorzoxazone2733SuperCypPMID 10534312show
Chlotrimazole2812SuperCyp2 PMIDsshow
Cinnarizine2761SuperCypPMID 8951176show
Cisclomiphene1548955SuperCypPMID 9054622show
Clozapine2818SuperCyp-show
cotinine854019BindingDB-show
Cyclophosphoramide2907SuperCypPMID 10348794show
D1G11171679BindingDB-show
D2G11229234BindingDB-show
Deltahydrocortisone5755SuperCypPMID 11978200show
Desoxynorephedrine3007BindingDB-show
Desoxynorephedrine3007SuperCypPMID 12746108show
Dextrofenfluramine3337SuperCypPMID 9825834show
Diaethylaether3283SuperCypPMID 9101044show
diethylcarbamothioylsulfanyl diethylaminomethanedithioate3117SuperCyp-show
Diethylparaoxon9395SuperTarget-show
Diethyltoluamide4284SuperCypPMID 11854147show
Diisopropylphenol4943PROMISCUOUSPMID 9764927show
Diisopropylphenol4943SuperCypPMID 9771309show
Dimethylcarbinol3776SuperCyp4 PMIDsshow
Dimethyloxyquinazine2206SuperCypPMID 8801065show
DIMETHYLQUINOLINES7060BindingDB-show
Dipropylacetate3121SuperCypPMID 15795555show
DL-tetrahydronicotyrine942SuperCyp9 PMIDsshow
Eletriptan77993SuperCypPMID 10611140show
Entacapone5281081SuperCyp-show
Enteropride2769SuperCypPMID 10780971show
Ethyl chlorophenoxyisobutyrate2796SuperCypPMID 11038160show
flunarizine dihydrochloride941361SuperCypPMID 8951176show
FLUNARIZINE DIHYDROCHLORIDE6365505SuperCypPMID 8951176show
Flunitrazepam3380SuperCyp2 PMIDsshow
Fluormethylprednisolone5743SuperCyp2 PMIDsshow
fluoromethyl hexafluoroisopropyl ether5206SuperCypPMID 7879937show
Fluorouracilum3385SuperCypPMID 11095583show
Fomepizole3406SuperCypPMID 9143352show
Furofutran5386SuperCyp4 PMIDsshow
Furofutran5386SuperTargetPMID 11376561show
Gelbkoerperhormon5994SuperCyp2 PMIDsshow
Huanghuahaosu68827SuperCypPMID 10583023show
Hydroxyacetanilide1983SuperCyp2 PMIDsshow
Indinol3712PROMISCUOUSPMID 17582584show
Isonicotinoylhydrazine3767PROMISCUOUS2 PMIDsshow
Isonicotinoylhydrazine3767SuperCyp2 PMIDsshow
Isophosphamide3690SuperCypPMID 12136253show
Isoquinaldine15592BindingDB-show
KETOCONAZOLE47576SuperCyp2 PMIDsshow
Ketoconazole3823SuperCyp2 PMIDsshow
Ketoconazole456201SuperCyp2 PMIDsshow
Letrozole3902SuperCyp-show
Lidocaine Monohydrochloride3676PROMISCUOUSPMID 15845683show
Lidocaine Monohydrochloride3676SuperCyp2 PMIDsshow
m-Toluquinaldine7138BindingDB-show
Medifoxamine36109SuperCypPMID 11996015show
MEMANTINE HYDROCHLORIDE4054SuperCypPMID 15378224show
Methbipyranone4174PROMISCUOUSPMID 10611146show
Methbipyranone4174SuperCyp3 PMIDsshow
Methoxifluranum4116SuperCypPMID 7879937show
Methoxybenzaldehyde31244BindingDB-show
Methylaminopropyliminodibenzyl2995SuperCyp-show
Methyldiphenylhydramine4601SuperCypPMID 9172960show
Methylmercaptoimidazole1349907SuperCyp2 PMIDsshow
Methylnaphthoquinone4055SuperCypPMID 11996015show
Miconazole4189SuperCypPMID 9143352show
NAPHTHALENE931BindingDB-show
Naphthalene, 1,2,3,6,7-pentachloro114908BindingDB-show
Nicotinyltartrate7510SuperCypPMID 18559554show
NILVADIPINE4494SuperCypPMID 14993813show
Norfloxacine4539SuperCypPMID 14738594show
p-Tolualdehyde7725BindingDB-show
p-Toluquinaldine13414BindingDB-show
Paracetophenetidin4754SuperCyp2 PMIDsshow
parachlorometaxylenol2723SuperCypPMID 11996015show
Paradichlorobenzene4685BindingDB-show
Pernazine4744PROMISCUOUSPMID 12523495show
Pernazine4744SuperCypPMID 15056479show
Phenanthracene995BindingDB-show
Phenylaethylbarbitursaeure4763SuperCyp4 PMIDsshow
Phenylaethylsenfoel16741PROMISCUOUSPMID 17582584show
Polytetrahydrofuran8028PROMISCUOUSPMID 9143352show
Pseudonicotine157672BindingDB-show
Relaspium3034812SuperCypPMID 10628907show
Rifampicinum5381226SuperCyp3 PMIDsshow
Rosigilitazone77999PROMISCUOUSPMID 15860655show
Rosigilitazone77999SuperCypPMID 12642470show
ROXATIDINE91276SuperCypPMID 11556126show
S1519_Selleck16202152BindingDB-show
Selegiline hydrochloride26757SuperCyp-show
SERATRODAST2449SuperCypPMID 9010637show
Sulconazole5318SuperCyp-show
Sulfaphenylpyrazole5335PROMISCUOUS6 PMIDsshow
Sulfaphenylpyrazole5335SuperCypPMID 11978200show
tariquidarth148201BindingDB-show
Tetrahydrocannabinols16078SuperCypPMID 1103455show
Tetrahydrocannabinols2977SuperCypPMID 1103455show
Tomaxithen2733526SuperCypPMID 8293548show
Transdermal Nicotine89594BindingDB-show
Tranylcypromine441233SuperCyp3 PMIDsshow
Tranylcypromine5530SuperCyp3 PMIDsshow
Triacetyloleandomycin202225PROMISCUOUS4 PMIDsshow
Triacetyloleandomycin202225SuperCypPMID 11978200show
Trichloormethaan6212SuperCypPMID 11996015show
Trichloraethylenum6575SuperTarget-show
WAY-18118710150497BindingDB-show
Xanthotoxine4114DrugBank-show
Xanthotoxine4114PROMISCUOUSPMID 12814958show
Xanthotoxine4114SuperCyp10 PMIDsshow
ZINC042279984730695BindingDB-show
Synonyms:
Coumarin 7-hydroxylase
CYP2A3
CYPIIA6
Cytochrome P450 2A6
P450 IIA3
P450(I)
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
CP2A7_HUMAN97.293.9
CP2AD_HUMAN96.693.7
CP2A5_MOUSE93.185.6
CP2B1_RAT72.954.3
CP2B4_RABIT72.352.2
CP2B6_HUMAN71.351.6
CP2F1_HUMAN70.652.5
CP2C5_RABIT70.250.6
CP2CJ_HUMAN69.950.5
CP2C9_HUMAN69.748.9
Q5VX92_HUMAN69.748.9
CP2CI_HUMAN68.948.7
CP2CB_RAT68.350
CP2C6_RAT68.149.3
CP2C8_HUMAN67.448.6
CP2E1_HUMAN67.147.5
Q3YA63_HUMAN67.147.5
Q6NWT7_HUMAN66.947.3
Q6NWT9_HUMAN66.747.3
CP2S1_HUMAN6647.2
CP2J2_HUMAN61.139.9
CP2D1_RAT56.935.6
Q6NWU0_HUMAN56.336.6
Q38LG2_HUMAN56.336.4
CP2D6_HUMAN56.336.6
Q38LG0_HUMAN56.136.4
Q6XP50_HUMAN55.235.1
Q14097_HUMAN54.938.9
CP2R1_HUMAN54.934.3
CP2W1_HUMAN52.636.9
Protein-Protein Interactions:
Uniprot nameSource
UD16_HUMANPMID 15608231