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Target Details

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Name:Catechol O-methyltransferase
Uniprot name:COMT_RAT
Accession Numbers:P22734
EC-Number:2.1.1.6
Organism:Rat
Rattus norvegicus
PDB IDs:1H1D 1JR4 1VID 2CL5 2ZLB 2ZTH 2ZVJ
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
3',4'-Dihydroxyisobutyrophenone21632BindingDB-show
3,4-Dihydroxy-5-nitrobenzaldehyde5748957BindingDB-show
3,4-Dihydroxy-5-nitrobenzonitrile5748958BindingDB-show
3,5-Dinitropyrocatechol3870203BindingDB-show
3,5-Dinitropyrocatechol3870203DrugBank-show
5,6-Dihydroxytryptamine21163BindingDB-show
alpha-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile3856780BindingDB-show
CHEMBL16690819389188BindingDB-show
CHEMBL16705418990348BindingDB-show
CHEMBL16717218990337BindingDB-show
CHEMBL16838944380641BindingDB-show
CHEMBL16845118990376BindingDB-show
CHEMBL16860018990372BindingDB-show
CHEMBL16881819389241BindingDB-show
CHEMBL16903314450997BindingDB-show
CHEMBL16920844381024BindingDB-show
CHEMBL16946515292583BindingDB-show
CHEMBL16967919389230BindingDB-show
CHEMBL16992618990395BindingDB-show
CHEMBL17054914450982BindingDB-show
CHEMBL1971159900163BindingDB-show
CHEMBL1986289857108BindingDB-show
CHEMBL26521844380615BindingDB-show
CHEMBL35092718990404BindingDB-show
CHEMBL35227018990346BindingDB-show
CHEMBL35301244380432BindingDB-show
CHEMBL35318822125755BindingDB-show
CHEMBL35398319389196BindingDB-show
CHEMBL35451718990390BindingDB-show
CHEMBL35501721852281BindingDB-show
CHEMBL35540218990374BindingDB-show
CHEMBL35573619069872BindingDB-show
CHEMBL43103124971980BindingDB-show
CHEMBL84769944173BindingDB-show
CHEMBL864917822019BindingDB-show
CHEMBL9020324971977BindingDB-show
CHEMBL9057124971979BindingDB-show
DB033364369285DrugBank-show
DIHYDROXYINDOLE114683BindingDB-show
Entacapone5281081BindingDB-show
Entacapone5281081PROMISCUOUS3 PMIDsshow
N-{3-[5-(6-AMINO-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YL]-ALLYL}-2,3-DIHYDROXY-5-NITRO-BENZAMIDE4369234DrugBank-show
Nebicapone9838389BindingDB-show
Nitecapone5464105BindingDB-show
Nitecapone5464105PROMISCUOUSPMID 11318939show
Phthalhydroquinone289PROMISCUOUSPMID 1325535show
Protocatechuate72PROMISCUOUSPMID 2597177show
Purpurocatechol10789PROMISCUOUSPMID 3561526show
Tolcapone4659569BindingDB-show
Tolcapone4659569PROMISCUOUS3 PMIDsshow
Synonyms:
Catechol O-methyltransferase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
COMT_HUMAN87.275.9
Q9BWC7_HUMAN62.954.7
Q6ZSP8_HUMAN35.318.5
G3P_HOMAM35.118.4
CMTD1_HUMAN34.619.1
KLK2_HORSE34.419.6
DHPS_ECOLI34.217.5
TRY2_MOUSE33.821
TRY2_CANFA33.719.1
AROE_HAEIN33.418.1
TRY2_RAT33.318.3
O29370_ARCFU33.117.8
SAMP_HUMAN3319.4
DRA_HUMAN32.918.7
FABI1_RHIME32.716.5
FABI_ECOLI32.520.4
FHUD_ECOLI32.519.8
DHPS1_MYCLE32.519.8
CCG1_HUMAN32.317.7
PRTN3_HUMAN32.317.7
RL4_THEMA32.116.7
Q9WYV8_THEMA3218.6
PIMT_PYRFU31.916.1
O58346_PYRHO31.919.4
DNAS1_BOVIN31.817.5
HCDH_HUMAN31.816.6
AOTC_XANCP31.819.2
O28262_ARCFU31.718
RMLA2_SHIFL31.617
IOD3_HUMAN31.619
Protein-Protein Interactions:
No data available