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Target Details

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Name:Catechol O-methyltransferase
Uniprot name:COMT_HUMAN
Accession Numbers:P21964 Q6IB07 Q6ICE6
EC-Number:2.1.1.6
Organism:Homo sapiens
Human
PDB IDs:3BWM 3BWY
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
3,4-Dihydroxy-5-nitrobenzaldehyde5748957BindingDB-show
6-NITROPROTOCATECHUALDEHYDE3782344BindingDB-show
Ambap50545-37-414845047BindingDB-show
Apormorphine6005SuperTargetPMID 002002449show
CHEBI:65376444459001BindingDB-show
CHEBI:65376445266258BindingDB-show
CHEBI:65376544458661BindingDB-show
CHEBI:65376545266259BindingDB-show
CHEBI:65376644458697BindingDB-show
CHEBI:65376645266260BindingDB-show
CHEBI:65376745266261BindingDB-show
CHEBI:65380444458672BindingDB-show
CHEBI:65380445266294BindingDB-show
CHEMBL108950446884860BindingDB-show
CHEMBL108950546884861BindingDB-show
CHEMBL108953646884907BindingDB-show
CHEMBL108953746865888BindingDB-show
CHEMBL108953846884908BindingDB-show
CHEMBL108953946884909BindingDB-show
CHEMBL108963046884905BindingDB-show
CHEMBL109120446884906BindingDB-show
CHEMBL109198146884939BindingDB-show
CHEMBL109198246884940BindingDB-show
CHEMBL109198346865889BindingDB-show
CHEMBL14185814450998BindingDB-show
CHEMBL26485810597449BindingDB-show
CHEMBL29206710498973BindingDB-show
CHEMBL30262510091045BindingDB-show
CHEMBL33470610352338BindingDB-show
CHEMBL35707210442360BindingDB-show
CHEMBL6035010812060BindingDB-show
CHEMBL6305210405332BindingDB-show
CHEMBL6427544304342BindingDB-show
Entacapone5281081DrugBank-show
Entacapone5281081PROMISCUOUS4 PMIDsshow
Entacapone5281081SuperTargetPMID 10363328show
HMNB94857BindingDB-show
Isopropylmeprobamate2576SuperTarget-show
L-Dihydroxyphenylalanine6047DrugBank-show
L-Dihydroxyphenylalanine6047PROMISCUOUSPMID 11147508show
L-Dihydroxyphenylalanine6047SuperTarget2 PMIDsshow
methylthioadenosine439176BindingDB-show
Tolcapone4659569DrugBank-show
Tolcapone4659569PROMISCUOUSPMID 9337447show
Tolcapone4659569SuperTargetPMID 012957500show
{[(2s,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-y167321BindingDB-show
Synonyms:
Catechol O-methyltransferase
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
COMT_RAT87.275.9
Q9BWC7_HUMAN67.266.8
CMTD1_HUMAN35.421.2
CAMT_MEDSA33.917.3
BLAB_PROVU33.418.2
CDIPT_HUMAN33.317.9
O58346_PYRHO32.917.1
DNAS1_BOVIN32.618
RMLA_SALTY32.515.8
PYRF_YEAST32.420.8
HSLO_THEMA32.319.2
AROD_SALTI32.217
KTHY_YEAST32.115.7
DHPS1_MYCLE32.120.9
FABI1_RHIME3216.9
Q9X1T2_THEMA31.916.7
BLO2_SALTY31.818
BLO2_ECOLX31.818
RL4_THEMA31.716.4
PPT1_BOVIN31.719.3
Q9NJI5_LEITA31.718.4
Q8U3I1_PYRFU31.615.6
Q9RYA6_DEIRA31.618.1
Q91Y95_MOUSE31.419.1
Q9WYV8_THEMA3116.2
Q9ZF13_THEFU3118.1
Q7KZP0_HUMAN3131
BIRA_ECOLI30.716.8
Q0QEP3_RAT30.518.5
ADH_SULSO30.517.7
Protein-Protein Interactions: