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Target Details

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Name:Cell division protein kinase 8
Uniprot name:CDK8_HUMAN
Accession Numbers:P49336 Q5VUF3 Q6ISB5
EC-Number:2.7.11.22
2.7.11.23
Organism:Homo sapiens
Human
PDB IDs:-
KEGG Pathways:-
Drugs:
NamePubChem IDSourceReferencesInteraction
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
ABT-86911485656BindingDB-show
AMG 70611667893BindingDB-show
AST-48711409972BindingDB-show
Canertinib156414BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:66834345481533BindingDB-show
CHEBI:66834445481534BindingDB-show
CHEMBL108215211560568BindingDB-show
CHEMBL124070352945601BindingDB-show
CHIR-26511656518BindingDB-show
CP-7247149874913BindingDB-show
Dasatinib3062316BindingDB-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Flavopiridol hydrochloride5287969DrugBank-show
Gefitinib123631BindingDB-show
GW-258011617559BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
kinase inhibitor-primary targets: CDK2, CDK9, other CDKs24867231BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
MLN805411712649BindingDB-show
Pazopanib10113978BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
Roscovitine160355BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1526_Selleck24889392BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
staurosporine451705BindingDB-show
staurosporine44299148BindingDB-show
SU-1481310138259BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
Synonyms:
Cell division protein kinase 8
Cyclin-dependent kinase 8
Mediator complex subunit CDK8
Mediator of RNA polymerase II transcription subunit CDK8
Protein kinase K35
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
CDK9_HUMAN41.427.5
MK10_HUMAN40.424.4
CDK7_HUMAN40.129
CDK5_HUMAN4025.7
CDK5_MOUSE4025.7
CDK2_HUMAN39.626.7
CDK6_HUMAN39.124.9
A4D1G0_HUMAN39.124.9
CDK1_HUMAN3926.7
CDC2H_PLAFK38.425.5
CSK21_HUMAN37.420.4
C4R3V7_PICPG37.325.2
CDK4_RAT37.125.8
MK12_HUMAN3724.7
CDK4_HUMAN36.925.8
MK03_MOUSE35.523.9
MK14_MOUSE35.224
MK14_HUMAN35.224
MK03_RAT34.923.3
MK03_HUMAN34.823.4
MK01_RAT34.222.7
MK01_MOUSE34.222.7
MK01_HUMAN34.122.6
Q1HBJ4_HUMAN34.122.6
Q499G7_HUMAN34.122.4
O75100_HUMAN33.422.4
KS6B1_HUMAN33.319.9
KS6B1_BOVIN33.319.9
GSK3B_HUMAN33.321.7
B5BUC0_HUMAN33.221.7
Protein-Protein Interactions: