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Target Details

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Name:APP secretase
Uniprot name:CATB_HUMAN
Accession Numbers:B3KRR5 P07858 Q503A6 Q96D87
EC-Number:3.4.22.1
Organism:Homo sapiens
Human
PDB IDs:1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3CBJ 3CBK 3PBH
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
1-Acetyl-3-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-urea654815BindingDB-show
1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione647501BindingDB-show
1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dio653297BindingDB-show
1yt75287498BindingDB-show
2,7-Dibromofluoren-9-one thiosemicarbazone3032999BindingDB-show
2-(9H-fluoren-9-ylidene)hydrazinecarbothioamide690107BindingDB-show
2-aminophenanthrene-9,10-dione254021BindingDB-show
2-iminoethanamine4471892DrugBank-show
2-[2-(4-Amino-furazan-3-yl)-benzoimidazol-1-yl]-1-piperidin-1-yl-ethanone653316BindingDB-show
2-{[(4-fluorobenzyl)amino]carbonyl}benzoic acid3240677BindingDB-show
3-anilinoisoquinolin-1(2H)-one2142225BindingDB-show
3-METHYLPHENYLALANINE2761494DrugBank-show
4-[1-(4-Methylbenzyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine571349BindingDB-show
Ac-D-CyclohexylGly-V-Naphthenylmethoxypro-Nva-OH481437BindingDB-show
AC1L230M65306BindingDB-show
AC1L8EV5380199BindingDB-show
AC1L9JN9446403BindingDB-show
AC1LA6D9482277BindingDB-show
AC1LA6DO482282BindingDB-show
AC1LA6DR482283BindingDB-show
AC1LA6DU482284BindingDB-show
AC1LA6DX482285BindingDB-show
AC1LA6E0482286BindingDB-show
AC1LA6E3482287BindingDB-show
AC1LA6E6482288BindingDB-show
AC1LA6E9482289BindingDB-show
AC1LA6EC482290BindingDB-show
AC1LA6EF482291BindingDB-show
AC1LA6EI482292BindingDB-show
AC1LAKM2490002BindingDB-show
AC1NR9VX5287549BindingDB-show
AC1OCELP6917747BindingDB-show
AC1OJPCR7272330BindingDB-show
Acomethylene9550PROMISCUOUSPMID 1284427show
AG-205/40650701599637BindingDB-show
AIDS097810482278BindingDB-show
AIDS097810482279BindingDB-show
AIDS097812482280BindingDB-show
AIDS0978259887581BindingDB-show
AIDS19557711343089BindingDB-show
AIDS2196743011883BindingDB-show
AIDS2196833011892BindingDB-show
allylthiosulfinate65036BindingDB-show
ASN 07460771648315BindingDB-show
Athylenglykol174SuperTarget-show
Azepan-3-one compound 15287468BindingDB-show
Azetidine-1-carbonitrile9812750BindingDB-show
Balicatib10201696BindingDB-show
BAS 028327435293426BindingDB-show
BAS 042382815310676BindingDB-show
Benz(h)quinoline-5,6-dione163098BindingDB-show
Benzophenone thiosemicarbazone3001308BindingDB-show
Benzyl N-[(1S)-1-[(2S)-oxiran-2-yl]-2-phenyl-ethyl]carbamate9861019BindingDB-show
Boceprevir10324367BindingDB-show
Bromcholitin10145BindingDB-show
Calpain Inhibitor III11199915BindingDB-show
Calpain Inhibitor XI9827472BindingDB-show
Calpain Inhibitor XII16760340BindingDB-show
CDS1_002676794694BindingDB-show
CHEBI:32458344356685BindingDB-show
CHEBI:40103344389580BindingDB-show
CHEBI:40106444389597BindingDB-show
CHEBI:40108044389605BindingDB-show
CHEBI:40112744389624BindingDB-show
CHEBI:5156523662696BindingDB-show
CHEBI:60638344584802BindingDB-show
CHEBI:60660444584935BindingDB-show
CHEBI:60661544584939BindingDB-show
CHEBI:60661644584941BindingDB-show
CHEMBL10001744332538BindingDB-show
CHEMBL1000959825191BindingDB-show
CHEMBL1003169888995BindingDB-show
CHEMBL10042844329582BindingDB-show
CHEMBL10048211743922BindingDB-show
CHEMBL10070244332540BindingDB-show
CHEMBL10089544332539BindingDB-show
CHEMBL10130644332714BindingDB-show
CHEMBL10323811028356BindingDB-show
CHEMBL10570844332915BindingDB-show
CHEMBL10749544338218BindingDB-show
CHEMBL107719346881448BindingDB-show
CHEMBL107736646882093BindingDB-show
CHEMBL10781844338212BindingDB-show
CHEMBL107841124822701BindingDB-show
CHEMBL107900046882092BindingDB-show
CHEMBL107909846882094BindingDB-show
CHEMBL107909946882095BindingDB-show
CHEMBL107910046882096BindingDB-show
CHEMBL108285746881449BindingDB-show
CHEMBL108285846881450BindingDB-show
CHEMBL108285946881451BindingDB-show
CHEMBL108411446865101BindingDB-show
CHEMBL108440011516307BindingDB-show
CHEMBL108440111703527BindingDB-show
CHEMBL108440246866398BindingDB-show
CHEMBL108440311669355BindingDB-show
CHEMBL108467911471738BindingDB-show
CHEMBL108642944254499BindingDB-show
CHEMBL108643144254582BindingDB-show
CHEMBL108643244254142BindingDB-show
CHEMBL108643444254314BindingDB-show
CHEMBL10874644338204BindingDB-show
CHEMBL11370644342511BindingDB-show
CHEMBL11376115858812BindingDB-show
CHEMBL11416144343301BindingDB-show
CHEMBL11441044342745BindingDB-show
CHEMBL11446244343028BindingDB-show
CHEMBL11507344342381BindingDB-show
CHEMBL11573410047111BindingDB-show
CHEMBL11582244342501BindingDB-show
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CHEMBL11640244343037BindingDB-show
CHEMBL11647744343531BindingDB-show
CHEMBL11672444343105BindingDB-show
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CHEMBL11691044342803BindingDB-show
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CHEMBL126965952946687BindingDB-show
CHEMBL126966052941833BindingDB-show
CHEMBL126971352941839BindingDB-show
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CHEMBL127226150898446BindingDB-show
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CHEMBL128964552942797BindingDB-show
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CHEMBL128985652943578BindingDB-show
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CHEMBL13176010745144BindingDB-show
CHEMBL13178144353801BindingDB-show
CHEMBL13187944353807BindingDB-show
CHEMBL13190910506703BindingDB-show
CHEMBL13258744353839BindingDB-show
CHEMBL13259544356381BindingDB-show
CHEMBL13265210716501BindingDB-show
CHEMBL13277344353544BindingDB-show
CHEMBL13283944353593BindingDB-show
CHEMBL13288644353632BindingDB-show
CHEMBL13301611800689BindingDB-show
CHEMBL13310644353846BindingDB-show
CHEMBL1331079891108BindingDB-show
CHEMBL13348644355268BindingDB-show
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CHEMBL13416710460031BindingDB-show
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CHEMBL18840010231447BindingDB-show
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CHEMBL18914944398659BindingDB-show
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CHEMBL19005310166544BindingDB-show
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CHEMBL19117844397609BindingDB-show
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CHEMBL19158410187920BindingDB-show
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CHEMBL19406811502586BindingDB-show
CHEMBL19491444403028BindingDB-show
CHEMBL19530144402175BindingDB-show
CHEMBL19550544402952BindingDB-show
CHEMBL19596344402055BindingDB-show
CHEMBL19624044402158BindingDB-show
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CHEMBL19896211656780BindingDB-show
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CHEMBL37712311636269BindingDB-show
CHEMBL37849411849845BindingDB-show
CHEMBL37857311849703BindingDB-show
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CHEMBL7778410069167BindingDB-show
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CHEMBL9883210341806BindingDB-show
CHEMBL9928844329608BindingDB-show
CHEMBL9956144329593BindingDB-show
CHEMBL9989010483128BindingDB-show
Chrysothios22318BindingDB-show
CID 1016496210164961BindingDB-show
CID 1016555710165557BindingDB-show
CID 1021086810210867BindingDB-show
CID 1030284310120133BindingDB-show
CID 1039293110257116BindingDB-show
CID 1039293110392931BindingDB-show
CID 1053157110531571BindingDB-show
CID 1053180110507960BindingDB-show
CID 1069871210461097BindingDB-show
CID 1155605611613973BindingDB-show
CID 1155605611556056BindingDB-show
CID 1165606011656060BindingDB-show
CID 136210507714BindingDB-show
CID 99158129915812BindingDB-show
CID 99338049933804BindingDB-show
CID 993380410072812BindingDB-show
CT110062713BindingDB-show
CT210062714BindingDB-show
Diethylcyanamide12050BindingDB-show
dipeptide-derived nitrile, 1714655218BindingDB-show
Diphenylethanoic acid8333DrugBank-show
Diphenylmethanone3102BindingDB-show
e-64439487BindingDB-show
e-644641099BindingDB-show
epiclusianone44565754BindingDB-show
EPOXOMYCIN11226684BindingDB-show
epoxysuccinyl derivative E64c123664BindingDB-show
FELODIPINE3333BindingDB-show
Furan-2-carboxylic acid 5-amino-1-(toluene-4-sulfonyl)-1H-pyrazol-3-yl651936BindingDB-show
Furazan, di-p-anisoyl-, 2-oxide286532BindingDB-show
garciniaphenone44565755BindingDB-show
Grassystatin A44255320BindingDB-show
ketoamide, 210231379BindingDB-show
ketone, 110673009BindingDB-show
Kinome_333410363069BindingDB-show
L-8737249913088BindingDB-show
Leupeptin72429BindingDB-show
LHVS23648296BindingDB-show
MDL 2817072430BindingDB-show
Methylcarbinol702SuperTarget-show
MLS000030905787437BindingDB-show
MLS000032366655872BindingDB-show
MLS000033886646749BindingDB-show
MLS000033898655490BindingDB-show
MLS000040740664291BindingDB-show
MLS0000432793241211BindingDB-show
MLS0000441523243128BindingDB-show
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MLS0000923243240711BindingDB-show
MLS0001103523250046BindingDB-show
MLS0001184645308489BindingDB-show
MLS000119200715594BindingDB-show
MLS0001193375308432BindingDB-show
MLS0001201814226014BindingDB-show
MORPHOLINE-4-CARBOXYLIC ACID (1-(3-BENZENESULFONYL-1-PHENETHYLALLYLCARBAMOYL)-3-METHYLBUTYL)-AMIDE5287864BindingDB-show
N-(4-anilinophenyl)cyclopropanecarboxamide730135BindingDB-show
N-acetylleucylleucylnorleucinal443118BindingDB-show
N-Benzyloxycarbonylphenylalanylalanine152128BindingDB-show
N-Cyanopyrrolidine73737BindingDB-show
n-[(benzyloxy)carbonyl]-l-phenylalanyl-l-phenylalanine114619BindingDB-show
N-[1-(cyanomethylcarbamoyl)cyclohexyl]-4-[2-(4-methylpiperazin-1-yl)-1,3-t9912381BindingDB-show
nchembio.70-comp323643986BindingDB-show
NSC721096404672BindingDB-show
PC-009491711834379BindingDB-show
PC-009491911834380BindingDB-show
PC-009492011834381BindingDB-show
PC-009492111834382BindingDB-show
PC-009493111834383BindingDB-show
PC-009493211834384BindingDB-show
PC-009493411834385BindingDB-show
PC-009493611834386BindingDB-show
PC-00949393685806BindingDB-show
PC-009494011834387BindingDB-show
PC-009494111834388BindingDB-show
PC-009494211834389BindingDB-show
PC-009494511834390BindingDB-show
PC-009574011834391BindingDB-show
PC-009574111834392BindingDB-show
PC-009574311834393BindingDB-show
PC-009574411834394BindingDB-show
PC-009574511834395BindingDB-show
Pepstatin A44304955BindingDB-show
petivericin10244468BindingDB-show
Phenyl 2-thiophenecarboxylate573755BindingDB-show
piperidinone analogue, 2710698950BindingDB-show
PTPase CD45 Inhibitor9926586BindingDB-show
s-propyl propane-1-sulfinothioate74761BindingDB-show
SB-4627956918602BindingDB-show
Schuttgelb3220PROMISCUOUSPMID 18789614show
SMR000014916653862BindingDB-show
SMR000014918647599BindingDB-show
SMR0000202853236798BindingDB-show
SMR0000215683241895BindingDB-show
SMR0000242273244032BindingDB-show
SMR0000242356023689BindingDB-show
SMR0000269793239534BindingDB-show
SMR0000274103236935BindingDB-show
SMR0000278983236055BindingDB-show
SMR000034597660518BindingDB-show
SMR000039022658111BindingDB-show
SMR000039053658152BindingDB-show
SMR000039734658724BindingDB-show
SMR000039890658964BindingDB-show
SMR000041595660829BindingDB-show
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SMR0000610632998380BindingDB-show
SMR0000616052997948BindingDB-show
SMR0000623492997975BindingDB-show
SMR0000680052612950BindingDB-show
SMR0000747871306035BindingDB-show
SMR0000750461265644BindingDB-show
SMR0000970793422818BindingDB-show
ST029236578663BindingDB-show
ST039286729558BindingDB-show
ST039289729563BindingDB-show
ST0769753240826BindingDB-show
ST0818763243025BindingDB-show
ST0819351506381BindingDB-show
STK3820273243168BindingDB-show
STK543199659720BindingDB-show
SYMMETRIC DIACYLAMINOETHYL KETONE5289345BindingDB-show
Telaprevir3010818BindingDB-show
Tert-butyl N-(1-oxohexan-2-yl)carbamate10420833BindingDB-show
Thiol protease inhibitor123985BindingDB-show
Xanthrothricin66541BindingDB-show
ZERO/005098573353BindingDB-show
ZERO/005290665203BindingDB-show
ZERO/0058235345915BindingDB-show
ZINC00110897714967BindingDB-show
ZINC00112082715538BindingDB-show
ZINC00448152561320BindingDB-show
ZINC00812573646525BindingDB-show
ZINC008144051093235BindingDB-show
ZINC009742361205147BindingDB-show
ZINC010581591248970BindingDB-show
ZINC014245161505224BindingDB-show
ZINC029426412883004BindingDB-show
ZINC046703495035758BindingDB-show
[1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE5288259BindingDB-show
Synonyms:
APP secretase
APPS
Cathepsin B
Cathepsin B1
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
CATB_BOVIN90.682.6
CATB_RAT88.578.2
CATB_MOUSE87.978.8
CATH_PIG40.825.7
CATS_HUMAN38.823.6
CATK_CANFA37.722.1
CATL2_HUMAN37.723.6
C1EGT7_MICSR37.523.5
CATK_MACMU36.421.9
CATL1_HUMAN35.923.1
CATK_RAT35.921.9
PAPA1_CARPA35.322.3
CYSEP_RICCO3523.1
MDH_HALMA34.819.8
CATL1_MOUSE34.121.9
CATL1_RAT33.820.9
Q7GDU7_ORYSJ33.321.7
CPGP2_ZINOF33.221.4
ABNA_BACSU3218.6
NUDT9_HUMAN31.618.8
SPEB_STRPY31.419.2
ERVB_TABDI31.119.9
TRXB2_ARATH3118.1
MMP8_HUMAN30.816.9
OMPC_KLEPN30.715.8
PPT1_BOVIN30.717.3
TRXB1_ARATH30.219
RIR2_MYCLE30.218.8
ERVC_TABDI3020
CYF_CHLRE29.919
Protein-Protein Interactions: