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Target Details

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Name:Aldehyde reductase
Uniprot name:ALDR_HUMAN
Accession Numbers:P15121 Q5U031 Q9BS21 Q9UCI9
EC-Number:1.1.1.21
Organism:Homo sapiens
Human
PDB IDs:1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(5-Chloro-2-{[(3-Nitrobenzyl)amino]carbonyl}phenoxy)acetic Acid16058630BindingDB-show
1-Ebpc5484384BindingDB-show
2,6-Dichlorophenylacetic acid81058BindingDB-show
2-(5H-Dibenzo(a,d)cyclohepten-5-one)-2-propionic acid173910BindingDB-show
2-Hydroxyphenylacetic acid11970BindingDB-show
3-Chloro-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-4-one214654BindingDB-show
3-Hydroxycoumarin13650BindingDB-show
4015840158DrugBank-show
4H-1-Benzopyran-2-carboxylic acid, 7-hydroxy-4-oxo-, ethyl ester5376802BindingDB-show
6-fluoro-2,3-dihydro-2'H,5'H-spiro[chromene-4,4'-imidazolidine]-2',5'-dion5252BindingDB-show
6-Hydroxycoumaran99477BindingDB-show
6-O-phosphono-alpha-D-glucopyranose439284DrugBank-show
7-Dsxca20291895BindingDB-show
AC1L9LFA447950BindingDB-show
AC1LQJOR1351633BindingDB-show
AC1LUMA91584822BindingDB-show
AC1MH8VZ2998139BindingDB-show
AC1NQGZ75221308BindingDB-show
AC1NU2BY5393159BindingDB-show
AC1NWJNT5706814BindingDB-show
AC1NWWZ15714586BindingDB-show
AC1NX8ML5748291BindingDB-show
AIDS141146375713BindingDB-show
Alrestatin2120BindingDB-show
Alrestatin2120PROMISCUOUS4 PMIDsshow
Alrestatin23683779PROMISCUOUS4 PMIDsshow
Ameisensaeure284PROMISCUOUSPMID 18492610show
Bendazac2313SuperTargetPMID 2517113show
benzofuran, 2211807954BindingDB-show
benzofuran, 2310968945BindingDB-show
beta-hydroxytricarballylic acid311DrugBank-show
beta-hydroxytricarballylic acid311SuperTarget-show
CHEBI:18386944298149BindingDB-show
CHEMBL1035010342270BindingDB-show
CHEMBL1038210402114BindingDB-show
CHEMBL1055210412732BindingDB-show
CHEMBL106159970648BindingDB-show
CHEMBL10949715708699BindingDB-show
CHEMBL11084915708700BindingDB-show
CHEMBL11428915708698BindingDB-show
CHEMBL13966615713962BindingDB-show
CHEMBL13989815133837BindingDB-show
CHEMBL14001215713973BindingDB-show
CHEMBL14004215133806BindingDB-show
CHEMBL14019915133810BindingDB-show
CHEMBL14037515133811BindingDB-show
CHEMBL14075015713972BindingDB-show
CHEMBL14098015133805BindingDB-show
CHEMBL14101315713969BindingDB-show
CHEMBL14113515133842BindingDB-show
CHEMBL14139015133821BindingDB-show
CHEMBL14211015713967BindingDB-show
CHEMBL14227415133830BindingDB-show
CHEMBL14251215133838BindingDB-show
CHEMBL14254215133803BindingDB-show
CHEMBL1425999805341BindingDB-show
CHEMBL14264715133844BindingDB-show
CHEMBL14270415713964BindingDB-show
CHEMBL14279015133836BindingDB-show
CHEMBL14287915133840BindingDB-show
CHEMBL14293415133847BindingDB-show
CHEMBL14298915133833BindingDB-show
CHEMBL14309815133824BindingDB-show
CHEMBL14311715133815BindingDB-show
CHEMBL14321115133831BindingDB-show
CHEMBL14323115133816BindingDB-show
CHEMBL14323415133835BindingDB-show
CHEMBL14324115133826BindingDB-show
CHEMBL14338715133809BindingDB-show
CHEMBL14355115133846BindingDB-show
CHEMBL14356944361448BindingDB-show
CHEMBL14363315713960BindingDB-show
CHEMBL14370815713958BindingDB-show
CHEMBL14386315133855BindingDB-show
CHEMBL14387215133845BindingDB-show
CHEMBL14390315133834BindingDB-show
CHEMBL1488649851899BindingDB-show
CHEMBL14891811308405BindingDB-show
CHEMBL1501989822749BindingDB-show
CHEMBL1519529874662BindingDB-show
CHEMBL16682544381246BindingDB-show
CHEMBL16861412512363BindingDB-show
CHEMBL17085320308817BindingDB-show
CHEMBL17094344381461BindingDB-show
CHEMBL17131544381460BindingDB-show
CHEMBL1885444272420BindingDB-show
CHEMBL1886513312639BindingDB-show
CHEMBL1906413312652BindingDB-show
CHEMBL1916214810761BindingDB-show
CHEMBL1918713312657BindingDB-show
CHEMBL1928914810762BindingDB-show
CHEMBL1931613312644BindingDB-show
CHEMBL1937314810719BindingDB-show
CHEMBL1939213312660BindingDB-show
CHEMBL1942713312668BindingDB-show
CHEMBL1949513312637BindingDB-show
CHEMBL1950213312646BindingDB-show
CHEMBL1953213312653BindingDB-show
CHEMBL1964913312643BindingDB-show
CHEMBL1970114677893BindingDB-show
CHEMBL1971113312659BindingDB-show
CHEMBL1974413312650BindingDB-show
CHEMBL1974644273113BindingDB-show
CHEMBL1975914810774BindingDB-show
CHEMBL1978113312634BindingDB-show
CHEMBL1978913312626BindingDB-show
CHEMBL1983814810771BindingDB-show
CHEMBL1987314810724BindingDB-show
CHEMBL1988513312640BindingDB-show
CHEMBL1989314810757BindingDB-show
CHEMBL1990614810773BindingDB-show
CHEMBL1995814810779BindingDB-show
CHEMBL1996614810722BindingDB-show
CHEMBL2000414810729BindingDB-show
CHEMBL2000514810766BindingDB-show
CHEMBL2000944273392BindingDB-show
CHEMBL2001514810716BindingDB-show
CHEMBL2002414810715BindingDB-show
CHEMBL2011514810755BindingDB-show
CHEMBL2011614810769BindingDB-show
CHEMBL2016114810759BindingDB-show
CHEMBL2016914810637BindingDB-show
CHEMBL2019714810721BindingDB-show
CHEMBL2019914810727BindingDB-show
CHEMBL2020714810737BindingDB-show
CHEMBL2022014810739BindingDB-show
CHEMBL2025314810744BindingDB-show
CHEMBL2030414810781BindingDB-show
CHEMBL2030614810743BindingDB-show
CHEMBL2036514810749BindingDB-show
CHEMBL2038014810746BindingDB-show
CHEMBL2044014810764BindingDB-show
CHEMBL2044114810718BindingDB-show
CHEMBL2051814810754BindingDB-show
CHEMBL2057514810750BindingDB-show
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CHEMBL23944011530302BindingDB-show
CHEMBL24072018468177BindingDB-show
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CHEMBL2408719922689BindingDB-show
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CHEMBL24157011551271BindingDB-show
CHEMBL24157222093457BindingDB-show
CHEMBL26077824853736BindingDB-show
CHEMBL26170324829377BindingDB-show
CHEMBL26270144273409BindingDB-show
CHEMBL26677244264089BindingDB-show
CHEMBL26677342798793BindingDB-show
CHEMBL26765144263974BindingDB-show
CHEMBL26908944263945BindingDB-show
CHEMBL27472713312661BindingDB-show
CHEMBL27586813312658BindingDB-show
CHEMBL27742713312645BindingDB-show
CHEMBL27752013312636BindingDB-show
CHEMBL27770814810758BindingDB-show
CHEMBL27792114810790BindingDB-show
CHEMBL27792814810776BindingDB-show
CHEMBL27793514810788BindingDB-show
CHEMBL27852214810770BindingDB-show
CHEMBL27856513953781BindingDB-show
CHEMBL27858314810756BindingDB-show
CHEMBL27858413312620BindingDB-show
CHEMBL27883214810734BindingDB-show
CHEMBL27899114810763BindingDB-show
CHEMBL27927413312629BindingDB-show
CHEMBL27927514810780BindingDB-show
CHEMBL27966614810767BindingDB-show
CHEMBL27967314810782BindingDB-show
CHEMBL27987813312649BindingDB-show
CHEMBL28016814810717BindingDB-show
CHEMBL28035744273138BindingDB-show
CHEMBL28036114810748BindingDB-show
CHEMBL28140714810784BindingDB-show
CHEMBL28162044273340BindingDB-show
CHEMBL28201714810785BindingDB-show
CHEMBL28226314810752BindingDB-show
CHEMBL28243514810775BindingDB-show
CHEMBL28268914810751BindingDB-show
CHEMBL28315119867112BindingDB-show
CHEMBL28336414810741BindingDB-show
CHEMBL28378714810778BindingDB-show
CHEMBL28398414810735BindingDB-show
CHEMBL28399614810720BindingDB-show
CHEMBL28401814810772BindingDB-show
CHEMBL29184214229976BindingDB-show
CHEMBL29185414229974BindingDB-show
CHEMBL29243744298252BindingDB-show
CHEMBL29266614783857BindingDB-show
CHEMBL29299814229994BindingDB-show
CHEMBL29347514229978BindingDB-show
CHEMBL29357914371717BindingDB-show
CHEMBL29386914229989BindingDB-show
CHEMBL29461214371712BindingDB-show
CHEMBL29748314422820BindingDB-show
CHEMBL30201415749976BindingDB-show
CHEMBL30205515749977BindingDB-show
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CHEMBL30321810221192BindingDB-show
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CHEMBL30341615074168BindingDB-show
CHEMBL30347413850115BindingDB-show
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CHEMBL30431414852845BindingDB-show
CHEMBL30478213850123BindingDB-show
CHEMBL30479744309018BindingDB-show
CHEMBL30479844309019BindingDB-show
CHEMBL30494513850097BindingDB-show
CHEMBL30499515669790BindingDB-show
CHEMBL30506415669768BindingDB-show
CHEMBL30535314229977BindingDB-show
CHEMBL30598513850143BindingDB-show
CHEMBL30598613850119BindingDB-show
CHEMBL30622214458649BindingDB-show
CHEMBL30624414458650BindingDB-show
CHEMBL30642915749972BindingDB-show
CHEMBL30659113850078BindingDB-show
CHEMBL30668715749978BindingDB-show
CHEMBL30712114773403BindingDB-show
CHEMBL30730515749973BindingDB-show
CHEMBL30784715572734BindingDB-show
CHEMBL30821614458654BindingDB-show
CHEMBL30888244309003BindingDB-show
CHEMBL30892044309111BindingDB-show
CHEMBL30913215669767BindingDB-show
CHEMBL31027413953813BindingDB-show
CHEMBL31073115572730BindingDB-show
CHEMBL31167913676777BindingDB-show
CHEMBL31229013676787BindingDB-show
CHEMBL31239213953763BindingDB-show
CHEMBL31250915572735BindingDB-show
CHEMBL31251513014152BindingDB-show
CHEMBL32339015708696BindingDB-show
CHEMBL32497615708695BindingDB-show
CHEMBL32573815708701BindingDB-show
CHEMBL32638315708694BindingDB-show
CHEMBL3279913014150BindingDB-show
CHEMBL33537615133823BindingDB-show
CHEMBL33577610047735BindingDB-show
CHEMBL34186415133819BindingDB-show
CHEMBL34233915133839BindingDB-show
CHEMBL34252415713961BindingDB-show
CHEMBL34278615133848BindingDB-show
CHEMBL34288715133804BindingDB-show
CHEMBL34297415133854BindingDB-show
CHEMBL34405715713959BindingDB-show
CHEMBL34424515133807BindingDB-show
CHEMBL34452615133813BindingDB-show
CHEMBL34506815133818BindingDB-show
CHEMBL35628615133825BindingDB-show
CHEMBL35654515133822BindingDB-show
CHEMBL35678915713963BindingDB-show
CHEMBL35707415713965BindingDB-show
CHEMBL35710011343202BindingDB-show
CHEMBL35720615133827BindingDB-show
CHEMBL35743515133812BindingDB-show
CHEMBL35746015133841BindingDB-show
CHEMBL35855015133858BindingDB-show
CHEMBL35871344366031BindingDB-show
CHEMBL35879215133832BindingDB-show
CHEMBL3592213053011BindingDB-show
CHEMBL36304040466856BindingDB-show
CHEMBL41420844264610BindingDB-show
CHEMBL41440514810789BindingDB-show
CHEMBL41449611215672BindingDB-show
CHEMBL41467614773443BindingDB-show
CHEMBL41600114810753BindingDB-show
CHEMBL41637014810768BindingDB-show
CHEMBL41687010018563BindingDB-show
CHEMBL41764314810723BindingDB-show
CHEMBL41800714810725BindingDB-show
CHEMBL41800814810733BindingDB-show
CHEMBL41910515572741BindingDB-show
CHEMBL41925414458660BindingDB-show
CHEMBL42002413953744BindingDB-show
CHEMBL42055013850141BindingDB-show
CHEMBL42111113850156BindingDB-show
CHEMBL42148714458662BindingDB-show
CHEMBL42247615133817BindingDB-show
CHEMBL42264715133820BindingDB-show
CHEMBL42282415133843BindingDB-show
CHEMBL42292023621307BindingDB-show
CHEMBL42292714810740BindingDB-show
CHEMBL42318715133808BindingDB-show
CHEMBL42448515713966BindingDB-show
CHEMBL42905913312651BindingDB-show
CHEMBL43091114810726BindingDB-show
CHEMBL43110814810760BindingDB-show
CHEMBL43292913676782BindingDB-show
CHEMBL44079013312647BindingDB-show
CHEMBL44125413850135BindingDB-show
CHEMBL44327113953795BindingDB-show
CHEMBL44349213312638BindingDB-show
CHEMBL5263915708693BindingDB-show
CHEMBL5279214422821BindingDB-show
CHEMBL53891713676784BindingDB-show
CHEMBL5434244298114BindingDB-show
CHEMBL5598310662710BindingDB-show
CHEMBL5612314371714BindingDB-show
CHEMBL5634610705949BindingDB-show
CHEMBL5642414371716BindingDB-show
CHEMBL5644710708015BindingDB-show
CHEMBL5645314371713BindingDB-show
CHEMBL5665010084377BindingDB-show
CHEMBL6195515750124BindingDB-show
CHEMBL6268511743455BindingDB-show
CHEMBL6290614229975BindingDB-show
CHEMBL6337715733202BindingDB-show
CHEMBL6338915074169BindingDB-show
CHEMBL6340115750120BindingDB-show
CHEMBL6342915750108BindingDB-show
CHEMBL6352715750121BindingDB-show
CHEMBL6363914792090BindingDB-show
CHEMBL6364014229984BindingDB-show
CHEMBL6365414229987BindingDB-show
CHEMBL6370244305972BindingDB-show
CHEMBL6377814229972BindingDB-show
CHEMBL6378014229971BindingDB-show
CHEMBL6381214229980BindingDB-show
CHEMBL6385514183548BindingDB-show
CHEMBL6386614229973BindingDB-show
CHEMBL6390914852846BindingDB-show
CHEMBL6397410469744BindingDB-show
CHEMBL6518115750125BindingDB-show
CHEMBL6531615750127BindingDB-show
CHEMBL6537214229968BindingDB-show
CHEMBL6538514229981BindingDB-show
CHEMBL6541815750118BindingDB-show
CHEMBL6547215074167BindingDB-show
CHEMBL6565914229979BindingDB-show
CHEMBL6570114229969BindingDB-show
CHEMBL6573115750123BindingDB-show
CHEMBL6586914229986BindingDB-show
CHEMBL6587014229988BindingDB-show
CHEMBL6596713850125BindingDB-show
CHEMBL6600615669789BindingDB-show
CHEMBL6615214229990BindingDB-show
CHEMBL6619214230005BindingDB-show
CHEMBL6632613850105BindingDB-show
CHEMBL6647610314257BindingDB-show
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CHEMBL6663614230004BindingDB-show
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CHEMBL6664612399888BindingDB-show
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CHEMBL6910415749969BindingDB-show
CHEMBL6918315669783BindingDB-show
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CHEMBL6928014773439BindingDB-show
CHEMBL6935015669786BindingDB-show
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CHEMBL6953715669792BindingDB-show
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CHEMBL6958613850075BindingDB-show
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CHEMBL6967513850107BindingDB-show
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CHEMBL8208813953808BindingDB-show
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CHEMBL8368915572752BindingDB-show
Cichorigenin5281416BindingDB-show
Cyclocumarol14101BindingDB-show
Dhocf3BTPA132323BindingDB-show
dihydrodiphosphopyridine nucleotide439153DrugBank-show
Dimethylarsino3034811DrugBank-show
EINECS 261-973-75409279BindingDB-show
epalrestat1549120BindingDB-show
Fidaresstat160024BindingDB-show
Fidaresstat160024DrugBank-show
FIDARESTAT(STEREOISOMER)449157BindingDB-show
FIDARESTAT(STEREOISOMER)449157DrugBank-show
Fir449156BindingDB-show
Flufenaminsaeure3371BindingDB-show
Glossypol dioxime deriv.5380200BindingDB-show
Gossylic iminolactone5479302BindingDB-show
Gossylic lactone5479154BindingDB-show
Gossypol3503BindingDB-show
Gossypol deriv.122660BindingDB-show
HOCCA5479463BindingDB-show
hydroxymethylbenzene244PROMISCUOUSPMID 16226225show
ID5448658BindingDB-show
Imirestat65673BindingDB-show
Indomethacinum3715BindingDB-show
INHIBITOR IDD 3841944BindingDB-show
INHIBITOR IDD 3841944DrugBank-show
Isoscopoletin69894BindingDB-show
Ketoprophene3825BindingDB-show
lactitolum493591SuperTarget-show
Lidorestat157839BindingDB-show
Methylesculetin5319502BindingDB-show
Methylesculetin5280460BindingDB-show
Methylumbelliferone5280567BindingDB-show
Methylumbelliferone10748BindingDB-show
Minalrestat190816BindingDB-show
NSC159493293170BindingDB-show
NSC35589233815BindingDB-show
NSC364753339231BindingDB-show
NSC3701499720BindingDB-show
NSC656255338490BindingDB-show
NSC784745357479BindingDB-show
NSC89311259386BindingDB-show
Orthohydroxybenzoic acid338BindingDB-show
Oxepinac41531BindingDB-show
Paraformaldehydum712PROMISCUOUSPMID 2157439show
Pentanecarboxylic acid8892BindingDB-show
Phenylacetate999BindingDB-show
Phenylaethylbarbitursaeure4763PROMISCUOUSPMID 2157439show
Pirinixic acid5694PROMISCUOUSPMID 17194029show
PONALRESTAT5278BindingDB-show
Quercetin 3-rhamnoside5353915BindingDB-show
Quercitrin5280459BindingDB-show
Quercitrin5280459PROMISCUOUSPMID 6820339show
Ranirestat153948BindingDB-show
rosmarinic acid5281792BindingDB-show
SORBINIL337359BindingDB-show
SORBINIL337359DrugBank-show
SORBINIL337359PROMISCUOUS7 PMIDsshow
Spiro-cimqat176053BindingDB-show
STK0198421135357BindingDB-show
STK0740831135340BindingDB-show
Sulindac5352DrugBank-show
Tetramethyleneglutaric acid85558BindingDB-show
Thiazolidinedione5437PROMISCUOUSPMID 18492610show
TIOPINAC43585BindingDB-show
Tolrestatin53359DrugBank-show
Tolrestatin53359PROMISCUOUS5 PMIDsshow
Tolrestatin53359SuperTarget-show
Triphosphopyridine nucleotide5886DrugBank-show
Triphosphopyridine nucleotide5885DrugBank-show
Umbelliferone5281426BindingDB-show
Xanthaurine5280343BindingDB-show
Xanthaurine5280343PROMISCUOUS2 PMIDsshow
Zenarestat5724BindingDB-show
Zenarestat5724DrugBank-show
ZINC001867645320203BindingDB-show
ZINC008767111135342BindingDB-show
ZINC008767141135345BindingDB-show
ZINC026354002098024BindingDB-show
ZINC026354005013622BindingDB-show
Zopolrestat1613BindingDB-show
Zopolrestat1613PROMISCUOUSPMID 9681469show
Synonyms:
Aldehyde reductase
Aldose reductase
AR
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
ALDR_BOVIN9486.4
ALDR_PIG93.786.7
ALDR_RAT9385.4
ALD2_CRIGR83.570.9
ALD2_MOUSE82.670.3
AK1A1_PIG68.848.6
AK1D1_HUMAN68.148.8
AK1C1_HUMAN67.848
PE2R_RABIT67.849.8
AK1C2_HUMAN67.548.3
AK1C3_HUMAN6747.5
AK1C4_HUMAN6747.2
DIDH_RAT6545.8
Q9GV41_9TRYP52.339.3
Q9X0A2_THEMA52.333.9
XYL1_CANTE51.938.2
DKGA_CORSC50.334.6
IOLS_BACSU37.821.1
GS69_BACSU37.120.9
PHZF_PSEFL36.816.3
YDHF_ECOLI36.121.3
POTD_ECOLI35.621.6
FABI_ECOLI35.319.9
NAGAB_CHICK34.619.8
CAH4_RABIT33.618.5
XYN1_GEOSE33.217.6
CDK5_MOUSE32.919
TPIS_GEOSE32.620.9
A8FHN4_BACP232.417.5
NAGB_BACSU32.217.7
Protein-Protein Interactions: