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Target Details

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Name:Proto-oncogene tyrosine-protein kinase ABL1
Uniprot name:ABL1_HUMAN
Accession Numbers:A3KFJ3 P00519 Q13869 Q13870 Q16133 Q17R61 Q45F09
EC-Number:2.7.10.2
Organism:Homo sapiens
Human
PDB IDs:1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
()-oxazepam hemisuccinate sodium salt44300143BindingDB-show
()-oxazepam hemisuccinate sodium salt44300176BindingDB-show
0LI24826799BindingDB-show
1,2-Dihydroxy-4-(nitroethenyl)benzene6439158BindingDB-show
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 465327893BindingDB-show
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 505327897BindingDB-show
2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 515327898BindingDB-show
2-methoxy-4-(2-nitrovinyl)phenol638439BindingDB-show
24A11957378BindingDB-show
3,4',5-trimethoxy-trans-stilbene5388063BindingDB-show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi9926791BindingDB-show
3cpc24812719BindingDB-show
4,5-dianilinophthalimide1697BindingDB-show
4-Anilinoquinazoline 225329048BindingDB-show
4-[(4-METHYLPIPERAZIN-1-YL)METHYL]-N-{3-[(4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO]PHENYL}BENZAMIDE4369496BindingDB-show
4-[(Z)-2-(3,5-dimethoxyphenyl)ethenyl]-2,6-ditert-butyl-phenol11199480BindingDB-show
4434037244340372BindingDB-show
ABT-86911485656BindingDB-show
AC1LKX7K1075248BindingDB-show
AC1M44RA2250919BindingDB-show
AC1MOHSZ3320547BindingDB-show
AC1NGINR4750207BindingDB-show
AC1NXB6N5775636BindingDB-show
Adenosintriphosphorsaeure5957DrugBank-show
AG-690/137070371728080BindingDB-show
AMG 70611667893BindingDB-show
anthranyl amide derivative C6398883BindingDB-show
AST-48711409972BindingDB-show
Bafetinib11387605BindingDB-show
BAS 003388721097674BindingDB-show
BAS 010557702447649BindingDB-show
BAS 029134533144222BindingDB-show
BAS 029137062180013BindingDB-show
BAS 029137111143580BindingDB-show
BAS 029137492130377BindingDB-show
BAS 05667948809029BindingDB-show
BAS 095343241094114BindingDB-show
Bio2_0004136610353BindingDB-show
Bisindolylmaleimide2399BindingDB-show
Bosutinib5328940BindingDB-show
Canertinib156414BindingDB-show
CCRIS 89573063374BindingDB-show
CHEBI:1043465459219BindingDB-show
CHEBI:22205114862531BindingDB-show
CHEBI:22235714862529BindingDB-show
CHEBI:25992444329707BindingDB-show
CHEBI:30525144348997BindingDB-show
CHEBI:49791447077BindingDB-show
CHEBI:5091524905142BindingDB-show
CHEBI:523095154691BindingDB-show
CHEBI:54743644560358BindingDB-show
CHEBI:58745744460481BindingDB-show
CHEBI:64572344318045BindingDB-show
CHEBI:64574344460234BindingDB-show
CHEBI:64575044460442BindingDB-show
CHEBI:64576244460776BindingDB-show
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CHEBI:64580644460503BindingDB-show
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CHEBI:66834345481533BindingDB-show
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CHEMBL1023019890746BindingDB-show
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CHEMBL47382644572431BindingDB-show
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CHEMBL59942845139991BindingDB-show
CHEMBL60079546232443BindingDB-show
CHEMBL60207446233108BindingDB-show
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CHEMBL6081610708835BindingDB-show
CHEMBL6404010002079BindingDB-show
CHEMBL7239310569366BindingDB-show
CHEMBL733910590515BindingDB-show
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CHEMBL7504913492269BindingDB-show
CHEMBL751779948215BindingDB-show
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CHEMBL7695814862522BindingDB-show
CHEMBL7710014862537BindingDB-show
CHEMBL7740114862527BindingDB-show
CHEMBL7768814862525BindingDB-show
CHEMBL777510066030BindingDB-show
CHEMBL78199883384BindingDB-show
CHEMBL7820614862536BindingDB-show
CHEMBL7824944318047BindingDB-show
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CHEMBL786610499619BindingDB-show
CHEMBL791410360970BindingDB-show
CHEMBL8003010318154BindingDB-show
CHEMBL809510043994BindingDB-show
CHEMBL822310434923BindingDB-show
CHEMBL8384711326339BindingDB-show
CHIR-26511656518BindingDB-show
CID 1000847410008474BindingDB-show
CID 1060380610651406BindingDB-show
CID 1062698810721885BindingDB-show
CID 1062698810626988BindingDB-show
CID 1067477910674779BindingDB-show
CID 1069932510699325BindingDB-show
CID 1069932510722796BindingDB-show
CID 1149662911696609BindingDB-show
CP-7247149874913BindingDB-show
DAPH 26711154BindingDB-show
Dasatinib3062316BindingDB-show
Dasatinib3062316DrugBank-show
Doramapimod156422BindingDB-show
Erlotinib176870BindingDB-show
Flt-3 Inhibitor II11601743BindingDB-show
Gefitinib123631BindingDB-show
Genisterin5280961BindingDB-show
GW-258011617559BindingDB-show
Imatinib Methansulfonate5291BindingDB-show
Imatinib Methansulfonate5291DrugBank-show
Imatinib Methansulfonate5291SuperTargetPMID 012435730show
Indolinone based inhibitor, 3g23647620BindingDB-show
K000046419834BindingDB-show
Kinome_248146224684BindingDB-show
Kinome_291844444843BindingDB-show
Kinome_6366420138BindingDB-show
Lapatinib ditosylate208908BindingDB-show
Lestaurtinib126565BindingDB-show
Methazolastone5394BindingDB-show
MLN805411712649BindingDB-show
MLS000029270644846BindingDB-show
MLS0005294531113641BindingDB-show
MLS0005294541113642BindingDB-show
MLS0007773675357223BindingDB-show
MLS00323094144129660BindingDB-show
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine9965429BindingDB-show
N-[4-(trifluoromethoxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine2475277BindingDB-show
nchembio.246-comp210318148BindingDB-show
nchembio.90-comp111715767BindingDB-show
nchembio760-comp15312285BindingDB-show
nchembio760-comp25311510BindingDB-show
Nilotinib644241BindingDB-show
NSC2559024183247BindingDB-show
NSC606429354471BindingDB-show
NSC606437354479BindingDB-show
NSC735424447700BindingDB-show
NVP-TAE68416038120BindingDB-show
oxindole i5908088BindingDB-show
Pazopanib10113978BindingDB-show
PD1739565330524BindingDB-show
Pelitinib6445562BindingDB-show
PHA-66575210461815BindingDB-show
Phenol, p-(2-nitrovinyl)-638437BindingDB-show
PI-1039884685BindingDB-show
PKC-4129829523BindingDB-show
pp1 analog4877BindingDB-show
Pterostilbene5281727BindingDB-show
Resveratrol445154BindingDB-show
Roscovitine160355BindingDB-show
RTKI cpd2051BindingDB-show
Ruboxistaurin153999BindingDB-show
RWJ-3872525330790BindingDB-show
S1018_Selleck9977819BindingDB-show
S1147_Selleck16007391BindingDB-show
S1194_Selleck24756910BindingDB-show
S1526_Selleck24889392BindingDB-show
Saracatinib10302451BindingDB-show
SB 2021905353940BindingDB-show
SB-4315424521392BindingDB-show
Semaxinib5329098BindingDB-show
SMR000008996644784BindingDB-show
SMR000072380889490BindingDB-show
SNS-0323025986BindingDB-show
sorafenibum216239BindingDB-show
STAUROSPORINE44259BindingDB-show
staurosporine44299148BindingDB-show
STK563487825387BindingDB-show
SU-1481310138259BindingDB-show
su66565312137BindingDB-show
Suberanilohydroxamic acid5311BindingDB-show
Sunitinib5329102BindingDB-show
Tandutinib3038522BindingDB-show
Vandetanib3081361BindingDB-show
Vatalanib151194BindingDB-show
Vatalanib succinate151193BindingDB-show
VX-6805494449BindingDB-show
VX-7453038525BindingDB-show
ZINC00134211726259BindingDB-show
ZINC00272085779445BindingDB-show
ZINC007259761049031BindingDB-show
ZINC007260171049055BindingDB-show
ZINC022590371886699BindingDB-show
ZINC022731801898760BindingDB-show
ZINC045400842964718BindingDB-show
ZINC050167562964715BindingDB-show
ZINC050167602964717BindingDB-show
Synonyms:
Abelson murine leukemia viral oncogene homolog 1
c-ABL
p150
Proto-oncogene tyrosine-protein kinase ABL1
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
Q59FK4_HUMAN95.395
Q59F19_HUMAN80.379.5
ABL_MLVAB61.659.3
ABL2_HUMAN59.850.3
ACK1_HUMAN33.922.3
FAK1_HUMAN30.219.3
Q26964_TRYCR3019.1
NOS3_PIG29.318.3
NOS3_HUMAN29.318.6
NOS3_RAT28.116.7
FAK2_HUMAN28.117.7
Q9F0I5_PAEMA27.716.1
FAK1_MOUSE27.717.2
SYJ1_SCHPO27.716.5
NOS3_MOUSE27.617.1
SCM_DROME27.216.6
A3LQL4_PICST27.216.3
Q0VQP0_ALCBS26.918.1
NOS3_BOVIN26.816
LCK_HUMAN26.718.3
CSKP_HUMAN26.615.3
SRC_RAT26.618.1
NMDE3_HUMAN26.616.9
HYSA_STRPN26.515.3
FYN_HUMAN26.518.1
SRC_HUMAN26.518.2
IKKA_HUMAN26.515
IL3RB_HUMAN26.417.7
RET3_HUMAN26.417
YES_HUMAN26.418.4
Protein-Protein Interactions:
Uniprot nameSource
ZDH16_HUMANPMID 12021275
ZAP70_HUMAN2 PMIDs
YTDC1_HUMAN3 PMIDs
YAP1_HUMAN4 PMIDs
WNK2_HUMAN5 PMIDs
WASL_HUMAN6 PMIDs
WASF4_HUMAN7 PMIDs
WASF1_HUMAN8 PMIDs
VPREB_HUMAN9 PMIDs
VP13A_HUMAN10 PMIDs
VINEX_HUMAN11 PMIDs
UHMK1_HUMAN12 PMIDs
TULP4_HUMAN13 PMIDs
TUB_HUMAN14 PMIDs
TSKS_HUMAN15 PMIDs
TRI39_HUMAN16 PMIDs
TLN2_HUMAN16 PMIDs
TGON2_HUMAN17 PMIDs
TERF1_HUMAN18 PMIDs
TAU_HUMAN19 PMIDs
SYNJ2_HUMAN20 PMIDs
SUV92_HUMAN21 PMIDs
ST5_HUMAN22 PMIDs
SREC2_HUMAN23 PMIDs
SRBS2_HUMAN24 PMIDs
SRBS1_HUMAN25 PMIDs
SPN90_HUMAN26 PMIDs
SP1_HUMAN27 PMIDs
SNX8_HUMAN28 PMIDs
SNX3_HUMAN29 PMIDs
SNX17_HUMAN30 PMIDs
SNX12_HUMAN31 PMIDs
SHIP2_HUMAN32 PMIDs
SHE_HUMAN33 PMIDs
SHD_HUMAN34 PMIDs
SHAN3_HUMAN35 PMIDs
SELN_HUMAN36 PMIDs
S22A3_HUMAN37 PMIDs
RYBP_HUMAN38 PMIDs
RTN4_HUMAN39 PMIDs
RPP38_HUMAN40 PMIDs
ROS_HUMAN41 PMIDs
RIN3_HUMAN42 PMIDs
RIN1_HUMAN43 PMIDs
RHG17_HUMAN44 PMIDs
RGS20_HUMAN45 PMIDs
RFX1_HUMAN46 PMIDs
RFRP_HUMAN47 PMIDs
PTN4_HUMAN48 PMIDs
PTN18_HUMAN49 PMIDs
PTN12_HUMAN50 PMIDs
PRIC3_HUMAN51 PMIDs
PRDX1_HUMAN51 PMIDs
PRAX_HUMAN52 PMIDs
PPIP1_HUMAN53 PMIDs
PP2BA_HUMAN54 PMIDs
PLS1_HUMAN55 PMIDs
PKD1_HUMAN56 PMIDs
PDIA2_HUMAN57 PMIDs
PCDA7_HUMAN58 PMIDs
PAX3_HUMAN59 PMIDs
P73_HUMAN60 PMIDs
P53_HUMAN61 PMIDs
P2RX7_HUMAN62 PMIDs
OSBL5_HUMAN63 PMIDs
NXPH3_HUMAN64 PMIDs
NMDE4_HUMAN65 PMIDs
NKX21_HUMAN66 PMIDs
NFS1_HUMAN67 PMIDs
NFASC_HUMAN68 PMIDs
NEK8_HUMAN69 PMIDs
NCKX1_HUMAN70 PMIDs
NBEA_HUMAN71 PMIDs
MUC1_HUMAN72 PMIDs
MLL4_HUMAN73 PMIDs
MIME_HUMAN74 PMIDs
MICA1_HUMAN75 PMIDs
MEPE_HUMAN76 PMIDs
MAAI_HUMAN77 PMIDs
M4K5_HUMAN78 PMIDs
M4K1_HUMAN79 PMIDs
LTBP2_HUMAN80 PMIDs
LRBA_HUMAN81 PMIDs
LAP2B_HUMAN82 PMIDs
KPCD_HUMAN83 PMIDs
KIT_HUMAN84 PMIDs
KIFC2_HUMAN85 PMIDs
KI67_HUMAN86 PMIDs
JAK2_HUMAN87 PMIDs
JAK1_HUMAN88 PMIDs
ICAL_HUMAN89 PMIDs
HXC8_HUMAN90 PMIDs
HEXA_HUMAN91 PMIDs
HCN4_HUMAN92 PMIDs
HCN2_HUMAN93 PMIDs
HCK_HUMAN94 PMIDs
GT2D1_HUMAN95 PMIDs
GSX2_HUMAN96 PMIDs
GRB10_HUMAN97 PMIDs
GPX1_HUMAN98 PMIDs
GPR45_HUMAN99 PMIDs
GASR_HUMAN100 PMIDs
GABR1_HUMAN101 PMIDs
G3BP2_HUMAN102 PMIDs
FYB_HUMAN103 PMIDs
FOXF2_HUMAN104 PMIDs
FLNC_HUMAN105 PMIDs
FETUA_HUMAN106 PMIDs
F110A_HUMAN107 PMIDs
ERBB4_HUMAN108 PMIDs
ERBB3_HUMAN109 PMIDs
EPS15_HUMAN110 PMIDs
EPHB2_HUMAN111 PMIDs
EPHA3_HUMAN112 PMIDs
EP300_HUMAN113 PMIDs
EFS_HUMAN114 PMIDs
EFNA5_HUMAN115 PMIDs
E41L3_HUMAN116 PMIDs
DYN3_HUMAN117 PMIDs
DUS15_HUMAN118 PMIDs
DOK3_HUMAN119 PMIDs
DOK2_HUMAN120 PMIDs
DOK1_HUMAN121 PMIDs
DOCK3_HUMAN122 PMIDs
DNSL2_HUMAN123 PMIDs
DLX4_HUMAN124 PMIDs
DLGP4_HUMAN125 PMIDs
DLGP3_HUMAN126 PMIDs
DLGP2_HUMAN127 PMIDs
DLGP1_HUMAN128 PMIDs
DKKL1_HUMAN129 PMIDs
DDX41_HUMAN130 PMIDs
DCE1_HUMAN131 PMIDs
DAAM1_HUMAN131 PMIDs
CUL7_HUMAN132 PMIDs
CTND2_HUMAN133 PMIDs
CTGE5_HUMAN134 PMIDs
CT046_HUMAN135 PMIDs
CSMD2_HUMAN136 PMIDs
CP4F2_HUMAN137 PMIDs
CNTP1_HUMAN138 PMIDs
CNTFR_HUMAN139 PMIDs
CHRD_HUMAN140 PMIDs
CENPA_HUMAN141 PMIDs
CELR3_HUMAN142 PMIDs
CDON_HUMAN142 PMIDs
CDKL5_HUMAN143 PMIDs
CD2AP_HUMAN144 PMIDs
CBL_HUMAN145 PMIDs
CATA_HUMAN146 PMIDs
CASL_HUMAN147 PMIDs
CABL2_HUMAN148 PMIDs
CABL1_HUMAN149 PMIDs
BTK_HUMAN150 PMIDs
BMP8B_HUMAN151 PMIDs
BIN1_HUMAN152 PMIDs
BCR_HUMAN153 PMIDs
BAZ2A_HUMAN154 PMIDs
ASB16_HUMAN155 PMIDs
ASAP1_HUMAN156 PMIDs
APOL5_HUMAN157 PMIDs
APBB1_HUMAN158 PMIDs
AKAP6_HUMAN159 PMIDs
AIRE_HUMAN160 PMIDs
ADA15_HUMAN161 PMIDs
ACTS_HUMAN162 PMIDs
ACAP1_HUMAN163 PMIDs
ABL2_HUMAN164 PMIDs
ABL1_HUMAN165 PMIDs
ABI2_HUMAN166 PMIDs
ABI1_HUMAN167 PMIDs
3BP2_HUMAN168 PMIDs
3BP1_HUMAN169 PMIDs
1433Z_HUMAN170 PMIDs
1433T_HUMAN171 PMIDs
1433S_HUMAN172 PMIDs
1433F_HUMAN173 PMIDs