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Target Details

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Name:5-HT-6
Uniprot name:5HT6R_HUMAN
Accession Numbers:P50406 Q13640 Q5TGZ1
EC-Number:-
Organism:Homo sapiens
Human
PDB IDs:-
KEGG Pathways:show KEGG Pathways
Drugs:
NamePubChem IDSourceReferencesInteraction
(4-fluorophenyl)-[1-[2-(2-iodophenyl)ethyl]-4-piperidyl]methanone11016205BindingDB-show
(4-fluorophenyl)-[1-[2-(4-iodophenyl)ethyl]-4-piperidyl]methanone10873805BindingDB-show
1-(2-aminopropyl)-2H-indazol-6-one9834183BindingDB-show
1-(2-Methoxyphenyl)piperazine hydrochloride1346BindingDB-show
1-(benzenesulfonyl)-3-[(1-methylpyrrolidin-2-yl)methyl]indole11624561BindingDB-show
1-Benzyl-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole563919BindingDB-show
1-Naphthylpiperazine1342BindingDB-show
1-sulfonylindazole, 6a25263297BindingDB-show
1-sulfonylindazole, 6b25263298BindingDB-show
1-sulfonylindazole, 6c23624307BindingDB-show
1-sulfonylindazole, 6d25263299BindingDB-show
1-sulfonylindazole, 6e25263300BindingDB-show
1-sulfonylindazole, 6f25263301BindingDB-show
1-sulfonylindazole, 6g24771124BindingDB-show
1-sulfonylindazole, 7a24771120BindingDB-show
1-sulfonylindazole, 7b25263302BindingDB-show
1-sulfonylindazole, 824771185BindingDB-show
1-[3-(3,5-dimethyl-1H-pyrazol-1-yl)-4-nitrophenyl]piperazine2771418BindingDB-show
1-[4-(benzenesulfonyl)phenyl]piperazine5113605BindingDB-show
2-(5-Methoxy-2-methyl-1H-indol-3-yl)ethanamine52899BindingDB-show
2-ethyl-5-methoxy-N,N-dimethyltryptamine6918513BindingDB-show
2-Methylserotonin1574BindingDB-show
2-[4-[4-(3-methoxyphenyl)piperazin-1-yl]butyl]-4-methyl-1,2,4-triazine-3,511948707BindingDB-show
2-[4-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]butyl]-4-methyl-1,2,4-tri11676174BindingDB-show
2-[5-(4-Methyl-piperazin-1-yl)-2-nitro-phenyl]-4-phenyl-2H-phthalazin-1-on2848343BindingDB-show
3-(2-dimethylaminoethyl)-N-methyl-1H-indole-5-sulfonamide4713248BindingDB-show
3-Mtpi152215BindingDB-show
4-(1,2,3,4-tetrahydrocarbazol-9-ylsulfonyl)aniline6918748BindingDB-show
4-(1-Piperazinyl)-1H-indole594590BindingDB-show
4-(1H-Inden-1-ylidenemethyl)aniline6476992BindingDB-show
4-(1H-indol-3-ylmethyl)aniline4301799BindingDB-show
4365 CT49756BindingDB-show
5-(4-methylpiperazin-1-yl)-2-nitro-N-(1-phenylethyl)aniline2906325BindingDB-show
5-Carboxyamidotryptamine1809BindingDB-show
5-methoxy-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole3066250BindingDB-show
5-thiazolylsulfonyl tryptamine, 11p24768513BindingDB-show
6-Methoxyharmalan5474706BindingDB-show
7-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole599482BindingDB-show
740873-06-711430856BindingDB-show
8-OH-Dpat1220BindingDB-show
9,10-Didehydro-N,N-diethyl-6-methylergoline-8-carboxamide (8alpha)-3083747BindingDB-show
9-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-5,7-diazabicyclo[4.3.0]nona-210267394BindingDB-show
A3008/01267482906559BindingDB-show
AC1MDYLE2845118BindingDB-show
AC1MEFXP2854567BindingDB-show
AC1MFADM2891368BindingDB-show
AC1MFEYE2870667BindingDB-show
AC1MHMQZ3028929BindingDB-show
AC1OCFJ36918515BindingDB-show
AG-205/365650313643745BindingDB-show
Almotriptan123606SuperTarget-show
Ambcb560770511632439BindingDB-show
BARETTIN11177588BindingDB-show
BAS 005470272855326BindingDB-show
BAS 027377763142696BindingDB-show
Bromlysergamide10171BindingDB-show
Bromoergocriptine31101BindingDB-show
CBMicro_002666627240BindingDB-show
CBMicro_002888616691BindingDB-show
CHEBI:42322844400749BindingDB-show
CHEBI:42323244400751BindingDB-show
CHEBI:42325344400759BindingDB-show
CHEBI:42325444400760BindingDB-show
CHEBI:42332344400787BindingDB-show
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CHEBI:42334344400792BindingDB-show
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CHEBI:42354544400876BindingDB-show
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CHEBI:42366344400916BindingDB-show
CHEBI:42367644400925BindingDB-show
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CHEBI:42369244400929BindingDB-show
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CHEBI:42402444401127BindingDB-show
CHEBI:64897144390043BindingDB-show
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CHEMBL10347910020895BindingDB-show
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CHEMBL57527044474624BindingDB-show
CHEMBL57631222028199BindingDB-show
CHEMBL57631510380133BindingDB-show
CHEMBL57696745483628BindingDB-show
CHEMBL57757044474628BindingDB-show
CHEMBL57768745484381BindingDB-show
CHEMBL57799445488171BindingDB-show
CHEMBL57802345483629BindingDB-show
CHEMBL57841145488131BindingDB-show
CHEMBL57863144474630BindingDB-show
CHEMBL57882611709684BindingDB-show
CHEMBL57906345484352BindingDB-show
CHEMBL58338945484322BindingDB-show
CHEMBL58367745487140BindingDB-show
CHEMBL58389645487112BindingDB-show
CHEMBL58404610067306BindingDB-show
CHEMBL58404945484384BindingDB-show
CHEMBL58427245488183BindingDB-show
CHEMBL58447445484339BindingDB-show
CHEMBL58455445482789BindingDB-show
CHEMBL58469045488152BindingDB-show
CHEMBL58509845484399BindingDB-show
CHEMBL58531345488156BindingDB-show
CHEMBL58593011725505BindingDB-show
CHEMBL58593122028185BindingDB-show
CHEMBL58914744126325BindingDB-show
CHEMBL58914846225000BindingDB-show
CHEMBL58914946225001BindingDB-show
CHEMBL58915046225027BindingDB-show
CHEMBL58938646224941BindingDB-show
CHEMBL58938844126272BindingDB-show
CHEMBL58938944126270BindingDB-show
CHEMBL59156846224878BindingDB-show
CHEMBL59156946224916BindingDB-show
CHEMBL59157046224917BindingDB-show
CHEMBL59180146224918BindingDB-show
CHEMBL59180346225002BindingDB-show
CHEMBL59193945378935BindingDB-show
CHEMBL59194045378936BindingDB-show
CHEMBL59227146224914BindingDB-show
CHEMBL59251446224915BindingDB-show
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CHEMBL59251646224944BindingDB-show
CHEMBL59275146224973BindingDB-show
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CHEMBL59544911957735BindingDB-show
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CHEMBL59700225122651BindingDB-show
CHEMBL59700925117677BindingDB-show
CHEMBL59822925123014BindingDB-show
CHEMBL59844325123013BindingDB-show
CHEMBL59844425117676BindingDB-show
CHEMBL59885025122653BindingDB-show
CHEMBL59885125122654BindingDB-show
CHEMBL59902325117681BindingDB-show
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CHEMBL59946625117680BindingDB-show
CHEMBL59966325122652BindingDB-show
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CHEMBL60130446224880BindingDB-show
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CHEMBL60640125123012BindingDB-show
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CHLORPROTHIXENE667466BindingDB-show
CID 1036536411743399BindingDB-show
CID 1047214310947658BindingDB-show
CID 1047214311121216BindingDB-show
CID 1047214310472143BindingDB-show
CID 69186016918601BindingDB-show
CID 98560419856041BindingDB-show
CID 986488211003533BindingDB-show
CID 99353879913554BindingDB-show
Clozapine2818BindingDB-show
Clozapine2818SuperTarget2 PMIDsshow
CPMPP-35311200BindingDB-show
Cyproheptadine2913SuperTarget-show
Cyproheptadine13770SuperTarget-show
Diethyltryptamine6090BindingDB-show
Dihydroharman5316718BindingDB-show
Dimeboline197033BindingDB-show
DIMETHYLTRYPTAMINE6089DrugBank-show
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Fluorophenazine3372BindingDB-show
GR 127935 hydrochloride107780BindingDB-show
Granisetron Monohydrochloride3510DrugBank-show
Granisetron Monohydrochloride3510SuperTarget-show
Haloperidol3559BindingDB-show
indenylsulfonamide, 1416112801BindingDB-show
indenylsulfonamide, 1516718920BindingDB-show
indenylsulfonamide, 2816718922BindingDB-show
indenylsulfonamide, 3016718919BindingDB-show
indenylsulfonamide, 47+4844263494BindingDB-show
indenylsulfonamide, 5144263496BindingDB-show
indenylsulfonamide, 5244263497BindingDB-show
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Leucoharmine5280953BindingDB-show
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meta-chlorophenylpiperazine1355BindingDB-show
Methiothepine4106BindingDB-show
Methoxydimethyltryptamines1832BindingDB-show
Methoxytryptamine1833BindingDB-show
Mianserin Monohydrochloride4184BindingDB-show
N,N-dimethyl-2-(1-phenethylindol-3-yl)ethanamine3028955BindingDB-show
N-(3-aminophenyl)benzenesulfonamide11849198BindingDB-show
N-Demethyllysergic acid diethylamide169713BindingDB-show
N-[9-(1-methyl-4-piperidyl)-2,7-diazabicyclo[4.3.0]nona-2,4,8,10-tetraen-39947817BindingDB-show
N1-arylsulfony indole, 724768514BindingDB-show
Neoperidole16362BindingDB-show
NSC681515356928BindingDB-show
Octahydro-2H-pyrido[1,2-a]pyrazine2876391BindingDB-show
Octoclothepine1238BindingDB-show
Olanzapine4585BindingDB-show
Olanzapine4585SuperTarget2 PMIDsshow
ONDANSETRON HYDROCHLORIDE4595DrugBank-show
ONDANSETRON HYDROCHLORIDE4595SuperTarget-show
PDSP1_0003726918542BindingDB-show
PDSP1_0013735312149BindingDB-show
PDSP1_0013746918553BindingDB-show
PDSP1_00138910331436BindingDB-show
PDSP2_0013566918648BindingDB-show
Phenothiazine4926BindingDB-show
piperidinylindole, 79902533BindingDB-show
pyridylpiperidine, 13a25263326BindingDB-show
pyridylpiperidine, 13b25263327BindingDB-show
pyridylpiperidine, 13c25263328BindingDB-show
pyridylpiperidine, 13d25263329BindingDB-show
pyridylpiperidine, 13e25263330BindingDB-show
pyridylpiperidine, 13f25263331BindingDB-show
pyridylpiperidine, 13g25263332BindingDB-show
pyridylpiperidine, 13h25263333BindingDB-show
pyridylpiperidine, 13j25263334BindingDB-show
pyridylpiperidine, 13k25263335BindingDB-show
pyridylpiperidine, 13m25263336BindingDB-show
pyridylpiperidine, 13n25263337BindingDB-show
pyridylpiperidine, 13p25263338BindingDB-show
pyridylpiperidine, 13q25263339BindingDB-show
pyridylpiperidine, 13r25263340BindingDB-show
pyridylpiperidine, 13s25263341BindingDB-show
pyrrolidinylindole, (R)-5b11351089BindingDB-show
pyrrolidinylindole, (S)-5b11235953BindingDB-show
pyrrolidinylindole, 610136837BindingDB-show
Quetiapine5002BindingDB-show
QUIPAZINE5011BindingDB-show
Risperidonum5073BindingDB-show
Risperidonum5073SuperTargetPMID 014741325show
Ro 04-6790 dihydrochloride5312145BindingDB-show
Ro 63-05635312144BindingDB-show
Ro-65-71996918531BindingDB-show
RO-66-00746918689BindingDB-show
SB 243213443391BindingDB-show
SB-2141116918647BindingDB-show
SB-2710466918455BindingDB-show
SB-74245711256720BindingDB-show
sertindole hydrochloride60149DrugBank-show
SMR000122729744368BindingDB-show
Spiroperidol5265BindingDB-show
ST0274305206725BindingDB-show
ST0531572771422BindingDB-show
ST0532434494260BindingDB-show
STK1488652906372BindingDB-show
STK1504272866185BindingDB-show
Sumatriptanum5358SuperTarget-show
Tetrahydronorharmane107838BindingDB-show
Thrombocytin5202BindingDB-show
Tocris-0912108029BindingDB-show
tolylpiperazine, 125263303BindingDB-show
tolylpiperazine, 5a25263304BindingDB-show
tolylpiperazine, 5b25263305BindingDB-show
tolylpiperazine, 5c25263306BindingDB-show
tolylpiperazine, 5d25263307BindingDB-show
tolylpiperazine, 5e25263308BindingDB-show
tolylpiperazine, 5f25263309BindingDB-show
tolylpiperazine, 5g25263310BindingDB-show
tolylpiperazine, 5h25263311BindingDB-show
tolylpiperazine, 5j25263312BindingDB-show
tolylpiperidine, 17a25263342BindingDB-show
tolylpiperidine, 17b25263343BindingDB-show
tolylpiperidine, 18a25263344BindingDB-show
tolylpiperidine, 18b25263345BindingDB-show
tolylpiperidine, 18c25263346BindingDB-show
tolylpiperidine, 18d25263347BindingDB-show
tolylpiperidine, 18e25263348BindingDB-show
tolylpiperidine, 18f25263349BindingDB-show
tolylpiperidine, 18g25263350BindingDB-show
tolylpiperidine, 18h25263351BindingDB-show
tolylpiperidine, 18j25263352BindingDB-show
tolylpiperidine, 18k25263353BindingDB-show
tolylpiperidine, 18m25263354BindingDB-show
tolylpiperidine, 18n25263355BindingDB-show
tolylpiperidine, 9a25263313BindingDB-show
tolylpiperidine, 9b25263314BindingDB-show
tolylpiperidine, 9c25263315BindingDB-show
tolylpiperidine, 9d25263316BindingDB-show
tolylpiperidine, 9e25263317BindingDB-show
tolylpiperidine, 9f25263318BindingDB-show
tolylpiperidine, 9g25263319BindingDB-show
tolylpiperidine, 9h25263320BindingDB-show
tolylpiperidine, 9j25263321BindingDB-show
tolylpiperidine, 9k25263322BindingDB-show
tolylpiperidine, 9m25263323BindingDB-show
tolylpiperidine, 9n25263324BindingDB-show
tolylpiperidine, 9p25263325BindingDB-show
Tryptamine hydrochloride1150BindingDB-show
WAY-18118710150497BindingDB-show
WAY-25680524894910BindingDB-show
WAY-46611431598BindingDB-show
ZERO/0062762771410BindingDB-show
ZERO/0062772771419BindingDB-show
ZINC041935716625986BindingDB-show
ZINC043133177183407BindingDB-show
ZINC043161227184883BindingDB-show
ZINC043161317184892BindingDB-show
ZINC043161347184895BindingDB-show
ZINC043162247184976BindingDB-show
ZINC044840287246142BindingDB-show
ZINC050432367470702BindingDB-show
Ziprasidone hydrochloride60854BindingDB-show
[2-(4-Chloro-phenoxy)-ethyl]-(2-nitro-5-piperazin-1-yl-phenyl)-amine2894562BindingDB-show
Synonyms:
5-HT-6
5-hydroxytryptamine receptor 6
Serotonin receptor 6
Similar targets:
Uniprot name% Sequence similarity% Sequence identity
DRD1_HUMAN46.530
ADA1A_HUMAN45.927.5
Q546Q1_HUMAN43.428.1
Q8IXH9_HUMAN43.428.1
5HT4R_HUMAN43.428.1
Q7Z5R9_HUMAN43.228.7
Q712M9_HUMAN42.627.6
ADRB3_HUMAN42.429.5
ADRB1_HUMAN4228.5
HRH2_HUMAN41.626.7
DRD5_HUMAN40.228
Q684M0_HUMAN40.226
ADRB2_HUMAN39.925.2
ADA1B_HUMAN3927.2
5HT1D_HUMAN38.824.3
5HT7R_HUMAN38.425.7
Q5VX03_HUMAN38.425.7
5HT2C_HUMAN37.723.2
5HT2A_HUMAN37.223.8
5HT2B_HUMAN37.223.8
TAAR1_HUMAN37.123.7
5HT5A_HUMAN37.123.4
DRD4_MOUSE36.924.4
5HT1F_HUMAN36.622.9
Q9P2Q4_HUMAN36.222.5
AA2AR_HUMAN36.123
5HT1E_HUMAN36.122.6
5HT1A_HUMAN36.123.6
Q5ZGX3_HUMAN35.923.2
SSR5_HUMAN35.823.7
Protein-Protein Interactions:
Uniprot nameSource
GNAS1_HUMANPMID 11916537