Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:969516
Structure:
Synonyms:
"curcumin; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione"
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
(1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,5-Di(vanillyliden)acetylaceton
1,5-Divanillyliden-2,4-pentandion
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
15845-47-3
2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-
33171-04-9
4-08-00-03697 (Beilstein Handbook Reference)
458-37-7
73729-23-4
79257-48-0
8024-37-1
91884-86-5
98% curcurmin)
AC-10434
AC1LJ6T6
AC1Q46A0
AIDS-040146
AIDS040146
AKOS001305497
BIDD:ER0479
Bio-0677
BRD-K07572174-001-02-2
BRN 2306965
C.I. 75300
C.I. Natural Yellow 3
C1386_SIGMA
C21H20O6
C7727_SIGMA
CCG-36020
CCG-36107
CCRIS 3257
CCRIS 5804
CHEBI:3962
CI 75300
CI Natural Yellow 3
cMAP_000052
CU-01000001305-2
Cucurmin
Curcuma
Curcuma longa l. oil
Curcuma longa l. oleoresin
Curcuma longa l. root oil
Curcuma longa l. root oleoresin
Curcuma longa oils
Curcuma oil
Curcuma oil (Curcuma longa)
CURCUMIN
Curcumin (Natural)
CURCUMIN (SEE ALSO TUMERIC, OLEORESIN (10105-J))
Curcumin I
Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Curcumine
Curcurmin
curouma
D003474
Diferaloylmethane
Diferuloylmethane
Diferulylmethane
E 100
E-100
EINECS 207-280-5
FEMA No. 3085
FEMA No. 3086
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
HMS2233K04
HSDB 4334
Hydrastis
I06-0010
Indian saffron
Indian turmeric
K00009
Kacha haldi
kachs haldi
Kurkumin
Kurkumin [Czech]
LS-125
LS-2189
Merita earth
MLS000069631
MLS001148449
MolPort-001-763-682
Natural yellow 3
NCGC00017159-04
NCGC00017159-05
NCGC00017159-06
NCGC00017159-07
NCGC00017159-08
NCGC00017159-09
NCGC00017159-10
NCGC00017159-11
NCGC00017159-12
NCGC00023332-03
NCGC00023332-04
NCGC00023332-05
nchembio.364-comp3
NCI-C61325
NSC 32982
NSC 687842
NSC-32982
NSC32982
NSC687842
oil of turmeric
Oils, curcuma
Orange Root
PREVENTION 4 (CURCUMIN) (SEE ALSO TUMERIC, OLEORESIN (10105-J))
safra d'inde
Safran d'Inde
SBB006495
SMR000058237
Souchet
ST055629
Terra Merita
Tu rmeric root oil
tumeric
Tumeric oleoresin
tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric extract
Turmeric extract (Curcuma longa L.)
turmeric oil
Turmeric oil (Curcuma longa L.)
Turmeric Oleoresin
Turmeric oleoresin (79%-85% curcumin)
Turmeric root oil
Turmeric root oleoresin
Turmeric yellow
Turmeric, oleoresin
TURMERIC, OLEORESIN (CURCUMIN) (SEE ALSO CURCURMIN (458-37-7))
Yellow ginger
Yellow puccoon
Yellow root
Yellow, Turmeric
Yo-kin
ZINC00899824
Zlut prirodni 3
Zlut prirodni 3 [Czech]

Target

show target details
Uniprot ID:Q62710_RAT
Synonyms:
Nitric oxide synthase
EC-Numbers:-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

14634121
Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia.. Hee Young Kim; Eun Jung Park; Eun-Hye Joe; Ilo Jou (2003) Journal of immunology (Baltimore, Md. : 1950) display abstract
Curcumin has been strongly implicated as an anti-inflammatory agent, but the precise mechanisms of its action are largely unknown. In this study, we show that the inhibitory action of curcumin on Janus kinase (JAK)-STAT signaling can contribute to its anti-inflammatory activity in the brain. In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma-stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes. These anti-inflammatory effects appear to be due, at least in part, to the suppression of the JAK-STAT inflammatory signaling cascade. Curcumin markedly inhibited the phosphorylation of STAT1 and 3 as well as JAK1 and 2 in microglia activated with gangliosides, LPS, or IFN-gamma. Curcumin consistently suppressed not only NF binding to IFN-gamma-activated sequence/IFN-stimulated regulatory element, but also the expression of inflammation-associated genes, including ICAM-1 and monocyte chemoattractant protein 1, whose promoters contain STAT-binding elements. We further show that activation of Src homology 2 domain-containing protein tyrosine phosphatases (SHP)-2, a negative regulator of JAK activity, is likely to be one of the mechanisms underlying the curcumin-mediated inhibition of JAK-STAT signaling. Treatment of microglial cells with curcumin led to an increase in phosphorylation and association with JAK1/2 of SHP-2, which inhibit the initiation of JAK-STAT inflammatory signaling in activated microglia. Taken together, these data suggest curcumin suppresses JAK-STAT signaling via activation of SHP-2, thus attenuating inflammatory response of brain microglial cells.