Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:969516
Structure:
Synonyms:
"curcumin; 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione"
(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
(1E,6E)-1,7-bis[4-hydroxy-3-(methyloxy)phenyl]hepta-1,6-diene-3,5-dione
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,5-Di(vanillyliden)acetylaceton
1,5-Divanillyliden-2,4-pentandion
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-
1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-
1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione
15845-47-3
2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-
33171-04-9
4-08-00-03697 (Beilstein Handbook Reference)
458-37-7
73729-23-4
79257-48-0
8024-37-1
91884-86-5
98% curcurmin)
AC-10434
AC1LJ6T6
AC1Q46A0
AIDS-040146
AIDS040146
AKOS001305497
BIDD:ER0479
Bio-0677
BRD-K07572174-001-02-2
BRN 2306965
C.I. 75300
C.I. Natural Yellow 3
C1386_SIGMA
C21H20O6
C7727_SIGMA
CCG-36020
CCG-36107
CCRIS 3257
CCRIS 5804
CHEBI:3962
CI 75300
CI Natural Yellow 3
cMAP_000052
CU-01000001305-2
Cucurmin
Curcuma
Curcuma longa l. oil
Curcuma longa l. oleoresin
Curcuma longa l. root oil
Curcuma longa l. root oleoresin
Curcuma longa oils
Curcuma oil
Curcuma oil (Curcuma longa)
CURCUMIN
Curcumin (Natural)
CURCUMIN (SEE ALSO TUMERIC, OLEORESIN (10105-J))
Curcumin I
Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Curcumine
Curcurmin
curouma
D003474
Diferaloylmethane
Diferuloylmethane
Diferulylmethane
E 100
E-100
EINECS 207-280-5
FEMA No. 3085
FEMA No. 3086
Gelbwurz
Golden seal
Haidr
Halad
Haldar
Halud
HMS2233K04
HSDB 4334
Hydrastis
I06-0010
Indian saffron
Indian turmeric
K00009
Kacha haldi
kachs haldi
Kurkumin
Kurkumin [Czech]
LS-125
LS-2189
Merita earth
MLS000069631
MLS001148449
MolPort-001-763-682
Natural yellow 3
NCGC00017159-04
NCGC00017159-05
NCGC00017159-06
NCGC00017159-07
NCGC00017159-08
NCGC00017159-09
NCGC00017159-10
NCGC00017159-11
NCGC00017159-12
NCGC00023332-03
NCGC00023332-04
NCGC00023332-05
nchembio.364-comp3
NCI-C61325
NSC 32982
NSC 687842
NSC-32982
NSC32982
NSC687842
oil of turmeric
Oils, curcuma
Orange Root
PREVENTION 4 (CURCUMIN) (SEE ALSO TUMERIC, OLEORESIN (10105-J))
safra d'inde
Safran d'Inde
SBB006495
SMR000058237
Souchet
ST055629
Terra Merita
Tu rmeric root oil
tumeric
Tumeric oleoresin
tumeric yellow
Turmeric
Turmeric (>98% curcurmin)
Turmeric extract
Turmeric extract (Curcuma longa L.)
turmeric oil
Turmeric oil (Curcuma longa L.)
Turmeric Oleoresin
Turmeric oleoresin (79%-85% curcumin)
Turmeric root oil
Turmeric root oleoresin
Turmeric yellow
Turmeric, oleoresin
TURMERIC, OLEORESIN (CURCUMIN) (SEE ALSO CURCURMIN (458-37-7))
Yellow ginger
Yellow puccoon
Yellow root
Yellow, Turmeric
Yo-kin
ZINC00899824
Zlut prirodni 3
Zlut prirodni 3 [Czech]

Target

show target details
Uniprot ID:AKT1_MOUSE
Synonyms:
AKT1 kinase
C-AKT
PKB
Protein kinase B
RAC-alpha serine/threonine-protein kinase
RAC-PK-alpha
Thymoma viral proto-oncogene
EC-Numbers:2.7.11.1
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

17182546
Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth.. Murali Gururajan; Trivikram Dasu; Seif Shahidain; C Darrell Jennings; Darrell A Robertson; Vivek M Rangnekar; Subbarao Bondada (2007) Journal of immunology (Baltimore, Md. : 1950) display abstract
Curcumin (diferuloylmethane), a component of dietary spice turmeric (Curcuma longa), has been shown in recent studies to have therapeutic potential in the treatment of cancer, diabetes, arthritis, and osteoporosis. We investigated the ability of curcumin to modulate the growth of B lymphomas. Curcumin inhibited the growth of both murine and human B lymphoma in vitro and murine B lymphoma in vivo. We also demonstrate that curcumin-mediated growth inhibition of B lymphoma is through inhibition of the survival kinase Akt and its key target Bad. However, in vitro kinase assays show that Akt is not a direct target of curcumin. We identified a novel target for curcumin in B lymphoma viz spleen tyrosine kinase (Syk). Syk is constitutively activated in primary tumors and B lymphoma cell lines and curcumin down-modulates Syk activity accompanied by down-regulation of Akt activation. Moreover, we show that overexpression of Akt, a target of Syk, or Bcl-x(L), a target of Akt can overcome curcumin-induced apoptosis of B lymphoma cells. These observations suggest a novel growth promoting role for Syk in lymphoma cells.