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Drug-Target Interaction

Drug

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PubChem ID:936
Structure:
Synonyms:
.beta.-Pyridinecarboxamide
11032-50-1
123574-63-0
1yc5
3 Pyridinecarboxamide
3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
37321-14-5
47865U_SUPELCO
55600-01-6
6-aminonicotinamide
63748-44-7
72340_FLUKA
72340_SIGMA
72347_FLUKA
78731-47-2
98-92-0
A186B02E-6C70-4E54-9739-79398D439AAA
AC-907/25014114
AC1L1ACZ
AC1Q4ZFV
Acid amide
AG-227/20370056
AG-I-00582
AI3-02906
AIDS-008919
AIDS008919
Amid kyseliny nikotinove
Amid kyseliny nikotinove [Czech]
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Antipellagra vitamin
Astra Brand of Niacinamide
Austrovit PP
B 3, Vitamin
B3, Vitamin
BB_NC-2290
Benicot
BEROCCA PN
beta-Pyridinecarboxamide
bmse000281
C00153
C6H6N2O
CCG-101149
CCRIS 1901
CERNEVIT-12
CHEBI:17154
CHEMBL1140
CPD000058212
D00036
D009536
DB02701
DEA No. 1405
Delonin Amide
Dipegyl
EINECS 202-713-4
EINECS 234-265-0
Endobion
Enduramide
Factor pp
Hansamid
HMS2052M21
HMS2090B05
HMS2093H03
HMS2236J03
HSDB 1237
I02-1741
I02-2250
INFUVITE PEDIATRIC
Inovitan PP
Jenapharm Brand of Niacinamide
Jenapharm, Nicotins?ureamid
LS-2051
m-(Aminocarbonyl)pyridine
M.V.C. 9+3
M.V.I. PEDIATRIC
M.V.I.-12
M.V.I.-12 LYOPHILIZED
Mediatric
Merck Brand of Niacinamide
Mixture Name
MLS000069714
MolMap_000061
MolPort-001-783-876
MULTI-12
MVC PLUS
N0078
N0636_SIGMA
N2142_SIGMA
N3376_SIGMA
N5535_SIAL
NA
NAM
Nandervit-N
NCA
NCGC00093354-03
NCGC00093354-04
NCGC00093354-05
NCGC00093354-06
nchembio.154-comp4
nchembio.73-comp6
Niacevit
niacin - Vitamin B3
NIACINAMIDE
Niacinamide (USP)
Niacinamide Astra Brand
Niacinamide Jenapharm Brand
Niacinamide Merck Brand
Niacinamide Pharmagenix Brand
Niacinamide [USAN]
Niacinamide, Nicotinic acid amide, Nicotinamide
Niacotinamide
Niamide
Niavit PP
Nicamide
Nicamina
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicosylamide
Nicota
Nicotamide
Nicotilamide
Nicotililamido
Nicotinamid
Nicotinamida
Nicotinamida [INN-Spanish]
nicotinamide
Nicotinamide (JP15/INN)
Nicotinamide (JP16/INN)
Nicotinamide (Niacinamide)
Nicotinamide, niacin, vitamin B3
Nicotinamide-carbonyl-14C
Nicotinamide-Supplied by Selleck Chemicals
Nicotinamidum
Nicotinamidum [INN-Latin]
Nicotine acid amide
Nicotine amide
Nicotinic acid amide
Nicotinic amide
Nicotins?ureamid Jenapharm
Nicotinsaeureamid
Nicotinsaureamid
Nicotinsaureamid [German]
Nicotol
Nicotylamide
Nicotylamidum
Nicovel
Nicovit
Nicovitina
Nicovitol
Nicozymin
Nikasan
Nikazan
Niko-tamin
Nikotinamid
Nikotinsaeureamid
Nikotinsaeureamid [German]
Niocinamide
Niozymin
NSC 13128
NSC13128
NSC27452
Papulex
Pellagra preventive factor
Pelmin
Pelmine
Pelonin amide
Pharmagenix Brand of Niacinamide
PP factor
PP-Faktor
Pyridine, 3-carbamoyl-
pyridine-3-carboxamide
Pyridine-3-carboxylic acid amide
S1899_Selleck
SAM001246860
Savacotyl
SBB004283
SGCUT00176
SMR000058212
to_000073
TPN SUSPENSION
UNII-25X51I8RD4
Vi-Nicotyl
Vitamin B
Vitamin B (VAN)
Vitamin B 3
Vitamin B3
Vitamin H1
vitamin PP
Vitamin- B3
Vitamin-?B3
VITAPED
Witamina PP
WLN: T6NJ CVZ
ZINC00005878
ATC-Codes:

Target

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Uniprot ID:DCHS_RAT
Synonyms:
HDC
Histidine decarboxylase
EC-Numbers:4.1.1.22
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

2521450
Induction of histidine decarboxylase in rat basophilic leukemia cells by interferon and prevention of its effect in coincubation with ADP-ribosyltransferase inhibitors.. T Kito; M Kubota; T Takimoto; Y Akiyama; T Heike; H Mikawa (1989) Biochemical and biophysical research communications display abstract
Treatment of rat basophilic leukemia cell line (2H3) with interferon-alpha significantly increased intracellular histamine levels. On the other hand, the histidine content was decreased reciprocally by interferon in a dose-dependent manner. Concomitantly, the activity of histidine decarboxylase, the enzyme responsible for histamine synthesis, was augmented. The increase in histidine decarboxylase activity was partially abolished in co-incubation with inhibitors of ADP-ribosyltransferase, such as 3-aminobenzamide or nicotinamide. These results suggest the pivotal role of activation of histidine decarboxylase, presumably through ADP-ribosylation of the enzyme, in interferon-induced histamine synthesis.