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Drug-Target Interaction

Drug

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PubChem ID:9321
Structure:
Synonyms:
1184-66-3
119775-10-9
13464-80-7
13464-97-6
13464-97-6 (mononitrate)
15823-35-5
215155_SIAL
302-01-2
309400_ALDRICH
31886-26-7
37836-27-4
37836-27-4 (nitrate)
433632_ALDRICH
5341-61-7
5341-61-7 (di-hydrochloride)
59779-45-2
634-62-8
634-62-8 (tartrate)
75013-58-0
7803-57-8
7803-57-8 (monohydrate)
AC1L1ST4
AC1Q54OK
AG-E-99009
AKOS000269060
Ambap10217-52-4
C05361
CCRIS 335
CHEBI:15571
CHEMBL1237174
Diamide
Diamine
diazane
EINECS 206-114-9
H2NNH2
HDZ
HSDB 544
Hydrazin
Hydrazine
Hydrazine (anhydrous)
HYDRAZINE (HYDRAZINE SULFATE)
Hydrazine base
Hydrazine solution
hydrazine sulfate
Hydrazine, anhydrous
Hydrazine, anhydrous or hydrazine aqueous solutions with >64% hydrazine, by mass [UN2029] [Corrosive]
Hydrazine, anhydrous or hydrazine aqueous solutions with >64% hydrazine, by mass [UN2029] [Corrosive]
Hydrazine, aqueous solution with not >37% hydrazine, by mass [UN3293]
Hydrazine, aqueous solution with not >37% hydrazine, by mass [UN3293] [Poison]
Hydrazine, aqueous solution with not >37% hydrazine, by mass [UN3293] [Poison]
Hydrazine/Hydrazine sulfate
Hydrazines
Hydrazyna
Hydrazyna [Polish]
Jsp005701
Levoxine
LS-1153
N2H4
Nitrogen hydride
Oxytreat 35
RCRA waste no. U133
RCRA waste number U133
ST5214533
UN2029
UN3293

Target

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Uniprot ID:A4TB13_MYCGI
Synonyms:
Amine oxidase (Copper-containing)
EC-Numbers:1.4.3.6
Organism:Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK
Mycobacterium gilvum
strain PYR-GCK
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8694842
Inhibition of bovine lung semicarbazide-sensitive amine oxidase (SSAO) by some hydrazine derivatives.. J M Lizcano; A Fernández de Arriba; K F Tipton; M Unzeta (1996) Biochemical pharmacology display abstract
Microsomal semicarbazide-sensitive amine oxidase (SSAO) from bovine lung was shown to be inhibited by a number of hydrazine derivatives, but the mechanisms of inhibition were found to differ. Hydralazine behaved as an irreversible and partially time-dependent inhibitor with an IC50 value of 1 microM under the conditions used. Phenylhydrazine was found to be a potent irreversible inhibitor of SSAO (IC50 30 nM). Semicarbazide behaved as a specific irreversible inhibitor (active-site-directed irreversible inhibitor) in first forming a non-covalent enzyme-semicarbazide complex (with a Ki value of 85 microM), which then reacted to give an irreversibly inhibited enzyme species in a reaction defined by the first-order rate constant k2 = 0.065 min-1. Phenelzine behaved as a reversible inhibitor, but dialysis at 37 degrees C was found to be necessary to obtain full recovery of enzyme activity. The dependence of inhibition on phenelzine concentration was complex and consistent with multiple binding sites for this inhibitor. This diversity in the action of a family of compounds with the same functional group must be taken into account in attempts to design more specific inhibitors of this enzyme.